18F-fluorodeoxyglucose whole-body positron emission tomography-computed tomography scan maximum intensity projection (12 h after stopping potassium chloride infusion): Normal biological distribution with minimal uptake in muscles.


Pretreatment intraoral photographs.


Normal intraoral appearance during the onset phase.


"Twin-Block" functional appliance used in the patient.


No relevant findings evident on orthopantomogram examination.


Bone marrow aspirate smear (from bone marrow biopsy) stained with May-Grunwald Giemsa showing amastigote forms of Leishmania spp.


Viral load and CD4+ T-cells count evolution following cART initiation and VL diagnosis. TRIP = travel in Greece; H = date of hospitalization; (c)ART = (combined) anti-retroviral therapy; BMB = bone marrow biopsy (VL diagnosis); M1 = first month after cART initiation; M3 = third month after cART initiation; M6 = sixth month after cART initiation; LAmB = intravenous liposomal amphotericin B administrations.


MRI of the patient showing the rt seminal vesicle sandwiched between bladder and rectum.


MRI showing the tumor's relationship to the ureter.


Intraoperative picture showing the tumor.


Enbloc removal of the rt seminal vesicle along with partial cystectomy.


The treatment procedures and corresponding leukocyte counts in the patient's cerebrospinal fluid. Monocytes were predominant among CSF white cells; they had a proportion of approximately between 60 and 90%. The CSF protein level was also elevated to 95.00-125.20 mg/dl. mNGS. P, metagenomic next-generation sequencing of cerebrospinal fluid detected Sarocladium strictum positive; Culture. P, Sarocladium strictum was positive in cerebrospinal fluid culture.


(A) Axial computed tomography (CT) image of the manubrium sterni obtained through the bone window showing an osteolytic lesion with expansion and a periosteal reaction with the appearance of sunrays around the periphery (arrows).


(B) Sagittal reconstructed CT image of the sternum showing the lesion involving the manubrium and almost all the body of the sternum. The lesion is slightly expansile and the cortex is partially destroyed.


(A) Axial computed tomography (CT) image of the manubrium sterni obtained through the soft tissue window showing that the bone marrow of the sternum has been substituted by homogeneous soft tissue.


(B) Axial contrast-enhanced CT image of the manubrium sterni showing marked homogeneous enhancement of the tumor.


(A) T1-weighted sagital image (repetition time/echo time, 590/21 msec) of the sternum showing an area of low signal intensity in the manubrium and body of the sternum.


(B) Short-tau inversion recovery T2-weighted sagittal image (repetition time/echo time, 4150/106 msec) of the sternum showing an area of high intensity in the same region; the soft-tissue mass is clearly demonstrated.


(A) Histopathological examination (hematoxylin and eosin stain; original magnification, x200) demonstrating proliferation of round cells with abundant cytoplasm and eccentric nuclei with coarse chromatin, indicating a plasmacytoma.


(B) Immunohistochemical analysis revealing positive cluster of differentiation 38 staining on the cell membrane (arrow), which is characteristic of a plasmacytoma (original magnification, x200).


Treatment timeline for CRKP infection.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. Histograms compared Chao1 index.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. Shannon index. Of the fecal microbiome in the donor and the patient pre- and post-FMT.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. PCoA plots showed the microbial community variation of the donor and the patient pre- and post-FMT based on weighted UniFrac distance.


Alpha and beta diversity of the gut microbiota of the donor and the patient pre- and post-FMT. And unweighted UniFrac distance FMT 1W, FMT 3W and FMT 2M represented 1 week, 3 weeks and 2 months after FMT.


The clinical course of the patient (schematic). Hematoxylin and eosin staining of the liver specimen shows some punctate necrosis on the lobule, apoptotic bodies in the hepatic cord, fatty degeneration of hepatocytes, mild inflammation in the portal area, and eosinophil infiltration in the inflammatory necrosis area.


Timeline with relevant data from the episode of care; curves of body temperature and eosinophils count. The blue line shows the body temperature values. The orange line shows the eosinophil counts. Horizontal thick lines show the medications administered. PIP-SBT, Piperacillin-sulbactam.


Imaging features of the patient. (A) Abdominal MRI enhancement showed that the right lobe of the liver scattered flakes, irregular shape, enhanced uneven enhancement on hospital day 2.


Imaging features of the patient. (B) Abdominal CT enhancement showed liver multiple nodules, mass slightly low-density shadow, edge enhancement on hospital day 13.


Imaging features of the patient. (C) Abdominal CT enhancement showed multiple cystic and tubular low-density shadows scattered in the liver, and some showed edge enhancement on day 33.


Imaging features of the patient. (D) Abdominal CT enhancement showed multiple cystic and tubular low-density shadows scattered in the liver, some showed edge enhancement, and a few lesions were smaller than those before on follow-up day 69.


Imaging features of the patient. (E) Abdominal MRI enhancement showed cystic and tubular shadows in the right lobe of the liver, with irregular shapes and edge enhancement in the enhanced part. Some lesions were smaller than before on follow-up day 137.


Imaging features of the patient. (F) Abdominal MRI enhancement showed the right lobe of the liver scattered flakes, irregular shape, enhanced edge uneven enhancement, lesions significantly reduced on follow-up day 418.


Lesion with hypersignal on T2 in the regions of midbrain and right parahippocampus.


Hyperintense lesion on T2 at the midbrain peduncle, mimicking a mesencephalic tumor.


Microphotograph showing clusters of round-to-oval cells (MGG, x100). Inset showing wisps of magenta-colored material (MGG, x400).


Microphotograph showing spindle-shaped endothelial cells (arrow) crossing a cluster of tumor cells (MGG, x400).


Histopathologic sections showing nests and sheets of tumor cells around endothelium-lined small blood vessels (Hand E, x100).


A; Brownish macule with a bluish center on the dorsum of the right foot.


B; Dermoscopy showing a blue-steel pigmentation in one part and a violaceous color in the other, with hypopigmented areas.


C; Histology showing dermal proliferation of spindle cells organized in fascicles with a storiform pattern or in nests. H&E. Original magnification, x10.


D; Melan-A was diffusely positive. Immunohistochemistry. Original magnification, x5.


MRI of the neck with gadolineum. A) Sagittal T1 image illustrating an intramedullary enhancing mass from the cervicomedullary junction to C4. Leptomeningeal enhancement is also present.


MRI of the neck with gadolineum. B) Axial T1 image illustrating the intramedullary mass and leptomeningeal enhancement.


MRI of the neck with gadolineum. C) Axial image of cervical spine illustrating a dumbbell mass extending through C5-C6 neural foramen and paraspinal mass.


MRI of the neck with gadolineum. D) Coronal T1 image illustrating intramedullary mass.


HandE staining illustrating small round blue cells with high mitotic rate, atypical mitosis (red arrow), and pleomorphic nuclei (green bracket) characteristic of a primitive neuroectodermal tumor.


Immunohistomchemical staining. A) GFAP positive b) Synapthophysin positive, illustrating positivity around a binucleated cell (red arrow).


Preoperative radiograph of the patient.


Preoperative CT images demonstrated extensive vertebral body destruction, several facet joint dislocations and mild retrolisthesis of C4 to C5 segment.


Sagittal cervicothoracic MR images demonstrated pathologic contrast enhancement on C4 to T7 segments along with vertebral body involvement and spinal canal compression at the level of C4 to T4. From coronal MR images, a large paravertebral abscess was presented anteriorly.


Postoperative radiograph demonstrated pedicle rod and screw construct that resulted in improved kyphotic deformity.


Abdominal CT scan shows massive ascites.


Umbilical cord cyst images. . A: Umbilical cord cyst first detected at 20 0/7 weeks of gestation (arrow).


Umbilical cord cyst images. B: Umbilical cord cyst was confirmed and a clear image of the connection between the bladder and the umbilicus was found at 22 5/7 weeks of gestation.


Umbilical cord cyst images. C: Doppler velocimetry demonstrated flow around the cyst.


Umbilical cord cyst images. D: Doppler ultrasound examined the size of the cyst.


Fusiform mass in dorsal aspect of the index finger.


Histopathologic examination revealed proliferation of fibroblasts, dposit of osteoid, osteoblasts, and giant cells.


Photograph of a 9-year-old Japanese boy showing corneal infiltrate with surrounding edema in the right eye.


Twelve months after the initial visit, there is slight corneal opacity in the patient's right eye.


Echocardiography of the three presented cases. . Notes: Parasternal long-axis views . (A and B) Case 1: granular sparkling appearance was seen in the interventricular septum (IVS), which was 11.5 mm in thickness.


Echocardiography of the three presented cases. Apical four-chamber views . (A and B) Case 1: granular sparkling appearance was seen in the interventricular septum (IVS), which was 11.5 mm in thickness.


Echocardiography of the three presented cases. . Notes: Parasternal long-axis views . (C and D) Case 2: granular sparkling appearance was seen in the IVS and the lateral wall.


Echocardiography of the three presented cases. Apical four-chamber views . (C and D) Case 2: granular sparkling appearance was seen in the IVS and the lateral wall.


Echocardiography of the three presented cases. . The IVS of Case 2 was less thickened (9.8 mm in thickness), but the left ventricular wall exhibited diffuse hypertrophy with diastolic dysfunction (E/e' 15.55) without valvular dysfunction. (E and F) Case 3: granular sparkling appearance was shown in the IVS and lateral wall, and the IVS was 13.0 mm in thickness.


Echocardiography of the three presented cases. . Are presented. (E and F) Case 3: granular sparkling appearance was shown in the IVS and lateral wall, and the IVS was 13.0 mm in thickness.


The abdominal computerized tomography of Case 3. . Notes: The abdominal wall around the navel was ~3-5 mm in thickness, where FNAB-AFP is usually performed. The white arrow indicates where FNAB of the hip was performed. . Abbreviations: AFP, abdominal fat pad; FNAB, fine-needle aspiration biopsy.


Coronal.


Sagittal.


