Patient showing NF with eschar formation in upper eyelid in the right eye at the day of admission at the hospital. NF, necrotizing fasciitis.


Tomography presenting preseptal edema and heterogeneous fluid, suggesting abscess in the right eyelid.


Patient presenting the upper eyelid aspect of the right eye minutes after the debridement.


Upper eyelid aspect after 15 days of the debridement.


Upper eyelid aspect after 2 months of debridement with closed.


Opened. Eyes.


(a) OCT macula.


(b and c) GCL OCT.


(d) OCT optic nerve. Stable condition from four months to one year of treatment, some recovery of ANFL from the initial drop after four months.


(a) CT scan showing swellings in the lymph nodes (arrows).


(b) Low-density areas in the spleen were also observed (arrows), suggesting metastasis from a malignant tumor of the left ovary.


18FDG avidity was observed in the lymph nodes (arrows).


In the spleen (arrows).


(a) Microscopic findings of the resected ovarian tumor and lymph nodes. Atypical cells with clear cytoplasm grew papillary, tubulocystic, and focally solid pattern (hematoxylin and eosin [HE.


(b) Non-caseating epithelioid granulomas were observed in the pelvic lymph node as well as in the spleen where there were no metastatic lesions (HE).


Bacilloscopy of smear showing positive bacillus (black arrow).


(A) Synovial fluid aspiration from the interphalangeal joint of the hand.


(B) Acid-fast staining of synovial material from the interphalangeal joint of the hand showed numerous acid-fast bacilli (black arrow).


The image shows a 17 mm high intensity area in the pons on T2-weighted.


Diffusion-weighted. Magnetic resonance imaging (MRI) of the brain.


Pathological specimens. . Notes: (A) Skin biopsy specimen taken from the lower abdomen reveals proliferation of large lymphoma cells filling the vessels of hypodermic adipose tissue. Hematoxylin and eosin staining; magnification.


Pathological specimens. (B) Numerous lymphoma cells with irregular nuclear contours and large nucleoli clustered are seen in small vessel lumens. X40. X100.


Magnetic resonance imaging (MRI) of the brain after receiving chemotherapy. . Notes: Pontine lesion on T2-weighted.


Magnetic resonance imaging (MRI) of the brain after receiving chemotherapy. Diffusion-weighted. MRI of the brain completely resolved after eight cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone therapy.


Transthoracic echocardiography (four-chamber view) showing an echogenic mass attached to the posterior leaflet of the mitral valve (MV) measuring 2.3 cm x 1.3 cm.


Intraoperative transesophegeal echocardiography (color flow Doppler, four-chamber view) showing prosthetic MV repair with severe mitral regurgitation jet.


Pictograph of mitral annuloplasty ring with remnant vegetation and part of the excised native mitral leaflet.


(a) Sagittal T1-W MRI without contrast injection, before the first surgery. An extradural hyposignal lesion is observed at S1-S3 level, which was neglected in the first intervention.


(b) Sagittal T1 MRI with contrast from the lumbosacral region after the first operation. Homogenous enhancement of the lesion is observed.


(c and d) Axial T1 MRI views of the lesion with and without contrast, after the first operation.


(A) CT revealed large dense shadows and cavity formation in the inferior lobe of the left lung.


(B) The results of CT re-examination suggested that, the area of infection in the inferior lobe of the left lung was significantly reduced and the cavity was smaller.


(C) The condition of the lung was further improved than before.


(A) The opening of the left lower lobe is narrow.


(B and C) There is a big and white neoplasm in the lower left lung, with a lot of white necrotic material in the subsegment.


Biopsy revealed chronic inflammation of bronchial mucosa with lymphoid follicular hyperplasia, but no definite tumor cells (400X).


Contrast-enhanced T1-weighted sequences show the brain abscess in the right parietal lobe.


Diffusion-weighted magnetic resonance imaging.


(a, b) Surgical site after durotomy. No pathological alteration of the brain surface under white light.


(a, b) Surgical site after durotomy. , intense fluorescent staining under YE560.


(a, b) Surgical site after opening of the abscess. Drainage of pus under white light.


(a, b) Surgical site after opening of the abscess. And under YE560 Note the nonfluorescence of the pus.


Radiography at eight years post-trauma.


Spherical bur to access the root apical area of the 11.


Apical lesion (granulation tissue) removed from maxillary central incisor.


Granulation tissue for histopathological analysis.


Radiography at six months after surgical procedure.


Follow-up radiography at 53 months from surgical procedure.


Ocular findings at presentation. . Notes:. Ciliary injection, corneal epithelial edema, mutton-fat keratic.


Ocular findings at presentation. . Notes: infiltrating cells in the anterior chamber of the right eye.


Ocular findings at presentation. ;. Pigmentation of the trabecular pigment band in the angle was increased in the right eye.


Ocular findings at presentation. ;. Compared with the left eye.


Ocular findings observed after treatment was started. . Note: Distorted pupil and fan-shaped iris atrophy were observed.


MRI of the patient's abdominal cavity (without contrast). (A) In the upper pole of the right kidney, the lesion of an irregular shape and inhomogeneous structure was connected with the pelvicalyceal system, coronal projection, SSFP mode.


MRI of the patient's abdominal cavity (without contrast). (B) The lesion had an irregular shape and a bumpy surface, 3D-reconstruction from the SSFP series.


MRI of the patient's abdominal cavity (without contrast). (C-E) The multinodular nature of the lesion and clear boundaries were determined in axial sections, T1 mode.


Fragments of the kidney and cystic lesion. Gross evaluation (A,B) demonstrates cystic lesion with adjacent renal parenchyma (p) separated by septa with varying wall thickness. Adhesions tightly connected the lesion with the kidney capsule and adjacent adipose tissue. The lumen was filled with gray-brown cheesy keratinized masses (k). It was connected to the small renal calyx (c) with the isthmus (i). Mucosa of the calyx was gray, smooth, with single overlays of horny masses.


Fragments of the kidney and cystic lesion. (C) The histological study revealed keratinized mass in the lumen of the lesion.


Fragments of the kidney and cystic lesion. (D) The renal parenchyma was separated from the cyst wall with adipose tissue of the renal sinus.


Fragments of the kidney and cystic lesion. (E,F) Three types of epithelium lined the cyst wall: stratified squamous epithelium (sq) with a developed granular layer and hyperkeratosis, urothelium (ur) and simple cuboidal epithelium (cub).


Fragments of the kidney and cystic lesion. (G) We also detected the focuses of chronic inflammatory infiltration.


Fragments of the kidney and cystic lesion. (H) Atrophic renal parenchyma was adjacent to the epithelial lining in some areas.


Immunohistochemical study of kidney cystic lesion. The cyst wall areas contained numerous smooth muscle cells.


Immunohistochemical study of kidney cystic lesion. , singular cells.


Immunohistochemical study of kidney cystic lesion. Or completely lacked the cells.


Immunohistochemical study of kidney cystic lesion. (D-F) The cuboidal epithelium, urothelium and epithelium of the kidney tubules were strongly positive for CK7, while the stratified squamous epithelium did not express the marker.


Immunohistochemical study of kidney cystic lesion. (G-I) The urothelium was positive for uroplakin III, while the cuboidal epithelium expressed this marker weakly and irregularly.


Immunohistochemical study of kidney cystic lesion. (J-L) The multilayer squamous epithelium and tubule epithelium were not stained with antibodies against uroplakin III, but expressed p63. The cuboidal cyst epithelium had weak and focal positive expression of p63, the epithelium of the tubules was not stained.


Photos of the patient before and after 6 cycles of neoadjuvant chemotherapy. (A) Before neoadjuvant chemotherapy, the skin of the left breast was mildly inflamed; the left nipple was inverted; and a hard, palpable mass was present in the left central breast.


Photos of the patient before and after 6 cycles of neoadjuvant chemotherapy. (B) After 6 cycles of chemotherapy, the size of the mass in the left breast was significantly reduced. Drawings show the lesion of interest.


Ultrasound (US) imaging of the left breast and left axilla. (A) Before neoadjuvant chemotherapy, US examination of the left breast mass showed a hypoechoic lesion with inhomogeneous internal echoes.


Ultrasound (US) imaging of the left breast and left axilla. (B) US of left axillary lymph nodes before neoadjuvant chemotherapy showed enlargement and cortical thickening.


Ultrasound (US) imaging of the left breast and left axilla. (C) After 6 cycles of chemotherapy, the size of the mass was significantly reduced.


Ultrasound (US) imaging of the left breast and left axilla. (D) Lymph node size was reduced and the shape nearly returned to normal after chemotherapy.


Magnetic resonance imaging (MRI) before and after chemotherapy. (A) Diffusion-weighted imaging (DWI) before chemotherapy. The signal in the left breast and inner side of the right breast showed heterogeneous enhancement.


Magnetic resonance imaging (MRI) before and after chemotherapy. (B) Arterial phase of enhanced MRI before chemotherapy. Both breasts were composed of asymmetrically distributed dense glands. The whole left breast was markedly enhanced.


Magnetic resonance imaging (MRI) before and after chemotherapy. (C) Time-intensity curve of dynamic contrast enhancement of left breast mass before chemotherapy (outflow type).


Magnetic resonance imaging (MRI) before and after chemotherapy. (D) DWI after chemotherapy. The signal in the left breast and inner side of the right breast showed heterogeneous enhancement that was weaker than before chemotherapy.


Magnetic resonance imaging (MRI) before and after chemotherapy. (E) Arterial phase of enhanced MRI after chemotherapy. Compared to before chemotherapy, the size of lesions in the left breast and upper quadrant of the right breast were significantly reduced.


Magnetic resonance imaging (MRI) before and after chemotherapy. (F) Time-intensity curve of dynamic contrast enhancement in the left breast mass after chemotherapy (plateau type).


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (A) Left breast biopsy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (B) Right breast biopsy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (C) Epithelial membrane antigen (EMA) in left lymph node biopsy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). After chemotherapy,. There were fewer cancer cells in the left breast , while interstitial fibrosis, nuclear enlargement, vacuolation, and number of cells with eosinophilic cytoplasm were increased.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). After chemotherapy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (F) Inflammatory cell infiltration after chemotherapy.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). HER2 positivity of left.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). Right. Breast cancers as detected by IHC.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). Monosomy of chromosome 17 of left.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). Right. Breast cancers detected by FISH.


CT scan of the chest from Day 2 of the 1st hospitalization, showing diffuse ground-glass attenuation and consolidation of the lungs with lower lobe predominance.


CT chest from Day 1 of 2nd admission showing airspace opacities with cavitation.


CT neck image from Day 1 of 2nd admission showing filling defect in R internal jugular vein (denoted by arrow), suggestive of septic thrombophlebitis and Lemierre Syndrome in the setting of Fusobacterium necrophorum bacteremia.