Axial images of chest computed tomography demonstrating a mass (arrow) invading the right pulmonary artery (PA).


(d) Image obtained during endobronchial ultrasound-guided transbronchial needle aspiration showing the sampling needle inside the intra-arterial mass (arrow) within the lumen of the pulmonary artery.


The fixed smears demonstrate loosely cohesive clusters of spindled cells with irregular elongated nuclei (Papanicolaou).


The air-dried smears show pleomorphic cells; many have large, irregular nuclei and finely vacuolated cytoplasm (Diff-Quik).


The gross resection shows the lumen of the pulmonary artery completely occulted by tumor.


(a) The resected tumor demonstrates spindled cells with a storiform pattern (H and E). (b). Higher magnification shows pleomorphic cells with convoluted to spindled nuclei, often containing nucleoli (H and E).


Surgical specimen. A; Macroscopic view.


Surgical specimen. B; Hematoxylin and eosin staining at 5-fold magnification revealing a fissure, transmural inflammation and architectural changes of the surrounding mucosa.


Surgical specimen. C; Hematoxylin and eosin staining at 100-fold magnification revealing non-caseating granulomas within a draining lymph node.


Magnetic resonance imaging of the lesion on the superior pole of the spleen.


Low power photomicrograph showing variable sized nodules (H&E 40x).


Renal biopsy - light microscopy. . Notes: Light microscopic examination of renal biopsy: (A) trichrome stain showing moderate tubular atrophy, interstitial fibrosis and interstitial inflammation (affecting 50% of cortical area). No interstitial granulomas are seen.


Renal biopsy - light microscopy. (B) Hematoxylin and eosin stain of glomeruli showing glomerular crescent.


Renal biopsy - light microscopy. (C) Trichrome stain of glomeruli showing necrotizing crescent. Out of 19 glomeruli examined, nine showed complete or near complete global sclerosis.


Renal biopsy - immunofluorescence microscopy. . Notes: Immunofluorescence microscopy of renal biopsy (A and B): Immunofluorescence (IF) staining shows weak linear staining of glomerular basement membranes for IgG. Area of non-staining in figure B represents crescent. The IF was also positive for kappa and lambda light chains (not shown). Segmental glomerular tuft staining for IgM, C3, and fibrinogen were also positive (not shown). The linear staining for IgG was not seen in the previous kidney biopsy and suggests the possibility of coexistent pauci-immune glomerulonephritis and anti-glomerular basement membrane nephritis.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (A) Hematoxylin and eosin (H&E) stain of glomeruli showing cellular crescent.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (B) H&E stain of another glomeruli showing cellular crescent.


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (C) Trichrome staining of glomeruli showing necrosis (red).


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (D) Trichrome staining of another glomeruli, showing necrosis (red).


Kidney biopsy from 3 years pre-presentation - light microscopy. . Notes: Light microscopy of kidney biopsy. (E) Trichrome staining showing moderate tubular atrophy and interstitial fibrosis. Immunofluorescence staining was negative (not shown). Electron microscopy revealed 30% foot process effacement but no immune type electron dense deposits or endothelial tubuloreticular inclusions (not shown).


(A) Examples of SEMP recorded from proximal (RF) and distal (TA) muscles during stimulation at Th9-10, Th10-11, Th11-12, Th12-L1, and L1-2 levels, in supine position.


(B) Changes in the thresholds, maximal amplitudes, and the latency of the SEMP recorded from proximal (RF and MH) and distal (TA, SOL) muscles with stimulation applied at Th9-10, Th10-11, Th11-12, Th12-L1, and L1-2 levels.


(C) Examples of the SEMP recorded from RF, MH, TA, and SOL with paired pulses stimulation (interstim interval of 50 ms) at Th11-12 level. Black arrow indicate the moment of the stim.


(D) The amplitudes of the SEMP recorded from right and left side during paired stimulation at Th11-12 level.


Examples of M wave.


(F) The amplitudes (%) of the H-reflex recorded from right and left side (n = 10) during performance of Jendrassik maneuver (gray bars). Dotted lines indicate the control values of the H-reflex (100.


(G) Examples of the SEMP recorded from RF and TA during stimulation at Th12-L1 without (black line) and with Jendrassik maneuver (gray line) in supine and in upright (less than 30% body weight support) positions. Gray circles indicate the facilitation of the SEMP bilaterally RF, and in left TA by Jendrassik maneuver.


Reflex recorded form SOL muscle at stimulation intensity varied from 8 to 25 mA with increment of 1 mA. Recruitment curves of the M wave (black line) and the H-reflex (light gray line) presented on the right. (H) The amplitudes (%) of the SEMP recorded from right and left proximal (RF and MH) and distal muscles (TA and SOL) with stimulation at Th12-L1 during performance of Jendrassik maneuver in supine (light gray) and upright (less than 30% body weight support) positions (dark gray) in subject with SCI (n = 4). Dotted lines indicate the control values of the SEMP (100%). Difference marked with an asterisk indicates significance (*p < 0.05).


(A) Examples of the SEMP recorded from TA muscle during stimulation at Th11-12 level in supine and upright (less than 30% body weight support) positions after the first verticalization before (gray lines) and after rehabilitation therapy (black lines).


(B) The thresholds of the SEMP recorded in supine (gray lines) and upright (less than 30% body weight support) position after the first verticalization (black lines) in TA, SOL, RF, and MH (n = 6).


(C) Changes in amplitude and threshold of SEMP recorded from RF, MH, TA, and SOL in supine position before (gray) and after (black) rehabilitation therapy (n = 4).


(D) Example of the SEMP recorded from TA during stimulation at Th11-12 level in upright position (less than 30% body weight support) before (gray line) and after rehabilitation therapy (black line). The black and gray numbers indicate the number of polysynaptic components of the SEMP. Histograms and cumulative percentage of latencies (ms) of polysynaptic components of the SEMP recorded from TA before and after rehabilitation. Counts - frequency of occurrence of latencies of LR in interval of 1 ms. Cumulative percent - cumulative percentage of frequency of occurrence of latencies of LR in interval of 1 ms. Difference marked with an asterisk indicates significance (*p < 0.05).


Positron emission tomography-magnetic resonance imaging fusion with T1 radial volumetric interpolated breath-hold examination with fat suppression acquired in the axial plane showed severely decreased radiotracer activity throughout the liver parenchyma (white arrow) (a).


Corresponding axial T1 radial volumetric interpolated breath-hold examination with fat suppression image (b) revealed generalized decreased magnetic resonance signal in the liver.


Axial positron emission tomography attenuation corrected image.


Showed severe decreased liver uptake (black arrow) which was not present on the nonattenuation corrected images.


Dixon three-dimensional volumetric interpolated breath-hold examination T1-weighted magnetic resonance sequence in the coronal plane demonstrates normal signal intensity in the liver parenchyma (arrow) on the out-of-phase image.


With drop in signal on the in-phase image indicating excessive iron accumulation.


The mu map showed the expanded boundary of the right lung instead of the correctly assigned soft-tissue density of the liver parenchyma (curved arrow) (c).


The coronal attenuation mu map was manually segmented by filling in the faulty liver reconstruction (thin arrow) with soft-tissue density instead of lung tissue (a). The resulting attenuation corrected positron emission tomography image in the coronal plane showed the properly corrected liver parenchyma tracer activity (thin arrow).


Unrelated to the liver, multiple osseous metastases are noted on the study (arrowheads) (b).


Fluorodeoxyglucose positron emission tomography-magnetic resonance imaging scan after oral chelator therapy with attenuation corrected positron emission tomography axial image demonstrating normal fluorodeoxyglucose uptake within the liver (a).


Corresponding T1 radial volumetric interpolated breath-hold examination with fat suppression image showed improved liver signal intensity reflecting decreased iron deposition (b).


Flexible endonasal fiberscopic findings of the left nasal cavity. Hypertrophy of the left inferior turbinate was present, and the left inferior nasal meatus had disappeared (white arrowheads).


A; Large pseudotumoral neoangiogenic lesion of the left perioral area.


B; Magnification of the pseudotumoral neoangiogenic process.


C; Complete crusting after 2 weeks of antiviral therapy.


D; Residual erythematous post-inflammatory pigmentation at 4 weeks.


A; Histology evidencing PG (HE. X10). The black arrow indicates epithelial cell islands in the PG. B, c High-power magnification illustrates some keratinocytes exhibiting CPE. D HSV-I-specific immunostaining (red signal) in giant epithelial cells (black arrows), some exhibiting cytopathic signs (x20).


Fluorescein angiographic images of the right.


Left. Eyes. . Note: Many arch-shaped hyperfluorescent linear lesions running circumferentially are observed in the peripheral fundus of both eyes (arrowheads), and part of these lesions can be seen to run in parallel.


Fundus autofluorescence of the right.


Left. Eyes. . Note: Linear hypoautofluorescent lesions are observed at sites corresponding to the hyperfluorescence in the FA images (arrowheads). . Abbreviation: FA, fluorescein angiographic.


Abdominal computed tomography revealing a right renal enhancing mass about 5 cm in length, accompanied by the parenchyma invasion and pelvis expansion of the right kidney. . Notes:. Cross section.


Abdominal computed tomography revealing a right renal enhancing mass about 5 cm in length, accompanied by the parenchyma invasion and pelvis expansion of the right kidney. Coronal plane.


(A and B) Removing the entire right kidney under robot-assisted laparoscopic nephrectomy.


Pathological features of the surgical specimen. . Notes: (A and B) Microscopic view of the tumor of the right kidney with H&E staining, revealing that tumors were composed of a monotonous population of small round cells. Magnification details:. 40x.


Pathological features of the surgical specimen. . Notes: (A and B) Microscopic view of the tumor of the right kidney with H&E staining, revealing that tumors were composed of a monotonous population of small round cells. 200x.


Pathological features of the surgical specimen. Immunohistochemical staining was positive for. CD99,. 100x.


Pathological features of the surgical specimen. SYN,. 100x.


Pathological features of the surgical specimen. FLI1, and . 200x.


Pathological features of the surgical specimen. Ki67. 100x.


Fluorescence in situ hybridization testing demonstrated that more than 10% of cells were positive indicating EWSR1 gene rearrangement.


Medical image.


68Gallium-prostate-specific membrane antigen positron emission tomography image fused with the corresponding T2-weighted magnetic resonance imaging. Showing focal tracer uptake (red arrow) on the side opposite to the magnetic resonance imaging-detected hypointense lesion (yellow arrow). While no obvious magnetic resonance imaging lesion is seen corresponding to the prostate-specific membrane antigen uptake.


T2-weighted magnetic resonance imaging of prostate showing a hypointense nodule involving the left anterior and posterior transitional zone at the base with low ADC values.


(e) Hematoxylin and eosin-stained specimen of radical prostatectomy showing the acinar adenocarcinoma (from both right and left lobe transition zones).


(a) Chest X-ray showing well-defined homogenous opacity in the left hemithorax (white arrow).


(b) Computed tomography chest showing cystic lesion in the middle and posterior mediastinum (white arrow).


(a) Peroperative finding showing cystic structure below the left lung.


(b) Histopathological examination of the cyst showing columnar lining with mild inflammation. Muscularis mucosa, subcutaneous layer, and muscularis propria can be appreciated confirming the diagnosis of enterogenous cyst.


Characterization of sSMC using chromosome 18 centromere (red) and short arm subtelomeric region (green) fluorescent probes. The result demonstrated that the sSMC is a derivative of chromosome 18.


The physical examination was notable for necrotic-appearing tissue in the entire penis and scrotum, with areas of induration and crepitus.


MRI of the upper arm showing a spindle shaped contrast enhancing mass in the median nerve course.


MRI of the upper arm showing a spindle shaped contrast enhancing mass in the median nerve course. Coronar view. Axial view.


A-B) Preoperative MRI. T1-weighted sagittal and T2-weighted axial images demonstrating the tumour mass with a cystic component and extension into the floor of the fourth ventricle and to the supravermian cistern. Partial obstruction of the fourth ventricle and secondary obstructive hydrocephalus is also observed.


C-D) Two-year postoperative MRI. No apparent residual tumour is shown at T1-weighted sagittal and T2-weighted axial images.


Microscopic features of the rosette-forming glioneuronal tumour. A) Histological features of the tumour showing both a neurocytic and an astrocytic component. Neurocytic rosettes are formed by the neurocytic components.


Microscopic features of the rosette-forming glioneuronal tumour. B) The eosinophilic core at the centre of the neurocytic rosettes displays strong positive staining with synaptophysin.


Microscopic features of the rosette-forming glioneuronal tumour. C) The astrocytic components of the tumour showed that the tumour cells had bipolar and spindle processes with positive immunostaining of GFAP.


Microscopic features of the rosette-forming glioneuronal tumour. D) The MIB-1 labelling index was about 5-7%. Original magnifications 400x.


A-B) MRI scans 48 months after the initial procedure. T1-weighted sagittal and T1-weighted axial contrast enhanced images reveal a nodular lesion close to the roof of the fourth ventricle.


C-D) T1-weighted sagittal and T2-weighted axial MRI images two years after radiosurgery show stabilisation of the lesions.


Treatment planning for gamma knife radiosurgery. A) Sagittal view.


Treatment planning for gamma knife radiosurgery. B) Axial view.


Treatment planning for gamma knife radiosurgery. C) Coronal view.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma associated with idiopathic thrombocytopenic purpura. Lung windows from computed tomography of the abdomen and pelvis demonstrate nodules in the left (red arrow) and right (yellow arrow) lower lobes.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma associated with idiopathic thrombocytopenic purpura. Follow-up computed tomography chest on lung window demonstrates stability of one of the larger nodules in the left lower lobe (red arrow). Additional nodules (yellow arrows) are seen at slightly different levels than on prior study due to differences in positioning and level of inspiration.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma associated with idiopathic thrombocytopenic purpura. Fused images from F-18 fluorodeoxyglucose positron emission tomography- computed tomography demonstrate the index lesion without abnormally increased glucose metabolism.


39-year-old woman with pulmonary nodules discovered incidentally diagnosed as pulmonary hyalinizing granuloma (PHG) associated with idiopathic thrombocytopenic purpura. A) x10 magnified H and E, stained microscopy of the two nodules from wedge resection (long arrows) shows clusters of lymphoplasmacytic infiltrate (short arrows) peripherally. B) x20 magnified view demonstrates whirled layers of collagen (dark pink) around small blood vessels (*), consistent with PHG. No multinucleated giant cells are present.


(A-D) Abdominal CT revealed a soft tissue nodule measuring 1.3x1.5 cm in the subcutaneous soft tissue of the right abdominal wall and a cystic density mass measuring 9.9x8.7 cm in the peritoneal cavity.


Abdominal CT scans before and after anlotinib therapy. . Notes: (A) Before anlotinib therapy, the CT scan shows the size of the enlarged right inguinal lymph node was 29.3x19.8 mm.


Abdominal CT scans before and after anlotinib therapy. (B) Before anlotinib therapy, the CT scan shows the size of the omental lymph node was 17.8x14.9 mm.


Abdominal CT scans before and after anlotinib therapy. (C) After two cycles of anlotinib treatment, the CT scan shows the size of the enlarged right inguinal lymph node was 12.2x10.7 mm.


Abdominal CT scans before and after anlotinib therapy. (D) After two cycles of anlotinib treatment, the CT scan showed the size of the omental lymph node was 9.9x7.9 mm, respectively.


Gross image of the uterus and tumor.


Mixed components: a close transition from the endometrial adenocarcinoma to the yolk sac tumor areas (hematoxylin and eosin, 100x).


Immunohistochemical staining results for alfa-fetoprotein confirm the existence of two components of endometrial adenocarcinoma and yolk sac tumor.


Axial.


Coronal. T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesion with parenchymal invasion along the right frontal lobe (arrow).


Axial ,. Along the falx cerebri.


Coronal. Right temporal lobe.


Sagittal. T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesions through the frontal sinus, and . Right sphenoid wing. (arrows).


Sagittal. T1-weighted magnetic resonance imaging showing a contrast-enhancing sinonasal mass with intracranial extension through the cribriform plate into the anterior cranial fossa, maxillary, and sphenoid sinuses.


Sagittal T1-weighted magnetic resonance imaging showing contrast-enhancing dural-based lesions posterior to C2 vertebral body.


Posterior to T9-T10 disc space.


Along the posterolateral dura at the L3-L4 level. (arrows).


A 4-month-old female with emesis. Coronal T2 3D magnetic resonance cholangiopancreatography shows the pancreas divisum with the main pancreatic duct draining into the duct of Santorini (arrow). The common bile duct drains into a complex conglomeration of pancreatic head cysts (asterisk). The common bile duct is mildly prominent, and there is ascites.


Same patient as above. Coronal T2 3D magnetic resonance cholangiopancreatography shows the 1.9 cm common cyst (arrow) that drains the duct of Santorini and the common bile duct. There are multiple cysts and ducts that extend throughout the pancreatic head with multiple connections to the duodenum (asterisk).


Same patient as above. Axial T2 fat-saturated image shows a large pancreatic pseudocyst (asterisk), with layering debris, exerting mass effect on the pancreatic head. There is ascites.


Axial view of a CT with contrast of neck showing peripherally enhancing fluid collection at the left submandibular space along with extensive gas collection extending from the left submandibular to the left parapharyngeal space.


CT scan with oral and rectal contrast (R) showing a pelvic mass with multiple heterogeneously enhancing soft tissue masses with central necrotic areas within pelvis not separately seen from the ovaries (EST).


Sagittal section showing heterogeneously enhancing soft tissue lesions within omentum (OM), M- pelvic mass seen indenting bladder base ,. Bowel. Loops are displaced upwards.


Intraoperative omental nodular metastatic deposits (OD).


Metastatic deposits (D) on the descending colon (DC).


H&E x 20: biphasic neoplasm showing both benign epithelial component and sarcomatous mesenchymal component.


Immunostain CK7x20:epithelium is positive for CK7 (brown).


Immunostain, CD10x- Mesenchymal component is positivity for CD-10 (brown).


Thyroid tuberculosis in a 45-year-old patient. (A) Sonogram image revealing an ovoid-shaped, heterogeneous, hypoechoic nodule with ill-defined margins in the left thyroid lobe, resembling a cystic nodule with fluid space (white arrow).


Thyroid tuberculosis in a 45-year-old patient. (B) Color Doppler examination revealing punctated and banded flow signals around the nodule.


Repeat ultrasound examination at three days post-admission. (A) Longitudinal sonograms revealing a nodule, closely adjacent to the left salivary gland and partially protruding from the upper pole of capsular tissue into the left lobe of the thyroid.


Repeat ultrasound examination at three days post-admission. (B) A blood flow signal can be observed around the nodule.


Repeat ultrasound examination at three days post-admission. (C) Fine-needle aspiration cytology of the nodule.


Repeat ultrasound examination at three days post-admission. (D) The aspiration yielded reddish pus that was revealed to be red blood cells with necrosed materials.


Repeat ultrasound examination at three days post-admission. (E) Follicular epithelial cells on a bloody background, with clusters of purple-stained colloid and a field of red-stained granular caseous necrosis.


Repeat ultrasound examination at three days post-admission. (F) Multifocal granulomatous nodules inbetween atrophic thyroid follicules, with fibrous tissue proliferation and chronic inflammatory cell infiltration. (E anf F: stain, hematoxylin and eosin; magnification, x200).


Repeat ultrasound examination six months after the initiation of anti-tuberculosis medication. (A) Significant shrinkage and echo enhancements can be observed. The nodule is solid and well-defined, with two tiny calcifications inside (white arrows).