Dual tracer positron emission tomography and computed tomography scan (18F-fluorodeoxyglucose positron emission tomography and computed tomography and 68Ga-DOTATATE positron emission tomography and computed tomography) showing both somatostatin receptor expressing and fluorodeoxyglucose avid hypodense liver lesions, largest in segment IVa and IVb measuring 6.6 x 5.0 cm with SUVmax (18F-fluorodeoxyglucose)-21.3 (panel A) and SUVmax (68Ga-DOTATATE)-33 (panel B).


Dual tracer positron emission tomography and computed tomography evaluation (18F-fluorodeoxyglucose and 68Ga-DOTATATE) demonstrates the progression of disease with fluorodeoxyglucose avid lesions of the lower third part of the esophagus (now measuring approximately 4.5 cm), multiple hypodense liver lesions (largest measuring 7.2 cm x 7 cm), multiple abdominal enlarged lymph nodes (largest perigastric lymph node measuring 4.1 cm x 2.9 cm) all showing more avidity on 18F fluorodeoxyglucose scan (panel A) compared to 68Ga-DOTATATE positron emission tomography and computed tomography (panel B).


(B) Interphase FISH analysis of case 2 using the dual-color BCL3 probe. FISH results demonstrated two intact red/green fusion signals, and 2 red and 2 green split signals, which indicated BCL3 gene break-apart. (Yellow arrows pointed to split signals of the rearranged gene).


Kidney biopsy showing a glomerulus with cellular crescent formation (H & E stain; 400x).


Kidney biopsy showing interstitial infiltrate of atypical lymphocytes (H & E stain; 100x).


Hypermucoviscous Klebsiella pneumoniae colonies with positive string test.


Bronchoscopy and ultrasound imaging of an abscess. (A,B) Right middle and left lower bronchoscopy, respectively.


Bronchoscopy and ultrasound imaging of an abscess. (C) Ultrasound imaging of an abscess in the left upper arm.


Timeline with relevant data from the case in our hospital; curves of body temperature and leukocyte counts. The arrows below indicate major events. Blue line shows body temperature values. Orange line shows leukocyte counts. TMP-SMX, trimethoprim-sulfamethoxazole; mNGS, metagenomic next-generation sequencing.


The present patient, a 29-year-old female.


Duodenal biopsies. (A) Hematoxylin and eosin staining shows normal duodenal mucosa without villous atrophy.


Duodenal biopsies. (B) CgA immunostaining of the duodenal biopsy shows complete loss of EE cells.


Duodenal biopsies. (C) Normal control duodenal mucosa immunostained with CgA, showing EE cell distribution in the crypt epithelium.


Duodenal biopsies. (D) Repeated biopsy shows normal immunostained CgA duodenal mucosa.


Extra-orally the swellings appeared ovoid in shape, with well-defined borders.


The orthopantamograph revealed multiple impacted teeth in the mandilble (red arrows) with multiloculated osteolytic lesions involving mandible and maxilla (blue arrows).


3-Dimensional computed tomography scan showing multiloculated cystic lesions affecting the body and rami of the mandible (blue arrows) and maxilla with raised orbital floor (red arrows).


Microscopy revealed highly cellular stroma consisting of plenty of multinucleated giant cells (black arrow). The cellular stroma consists of spindle cell fibroblasts with vesicular nuclei arranged in fascicles (blue arrow).


Surgical specimen showing decorticated and curetted material along with impacted teeth.


Two-year postoperative follow-up photograph with acceptable esthetics.


Craniocaudal.


Mediolateral. Radiographs of the right elbow. Note the smoothly marginated bony proliferation arising from the craniodistolateral humerus. Post-contrast transverse computed tomographic image of the right distal humerus.


Three-dimensional reformatted CT imaged displayed in a bone window.


Lateromedial post-contrast transverse computed tomographic image of the right distal humerus. Note the lobular mineral proliferation arising from the craniodistolateral humeral metaphyseal cortex and lack of underlying humeral bone lysis.


Left lateral thoracic radiograph (E): 5mm rounded nodule within the dorsal third intercostal space (white arrow).


Transverse lung window.


Dorsal reformatted bone window. CT showing the pulmonary nodule within the right cranial lung lobe (black and white arrows).


The thin, mineralized rim with a soft tissue center is evident on the enlarged transverse CT image displayed in a bone window (H).


Transverse.


Dorsal. Plane CT images in a bone window of the right elbow from repeat CT scan 217 days after completion of SBRT. Note that the soft tissue portions of the mass are more mineralized and the humeral cortex remains intact.


Macroscopic view of the 2.0-cm subcutaneous tumor on the right elbow.


A-c Cell morphology of the primary and recurrent tumors. A; The primary tumor showed irregularly arranged collagen fibers mixed with scattered proliferating fibroblast.


B; The first recurrent tumor, composed of slimmer spindle cells.


C; The second recurrent tumor, composed of slimmer spindle cells. Cells in the recurrent tumors were more monomorphic and showed higher cellularity.


D-f Immunostaining for Ki-67. The Ki-67 labeling index of the primary tumor was 2% ,that of the first.


Second recurrent tumors 10.


7% , respectively.


Skin colored, lobulated mass over the tip and dorsum of nose.


T1 MRI axial images show the stability of the colloid cyst within the third ventricle, followed by regression images were acquired in July 2015.


August 2017.


August 2019 The cyst measured 5 mm initially and at follow-up scans 2 years later, and 2.5-3 mm at his follow-up scan in 2019. The 2019 scan also shows hyperintense signal in the cyst, suggesting colloid cyst involution.


Mutation analysis and identification of the c.1858+1G>T mutation of the CSF1R gene. (A) Sequence chromatograms from parts of the CSF1R gene of this case. It displays a splice-site mutation (c.1858+1G>T) in intron 13 of CSF1R.


Mutation analysis and identification of the c.1858+1G>T mutation of the CSF1R gene. (B) Pedigree of the family studied in this report. The affected individuals are indicated with filled squares and circles. The proband is indicated with an arrow. A plus sign indicates that DNA was examined for the CSF1R sequencing analysis.


Histopathology of affected lymph node of case 1 (A,B): Patchy circumscribed areas with eosinophilic fibrinoid necrosis in the paracortex and cortex and absence of granulocytes in the areas of necrosis are shown. A variety of cells surround the necrotic area, and a large number of apoptotic cell fragments exist outside the cells.


Diagnosis of Legionella pneumophila infection using mNGS. (A) The majority of reads mapped to the L. Pneumophila genome with coverage of 28.12.


Diagnosis of Legionella pneumophila infection using mNGS. (B) The majority of reads mapped to the L. Pneumophila genome with coverage of 13.35.


(A,B) Gram stain of bronchoalveolar lavage fluid (BALF) with arrows indicating Legionella pneumophila, magnification x1,000.


(D) Gram stain of L. Pneumophila colonies (magnification x1,000).


Patient's hair at diagnosis of Crohn's disease.


Patient's hair one year after treatment.


Control abdominal CT showing left adrenal gland metastasis.


Comparison of cross-sectional chest CT images obtained from the patient at different time points. A1-4 October 5th, 2020: The day of admission; B1-4 Eighth day after admission on October 13th, 2020; C1-4 October 22nd, 2020 The day of discharge; D1-4 November 14th, 2020 20 days after discharge; E1-4 February 6th, 2021 Nearly 4 months after discharge.


A flow chart describing the patient diagnosis process.


Photograph of the patient's subcutaneous hemorrhage.


Hess chart (orbital Burkitt lymphoma: an aggressive presentation).


Orbital magnetic resonance imaging of axial.


Coronal. At the first medical examination. White arrows indicate a tumor of the lacrimal gland.


Pathologic examination and tissue immunostaining of the tumor. Hematoxylin, and ,eosin stain (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with CD20 (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with MiB1 (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with CD10 (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with Bcl-6 (original magnification x400).


Image of the dilated fundus of the right eye shows an elevated amelanotic yellow-creamy lesion located in the posterior pole (greater diameter of 4 disc diameter [DD]) with focal round pigmented lesion of 1 DD located superotemporally to the optic nerve. There is also a more peripheral amelanotic lesion extending from 6 to 9 o'clock clockwise inferotemporally.


Macular optical coherence tomography (OCT) examination shows the elevated choroidal lesion (*) associated with exudative changes (subretinal fluid [#] and intraretinal cysts [^]).


An ultrasound of the right eye shows diffuse choroidal thickening (*). There is also a small elevated lesion (#) (<2 mm) located at the macula.


The choroid biopsy shows a dense lymphoplasmacytic infiltrate composed of a majority of small lymphocytes with a slightly irregular nucleus, occasional blasts, and a minor component of cells with plasmacytic features, for example, eccentric nuclei and perinuclear halo.


Images from the initial abdominal ultrasound (A) Jejunal ulcerations with gas inclusions (red arrows).


Images from the initial abdominal ultrasound (B) Enlarged jejunal lymph node with gas (red arrows).


Endoscopy (C,D) Colonic mucosa showing marked generalized hyperemia with small (~1 cm diameter) and diffuse colonic circular erosions.


Endoscopy (E) Ileum mucosa with hyperemia and striations.


Timeline of the dog's clinical course and treatments. Serum albumin values are depicted in the orange line; the reference interval indicated by the faint orange background. The dog's body weight is depicted in the blue line. Pink stars indicate cobalamin injections. Details about the products and dosages can be found in the main text.


Histopathology of the colonic pinch biopsies. H&E (20x) with intact crypts ,overlying fibrino-suppurative exudate.


Histopathology of the colonic pinch biopsies. Areas of complete effacement of normal architecture. With inflammation and marked fibroplasia and neovascularization.


Histopathology of the colonic pinch biopsies. (C) PAS (20x) with no PAS positive macrophages.


Histopathology of the colonic pinch biopsies. (D) PAS (40x) stained colon from a dog with E. Coli-associated GC with PAS positive macrophages for comparative purposes.


Hemispherical nodule in the subungual region of the right great toe.


Fine needle aspiration smear showing benign plump oval to spindle-shaped cells in groups, sheets and cohesive clusters in a background of myxoid material and insert showing the histopathological section, confirming the cytological findings (Pap, x400).


The computed tomography scan with intravenous contrast revealed a large mass in right nasal cavity with destruction of pterygoid plates, the body and the greater wing of the sphenoid, inferior orbital wall and the posterior wall of the maxillary sinus.


The computed tomography scan with intravenous contrast revealed a large hypervascular mass in right nasal cavity with orbital involvement.


MRI showed a hypervascular mass with plenty of flow voids signal, due to containing large vessels, in the right nasal cavity with extension to intracranial and infratemporal spaces.


The angiographic study showed a filling defect in ophthalmic vein according to intraluminal tumor growth.


The excised specimen with an intraluminal extension in to ophthalmic vein (marked in the red box), which was completely excised endoscopically.


Case 1. Preoperative MRI cervical spine T1-weighted with contrast.


Case 1. And T2 weighted There is a large-enhancing expansile mass of the cervical spinal cord extending from the level C1-C7 measuring 9.8 x 1.2 cm. A large tumor cyst extends from end of mass at C7 inferiorly into the thoracic spine.