Repeat ultrasound examination six months after the initiation of anti-tuberculosis medication. (B) Color Doppler examination revealing punctate and strip-shaped blood flow around and inside the nodule.


Contrast-enhanced computed tomography scan of the abdomen showing a diffuse circumferential thickening of the distal pyloric antrum of the stomach with a few ulcerative areas.


A; On magnetic resonance imaging, an heterogeneous multinodular mass was observed on sagittal T1-weighted images (TR/TE: 1,200/120). Dark signal nodules, compatible with hemosiderin deposition, were identified.


B; On macroscopy a multinodular lesion was evident in the leg and in the thigh showing variegated colour.


C, d On haematoxylin and eosin staining the lesion showed synovial-like mononuclear cells without cytologic atypia, admixed with multinucleate giant cells.


Preopertaive axial view of current case showing. T1 (without contrast).


T1 (with contrast).


T2 (without contrast).


Immunohistochemically, the cells were positive for CD99. The complete reactivity pattern of the specimen is shown in Table 2.


The patient showing left eye proptosis with inferior displacement of the globe.


(a) MRI, coronal view of a heterogeneous intermediate signal (white arrow) of the left superior orbital mass, infiltrating the superior rectus muscle.


(b) The transverse view of the same heterogeneous mass (black arrow) displacing the globe anteriorly (proptosis).


Mature adipocytes (black arrow) intermingled with zones of atypical stromal cells (white arrow) (200x, H & E stain).


A; Hematoxylin and eosin, x10. Skin punch biopsy from right leg showing psoriasiform hyperplasia with subtle papillomatosis and hyperparakeratosis.


B; Hematoxylin and eosin, x40. Skin punch biopsy from the right leg exhibits almost confluent parakeratosis and an absent granular layer with Munro's microabscesses. Some dilated papillary dermal vessels are noted.


C; Hematoxylin and eosin, x20. Skin punch biopsy from left leg showing psoriasiform hyperplasia with subtle papillomatosis and hyperparakeratosis. Absent granular layer is evident, with denuded foci. Also seen is a hair follicle with parakeratotic plugging.


D; Hematoxylin and eosin, x40. Skin punch biopsy from left leg exhibiting almost confluent parakeratosis and an absent granular layer with Munro's microabscesses.


A; Improvement of both legs after 52 weeks of treatment with etanercept.


B; Improvement of both elbows after 52 weeks of treatment with etanercept.


Yellowish brown plaques and nodules around the eye.


Epitheloid histiocytic granulomas in the dermis with Touton and foreign body giant cells. The inset picture shows foci of the degenerated collagen with Touton giant cells.


Intra-operative photograph showing the released full thickness flap over the cheek.


Color Doppler ultrasound imaging. a on November 3, 2017 (23 + 4 weeks of gestation), color Doppler ultrasound imaging showed a hyperechogenic mass in the fetal left ventricle, measuring 1.8 cm x 1.57 cm, broadening of the left lateral ventricle (1.11 cm) and a strong dot-like echo in the left ventricle; b on December 7, 2017, color Doppler ultrasound reexaminations displayed multiple strong echoes in the fetal left ventricle (measuring 3.3 cm x 2.03 cm), compression of the left ventricular outflow tract, obvious enlargement of the tumor, and a 0.92 cm internal diameter of posterior horn of the left lateral ventricle.


Chromosomal microarray analysis detects a 1.8 Mb-duplication of the chromosome 15q13.2q13.3 region containing 7 genes, which occurs in the region between BP4-BP5 on chromosome 15q13.3.


Clinical response to long-term immunotherapy and the effect of surgery. (A) Schematics showing the time line of patient's diagnosis, treatment and response.


Clinical response to long-term immunotherapy and the effect of surgery. (B) Computed tomography scans and Magnetic resonance imaging showing clinical response to immunotherapy and the effect of surgery.


Clinical response to long-term immunotherapy and the effect of surgery. (C) The result of PD-L1 staining before immunotherapy.


Clinical response to long-term immunotherapy and the effect of surgery. (D) PET-CT scan before Lung tumor resection. TC, paclitaxel+carboplatin; Pembro, pembrolizumab.


Neck lymph node (LN) shows metastatic extremely well differentiated papillary thyroid carcinoma (EWD-PTC) E stain, x12.5.


Inset x400) with focal positivity of CK19. X400) in the first metastatic lesion.


The left thyroid shows follicular variant papillary thyroid carcinoma (FVPTC) without capsular (arrow) invasion E stain, x40.


Loss of CD56. X40) in second episode.


The LN also shows metastatic EWD-PTC E stain, x12.5.


Inset x400) with focal positivity of CK19. X400).


Neck lymph node (LN) shows metastatic extremely well differentiated papillary thyroid carcinoma (EWD-PTC) E stain, x12.5, and . The left thyroid shows follicular variant papillary thyroid carcinoma (FVPTC) without capsular (arrow) invasion E stain, x40, and . The LN also shows metastatic EWD-PTC E stain, x12.5, and . CD56. X400) in the second metastatic lesion. The skull lesion shows metastatic FVPTC E stain, x100.


The skull lesion shows metastatic FVPTC E stain, x100.


CD56. X400).


Sagittal CT scan image showing a mesenteric amorphous aggregate surrounding the portal vein (arrows). The contrast media is visualized in the perianal area (arrow head) without appropriate visualization of the lymphatic system.


Transverse CT scan image showing a contact (star) between the caudal extremity of the right lobe of the pancreas (arrow) and the mesenteric aggregate (arrow head).


Hematoxylin and eosin staining. Pancreatic carcinoma displaying a sheet of large polygonal neoplastic cells with moderate anisokaryosis and a low mitotic index (star) with residual pancreatic acini (arrow head).


Hematoxylin and eosin staining. Mesenteric fat showing necrotic area (star) surrounded by vacuolated macrophages (arrow head).


(A)
Chlamydia psittaci detection in bronchoalveolar lavage fluid (BALF) using metagenomic next-generation sequencing (mNGS) on October 25, 2020.


Positron emission tomography-computed tomography chest image demonstrates a localized mass in right posterior mediastinal/ paraspinal region with maximum standardized uptake value of 6.6.


Field's stained smear shows cohesive group of cells on a myxoid background (MGG, x2.5). This smear pattern correlates with groups of tumor cells surrounded by fibrous septa on histology. High power view of vacuolated cells somewhat resembling physalipherous cells, but differentiated from them by pleomorphic large nuclei and prominent nucleoli (inset).


Loosely cohesive epithelioid cells with eccentric nuclei, prominent nucleoli, and ample cytoplasm resembling adenocarcinoma. Note the cell showing vacuolated cytoplasm with magenta droplet (arrow) (myxoid background, x63). Mucicarmine stains were negative to faintly positive.


Clusters of epithelioid cells with abundant, poorly defined cytoplasm, mildly pleomorphic nuclei with irregular nuclear membranes (grooves and notches), prominent eosinophilic nucleoli, and chromatin condensation. Rare signet-ring like cells are seen. The myxoid stroma is less obvious in the Papanicolaou (Pap)-stained smear (Pap, x63).


Immunohistochemical results. Tumor cells are positive for calretinin, WT-1, and D2-40, and negative for high molecular weight keratin and thyroid transcription factor-1 supporting mesothelial origin. Mucicarmine stain is negative excluding adenocarcinoma.


Dorsal plane whole-body CT, fused PET/CT, gray-scale PET, and axial plane fused PET/CT at the level of the kidneys (left to right). Showing increased 18F-FDG uptake in the region of the left medial retropharyngeal lymph node mass, as well as the nasal tissues, nasopharynx, right lung, mediastinum, liver, and both kidneys. Histopathology post-mortem confirmed large-cell high-grade lymphoma causing increased uptake in the kidneys. The increased 18F-FDG uptake in the urinary bladder is a normal finding. The increased 18F-FDG uptake in the small intestine is likely due to normal digestion.


Gingival recession in tooth 4.1.


Removal of epithelial-connective tissue from the palate.


Epithelial-connective tissue graft.


Positioning the amniotic membrane at the donor site.


Horizontal mattress sutures.


Resolution of gingival recession 30 days after the procedure.


Reepithelialization of the palate 14 days after HAM grafting, before.


After. Removal of stitches.


Appearance of the palate 30 days after the procedure.


Thyroid FNA ThinPrep: On the left are the mesothelioma cells, which are in three-dimensional groupings compared to the Hurthle cell population on the right, that forms two dimensional sheets. The mesothelioma cells have waxy cytoplasm with multiple nucleoli and more nuclear variation. The Hurthle cell population has abundant granular cytoplasm and generally one nucleolus. Papanicolaou stain x600.


Surgical Resection: Panel A (x40) shows nodular thyroid tissue. Panel B (x40): Two populations of cells seen within the nodule. Hurthle cells (black arrow) shows abundant pink cytoplasm. However, the tissue contains mostly mesothelial cells (white arrow) which are smaller polygonal cells with less cytoplasm. Panel C (x100): Mesothelial cells are positive for keratin 5/6. Panel D (x100): Mesothelial cells are positive for calretinin. Other immunostains (not shown) that were positive in the mesothelial cells include CK7 and HBME1, while TTF-1 and Thyroglobulin were both negative.


A; Large tumor on the left side of the head (male, 79 years).


B-d The waxy tumor exhibited a sulcated, mostly yellowish and reddish surface, and in some areas hemorrhages. A punch biopsy showed amorphous eosinophilic material in the dermis (b), and these masses extended down to the subcutis.


Immunohistochemistry showed that the entire dermis and parts of the subcutis were filled with amyloid consisting of both kappa and lambda immunoglobulin light chains (c, d).


E; In electron microscopy, the typical amyloid fibrils (7-10 nm in diameter) were found (bar = 0.5 microm).


The patient at follow-up 1 month after surgery. He showed no signs of local tumor recurrence or systemic disease.


(a) Maximum intensity projection image - increased fluorodeoxyglucose avidity in the midline of the neck.


(b) Fused axial image - markedly increased metabolic activity in left-sided mass lesion (large single arrow). Another large solid-cystic mass lesion arising from the right lobe of the thyroid gland with mildly increased fluorodeoxyglucose uptake (small double arrow).


(c) Axial computed tomography scan of the neck - left-sided mass lesion is not separable from the isthmus of the thyroid, thyroid cartilage, and obstructing the supraglottic larynx.


(d) Small soft-tissue parenchymal nodules in the lingular segment of the left lung with minimally increased metabolic activity.


Axial section of follow-up positron emission tomography/computed tomography scan shows the partial regression of the metabolically active thyroid mass. The benign lesion in the right lobe of thyroid remains unchanged.


Anterior Posterior view of the right arm taken in the emergency department demonstrating significant subcutaneous free air.


Lateral view of the right arm taken in the emergency department demonstrating significant subcutaneous free air.


Coronal chest computerized tomography scan demonstrating subcutaneous free air throughout the chest secondary to a pneumothorax.


Axial chest computerized tomography scan demonstrating subcutaneous free air throughout the chest secondary to a pneumothorax.


Lateral view of the right arm taken eight days after initial presentation demonstrating resolution of subcutaneous free air.


(a) Fundus photo oculus dextrus showing disc edema and retinal straie.


(b) Fundus photo oculus sinister normal.


B-scan ultra sound oculus dextrus showing typical "T sign.


Fundus fluorescein angiogram oculus dextrus showing leak from disc.


(a) Magnetic resonance imaging brain and orbit - isointense diffuse thickening of right ocular coats.


(b) Magnetic resonance imaging brain and orbit - T1-weighted image with contrast - showing hyperintense diffuse thickening of the right ocular coats.


(c) Magnetic resonance imaging brain and orbit - T2-weighted image showing hypo intense diffuse thickening of right ocular coats.


(a) Fundus picture oculus dextrus posttreatment - absent disc edema retinal straie.


(b) Optical coherence tomography macula oculus dextrus - eye - flattening of retinal straie posttreatment.


Cut-surface of the mass shows whitish, nodular, round, glistening areas with yellow-brown soft areas in the centre.


FISH analyses with chromosomes 4 and 22 probes. . Notes: Image showing the results of FISH on a metaphase spread, with painting probes for chromosomes 4 (orange) and 22 (aqua). The yellow arrows indicate normal chromosome 4 (orange - in the upper), residual chromosome 4 (orange - in the middle) and chromosome 22 (aqua); the red arrow indicates derivative chromosome 4 (orange + aqua). . Abbreviation: FISH, fluorescence in situ hybridization.


Brain MRI in the 7th . FLAIR and DWI show a mass involving the right basal ganglia and thalamus (a, b).


Brain MRI in the 7th . The mass was clearly enhanced (c).


9th. Week after admission. Two weeks later, the mass had enlarged (d-f).


Postsalvage chemotherapy biopsy.


Soft, nontender compressible diffuse swelling involving the left parotid gland.


Simple magnetic resonance imaging of the neck.


Scanner view shows cystic cavity lined by thin epithelium and subjacent C. T with Germinal centers.


Highpower view of cystic cavity lined by thin epithelium & showing subjacent C. T with germinal centers.


High-power view showing cystic cavity lined by thin epithelium and subjacent connective tissue with germinal centers.


High-power magnification showing germinal centers with subjacent connective tissue.


Abdominal computed tomography after 3 months of treatment with everolimus showed stationary pancreatic neuroendocrine tumors.


White arrow) but decreasing liver metastasis nodule numbers , suggesting a partial response to everolimus.


FNAC smears showing cohesive clusters of small, uniform, ovoid to round epithelial cells (MGG, x100).


Preoperative Xray.


CT scan.


CT scan done during CT guided biopsy.


MRI showing the tumor compressing the cord.


MRI showing the tumor arising from the D7, D8, D9 vertebral levels.


Intraoperative image showing a friable tumor mass compressing the cord.


Excised tumor mass.


Histopathological slide showing polygonal stromal cells, osteoclastic giant cells and many hemosiderin laden macrophages on high power view.


Whole body fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) maximum intensity projection image.


Axial fused PET/CT showed a intense uptake in the soft-tissue lesion in the left breast.


Liver lesions.


Bone lesion.


Axial CT showing lytic bone lesion in D4 vertebra.


Immunohistochemistry staining showing positive for chromogranin.


Synaptophysin.


Midsagittal images of computed tomography scan of the lumbar spine.


Coronal imagining of the lumbar spine demonstrating a left L5 transverse process fracture.


Midsagittal imaging of the lumbar spine demonstrating a large fluid collection of subcutaneous tissue in the lumbar spine.


Coronal imaging of the lumbar spine, further demonstrating a large fluid collection of the lumbar spine subcutaneous tissue.


Extraoral view showing facial asymmetry.


Birds eye view showing deviated chin button toward right side.


Intraoral view showing enlargement of the maxilla and the mandible.


PNS view showing expansile, ill defined mixed radiopaque-radiolucent lesions in the frontal bone, ground glass radiopaque lesion in the right maxilla.


OPG showing extensive multilocular lesion of the right ascending ramus extending upto the mandibular left first molar.


Axial.


Sagittal. T1-weighted magnetic resonance imaging scans revealed a heterogeneous osteolytic mass in the right parietal region.


The lesion intensely enhanced after contrast administration in the axial.


Sagittal. T1-weighted magnetic resonance imaging scans.


Selected axial sections (a-c) of cranial computed tomography scans demonstrating the skull defect with associated large subgaleal and extradural hematoma.


Photomicrograph showing polymorphic infiltrate of Langerhans histiocytes (polygonal cells with kidney-shaped and elongated nuclei had longitudinal groove) admixed with many eosinophils.


Six-year follow computed tomography scan without.


With contrast. Demonstrating no recurrence and spontaneous bone formation and closure of the skull defect.


(a and b) A three-phase whole body 99mtechnetium labeled methylene diphosphanate bone scan showing focal hot spot in sacrum (arrow) with no increased vascularity. There were no other abnormal hot spots in rest of skeletal survey.


Myelo computerized tomography (CT) of pelvis. Initial and a 6-h delayed CT scans, revealed no free communication between the Tarlov cyst (TC) and subarachnoid space. However, surrounding sacral bony erosion around TC in S2 level produced the increased methylene diphosphanate uptake in the bone scan as a result of new bone formation.


Patient's pedigree. Arrow indicates proband. Proband's mother and husband are indicated by an asterisk. Only these family members were tested. 'N' means normal karyotypes. Only in proband both cytogenetic and FISH testing were performed.


Histological view of biopsy specimens obtained from. Surgical excision of the supraclavicular fossa lymph node.


Fiberoptic bronchoscopy. The two images show caseous necrosis, epithelioid cell nodules and Langhans giant cell. Magnification, x100.


Pretreatment clinical findings of periorbital necrobiotic xanthogranuloma demonstrating multiple yellow, firm papules coalescing into plaques and resulting in cicatricial lagophthalmos.


Skin biopsy of necrobiotic xanthogranuloma lesions revealing a diffuse dermal infiltrate of histiocytes with multinucleated giant cells along with cholesterol clefts, Touton forms, and geographic necrobiosis. Hematoxylin and eosin, x100.


Treatment outcome of periorbital lesions of necrobiotic xanthogranuloma after 16 cycles of intravenous immunoglobulin.


Composite photomicrographs. (a) Lesion with superficial epithelium and connective tissue stroma with numerous amelobastic follicles (x4 OM.


Composite photomicrographs. (b) Follicle showing ameloblast-like cells, stellate reticulum and dentinoid tissue (x10 OM.


Composite photomicrographs. (c) Numerous ameloblastic follicles seen with interspersed dentinoid-like material (x10 OM.


Composite photomicrographs. (d) Dentinoid secreted by odontoblast (x40 OM*). *Original magnification.


Anteroposterior and lateral radiograph of the right leg showing lytic lesion with large soft-tissue component and hair-on-end periosteal reaction in mid-diaphysis of tibia.


Left eye. Total ptosis.


Left eye. Total ophthalmoplegia.


(a) H and E-stained section of nasopharyngeal punch biopsy specimen showing nests of small round blue cells, (b) Strong CD99 immunoreactivity.


Single, non-tender, pedunculated, polypoid growth, about 6 x 7 cm, hanging from the left labium minus (P), and ,minimal swelling of the left labium majus.


Multiple "knife-cut" ulcers on the external genitalia, in the inguino-crural fold, and in the interlabial creases.


Multiple typical "knife-cut" ulcers on the external genitalia in the inguino-crural fold,. Interlabial creases.


Natal cleft.


Massive edema of genitalia more marked on the left labium majus.


Case 1: (a) Noncontrast computerised tomography axial images of 29-year-old male following road traffic accident developed intraparenchymal contusion (broad arrow) showing hemorrhagic contusion in right frontotemporoparietal lobe causing transfalcine herniation with midline shift. SDH was seen in right frontal region.


(b) Axial bone window sections showing fracture of right frontotemporoparietal bone (long arrow) with depressed fracture involving right orbital roof (not shown).


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done. (a and b) Noncontrast computerised tomography showed two similar appearing well defined hyperdense lobulated mass.


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done. (a and b) Noncontrast computerised tomography showed two similar appearing well defined hyperdense lobulated mass. One measuring approximately 2.2 cm x 1.5 cm around right sylvian fissure is seen abutting insular cortex with surrounding gliotic changes and another rounded hyperdense mass noted in right temporal lobe (long arrow in a and b).


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done.


Case 1: Patient presented for cranioplasty after 2 months of operation. Noncontrast computerised tomography followed by contrast-enhanced computerised tomography was done. Axial postcontrast brain sections showing prominent peripheral enhancement of lesions in insular cortex and temporal lobe (broad yellow arrow in c.


(a) MRI, T1W image showing hypointense lesion in the left frontal lobe.


(b and c) showing peripheral enhancement on contrast administration.