Case 1. Postoperative sagittal T1-weighted with contrast.


Case 1. T2-weighted. MR images of the cervical spine after laminectomy and posterior fusion. Gross total resection was achieved with no residual tumor.


Case 2. Preoperative sagittal T1-weighted with contrast.


Case 2. T2-weighted. MR images demonstrating a heterogeneous mass within the cervical cord from C1-C7. The superior portion of the mass demonstrates 1.7 x 3.6 cm cystic component.


Case 2. Postoperative sagittal T1-weighted with contrast.


Case 2. T2-weighted. MR images after laminectomy and posterior fusion. Gross total resection was achieved, albeit with marked spinal cord myelomalacia from C2-C3 through C6.


Erythema and swelling around CRT-P insertion site.


TEE revealing vegetation at the anterior leaflet of the mitral valve.


Initial lesion before biopsy. A pedunculated lesion at the right posterior forearm which resembled pyogenic granulomacases.


Scar from previous biopsy. Wide excision with 2 cm peripheral margin and depth until fascia level.


HE staining of lymph nodes. A) Pulmonary hilar lymph node. Note
expansion of extrafollicular areas. Lymph follicles are not abundant and only focally
observed (inset). Scales: 500 mum.


HE staining of lymph nodes. B) Retroperitoneal lymph node as a control. Scales: 500 mum.


HE staining of lymph nodes. Mid-power and . 50 mum
10 mum (D including the inset).


HE staining of lymph nodes. High-power views of the
extrafollicular area of the pulmonary hilar lymph node, showing proliferation of round
cells (plasmablasts). Inset in D) shows small lymphocytes observed in
the paracortex of pulmonary hilar lymph nodes as size controls at the same
magnification.


Scales: 20 mum (A-D).


Immunohistochemistry for round cells (plasmablasts) in the extrafollicular areas of the
pulmonary hilar nodes, labeled by antibodies against A) CD19,. CD20,. Scales: 20 mum (A-D).


IgG,. Scales: 20 mum (A-D).


IgM,. Scales: 20 mum (A-D).


Kappa chain.


Lambda chain. Plasmablasts are
CD19+ CD20- IgG+ IgM-. Sparse
CD20+ cells were judged to be reactive B cells. No monotypia was observed
for kappa and lambda chains.


Multi-labeling immunohistochemistry for phenotypic characterization of plasmablasts in
the pulmonary hilar lymph nodes. A) Chromogenic method. Ki-67+ cells (brown) did not correspond to CD20+ (red) or
CD3+ (green) cells. Scales: 20 mum (A-C). Methods are described in the legends of Supplementary Figure 5.


Multi-labeling immunohistochemistry for phenotypic characterization of plasmablasts in
the pulmonary hilar lymph nodes. ,. Merged figures showing that IgG+ cells
 green), and . Scales: 20 mum (A-C). Methods are described in the legends of Supplementary Figure 5.


Multi-labeling immunohistochemistry for phenotypic characterization of plasmablasts in
the pulmonary hilar lymph nodes.
Immunofluorescence method. VS38c+ cells. Green)
were frequently double-positive for Ki-67 (red). Note that Ki-67 is positive in the
nucleus (located in the center). Round cells in the extrafollicular areas were finally
identified as plasmablasts. Scales: 20 mum (A-C). Methods are described in the legends of Supplementary Figure 5.


(A) Top-10 up-regulated (green color, top) and top-10 down-regulated (red color, bottom) molecular pathways in the patient's tumor.


Line width for each pathway is proportional to the pathway activation level (PAL), scale for PAL values is presented on the right; (B) Gene expression level of Regorafenib targets. Targets included in the "KEGG Pathways in cancer" pathway are highlighted in red.


"KEGG Pathways in cancer" signaling pathway shown as an interacting network. This pathway was hyperactivated in the patient's tumor tissue. Green arrows indicate activation, red arrows-inhibition. Transcript nodes are shown in ovals. The color depth of transcript nodes reflects the extent of node activation (logarithms of the case-to-normal (CNR) expression rate for each node, in which "normal" is a geometric average between expression levels in normal tissue samples). Molecular targets of regorafenib are indicated by black arrows. Visualization was implemented using Oncobox software. The PI3Ks-AKT signaling axis is marked in blue ellipse.


18F-fluoride positron emission tomography/computed tomography bone scan - abnormalities found in the brain parenchyma.


68Ga DOTANOC positron emission tomography/computed tomography - abnormal uptake in brain parenchyma.


Contrast-enhanced computed tomogram(CECT) image (transverse cut) showing tumor in left hypochondrium displacing major vessels.


Histopathology showing pseudo papillary pancreatic epithelium.


The Papanicolaou stain cytology smear slide shows numerous papillary groups of epithelioid cells in a background of lymphoid cells (x100).


The Papanicolaou stain cytology smear slide shows that the epithelioid cells were relatively uniform. The cells had a high nuclear-to-cytoplasmic ratio. The nuclei were predominantly oval and exhibited fine nuclear chromatin. Quite prominent nuclear grooves and irregular nuclear membrane were also noted (x400).


The Papanicolaou stain cytology smear slide shows several psammoma bodies associated with tumor cells (x400).


The tumor cells are immunoreactive with estrogen receptor (x200).


The tumor cells are immunoreactive (nuclear staining) with WT-1 (x200).


Clinical features of the patients. Note the facial profile, dolicocephaly and low-set posteriorly rotated ear.


Clinical features of the patients. ; hypertelorism, low nasal bridge and short philtrum.


Clinical features of the patients. ; short fifth fingers.


A) Computed tomography scan. RA, right atrium; RV, right ventricle; LA, left atrium; LV, left ventricle; asterisk, pericardial effusion.


B) Site of bone marrow biopsy puncture (encircled).


C) Site of ascending aorta stab injury (showed by forceps).


Fluctuant region beneath scalp. Note that there is no discoloration, and the collection does not obey suture lines (a).


Fluctuant region beneath scalp. The arrow indicates the edge of fluid collections, which is migratory depending on patient position (b).


The important diagnosis feature showing subaponeurotic fluid collections crossing above the cranial suture (a).


Ultrasonography revealed mobile hypodense anechoic fluid collections beneath the scalp aponeurosis without the presence of cyst wall and crossed sagittal suture lines (b).


A diagnostic aspirate tap confirmed the presence of serosanguinous subaponeurotic fluid collections.


Transthoracic echocardiography in 4-chamber view showing mass in right atrium (arrows) attached to wall, measuring approximately 5.6 cm x 2.2 cm.


18F-fluoro-deoxyglucose (FDG) contrast enhanced positron emission tomography-computed tomography (PET-CT) images. Transaxial CT, and ,corresponding fused PET-CT.


18F-fluoro-deoxyglucose (FDG) contrast enhanced positron emission tomography-computed tomography (PET-CT) images. Coronal CT and corresponding fused PET-CT sectional images showing non-FDG avid thrombus in right superior pulmonary vein extending upto the left atrium (arrow).


Left nephrostogram showing persistent focal narrowing in the proximal ureter (black arrow) with proximal hydroureteronephrosis. Central pooling of contrast is seen in interpole medulla (white arrow) giving the egg-in-a cup appearance.


X-rays of L4-S1 instrumentation and fusion.


(a) Early phase spinal angiogram of the left T-10 intercostal artery injection, showing filling of the anterior spinal artery and the site of the filum terminale arteriovenous fistulas.


(b) Later phase spinal angiogram showing initial fistulization.


(c) Venous phase of spinal angiogram showing dilated and tortuous draining veins of the malformation.


DynaCT demonstrating serpentine vessel opacification, unable to localize exact fistula site from this study. Lumbar fusion instrumentation (pedicle screws) is visible.


Intraoperative photograph showing the enlarged filum terminale artery connected to the arterialized dilated venous plexus.


Intraoperative photograph showing ligated filum terminale fistula.


Artery and vein penetrating the thick, fibrous dura at the filum terminale with fibrofatty changes (bold arrow). Abrupt transition occurs between the feeding arterial vessel and venous vessel. Filum terminale vein at the center of the image is enlarged and filum terminale artery is distorted (black arrow).


Slit-lamp examination; nasal limbal gelatinous mass with inferior corneal infiltration.


A) One month later, the lesion had decreased.


B) At the third month, CIN had disappeared.


A) Slit-lamp examination: a gelatinous temporal conjunctival mass (7x10 mm) with dilated superficial vessels without corneal involvement is exposed.


B) Abduction limitation in right eye.


Anatomopathological study: moderately differentiated squamous cell carcinoma was confirmed; tumour cells present in corion.


Tumor progression involving ocular globe tissues and soft periorbital structures.


Mediastinal lymphadenopathy in a child with Kawasaki disease:. At presentation.


Eight weeks later.


MRI (T1-weighted with gadoliunium) at presentation in April 2008.


MRI (T1-weighted with gadolinium) at detection of seeded metastasis September 2009.


Clinical appearance of lesion.


Traumatic deep bite interfering with the lesion during occlusion.


Pre-operative scaling.


Occlusal correction.


Full thickness flap elevation facial to tooth 11, 21 using crevicular incision.


Excision of lesion.


Suturing with 3-0 silk suture.


Superficial erosion of bone upon reflection of full thickness flap.


Excised tissue.


Photomicrograph showing features of peripheral ossifying fibroma.


Satisfactory healing seen after 45 days.


Specimen after opening the cyst.


Squamous metaplasia in the cyst.


Solid pseudopapillary neoplasm in pancreatic tail at the time of presentation.


Recurrent mass in the splenic fossa.


Histological features of the recurrent tumor:. Characteristic pseudopapillary architecture observed on microscopy (H&E 100 x.


Lymphovascular invasion by tumor.


Mitotic figures (6 in 10 high-power fields).


Fibrovascular core with discohesive tumor cells.


A diffuse extraoral swelling in the lower one-third of face extending to submandibular region.


Lateral view of the swelling.


Panoramic radiograph showing generalized bone loss.


Posterior-anterior chest radiograph, showing a normal study.


Computed tomography of neck with contrast, axial section demonstrating enlarged lymph nodes without any enhancement or necrosis.


Computed tomography, coronal section demonstrating enlarged lymph node pushing the submandibular gland to one side.


Computed tomography of neck with contrast, sagittal section demonstrating lymph node enlargement at level Ib, II, III and V.


Positron emission tomography/computed tomography images showing fluoro-2-deoxyD-glucose avid supra, and ,infra diaphragmatic lymph nodes, and ,focal fluoro-2-deoxyD-glucose avid in spleen.


Positron emission tomography/computed tomography images after chemotherapy showing complete metabolic and near complete anatomical resolution of supra/infra diaphragmatic lymph nodes and splenic deposits.


(a) Large swelling in the left ankle.