The vessels showing perivascular infiltrate of lymphocytes and neutrophils causing wall destruction. H and E, x100.


MR angiography in the postoperative period shows focal narrowing of vessels in the left frontal region, indicating vasculitis.


Necrotizing fasciitis of the patient's left leg at admission. Note violet purpuras with unclear margins and bullae of lateral malleolar area.


Intra-operative findings:. Right hand.


Left lower leg. It was easy to separate the fascia from the subcutaneous tissue.


Histopathological findings of the soft tissue. (A) The subcutaneous fat tissues showed edematous changes and infiltrates of inflammatory cells mixed with neutrophils (H&E stain, x 100).


Histopathological findings of the soft tissue. (B) It shows inflammatory infiltration and thrombosis in the blood vessels (H&E stain, x 400).


Genetic analysis, physical features (as an adult), and computed tomography (CT) of the chest at the age of 14 years. (A) Pedigree of the family: electropherograms depict the relevant sequence section around the causative C-to-T transition at position c.3028 in exon 23 and the generation of a premature stop codon at position p. Q1010.


Genetic analysis, physical features (as an adult), and computed tomography (CT) of the chest at the age of 14 years. (B) Physical features and final height (133 cm) of the patient (reproduction with permission of the patient).


Genetic analysis, physical features (as an adult), and computed tomography (CT) of the chest at the age of 14 years. (C) Chest CT demonstrates bronchiolitis obliterans, lower lobe right side: small area of ground-glass opaque consolidation, swelling, and widening of bronchial tubes.


Medical image.


Lateral. Radiograph demonstrating hardware failure and destruction of the tibiotalar joint with severe valgus deformity and non-union.


Lateral. Radiographs following removal of hardware, placement of tibiotalar antibiotic spacer and ringed external fixator.


Lateral. Radiographs following definitive ankle fusion after eradication of infection.


Right lower extremity (A-C) following successful infection eradication and tibiotalar fusion demonstrating healing of prior surgical sites and sinus tracts.


Preprocedural presentation of the patient.


Micro-retention beads sprinkled on wax pattern.


Bresol investment liquid and investment material.


Seven grams of polyetheretherketone dental material.


For2Press unit used for vacuum pressing the material.


Polyetheretherketone framework try in.


Postcementation.


O. P. G. Revealing bone loss from the alveolar ridge on the right side.


Excised specimen.


Post operative healing after 7 days.


Photomicrograph.


Intra oral growth.


Extra oral view.


Computed tomography images of the patient. A; Nonenhanced computed tomography image.


Computed tomography images of the patient. B; Arterial phase.


Computed tomography images of the patient. C; Venous phase.


Computed tomography images of the patient. D; Delayed phase.


Medical image.


Immunohistochemistry. For CD79a.


Digital subtraction angiography image showing mild stenosis in the thoracic aortic lesion without an obvious intimal flap.


The implanted stent.


Axial nonenhanced CT image.


CTA. Showing enlargement of the false lumen three months after stent implantation, with nonhomogeneous enhancement and mediastinal extensions of the false lumen, which was interpreted by radiologists in our hospital and other medical centers during follow-up as an endoleak and periaortic hematoma.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. T1WI image.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. Contrast-enhanced T1WI image.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. Showing a nonhomogeneous enhancement of the "false lumen," which correspond to the hyperintense regions in DWI (b = 800 s/mm2) image.


Magnetic resonance imaging showing gradual enlargement of false lumen with mediastinal extensions and a new lesion in the azygos vein. T2WI image. Showing the heterogeneous of "false lumen" with bleeding area (green arrow).


Histopathology of aortic tissues showed that the tumor was composed of malignant spindle cells and demonstrated nuclear pleomorphism and atypia (hematoxylin and eosin staining x200).


Frontal view of fluoroscopic images during inguinal injection of Lipiodol. At abdominal level there is opacification of lymph vessels with drainage of Lipiodol into the cysterna chyli and thoracic duct (TD). Image of occlusion of the TD on the passage from abdominal to thoracic level. Black arrow: droplets of ethiodized oil at the passage from the inferior caval vein to the TCPC conduit, revealing early lymphovenous shunting. At thoracic level there is drainage of Lipiodol through multiple collaterals to hilar, peribronchial, mediastinal, and axillar dilated lymph vessels. Right mediastinum is more affected than the left.


Cone-beam computed tomography image during Lipiodol-based lymphangiography shows filling of several mediastinal abnormal dilated lymph vessels, predominantly peribronchial right (yellow arrows). This is similar to the fluoroscopic image of Figure 1.


Operative procedure. A; The hilar Glissonean pedicle was taped to clamp the inflow from the proper hepatic artery without cystic artery flow.


Operative procedure. B; Under ICG mode, the stained area of the hepatic parenchyma was marked by electrocautery to identify the perfusion area of the cystic vein.


Operative procedure. C; Extended cholecystectomy was performed along the demarcation line.


Operative procedure. D; We performed lymphadenectomy of the hepatoduodenal ligament. ICG, indocyanine green.


CT for head segment.


Clinical image of eccrine spiradenoma presenting as erythematous nodule on the scalp.


Trichoscopy of eccrine spiradenoma showing "serpentine-like" linear reddish structure (yellow arrow) surrounded by whitish areas (black arrows).


Partial karyotype of Normal Chromosome and Abnormal chromosome 6 with Ideogram of normal Chromosome 6.


Giemsa Banded Karyotype image of wife.


Giemsa Banded Karyotype image of Husband.


Partial karyotype of normal and abnormal chromosome 1 and 9 and normal chromosome ideogram respectively.


Abdominal ultrasound of the patient. . A hyperechogenic 5.6 x 7.3 cm anchor is observed in segment V of the right hepatic lobe suggestive of an incidental hemangioma.


Myelolipoma evaluation. . Surgical specimen, macroscopic. Amado Polyclinic, Maracaibo- Edo Zulia (10/04/2013).


Medical image.


Show generalized diffuse scleritis with scleral abscess inferotemporal area.


A scleral tissue biopsy showing mucosal erosion and submucosal fibrosis with necrobiosis of collagen and sheets of mononucleated foamy histiocytes (xanthoma cells), infiltrating the submucosal fibrous tissue, accompanied by variable numbers of dispersed lymphocytes and plasma cells (hematoxylin-eosin; original magnification: x40).


Another scleral tissue biopsy predominantly containing fibrosis with necrobiosis of collagen and scattered necrotic cellular debris of inflammatory cells (hematoxylin-eosin; original magnification: x200).


Sheets of xanthoma cells and scattered hemosiderin- laden macrophages, neutrophils, lymphocytes, plasma cells, and erythrocytes. The xanthoma cells have small, round nuclei and abundant clear or vacuolated cytoplasm (hematoxylin-eosin; original magnification: x400).


Some of infiltrating histiocytes show hemophagocytic activity characterized by intracytoplasmic nuclear debris (hematoxylin-eosin; original magnification: x400).


Small- and medium-sized vasculitis characterized by lymphocytic and neutrophilic infiltrate in wall of subcutaneous vessels obtained from sural nerve biopsy (hematoxylin-eosin; original magnification: x200).


Axial view of the patient's computed tomography sca. Contrast-enhanced computed tomography.


Axial view of the patient's computed tomography sca. Bone window.


Intraoperative findings of the lesion. The tumor was noted to have a well-demarcated fibrous outer capsule, with erosion of the pericranium, and ,tight dura adherence.


Intraoperative findings of the lesion. The lesion received its main blood supply from the engorged middle meningeal artery.


Intraoperative findings of the lesion. Superior view of the lesion.


Intraoperative findings of the lesion. Inferior view of the lesion.


Anteroposterior radiograph of index finger showing soft tissue swelling but no bony involvement.


Gross histological specimen measuring 2.1cm x 1.5 cm x 1.5 cm.


Abundant giant cells, foamy macrophages, and spindle cells in the background of collagen bundle.


Sheets of mononuclear cells mixed with foamy macrophages and focal presence of osteoclastic type multinucleate cells evenly distributed in the fibrotic stroma.


Fournier's gangrene involving the anterior scrotum before debridement.


Integra placement over the scrotal defect.


The incorporated Integra following removal of the outer silicone sheet at the time of split-thickness skin-graft placement, 2 weeks following initial Integra placement.


Well-healed skin graft, 1 week following skin-graft placement.


Well-healed skin graft, 3 weeks following skin-graft placement.


CT scan of a patient with an SPT. Abdominal contrast-enhanced CT scan shows an enlarged pancreatic head containing a well-defined, encapsulated solid cystic mass about 4 cm in diameter (arrow). CT, computed tomography; SPT, solid pseudopapillary tumor.


Gross examination of an SPT. Photograph of the.


Gross examination of an SPT. Gross specimen shows the. Smoothly encapsulated tumor with areas of necrosis and hemorrhage. The ruler shows distance in centimeters.


The immunohistochemical features of an SPT. The tumor cells showed positive for. Vimentin.


The immunohistochemical features of an SPT. CD10.


The immunohistochemical features of an SPT. Alpha-antichymotrypsin.


The immunohistochemical features of an SPT. Alpha-antitrypsin.


The immunohistochemical features of an SPT. Beta-catenin.


The immunohistochemical features of an SPT. Neuron-specific enolase.


The immunohistochemical features of an SPT. Synaptophysin.


The immunohistochemical features of an SPT. Progesterone receptor.


A gray-scale ultrasound image shows a well-defined circumscribed ovoid heteroechogenic placental mass with a 4.99 cm diameter. . Note: The mass protrudes from the fetal surface of the placenta and is in contact with the amniotic cavity.


A gray-scale ultrasound image shows the protruding placental mass into the amniotic cavity from a placenta with the thickest anteroposterior diameter of 5.5 cm.


Macroscopic appearance of the placenta after normal vaginal delivery. . Note: A 5-cm-diameter mass on the fetal surface of the placenta near its edge is shown.


The atypical marginal location of the placental chorioangioma near the placental edge.


(a) The clinical image irregular asymmetric lump in the medial aspect of the left nipple-areolar complex.


(b) Ultrasonography image: Heterogeneous lesion with multiple hypoechoic areas and internal moving echoes was noted.


(c) Giemsa stain (x200): Smears show polymorphs and mature squamous cells.


(d) Pap stain (x200): Smear shows a multinucleated foreign body type of giant cell.


Plain and contrast-enhanced computerized tomography showing the hilar Bosniak type 4 cyst with enhancing soft-tissue component (arrow).


Intraoperative picture showing the grayish tumor closely adherent to renal vessels.


Tumor cells staining negatively for Hale's colloidal iron stain (x40).


Axial CT image of the pelvis demonstrates a large fat containing mass within the presacral region (arrowheads). Fat within the mass is dark on the CT images (arrow).


Axial nonfat saturated . Bright fat on nonfat saturated image.


Fat saturated. T2-weighted MRI images of the pelvis also demonstrates a large fat containing mass within the presacral region (arrowheads). Saturates out on the fat saturated image. (arrows).


Clinical photograph showing diffuse scrotal swelling.


A; Axial CT image of the chest showing pneumomediastinum along with subcutaneous emphysema involving the chest wall on the left side.


B; Axial CT of the abdomen showing pneumoretroperitoneum surrounding the right kidney along with subcutaneous emphysema.


Optical coherence tomography angiography (OCTA) with the right eye represented by the right column.


The left eye by the left column The structural slabs a, b of the lesions in both eyes were obtained using an RPE-RPE fit segmentation.


Optical coherence tomography angiography (OCTA) with the right eye represented by the right column En face OCTA with customized segmentation between RPE and Bruch's membrane shows a type 1 neovascular network with evident aneurysmal dilatation, as demarcated by the crossing blue and green lines (c, d). Dense B-scan with angiographic flow overlay e, f demonstrates the corresponding cross-sectional view and the customized segmentation of the respective lesions.


The left eye by the left column The structural slabs a, b of the lesions in both eyes were obtained using an RPE-RPE fit segmentation. En face OCTA with customized segmentation between RPE and Bruch's membrane shows a type 1 neovascular network with evident aneurysmal dilatation, as demarcated by the crossing blue and green lines (c, d). Dense B-scan with angiographic flow overlay e, f demonstrates the corresponding cross-sectional view and the customized segmentation of the respective lesions.


Chest radiography revealed consolidation in the right lower lung field at the initial visit.


Pulmonary findings of chest high-resolution computed tomography. (A) At the initial visit, subpleural consolidation with volume reduction in the right lower lobe and localized ground-glass opacity in the left lower lobe were present.


Pulmonary findings of chest high-resolution computed tomography. (B) Two weeks after she began receiving prednisolone (PSL), consolidation had not improved.


Pulmonary findings of chest high-resolution computed tomography. (C) Two months after discontinuation of PSL, bilateral consolidation developed. Then, a surgical lung biopsy (SLB) of the right upper lobe was performed (arrow).


(A) Mechanic's hand (arrows).


(B) Gottron's papules on the dorsum (arrowheads).


Pulmonary findings of chest high-resolution computed tomography. (A) One month after the surgical lung biopsy, bilateral subpleural consolidation and ground-glass opacity had worsened.


Pulmonary findings of chest high-resolution computed tomography. One month.


Pulmonary findings of chest high-resolution computed tomography. Six months after starting the treatment, these findings had improved.


Reddish and ulcerated lesion in the left great toe.


Histopathological findings. (a) Low-magnification view showing the architecture with ulcerated epidermis.


Histopathological findings. (b) High-magnification view showing myofibroblastic and fibrovascular proliferations, with mature woven bone rimmed by osteoblasts. No evidence of abnormal mitotic activity or cellular atypia was observed.


Follow-up image showing no recurrence of the mass after 6 months.


Preoperative photograph of the patient, taken anteriorly.


T1 weighted contrast bilateral breast MRI demonstrating a soft tissue intensity mass-like area attached to the right breast capsule with internal enhancing foci and trace periprosthetic fluid, in addition to enhancing foci at the deep margin of the left breast capsule.


Intraoperative photograph of bilateral explanted, textured, silicone breast prostheses and right breast capsule. There is evidence of bilateral rupture with hematoma within the implants.


Immunohistochemistry for CD68, a histocyte marker, highlights numerous foam histocytes within the lesion on the external surface of the right capsule.


This image shows vacuolated histiocytes and a foreign body-type giant cell, features of the silicone granuloma taken from the lesion on the external surface of the right capsule.


Intact insular aggregates of small cells amidst fibrovascular stroma (Pap, x100) with (inset) an intact insula enveloped by a single layer of endothelial cells (Pap, x400).


Cellular smears containing pleomorphic cells having very large nuclei (monster cells) with scanty cytoplasm. Few of the nuclei revealing nucleoli (Giemsa, x400).


Lesional cells revealed positive staining for vimentin (IHC, x200).


Renal biopsy specimen from the patient with serum creatinine of 1.98 mg/dL. A proximal tubule with denuded epithelium, exfoliating brush borders (black arrows) and mitotic figure (white arrow) is shown (x 400).


Preoperative view.


Suture placement (Intraoperative).


Post suture placement.


Postoperative day 100.


CT from March 1, 2018 shows extensive ascites with small bowel clumped from mesenteric retraction by cancer.


Case 1. Pre-chemotherapy imaging findings. The tumor was 2 cm in size.


Case 1. Pre-chemotherapy imaging findings. And had a maximum standardized uptake value (SUVmax) of 5.1 in positron emission tomography findings.


Preoperative magnetic resonance imaging views of the patient (a) Sagittal T1-weighted cerebral magnetic resonance imaging showing a third ventricular colloid cyst and significant hydrocephalus with ballooning of the corpus callosum.


(b) Axial T1 view of the same patient.


Gammknife plan summary showing axial, coronal and sagittal T1 weighted with contrast MRI views. 13 Gy at 65% was prescribed.


43 months Postoperative and Postradiosurgical Gammaknife treatment MRI views (a) Sagital T1 weighted cerebral MRI showing that the third ventricular colloid cyst has remained essentially the same with complete resolution of the hydrocephalus. Corpus callosum with normal thickness.


(b) Axial T1 views of the same patient.


Clinical photographs of the patient with 1p36 triplication. (A) Front view of the face.


Clinical photographs of the patient with 1p36 triplication. (B) Lateral view of the face. The major facial phenotype included strabismus, hypertelorism, low hairline, ear malformations, broad nasal bridge, wide mouth, thick lips and prominent incisors.


Fundus appearance of the right eye showing multifocal retinal opacities and superficial retinal hemorrhages involving the posterior pole. There is an associated optic disc swelling and mild vitritis.


Photomicrographs showing multinucleated giant cells shown by arrow, large number of elongated cells lying singly and clusters (Giemsa, x400).


Timeline for blood pressure and BMI of the patient. (A) The blood pressure and BMI of the patient during the follow-up are showcased as a timeline.


Timeline for blood pressure and BMI of the patient. (B) The blood pressure of the patient indicated as the mean arterial pressure had been maintained normal without anti-hypertensive drug treatment postoperatively.


Timeline for blood pressure and BMI of the patient. (C) BMI of the patient decreased lower than preoperative level 2 weeks postoperatively and then recovered 3 months after the operation.


T2 FLAIR image showing bilateral medial temporal hyperintensity. FLAIR = Fluid-attenuated inversion recovery.


FA of the patient's right eye taken over a 2-year period. . Notes: (A and B) Initial visit (early phase of FA of the right eye reveals a small irregular hyperfluorescence area inferonasal to the fovea with late-phase leakage that corresponds to the juxtamacular CNV lesion; arrows).


FA of the patient's right eye taken over a 2-year period. (C and D) One week after cessation of steroid therapy (a fulminant recurrence and development of CNV membrane with involvement of the fovea; arrows).


FA of the patient's right eye taken over a 2-year period. (E and F) Three months after PDT (progressive enlargement of CNV membrane).


FA of the patient's right eye taken over a 2-year period. (G) Recurrent activity of CNV membrane 8 months after the second intravitreal ranibizumab injection (circle).


FA of the patient's right eye taken over a 2-year period. (H) Two months after periocular triamcinolone injection combined with intravitreal ranibizumab injection (almost complete regression of active CNV membrane). . Abbreviations: CNV, choroidal neovascular membrane; FA, fluorescein angiography; PDT, photodynamic therapy.


Metastases of ductal carcinoma breast (WD) (fine-needle aspiration cytology) malignant cells in ductal configuration, (Pap stain, x40).


Metastases of ductal carcinoma breast (WD) (fine-needle aspiration cytology) malignant ductal cells in sheets with cellular discohesion and attempted internal ducts, (Pap stain, x40).


Metastases of melanocarcinoma (fine-needle aspiration cytology) dissociated round to polygonal melanocytes showing prominent nucleoli, binucleation and cytoplasmic fine melanin pigments, background shows melanin containing macrophages (Giemsa stain, x40).


Metastases of small cell carcinoma lung (fine-needle aspiration cytology) nested population of small to intermediate size cell with high N: C, nuclei show pepper salt chromatin and significant nuclear fragility (Giemsa stain, x40).


Metastases of clear cell renal cell carcinoma (fine-needle aspiration cytology) Sheet and tubular structures of cuboidal epithelial cells with low-grade malignant nuclei and cytoplasmic fine vacuoles, (Pap stain, x40).


T2 weighted MRI showing an expansile lesion involving C2 vertebra with cord compression.


Patient showing NF with eschar formation in upper eyelid in the right eye at the day of admission at the hospital. NF, necrotizing fasciitis.


Tomography presenting preseptal edema and heterogeneous fluid, suggesting abscess in the right eyelid.


Patient presenting the upper eyelid aspect of the right eye minutes after the debridement.