(b) X-ray left ankle revealed expansile osteolytic destruction of the body of talus extending to lower end of tibia and fibula with soft tissue involvement.


A; Widefield Optos imaging of the right eye of a patient with von Hippel-Lindau disease demonstrates a retinal hemangioblastoma in the superotemporal quadrant with associated dilated feeding and draining vessels.


B; Widefield fluorescein angiography of the right eye reveals fluorescein uptake and leakage from the hemangioblastoma with peripheral retinal nonperfusion in the superotemporal quadrant anterior to the tumor.


Optical coherence tomography of the right eye reveals intraretinal fluid extending from the hemangioblastoma towards the temporal macula.


Mucosal colored swelling of approximately 3 cm in diameter on the lingual aspect of mandible on the right side, extending from 32 to 44.


Swelling of approximately 3 cm in diameter on the lingual aspect of mandible on the right side, extending from 32 to 44.


IOPA shows a diffuse radiolucent area with scattered flecks of radiopacities at the apical region of 41-43.


Odontogenic epithelial cells arranged in the form of follicles and stellate reticulum like cells in the center which are surrounded by ectomesenchymal cells (4x).


tall columnar ameloblast like cells on the periphery with stellate reticulum like cells at the center and surrounded by condensed mesenchymal cells (10x).


Neoplastic odontogenic epithelium in the form of large follicles (10x).


Tall columnar ameloblasts like cells showing nuclear palisading, reversal of polarity and stellate reticulum like cells (40x).


Dense ectomesenchymal cells present in the connective tissue stroma (40x).


large masses of dysplastic dentin arranged in a haphazard pattern. (10x).


Irregular masses of dysplastic dentin, areas of calcification and stromal connective tissue(10x).


Cervical computed tomography scan in axial view displaying a right cervical mass of 27.5x17.5 mm. P denotes posterior, L denotes left.


Orbital magnetic resonance imaging in the left eye shows a circumscribed lesion in suprachoroidal space (a).


High hypercaptation of lesion under gadolinium contrast (b).


Circular genome diagrams of the patient. The outer circle (outside the green circle) represents the structure and scale of the chromosome. The middle circle indicates the somatic variation, in which, its Y-axis represents the allelic fraction (AF) value of each locus. 0 is the minimum and 1 is the maximum. The inner circle represents copy number variation (CNV). Orange color indicates deletion; green color indicates amplification, and blue color indicates neutral.


Clinical course of the case.


Chest roentgenogram shows bilateral diffuse micronodular opacities.


Histopathology shows malignant glands and papillary structures with psammoma bodies and cells with classic papillary thyroid carcinoma nuclear features (H&E, 400x magnification).


TTF1 immunohistochemistry labels the neoplastic cells (400x magnification).


(a) Left leg with multiple subcutaneous swellings and few ulcerated nodules.


(b) Axial computed tomography: Homogeneously enhancing relatively hypodense left suprarenal mass with loss of fat plane in anterior pararenal space.


(c) Axial computed tomography: Heterogeneously enhancing left inguinal lymph nodal mass.


Preoperative view of the lesion.


Intraoral periapical radiograph.


Preoperative orthopantogram.


Chest radiograph with no evidence of secondary malignancy.


Postoperative view Figure.


Postoperative orthopantogram.


Clinical photograph of I. O lesions.


Orthopantomogram of the patient showing patchy radiolucency with irregular margins in the left anterior region extending as poorly defined radiolucency into the body of mandible region.


H & E stained sections in x5 magnification showing diffuse presence of round cells in deep connective tissue.


H & E stained sections in x10 magnification showing diffuse presence of two different morphologies of cell populations in deep connective tissue.


H & E stained sections in x40 magnification showing diffuse presence of two different morphologies of cell populations in deep connective tissue.


Cytokeratin-high molecular weight negative staining of the tissue cells.


Cytokeratin 7 negative staining of the tissue cells.


P63 mild positivity of tumor tissue cells.


(a): Panoramic view of haematoxylin and eosin (H&E) stained sections of cystectomy specimen showing a highly infiltrative neoplasm through the vesical muscular wall (40x).


(b): H&E high power view analysis of cystectomy (200x) with invasive carcinoma in muscular propria and intratumoral lymphocyte infiltration.


(c): H&E analysis of metastatic lymph node with carcinoma (200x).


(d): IHC with strong and diffuse positivity for PD-L1 22C3.


Wright-stained bronchoalveolar lavage fluid smears. . Notes: (A-D) Arrows indicate extracellular "tachyzoites", also known as "trophozoites", which can be propagated within the nucleated cells. No intracellular parasites are present. Magnification x1,000.


Macroscopic tumour: an 8 cm tumour with a myometrial infiltration of more than 50%, reaching the uterine serosa B).


E 20x: Solid tumoural nests are observed, consisting of small cells with limited cytoplasm.


The main milestones of the proband's medical history. Reconstructed by the patient's reports and medical records.


The endomyocardial biopsy of the right ventricle (10-50 micron scale). Hematoxylin eosin staining showed: the endocardium is thin. Cardiomyocytes with foci of enlightenment in the perinuclear zone, disarray, with homogenization of the cytoplasm. In individual cardiomyocytes, there are foci of myolysis with the formation of voids in the cytoplasm. Microvessels with red blood cell sludge phenomenon, sclerosed walls, proliferation of endothelial cells, stenosis of the lumen and single perivascular lymphohistiocytic cells. There are minor hemorrhages, mild sclerosis. Staining of congo red (in non-polarized and polarized light), Perls reaction, the PAS reaction are a negative.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. Brain computed tomography (CT) scan without contrast.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. CT scan with contrast.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. Axial T2 weighted.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. Axial T1 weighted without contrast.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. Postcontrast axial T1 weighted.


Preoperative brain neuroimaging showing an extra-axial vascular mass lesion involving the right cerebellopontine angle (CPA) with associated venous anomaly. MR angiography. Double arrow: associated venous anomaly, arrow: sinusoid pools in the site of the lesion in the right CPA, asterisk: small intraparenchymal hematoma in the site of VP shunt insertion.


Intraoperative views showing:. The gross appearance of the extra-axial lesion in the cerebellopontine angle.


Dissection of the trigeminal nerve, and ,the facial/vestibule-cochlear complex.


Dissection of the lower cranial nerves and posterior inferior cerebellar artery.


(d) Early postoperative brain magnetic resonance imaging showing total resection of the lesion. 5: Trigeminal nerve, 7/8: Facial/vestibulocochlear complex, LCN: Lower cranial nerves, PICA: Posterior inferior cerebellar artery.


Tanycytic ependymoma. (a) T2-axial MRI showing a hyperintense lesion in the left CPA with extension into the internal auditory canal.


Tanycytic ependymoma. The same lesion in axial.


Tanycytic ependymoma. Coronal. Views on T1-weighted MRIs. Postgadolinium enhancement showing a homogenously enhancing lesion extending from the ICA into the left CPA. There are clear mass effect shown on the brainstem and absence of hydrocephalus.


Dynamic computed tomography of the spleen. A gradually enhancing mass (65 x 65 x 55 mm) is observed in the spleen (arrow). No radial visualization of the inside of the tumor is observed. A; Simple phase.


Dynamic computed tomography of the spleen. A gradually enhancing mass (65 x 65 x 55 mm) is observed in the spleen (arrow). No radial visualization of the inside of the tumor is observed. B; Arterial phase.


Dynamic computed tomography of the spleen. A gradually enhancing mass (65 x 65 x 55 mm) is observed in the spleen (arrow). No radial visualization of the inside of the tumor is observed. C; Portal vein phase.


Dynamic computed tomography of the spleen. A gradually enhancing mass (65 x 65 x 55 mm) is observed in the spleen (arrow). No radial visualization of the inside of the tumor is observed. D; Equilibrium phase.


Chest X-ray showing massive left side pleural effusion and right upper zone nodular opacity (small air pocket in left apex is due to previous aspiration).


Cytological examination of the pleural fluid showing numerous atypical plasma cells with binucleate forms and plasmablasts.


(a) Computed tomography scan of the chest with contrast showing bilateral effusion with pleural infiltration, right upper lobe involvement, soft tissue lesion in the posterior mediastinum.


(b) Computed tomography scan of the abdomen showing lytic lesions in pelvis and sacrum.


Bone marrow biopsy showing extensive replacement of marrow by sheets of atypical plasma cells, with binucleate and plasmablasts.


Preoperative imaging (a) coronal T2-weighted magnetic resonance imaging (MRI) shows a hyperintense mass measuring 2.4 x 2.6 x 1.9 cm in the sellar and suprasellar region.


(b) Coronal T1-weighted MRI shows a hyperintense mass with a hypointense, nonenhancing nodule.


Postcontrast T1-weighted MRI in the axial.


Sagittal. Planes shows a heterogeneously enhancing mass.


Preoperative imaging noncontrast computed tomography image in sagittal.


Axial. Planes shows a sellar mass extending into the suprasellar region. No calcifications are seen in the lesion.


Intraoperative imaging intraoperative images of tumor texture and behavior, including. Motor oil drainage.


Thick, fibrous cystic capsule.


Cholesterol granuloma.


Adhesion to the optic chiasm.


Postoperative imaging postcontrast axial T1-weighted image in sagittal.


Coronal. Planes shows gross total resection of the tumor with decompression of the optic chiasm. The residual fat graft is noted in the inferior portion of the resection cavity (yellow star). The orange arrow in Figure 4a shows the placement of the Medpor graft, and the green arrow points to the layering of the pedicled nasoseptal flap for a multilayered closure.


Beta-catenin stain beta-catenin immunostaining at x100 demonstrating dense fibrous walled cyst with squamous cells.


Panoramic radiograph showing well defined periradicular radiolucency.


Axial T1-weighted image shows hypointense, lobulated contour lesion (arrow) within the confluens sinuum.


Axial T2-weighted image demonstrates lesion is hyperintense relative to brain parenchyma.


Sagittal T2-weighted image indicates hyperintense lesion (arrow) extending from confluens sinuum through the superior sagittal sinus and scallop-shaped area of erosion in the neighboring bone.


Sagittal magnetic resonance venography maximum intensity projection image revealing obvious venous flow, which divided into 2 channels around filling defect (arachnoid granulation), and joined distally.


External clinical photograph. Cystic mass in the upper lip.


Fine-needle aspiration cytology showing many anucleated squames and few benign nucleated squamous cells in a dirty background (May-Grunwald-Giemsa, x100).


Magnetic resonance imaging T2.


Sagittal view.


Axial view. Coronal view. It evidence lesion type C T8-T9.


Computer tomography Scan.


Medical image.


Infected surgical wound. Placement of negative pressure treatment.


Radiography of thoracic spine.


Radiography of thoracic spine. Anterior - Posterior view. Lateral view. It observe correct placement of pedicle screws without signs of misplacement or vertebral lysis.


X-ray skull was normal showing no bony lesion or lytic lesion. Inset (upper left) demonstrates the occipital swelling of the case.


Cytological smear showing cohesive clusters and scattered single meningothelial cells having indistinct cytoplasmic borders, round to oval nuclei and inconspicuous nucleoli. Inset (lower left) exhibits a psammomatous calcification. (Leishman-Giemsa, x400).


Section showing immunostaining positivity for epithelial membrane antigen in meningothelial cells (x100).


Lesion at presentation as erythematous friable papule, measuring 1 cm in diameter, on the right half of the lower lip.


5 days after suture removal of the partially excised lesion when a two cycles of cryotherapy was done.


After one week of topical salt use, the lesion was markedly reduced in size and became a small papule.


Complete resolution of the lesion after two weeks of topical salt.


Timeline of the clinical course.


Skull film, lateral projection showed a rounded osteolytic lesion with a nonsclerotic rim in the left parietal bone.


Lesion manifested as a mass in hard palate.


CT scan of the lower abdomen.


Leptomeningeal enhancement involving brain and cervical spinal cord.


Ill defined granuloma with multinucleated giant cells (arrow) and bone fragments, HE staining, 4x.


(a) A dome-shaped pearly white nodule on the right areola adjacent to the nipple. (b) Photomicrograph showing a cyst lined with stratified squamous epithelium and the lumen was filled with keratinous material (H and E, x40).


(a) A well-defined, pearly white nodule on the right nipple. (b) Photomicrograph revealed that the cyst wall was lined with stratified squamous epithelium and its lumen filled with keratinous material (H and E, x40).


Orthopantomogram of the patient; asterix indicates the extent and nature of the radioluceny in between the apices of the right maxillary canine and lateral incisor. Inset shows the periapical radiograph of the area.


The lesional area after raising the semilunar flap. Note the shape of the lesion and bone overlying the cyst.


Total removal of the cystic content in toto.


Timeline.


(A) One of the two smaller trichilemmal cysts (TCs).


(B) Proliferating trichilemmal cyst (PTC) peroperative.


(C) PTC with an ulcerating center.


(D) Defect after removal of PTC.


(E) Closure with local fasciomusculocutaneous flaps.


(F) Small wound 6 months after primary closure.


(A) One of the two smaller TCs.


(B) PTC axial view.


(C) PTC coronal view.


(D,E) Macroscopy of the PTC.


(F) Macroscopic view of sliced PTC.


(G) Microscopy of PTC, depicting surface epithelia and a tumor process.


(H) Microscopy depicting the compact keratin and calcifications.


(I) Microscopy with squamous epithelial cells without a granular cell layer.


Preoperative axial noncontrast computed tomography image shows a heterogeneous intraventricular mass predominantly isodense to grey matter, with a right posterior hypodense component. There is left greater than right lateral ventricular hydrocephalus.


(a) Axial T2-weighted magnetic resonance imaging (MRI) shows a heterogeneous intraventricular lesion containing T2-hypointense components anteriorly and a cystic component at the right posterior aspect.


Postcontrast axial.


Coronal.


Sagittal. T1-weighted MRI sequences show a heterogeneously enhancing mass following intravenous contrast. The sagittal image also shows extension of the posterosuperior extent of the lesion in the undersurface of the posterior body of the corpus callosum.


Postoperative imaging. (a) Postcontrast axial T1-weighted image shows resolution of hydrocephalus with a small residual intraventricular enhancing mass consistent with sub-total resection.


Postoperative imaging. (b) Axial noncontrast head computed tomography scan shows postoperative pneumocephalus with residual tumor better seen on magnetic resonance imaging. A partially visualized shunt traversing the body of the left lateral ventricle is seen with resolution of previous hydrocephalus.


Postoperative imaging. (c) 6-month postcontrast axial T1-weighted image shows stable lesion with minimal enhancement.


Hyalinized vessels in glial component.


Vague neurocytic rosettes: ring-like arrangement of neurocytic tumor cells around eosinophilic core.


Ct-scan showing the invaginated tract containing a 24 mm mass.


H&E, 100x magnification: Ileal submucosal spindle cell proliferation.


H&E, 200x: hypercellular proliferation composed of spindle cells with nuclear atypia and intermingled moderate amount of inflammatory cells.


MDM2, 20x: immunohistochemistry against MDM2-antibody shows diffuse and intense nuclear reaction.


Incision of the right corpus cavernosum contributed to drainage of a large amount of pus.


(a) With repeated hemoptysis, investigation with high resolution computed tomography after a month (selected axial image) showed the left upper lobe mass is significantly enlarged (arrow).


(b) Selected coronal image of high resolution computed tomography could appreciate the ground glass halo around the enlarged lung mass (arrow).


A-C. Coronal CT reconstruction in early venous phase after i. V. Contrast application, depicting primary tumor and vascular extent.


Ultrasound images in Doppler mode highlighting hepatoatrial transition. As well as atrial dilation and movement of the sacciforme intravascular tumor extension over the tricuspid valve into the right cardiac ventricle All depicted images represent the initial diagnosis.


A. Intravascular tumor extensions along centimeter scale: * subhepatic VCI; ** intrahepatic VCI; *** intracardiac.


B. Dissected kidney along centimeter scale.


Clinical picture showing exophytic growth on lingual surface of mandibular lower left canine.


A photo micrograph showing variably sized blood vessel which were lined by plump endothelial cells.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. Non-contrast head CT image demonstrated a densely calcified mass (arrow) in the left temporal lobe.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. (a) Brain MRI T2/FLAIR image revealed a hypointense lesion (arrow) in the left temporal lobe.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. (b) Brain MRI T1-weighted image showed corresponding heterogeneous hypointense signal (arrow).


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. (c) Brain MRI post-contrast T1-weighted image further demonstrated irregular enhancement (arrow) in close association with the left middle cerebral artery.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. Hematoxylin and eosin stained tissue sample demonstrated. Innumerable.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. Confluent psammoma bodies (blue arrows) intimately associated with.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. Extensive fibrotic bundles (red asterisks) as well as. Perivascular proliferation of spindle cells (green arrows), which are characteristic findings of meningioangiomatosis.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. (a) Brain MRI T2 image revealed a CSF-filled hyperintense resection cavity (arrow) in the anterior left temporal lobe.


A 17-year-old woman with meningioangiomatosis presented with seizures and persistent headache and dizziness. (b) Brain MRI post-contrast T1-weighted image demonstrated irregular residual enhancement (arrow) intercalated with the middle cerebral artery consistent with residual disease.


Ultrasonographic and radiographic findings. (a) A relatively well-demarcated, lobulated, hypoechoic mass with mild heterogeneous echogenicity is noted, showing a focal, ill-defined border, suggesting the possibility of malignancy.


Ultrasonographic and radiographic findings. (b) Positron emission tomography-computed tomography revealing focal fluorodeoxyglucose uptake in the same lesion.


Abdominal magnetic resonance imaging. T2 sequences show a small nodular mass (arrow) with a hypointense signal at the level of the major duodenal ampulla, measuring approximately 10.2 mm in its largest axis.


Abdominal magnetic resonance imaging. Pancreas divisum diagnosis, arrow 1 shows the ventral pancreatic duct, arrow 2 shows the dorsal pancreatic duct, and between those, the arrow 3 shows the common bile duct.


Macroscopy specimens of pylorus-preserving pancreaticoduodenectomy. Pancreas divisum, arrow 1 shows the dorsal duct with a vegetative lesion (17.0 x 2.0 mm) extending to the major ampulla (star), arrow 2 shows the ventral duct, and ,the arrowhead shows a poorly defined densification area near the minor ampulla (5.0 mm).


Macroscopy specimens of pylorus-preserving pancreaticoduodenectomy. Duodenal wall mass (12.0 mm).


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining.


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining. The poorly-differentiated adenocarcinoma of the major ampulla H&E. And CK7 IHC staining.


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining. The well-differentiated neuroendocrine tumor of the minor ampulla H&E.


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining. And synaptophysin IHC staining.


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining. Spindle cells in the gastrointestinal stromal tumor H&E.


Histological and immunohistochemical features of the synchronic gastrointestinal tumors by hematoxylin-eosin (H&E) and immunohistochemical (IHC) staining. And DOG1 IHC staining. The histological sections stained are presented at x100 magnification and the right small squares represent x40 magnification.


Transversal CT scan. The yellow arrow indicates bowel in the obturator foramen.


Coronary CT scan. The yellow arrow indicates bowel in the obturator foramen.


Intraoperative finding. A segment of the small bowel was trapped in the obturator canal.


Laparoscopic management of the obturator hernia using an endoloop.


Intraoperative real-time ICG fluorescence angiography following bowel reduction. The left upper image demonstrates the laparoscopic mode; the middle image indicates the angiographic mode while the lower image indicates the fluorescence mode (corresponding to the enlarged image). Note the longitudinal discolouration in the middle of the anti-mesenteric bowel surface with lack of perfusion.


Real-Time ICG fluorescence image following anastomosis showing a well perfused anastomosis.


Cells arranged in 3D clusters. MGG.


40X) Microfilaria. MGG,40X).


Grey white to grey brown solid and cystic mass with multiloculated cystic cavities being filled with mucoid material and serous fluid.


Axial T1-weighted magnetic resonance images without.


With. Gadolinium demonstrating a 7-cm homogeneously enhancing left neck mass circumferentially encasing the left internal carotid artery, extending from C2 to C4.


Sagittal.


Axial. T2-weighted magnetic resonance images, again showing the left neck mass encasing the left internal carotid artery.


Mid-to-late arterial phase of a left common carotid artery injection before.


After coil embolization. Of the common, internal, and external carotid showing reduced vascularity of the mass.


(a) Hematoxylin and eosin (H and E) stain at low-power magnification (x40) demonstrating lymph node hyperplasia with vascular proliferation magnification.


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. Front view shows the swelling extending from the right ramus (arrow black outline) crossing the midline up to the left parasymphysis region (solid black arrow) of the mandible.


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. Inferior profile view shows numerous tortuous veins (black arrows) owing to the stretching of the skin overlying the huge swelling.


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. Intraoral view reveals a swelling with bicortical expansion, obliterating the buccal sulcus, (arrow black outline) lobulations present lingually (solid black arrows) with displacement of mandibular and maxillary teeth (white arrows) on the right side.


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. Panoramic radiograph shows a single well-defined circular mixed radiopaque-radiolucent lesion on the right side of the mandible with displacement of the mandibular and maxillary teeth. Presence of a radiopaque mass in the center of the lesion (black arrow) with radiopaque streaks has the appearance of "driven snow".


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. Axial view computed tomography scan shows a huge well-defined heterodense tumor mass on the right side of the mandible with the presence of a hyperdense irregular mass at the center of the lesion (black arrow).


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. Sagittal view computed tomography scan reveals a well-defined heterodense tumor mass with an irregular central hyperdense mass (black arrow) and expanded inferior border (white arrow) of the mandible without any perforation.


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. Coronal view computed tomography scan shows a well-defined heterodense tumor mass on the right mandible having a central irregular hyperdense mass (solid black arrow) with multiple irregular calcifications with a "snow flake" pattern (black outline arrows).


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. A multidimensional computed tomography reconstruction using a hard tissue algorithm exhibits the extent of the well-circumscribed giant tumor (white arrow).


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. A three-dimensional reconstructed profile image using a bone window exhibits the predominantly calcified well-defined tumor mass on the right side (white arrow) which has clearly spared the condyle (solid black arrow) and coronoid process (arrow black outline) on the affected side.


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. Hematoxylin and eosin stained biopsy section (x20) shows epithelial cells in sheets and islands dispersed throughout the connective tissue matrix along with numerous circular ring like calcifiactions (black arrows).


38-year-old female patient with a huge swelling on the right side of the face diagnosed with calcifying epithelial odontogenic tumor. Hematoxylin and eosin-stained biopsy section shows polygonal squamous epithelial cells exhibiting distinct intercellular bridges (black arrow) along with cellular and nuclear polymorphism (white arrows), and areas of irregular calcification and eosinophilic material.


A; Sagittal section of MRI of the brain showing destruction of the clivus by the clivus tumor.


B; Coronal section of the MRI of the brain showing destruction of the clivus by the clivus tumor.


C; Poorly differentiated squamous cell carcinoma of the neoplastic cells are arranged in groups surrounded by nonneoplastic lymphoid cell component. H&E. Magnification x200.


A; CT scan reveals enhancing mass lesion with central necrosis and peripheral edema in the left pons compressing the fourth ventricle.


A : Granulomatous inflammations with Cryptococcus yeasts in the macrophages and multinucleated giant cells (H&E, x200).


B : Many Cryp-tococcus yeasts capsules stained with mucicarmine (x200).


C : Methenamine silver stains reveal numerous Cryptococcus yeasts (x200).


Panorama radiographs, and ,standard radiographs (inlet square) after temporary root canal dressing material using Calcipex II, which was spilled into the periapical area.


Panorama and standard radiographs (inlet square) in one and half year. Some Calcipex II granules were gradually migrated into maxillary sinus through the mucoperiosteal space, although their radiopacity was reduced.


(A) Enhanced computed tomography (CT) image demonstrating a large mass replacing the lower part of the right kidney (star); the mass had invaded the perirenal space and Gerota's fascia (arrow).


(B) Enhanced CT image of the upper abdomen reveals a thrombus in the renal vein and inferior vena cava (arrow).


(A) Histological examination of the kidney demonstrates that the tumor mass had infiltrated the cortex and medulla (original magnification, x40).


(B) Small, round tumor cells with scanty cytoplasm and round nuclei (original magnification, x400).


(C) Neoplastic cells infiltrating blood vessels (original magnification, x400).


(D) Similar neoplastic cells in the tumor thrombus (original magnification x400). Staining, hematoxylin and eosin.


Immunohistochemical staining reveals that the tumor cells were positive for. Cluster of differentiation 99.


Friend leukemia integration 1.


Integrase interactor-1 (original magnification, x400).


Fluorescence in situ hybridization analysis using a Vysis LSI EWSR1 Dual Color, Break Apart Rearrangement probe for 22q12 demonstrates the green and red probe breaking apart, confirming the Ewing's sarcoma breakpoint region 1 translocation.


MRI of the brain. (A) T2/fluid-attenuated inversion recovery (FLAIR) coronal view shows hyperintensity in the right caudate, internal capsule, and putamen.


MRI of the brain. (B) T2/FLAIR axial view shows additional lesions involving left thalamus and lenticular nuclei.


MRI of the brain. (C) Diffusion-weighted imaging axial view shows three lesions with restricted diffusion. Arrows indicate CNS lesions.


MRI of the brain after 3 months of follow-up. T2/fluid-attenuated inversion recovery (FLAIR) coronal.


MRI of the brain after 3 months of follow-up. Axial. Views show size reduction of the pre-existing lesions in the basal ganglia, thalamus, and internal capsule.


MRI of the brain after 3 months of follow-up. (C) Diffusion-weighted imaging axial view showing no signal alteration. Arrows indicate CNS lesions.


T2-weighted. Sagittal magnetic resonance images. An intradural spinal tumor existed at the level of L1 vertebral body. The tumor appeared isointense on both T1-weighted and T2-weighted MR images. Peritumoral cyst was seen at the cranial and caudal sides.


T2-weighted axial magnetic resonance images, T12-L1 intervertebral disc level.


L1 vertebral body level Peritumoral cyst was evident.


T1 image with gadorinium MR image, sagittal view.


Axial views T12-L1 intervertebral disc level.


L1 vertebral body level Homogeneously enhanced and lobulated tumor was clearly seen.


(a) Intraoperative view when opening the dura matter. A reddish tumor associated with peritumoral cysts at both cranial and caudal sides was found.


(b) The tumor arose from the film terminale.


Intraoperative indocyanine green (ICG) videoangiography showing the tortuous feeding arteries from the both poles and the draining vein along the film terminale.


Histopathological findings of the tumor (HE stain). The tumor was composed of vacuolated stromal cells and small nucleus in a rich capillary network with several enlarged vessels.


Swelling on the thenar aspect of the right palm.


Magnetic resonance imaging (T2-weighted) showing a well-defined, sharply demarcated, heterogeneously hyperintense lesion.


(a) Intraoperative view of the lesion while dissection.


(b) Specimen after complete excision.


Image of the right hand after 3 weeks of surgical excision of the space-occupying lesion.


Tumor is composed of small, round cells with inconspicuous nucleoli and scanty cytoplasm, which are arranged in sheets or solid nests (Hematoxylin-Eosin staining, X400).


Tumor displays a diffusely infiltrative growth pattern. Rare residual breast ducts are also seen (Hematoxylin-Eosin staining, X100).


On immunohistochemistry, the tumor cells show strong membranous staining for CD99 (CD99, X400).


Gallium-68 prostate-specific membrane antigen positron-emission tomography computed tomography maximum intensity projection.


Fused coronal.


Fused axial. Images. Images showed prostate-specific membrane antigen-avid lesions in the prostate and right testis.


A correlative ultrasonography of the scrotum showing a hypoechoic lesion in the right testis (d).


Fused axial. Images. Images showing a prostate-specific membrane antigen-avid lesion in the left testis.


A correlative ultrasonography of the scrotum showing a hypoechoic lesion in the left testis (d).


A 1.5 cm diameter nodule on left half of upper lip before excison.


FNAC: aggregates, acini and single scattered benign epithelial cells along with myoepithelial cells and chondromyxoid stromal fragments (Giemsa stain, x40). . Abbreviations: FNAC, fine needle aspiration cytology.


(A) FNAC smear showing sheet of myoepithelial cells with basophilic dense cytoplasm and central to eccentric, round to oval nuclei with bland chromatin (Giemsa stain, x200).


(B) Cluster of epithelial cells with scattered myoepithelial cells in a chondromyxoid background (Giemsa stain, x200). . Abbreviations: FNAC, fine needle aspiration cytology.


Endoscopic features of the lesion at the caecum. A; Colonoscopy detected a 20 x 16 mm white, flat, elevated lesion with a reddish nodule in the center of the mass.


Endoscopic features of the lesion at the caecum. B; Chromoendoscopy of crystal violet solutions showed mucus covering a wide-open pit (square yellow box).


Endoscopic features of the lesion at the caecum. C; Crystal violet solutions revealed mucus covering a dendritic structure (square blue box).


Endoscopic features of the lesion at the caecum. D; The central reddish nodule demonstrated an irregular glandular structure (square red box).


Whole body Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography maximum projection image shows uptake in primary prostate lesion and penile metastasis.


Sagittal computer tomography.


Positron emission tomography.


Positron emission tomography/computed tomography.


Maximum projection image , Gallium-68 prostate-specific membrane antigen positron emission tomography/computer tomography showing soft-tissue enhancing lesion in the prostate gland and corpora cavernosa thickening of penis with intense prostate-specific membrane antigen uptake suggesting metastasis.


(A) Multiple translucent skin-colored, bluish cystic lesions in periorbital distribution, cheeks, and zygomatic region.


(B) Unilocular cyst lined by two layers of flattened cuboidal epithelium without any evidence of decapitation in lining cells (hematoxylin and eosin, x40 magnification).


(C) Whitish clod (yellow arrow) without crater seen on dermoscopy (nonpolarized mode, x170 magnification).


(D) Yellowish globules (blue arrow) with multiple telangiectasias (white arrow) seen on dermoscopy (polarized mode, x170 magnification).


Chest x-ray. Right diaphragmatic paresis and poorly inflated right lower lobe.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (A) The section shows muscle tissue (big arrow) of the diaphragm and granuloma (star) surrounded by adipose tissue (white arrow) close to the serosa (small arrow) of the pleura, at magnification 200x.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (B) Granuloma (star) at magnification 400x.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (C) Non-caseating granuloma consisting of Langerhans giant cells (big arrow) and epithelioid cells (small arrow), magnification 800x.


Hematoxylin and eosin (H&E) stain of diaphragm sections. (D) Myositis with lymphocytic infiltrate (star) of the muscle tissue, already showing destruction of the muscle cells, magnification 800x.


Chest computed tomography scan. Bronchiectasis and multiple granular shadows are randomly distributed in the bilateral lobes, and consolidation in the lower left lobe is present.


Flow cytometric analysis of phosphorylationed STAT1 (pSTAT1) in monocytes after the stimulation with interferon-gamma (500 U/mL). The analysis gate was set in CD14+ cells. Blue areas indicate healthy adults (n = 3), whereas pink areas indicate the patient. Gray and purple areas indicate pSTAT1 in monocytes without interferon-gamma stimulation in healthy adults and the patient, respectively.


Gram-stain of bronchoalveolar lavage. Black arrows indicate capsulated Gram-negative large rod.


Multiplex PCR. The isolated strain possessed iutA, rmpA, entB, and mrkD.


X-ray right hand A-P pre operative showing osteolytic lesion in 3rd metacarpal.


Excision of the lesion and fibular grafting.


Imaging of a hepatic perivascular epithelioid cell tumor. (a) Contrast-enhanced arterial phase of computed tomography reveals a poorly defined mass with marked enhancement and inferior vena cava invasion.


Imaging of a hepatic perivascular epithelioid cell tumor. (b) Coronal reconstruction of venous phase contrast-enhanced computed tomography shows relatively washout of mass with unclear borders. Tumor thrombus in inferior vena cava is also seen clearly in coronal multidetector computed tomography image.


Axial T1-weighted.


Fat-suppressed T2-weighted. Magnetic resonance imaging images demonstrate T1-isointense, T2 and fat-suppressed T2-hyperintense mass component of liver perivascular epithelioid cell tumor in vena cava inferior.


Postgadolinium fat-suppressed axial arterial phase (a), and coronal venous phase images demonstrate a large liver perivascular epithelioid cell tumor that marked heterogeneous enhancement in arterial phase, and washout in venous phase with prominent invasion of inferior vena cava.


Tumor thrombus is markedly seen in late venous phase (b).


Diffusion-weighted image of perivascular epithelioid cell tumor (black arrow). Marked diffusion restriction of malign perivascular epithelioid cell tumor is seen as hypointense signal change on apparent diffusion coefficient map.


(a) Giant earlobe epidermoid cyst.


(b) Giant epidermoid cyst resection and content.


Optical coherence tomography showing an area with subretinal fluid leakage.


Fluorescein angiography showing the presence of significant pigment epithelial detachment in the perifoveal capillary network (venous phase) just before starting treatment with ranibizumab No polyps were observed.


C; Indocyanine green angiography performed 3 months later (after initial loading dose of ranibizumab 0.5 mg) showing 3 hyperfluorescent polyps in the superior papillary area of the right eye.


Optical coherence tomography at the follow-up visit 4 weeks after combination therapy with ranibizumab 0.5 mg and photodynamic therapy (right eye).


Optical coherence tomography performed 4 weeks after administration of the loading dose of aflibercept followed by half-fluence photodynamic therapy (right eye).


Anterior segment photograph at the first visit showing a totally detached retina in contact with the posterior surface of the lens. The peripheral retina could not be observed.


MRIs taken at two different periods. T1.


MRIs taken at two different periods. T2. Images taken 3 months before the first visit show a hyperintense lesion and a slightly hypointense lesion in the subretinal space, respectively.


MRIs taken at two different periods. Both T1.


MRIs taken at two different periods. T2. Images taken at the first visit show hyperintense lesions in the subretinal space. Tumor structure is not observed in the eye.


Fundus photograph of the right eye during the first operation under perfluoro-n-octane. Dilated retinal vessels, numerous microaneurysms, and intra- and subretinal exudates became visible.


Fundus photograph of the right eye during the second operation under perfluoro-n-octane. The amount of exudates were reduced.


Fundus photos of the initial visit of the right eye.


Fundus autofluorescence of the initial visit of the right eye.


Late-phase fluorescein angiography of the initial visit of the right eye.


Left eye.


Left eye. Showed absence of the normal foveal hypoautofluorescence.


Left eye. Showed diffuse leakage.


Horizontal sections of optical coherence tomography on the initial visit showed a large foveal cyst in the right eye.


Horizontal section of optical coherence tomography on follow-up showed a decrease in the size of cavitation due to "collapse" of the roof in the right eye.


A defect of the cone outer segment and ellipsoid zone in the left eye.


Partial resolution of the initial defects in the ellipsoid zone and outer segments of the photoreceptors of the left eye.


Optical coherence tomography angiogram showed vascular remodeling and capillary plexus thinning in the inner retinal layers (right eye,. Left eye.


Retinal vessels are noted in the normally avascular outer retina (right eye.


Middle retinal layers (right eye.


Temporal to the fovea.


Bilateral necrosis of the patient's lower extremities involving the pedal and tibial area with some areas of the thighs affected.


Bilateral Autoamputation of the patient's lower extremities showing both tibial stumps with exposed bones surrounded by dry necrotic tissue.


X-Ray of the Patient's Lower Extremities showing no signs of bone and surrounding inner soft tissue destruction.


The patient's Lower Extremities after debridement.


Computed tomography scan of abdomen (axial section) showing a right iliopsoas abscess.


T1-weighted magnetic resonance imaging of the abdomen (coronal section) showing right iliopsoas abscess.


T2-weighted magnetic resonance imaging of the abdomen (coronal section) showing right iliopsoas abscess.


Intraoperative mucinous material mixed with pus from psoas muscle.


Mandibular occlusal radiograph showing expansion of the cortical plates.


Axial CT image of the mandible showing cortical expansion and thinning.


Postoperative panoramic radiograph, 1 year after curettage, showing no recurrence.


Anterior view of patient s face and body.


Lateral view of patient s face and body.


Brain MRI - Increased signal in T2-weighted images in the withe matter territories adjacent to the lateral ventricles bodies and subcortical zone.


Brain MRI - Increased signal in FLAIR images in the withe matter territories adjacent to the lateral ventricles bodies and subcortical zone.


EEG showing non specific slow background activity, as well as no epileptiform discharges.


Immunohistochemical study proved to be positive for CD68. Immunophenotyping confirms the histiocytic lineage through an overexpression of the CD68 antigen.


Immunohistochemical study showing atypical histiocytic proliferation, diffuse proliferation of large cells with irregular nuclei, conspicuous nucleoli and abundant cytoplasm.


Gray white tumor with pushing borders and with tiny cystic spaces filled with gray brown material.


Initial 9 cm right renal cyst.


Paracolonic cystic lesion (white arrow) along the ascending colon in relation to recurrent right renal mixed epithelial stromal tumor cyst (red arrow).


Mesenteric multiloculated paracolonic mixed epithelial stromal tumor lesion (arrows).


Immunohistochemical stain of stroma is positive for estrogen receptor (x200).


Tc-99m glucohepatonate single-photon emission computed tomography done after 1 week of magnetic resonance-positron emission tomography. Single-photon emission computed tomography image.


Tc-99m glucohepatonate single-photon emission computed tomography done after 1 week of magnetic resonance-positron emission tomography. Fused single-photon emission computed tomography/ computed tomography. Acquired post-Tc-99m glucohepatonate injection showing uptake corresponding to the areas of enhancement on magnetic resonance imaging (white arrow in a and black arrow in b). Note that the areas of gyral uptake seen on positron emission tomography images are no longer appreciated.


G-banded karyotype of the bone marrow cells showing t(9;14)(p24;q13).


Computed tomography (CT) scans of the thorax of the patient. (A) CT scan before the treatment.


Computed tomography (CT) scans of the thorax of the patient. (B) Image of the best response of pembrolizumab therapy.


Computed tomography (CT) scans of the thorax of the patient. (C) Image of progression of pembrolizumab therapy and before atezolizumab therapy.


Computed tomography (CT) scans of the thorax of the patient. (D) Image of best response of atezolizumab therapy. CR, complete response; SD, stable disease; PD, progressive disease.


Clinical picture showing a diffuse extraoral swelling of size 4.5 cm x 3.5 cm present on the right side of the face (maxilla).


Intraoral picture showing erythematous growth on the right side of the maxilla extending from 14 to 17.


Radiograph revealing ill-defined radiolucency and significant bone loss on the right side of the maxilla.


Odontogenic epithelium in follicular pattern, few of the follicles showing stellate reticulum-like cells, along with increase in cellular atypia and mitotic activity.


CK19 was found to be positive.


Timeline of the diagnosis and treatment. M1, the mass adjacent to the left hilum; M2, the mass on the basal segment; chemo, chemotherapy; pembr, pembrolizumab; CA-125, carbohydrate antigen 125; CEA, carcino-embryonic antigen; i. V. , intravenously.


CT image showing homogeneously enhanced lesion in the scalp of occipital region.


CT bone window showing a minimal osseous gap in the midline but no intracranial extension of the lesion.


Excised specimen showing the giant lesion, of firm consistency and with no visible necrotic areas.


Photomicrograph of tissue taken from the lesion excised from the patient, showing characteristic spindle cells forming perivascular rosettes and staining with smooth muscle actin (SMA).


solid pseudopapillary neoplasm; pseudo-papillary component with vessels surrounded by loosely cohesive cells.


solid pseudopapillary neoplasm; cystic pattern with large hemorrhagic changes and foamy cells.


solid pseudopapillary neoplasm; the neoplastic cells show nuclear immunolabelling for beta-catenin.


solid pseudopapillary neoplasm; diffuse intracytoplasmic dot-like imunoreactivity for CD99.


Clinical presentation of the patient. Body scheme showing the distribution of six cafe-au-lait macules (CALMs) (a).


Clinical presentation of the patient. Colonoscopy image showing multiple polyps in a section of the left hemicolon (b).


Clinical presentation of the patient. Representative CALMs from trunk, note the irregular (cost of Maine shaped) border.


Clinical presentation of the patient. And right hip.


MRI of the dorsolumbar region sagittal section, T1WI.


T2WI , demonstrates a large intradural extramedullary cystic lesion with multiple internal septations, having significant compression over spinal cord, conus medullaries, and cauda equine.


MR myelogram (c) showing variable extension into bilateral neural foramen.


MRI of the dorsolumbar spine, axial section T1WI.


T2WI , demonstrates that intensity is similar to that of CSF which is isointense in T1WI and hyperintense in T2WI.


Peroperative photograph demonstrated a large cystic lesion after laminectomy of D11, D12, L1, and L2.


En bloc removal of the cyst.


(a) Clinical image showing a tan-red exophytic, lobulated mass of the maxillary anterior facial gingiva.


(b) A separate, similar appearing smaller lesion was identified in the right maxillary vestibule.


Periapical radiograph showing no changes in the quality or quantity of bone and no evidence of odontogenic infections.


(a) Histopathologic image showing tumor cell nests completely effacing the lamina propria, (H&E, x40).


(b) These tumor nests were arranged in lobular aggregates separated by thin fibrous septae, (H&E, x100).


(c) On high power magnification, the cells displayed pink to vacuolated cytoplasm with vesicular nuclei and prominent nucleoli. Significant nuclear pleomorphism was present and the lesion demonstrated brisk mitotic activity, (H&E, x400).


Admission CT scan showing multiple intrahepatic abscesses (arrowhead). Axial.


Admission CT scan showing multiple intrahepatic abscesses (arrowhead). Coronal. Views are shown.


Microscopic examination showed fragments of neutrophil-rich debris (consistent with abscess) and liver parenchyma embedded in fibrous tissue (consistent with abscess wall). Immunohistochemical stains for tumor were negative (not shown) and no definite organisms were detected on H&E.


Microscopic examination showed fragments of neutrophil-rich debris (consistent with abscess) and liver parenchyma embedded in fibrous tissue (consistent with abscess wall). Or Gram-stained sections. (1,000x).


Microscopic examination showed fragments of neutrophil-rich debris (consistent with abscess) and liver parenchyma embedded in fibrous tissue (consistent with abscess wall). WS silver stain (c, d), however, revealed long rod-shaped bacteria, consistent with Fusobacterium sp. (arrowheads) (1,000x).


PET/CT scans of the patient. (A) Baseline. The fluorodeoxyglucose (FDG) uptakes increased in multiple patchy shadows and massive consolidations of the bilateral lungs (SUVmax = 22.1), multiple partial bones (SUVmax = 19), multiple swelling lumbosacral nerve roots (SUVmax = 16), masses in the bilateral adrenal glands (SUVmax = 31.2), and a nodule (0.7 cm) between cervical rear muscles.


PET/CT scans of the patient. (B) Disease progression after first-line chemotherapy. The sizes and FDG uptakes of massive consolidations in the bilateral lungs increased with SUVmax of 31.5. FDG uptakes of other lesions decreased.


PET/CT scans of the patient. (C) The patient achieved a complete response after four cycles of sitilimab and chidamide. The SUVmax of lesions in the left and right lungs were 2.4 and 2.1, which indicated a Deauville score of 2.


Computed tomography (CT) scan of the neck showing lymphadenopathy.


Histopathological findings of the lymph node. A) View of necrotic area and karyorrhectic debris (hematoxylin and eosin strain x 40).


Histopathological findings of the lymph node. B) CD68+ histiocytes.


Histopathological findings of the lymph node. C) CD3+ T-Cells.


Histopathological findings of the lymph node. D) CD20+ B-cells.


Cytospin-processed smear of pleural fluid revealing uniformly dispersed haematolymphoid blasts intermixed with mesothelial cells (H&E x400).


Pathogen identification from cerebrospinal fluid sample using next-generation sequencing method. (A) The number of sequencing reads identified corresponding to Human polyomavirus 2 [also known as JC virus ] was 34; with genome coverage 35.1825.


Pathogen identification from cerebrospinal fluid sample using next-generation sequencing method. (B) Reads distribution of total DNA sequence in the CSF sample without human host.


Maximum likelihood phylogenetic tree of Human polyomavirus. Human polyomavirus 2 AB103411 (in red) was the most similar strain in the cerebrospinal fluid of the patient.


Frontal view of the patient showing a well defined swelling on left side and diffuse swelling on the right side of the mandible.


Intra-oral photograph shows an expansile swelling of the mandible with complete bucco-lingual cortical plate expansion and lingually displaced teeth.


Orthopantomogram reveals a massive high density, mixed radiopaque-radiolucent lesion exhibiting cotton -wool appearance. Demarcation between the lesion and normal bone with bowing of the inferior border of mandible is appreciable.


Lower occlusal radiograph shows irregular bucco- lingual cortical plate expansion.


Posterior Anterior mandible view reveals an expansile mixed radiolucent radiopaque lesion extending from the ramus of left side to the right angle of the mandible.


F-18 fludeoxyglucose positron emission tomography maximum intensity projection image of the patient showing hypermetabolism in the bilateral knee joint region and right pelvic region.


Fludeoxyglucose-avid fibrocavitatory changes in apical segment of the right lung upper lobe and nonfludeoxyglucose-avid cavitating groundglass density nodule in apicoposterior segment of the left lung upper lobe.


Hypermetabolic subcarinal lymph node (maximum standardized uptake value 4.2).


Hypermetabolic collection in the pericecal region along the base of the cecum (maximum standardized uptake value 4.0).


Effusion with fludeoxyglucose uptake in the right knee joint (maximum standardized uptake value 4.7). Fludeoxyglucose uptake in the left proximal tibia (maximum standardized uptake value 3.4).


(A) Transabdominal scan performed at 25 weeks 4 days in coronal plane: the cleft lip appeared as an anhecogenic area at the level of the left upper lip.


(B) Transverse section of fetal chest at 25 weeks 4 days: the red arrow pointed to the defect between the left atrium (LA) and the coronary sinus (CS).


(C) The three-vessel and tracheal (3VT) view at the upper mediastinum showed a supernumerary vessel to the left of the pulmonary trunk and arterial duct. The red arrow pointed to the persistent left superior vena cava (PLSVC) draining into the right atrium.


Single nucleotide polymorphism (SNP) array results of the fetus: the red rectangle showed the deletion region of 1q23.3q31.2.


3D spoiled gradient-echo MRI image obtained at 55 min shows dilated lymphatics (arrow) reaching upto the groin.


(A and B) Histopathological findings of lung biopsy of right upper lobe, medium-sized vessels (arteries and veins) are rarely seen and are probably destroyed by the inflammation and replaced by scattered relatively small necrosis consisting of degenerating karyorrhectic neutrophils with basophilia and eosinophils with fibrinoid necrosis (probable foci of leukocytoclastic vasculitis). 8, there are small epithelioid granulomatous collections with occasional central small necrosis, and few multinucleated giant Langerhans-type cells are noted.


Cross section chest CT scan.


Coronal section chest CT scan. . Chest CT scan: revealed multifocal cavity lesions, most prominent in the apices, consolidative volume loss greatest in upper zones, right greater than left.


Coronal section chest CT scan. . Chest CT scan: revealed progressive airspace opacities and traction bronchiectasis in the right base with small right pleural effusion on the background of severe thick-walled cystic changes in the apices.


Coronal section chest CT scan. . Chest CT scan: revealed enlarged thick -walled cavities in the bilateral apices, worsening the cavitary lung disease.


Contrast-enhanced abdominal CT shows the presence of a partially septated giant cystic lesion measuring 20 x 11 x 13 cm in the abdominal cavity.


On magnetic resonance cholangiopancreatography, the pancreatic body lesion detected by the CT scan was depicted as high-intensity area on a T2-weighted image.


A distal pancreatectomy with splenectomy was performed. The cystic content was serous fluid of a dark, muddy color, suggesting previous bleeding.


On histopathological examination, the lining membrane had a papillary structure composed of cuboidal cells with round nuclei (a).


The cells stained PAS-positive.


Diastase PAS-negative , thus indicating the presence of glycogen. These findings led to the definitive diagnosis of SCN.


Extraoral view of the upper lip swelling.


Intraoral view of the lesion before enucleation.


Intrasurgical photograph of sebaceous cyst.


Formalin-fixed resected tissue.


Hemophagocytosis in the bone marrow. An activated macrophage engulfing blood cells; Papanicolaou's stain (oil immersion).


Leishmania sp. Amastigote in bone marrow aspiration; Papanicolaou's stain (oil immersion).


Thoracic radiography showed cardiomegaly, and computed tomography revealed a left lung mass with invasion of the heart and pleural effusion.


MRI showed a large mass surrounding the heart. The arrow indicates endocardial invasion of a lesional mass.


Preoperative axial T1-weighted.


Fluid-attenuated inversion recovery.


Diffusion-weighted.


Gadolinium-enhanced T1-weighted.


Magnetic resonance imaging shows a solid mass at the dorsal medulla oblongata The tumor shows prominent homogeneous enhancement with gadolinium.


(a-c) Three months after starting treatment, magnetic resonance imaging shows marked reductions in mass size on fluid-attenuated inversion recovery imaging and gadolinium-enhanced T1-weighted imaging (white arrows).


(d-f) All residual lesions have disappeared by the 1-year follow-up.


Wet mount examination of trophozoites of Balantidium coli.


Trichrome stained trophozoites of Balantidium coli.


Image of patient exhibiting edematous erythema, ulcer, and necrosis over the right nasal alae and upper lip.


Microscope image of biopsied lesion tissue showing numerous hyaline and septate hyphae with branches at acute angles scattered in the dermis (arrowhead) (periodic acid-Schiff, original magnification x 400).


Blood cell counts during hospitalization.


Clinical presentation of the case with IL12RB1 deficiency. Pictures were taken on different occasions:. Skin lesion in the form of multiple erythematous maculo-papular rash, over the upper limbs.


Clinical presentation of the case with IL12RB1 deficiency. Pictures were taken on different occasions: , lower limbs.


Clinical presentation of the case with IL12RB1 deficiency. Pictures were taken on different occasions: over the abdominal wall surrounding the umbilicus.


Clinical presentation of the case with IL12RB1 deficiency. Pictures were taken on different occasions: (D) A swelling is shown in the left groin, due to left inguinal lymphadenitis (arrowed).


CT scan showing the stent in the enlarged cyst.


A partially clogged stent.


Endoscopic view of stents. Purulent drainage is also seen.


Follow-up MRI showing only small residual collection.


A: T1 MRI demonstrating PVH in the left trigone.


B: T2 Coronal MRI status-post implantation of intracranial electrodes.


C: Dose plan for Case 1.


D: Axial T2 MRI showing left trigone PVH.


A: Coronal T2 MRI showing left trigone PVH.


B: CT scan demonstrating cerebral edema from radiation necrosis.


C: Dose plan for initial LINAC treatment for Case 2.


D: Dose plan for second LINAC treatment for Case 2.


Computed tomography scan images of. Whole chest.


Computed tomography scan images of. Enlarged scan of the tumor.


Immunohistological staining with. Hematoxylin, and ,eosin.


Anti-napsin A antibody.


Anti-cytokeratin AE1/AE3 antibody.


Anti-thyroid transcription factor 1 antibody (magnification, x20).


Imaging findings in case 1. On MRI of the sacral spine, the tumorous lesion has clear margins and is enclosed by the S1 vertebral body. The signal intensities are homogeneously low in T1-weighted images.


Imaging findings in case 1. On MRI of the sacral spine, the tumorous lesion has clear margins and is enclosed by the S1 vertebral body. And high in T2-weighted images.


Imaging findings in case 1. On MRI of the sacral spine, the tumorous lesion has clear margins and is enclosed by the S1 vertebral body.no enhancement is observed in T1-weighted images with a gadolinium contrast medium No extraosseous lesion or enlargement is observed.


Imaging findings in case 1. On MRI of the sacral spine, the tumorous lesion has clear margins and is enclosed by the S1 vertebral body. CT image demonstrates slight osteosclerosis throughout the tumorous lesion and no osteolytic changes in the vertebral body (D).


An image of CT-guided needle biopsy procedure in case 1. The vertebral tumor has been accessed through the sacroiliac joint to obtain a biopsy specimen.


Imaging findings in case 2. On MRI of the sacral spine, the signal intensities of the tumorous lesion are homogeneously low in T1-weighted images and high in T2-weighted images, and no enhancement is observed in fat-suppression T1-weighted images with a gadolinium contrast medium in the S2 vertebral body (A-C).


Imaging findings in case 2. CT image demonstrates slight osteosclerosis throughout the tumorous lesion and no osteolytic changes (D).


Pre-operative chest X-rays of the patient (not intubated). Widening of the superior mediastinum with early left lower-lobe patchy
infiltrates and right lung upper-lobe early herniation to the left.


Bronchoscopy showing narrowing of the left main bronchus.


Patient intubated, rotated, left-lung early collapse consolidation
and middle lobe consolidation.


Middle mediastinal cystic mass lesion. Displacing and compressing
the airway and the oesphagus.


Atresia of left bronchus due to chronic mass effect.


Middle mediastinal cystic mass with mass effect on the superior
vena cava and trachea and with associated anterior displacement of the
anterior mediastinum, left lung collapse and right lung compensatory
hyperinflation.


Right lung hyperinflation with multiple diffuse patchy infiltrates
suggestive of infection and early consolidation.


Solitary erythematous, slightly verrucous nodule, 3 cm in diameter, arising on a yellowish, verrucous plaque measuring 3 x 6 cm on the left frontoparietal scalp.


Histopathologic findings demonstrate mild epidermal papillomatosis associated with increased sebaceous gland and abortive hair follicles. HE. Original magnification x100.