Upper eyelid aspect after 15 days of the debridement.


Upper eyelid aspect after 2 months of debridement with closed.


Opened. Eyes.


(a) OCT macula.


(b and c) GCL OCT.


(d) OCT optic nerve. Stable condition from four months to one year of treatment, some recovery of ANFL from the initial drop after four months.


(a) CT scan showing swellings in the lymph nodes (arrows).


(b) Low-density areas in the spleen were also observed (arrows), suggesting metastasis from a malignant tumor of the left ovary.


18FDG avidity was observed in the lymph nodes (arrows).


In the spleen (arrows).


(a) Microscopic findings of the resected ovarian tumor and lymph nodes. Atypical cells with clear cytoplasm grew papillary, tubulocystic, and focally solid pattern (hematoxylin and eosin [HE.


(b) Non-caseating epithelioid granulomas were observed in the pelvic lymph node as well as in the spleen where there were no metastatic lesions (HE).


Bacilloscopy of smear showing positive bacillus (black arrow).


(A) Synovial fluid aspiration from the interphalangeal joint of the hand.


(B) Acid-fast staining of synovial material from the interphalangeal joint of the hand showed numerous acid-fast bacilli (black arrow).


The image shows a 17 mm high intensity area in the pons on T2-weighted.


Diffusion-weighted. Magnetic resonance imaging (MRI) of the brain.


Pathological specimens. . Notes: (A) Skin biopsy specimen taken from the lower abdomen reveals proliferation of large lymphoma cells filling the vessels of hypodermic adipose tissue. Hematoxylin and eosin staining; magnification.


Pathological specimens. (B) Numerous lymphoma cells with irregular nuclear contours and large nucleoli clustered are seen in small vessel lumens. X40. X100.


Magnetic resonance imaging (MRI) of the brain after receiving chemotherapy. . Notes: Pontine lesion on T2-weighted.


Magnetic resonance imaging (MRI) of the brain after receiving chemotherapy. Diffusion-weighted. MRI of the brain completely resolved after eight cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone therapy.


Transthoracic echocardiography (four-chamber view) showing an echogenic mass attached to the posterior leaflet of the mitral valve (MV) measuring 2.3 cm x 1.3 cm.


Intraoperative transesophegeal echocardiography (color flow Doppler, four-chamber view) showing prosthetic MV repair with severe mitral regurgitation jet.


Pictograph of mitral annuloplasty ring with remnant vegetation and part of the excised native mitral leaflet.


(a) Sagittal T1-W MRI without contrast injection, before the first surgery. An extradural hyposignal lesion is observed at S1-S3 level, which was neglected in the first intervention.


(b) Sagittal T1 MRI with contrast from the lumbosacral region after the first operation. Homogenous enhancement of the lesion is observed.


(c and d) Axial T1 MRI views of the lesion with and without contrast, after the first operation.


(A) CT revealed large dense shadows and cavity formation in the inferior lobe of the left lung.


(B) The results of CT re-examination suggested that, the area of infection in the inferior lobe of the left lung was significantly reduced and the cavity was smaller.


(C) The condition of the lung was further improved than before.


(A) The opening of the left lower lobe is narrow.


(B and C) There is a big and white neoplasm in the lower left lung, with a lot of white necrotic material in the subsegment.


Biopsy revealed chronic inflammation of bronchial mucosa with lymphoid follicular hyperplasia, but no definite tumor cells (400X).


Contrast-enhanced T1-weighted sequences show the brain abscess in the right parietal lobe.


Diffusion-weighted magnetic resonance imaging.


(a, b) Surgical site after durotomy. No pathological alteration of the brain surface under white light.


(a, b) Surgical site after durotomy. , intense fluorescent staining under YE560.


(a, b) Surgical site after opening of the abscess. Drainage of pus under white light.


(a, b) Surgical site after opening of the abscess. And under YE560 Note the nonfluorescence of the pus.


Radiography at eight years post-trauma.


Spherical bur to access the root apical area of the 11.


Apical lesion (granulation tissue) removed from maxillary central incisor.


Granulation tissue for histopathological analysis.


Radiography at six months after surgical procedure.


Follow-up radiography at 53 months from surgical procedure.


Ocular findings at presentation. . Notes:. Ciliary injection, corneal epithelial edema, mutton-fat keratic.


Ocular findings at presentation. . Notes: infiltrating cells in the anterior chamber of the right eye.


Ocular findings at presentation. ;. Pigmentation of the trabecular pigment band in the angle was increased in the right eye.


Ocular findings at presentation. ;. Compared with the left eye.


Ocular findings observed after treatment was started. . Note: Distorted pupil and fan-shaped iris atrophy were observed.


MRI of the patient's abdominal cavity (without contrast). (A) In the upper pole of the right kidney, the lesion of an irregular shape and inhomogeneous structure was connected with the pelvicalyceal system, coronal projection, SSFP mode.


MRI of the patient's abdominal cavity (without contrast). (B) The lesion had an irregular shape and a bumpy surface, 3D-reconstruction from the SSFP series.


MRI of the patient's abdominal cavity (without contrast). (C-E) The multinodular nature of the lesion and clear boundaries were determined in axial sections, T1 mode.


Fragments of the kidney and cystic lesion. Gross evaluation (A,B) demonstrates cystic lesion with adjacent renal parenchyma (p) separated by septa with varying wall thickness. Adhesions tightly connected the lesion with the kidney capsule and adjacent adipose tissue. The lumen was filled with gray-brown cheesy keratinized masses (k). It was connected to the small renal calyx (c) with the isthmus (i). Mucosa of the calyx was gray, smooth, with single overlays of horny masses.


Fragments of the kidney and cystic lesion. (C) The histological study revealed keratinized mass in the lumen of the lesion.


Fragments of the kidney and cystic lesion. (D) The renal parenchyma was separated from the cyst wall with adipose tissue of the renal sinus.


Fragments of the kidney and cystic lesion. (E,F) Three types of epithelium lined the cyst wall: stratified squamous epithelium (sq) with a developed granular layer and hyperkeratosis, urothelium (ur) and simple cuboidal epithelium (cub).


Fragments of the kidney and cystic lesion. (G) We also detected the focuses of chronic inflammatory infiltration.


Fragments of the kidney and cystic lesion. (H) Atrophic renal parenchyma was adjacent to the epithelial lining in some areas.


Immunohistochemical study of kidney cystic lesion. The cyst wall areas contained numerous smooth muscle cells.


Immunohistochemical study of kidney cystic lesion. , singular cells.


Immunohistochemical study of kidney cystic lesion. Or completely lacked the cells.


Immunohistochemical study of kidney cystic lesion. (D-F) The cuboidal epithelium, urothelium and epithelium of the kidney tubules were strongly positive for CK7, while the stratified squamous epithelium did not express the marker.


Immunohistochemical study of kidney cystic lesion. (G-I) The urothelium was positive for uroplakin III, while the cuboidal epithelium expressed this marker weakly and irregularly.


Immunohistochemical study of kidney cystic lesion. (J-L) The multilayer squamous epithelium and tubule epithelium were not stained with antibodies against uroplakin III, but expressed p63. The cuboidal cyst epithelium had weak and focal positive expression of p63, the epithelium of the tubules was not stained.


Photos of the patient before and after 6 cycles of neoadjuvant chemotherapy. (A) Before neoadjuvant chemotherapy, the skin of the left breast was mildly inflamed; the left nipple was inverted; and a hard, palpable mass was present in the left central breast.


Photos of the patient before and after 6 cycles of neoadjuvant chemotherapy. (B) After 6 cycles of chemotherapy, the size of the mass in the left breast was significantly reduced. Drawings show the lesion of interest.


Ultrasound (US) imaging of the left breast and left axilla. (A) Before neoadjuvant chemotherapy, US examination of the left breast mass showed a hypoechoic lesion with inhomogeneous internal echoes.


Ultrasound (US) imaging of the left breast and left axilla. (B) US of left axillary lymph nodes before neoadjuvant chemotherapy showed enlargement and cortical thickening.


Ultrasound (US) imaging of the left breast and left axilla. (C) After 6 cycles of chemotherapy, the size of the mass was significantly reduced.


Ultrasound (US) imaging of the left breast and left axilla. (D) Lymph node size was reduced and the shape nearly returned to normal after chemotherapy.


Magnetic resonance imaging (MRI) before and after chemotherapy. (A) Diffusion-weighted imaging (DWI) before chemotherapy. The signal in the left breast and inner side of the right breast showed heterogeneous enhancement.


Magnetic resonance imaging (MRI) before and after chemotherapy. (B) Arterial phase of enhanced MRI before chemotherapy. Both breasts were composed of asymmetrically distributed dense glands. The whole left breast was markedly enhanced.


Magnetic resonance imaging (MRI) before and after chemotherapy. (C) Time-intensity curve of dynamic contrast enhancement of left breast mass before chemotherapy (outflow type).


Magnetic resonance imaging (MRI) before and after chemotherapy. (D) DWI after chemotherapy. The signal in the left breast and inner side of the right breast showed heterogeneous enhancement that was weaker than before chemotherapy.


Magnetic resonance imaging (MRI) before and after chemotherapy. (E) Arterial phase of enhanced MRI after chemotherapy. Compared to before chemotherapy, the size of lesions in the left breast and upper quadrant of the right breast were significantly reduced.


Magnetic resonance imaging (MRI) before and after chemotherapy. (F) Time-intensity curve of dynamic contrast enhancement in the left breast mass after chemotherapy (plateau type).


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (A) Left breast biopsy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (B) Right breast biopsy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (C) Epithelial membrane antigen (EMA) in left lymph node biopsy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). After chemotherapy,. There were fewer cancer cells in the left breast , while interstitial fibrosis, nuclear enlargement, vacuolation, and number of cells with eosinophilic cytoplasm were increased.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). After chemotherapy.


Images of core needle biopsy and histologic analysis by hematoxylin and eosin staining (100x magnification). (F) Inflammatory cell infiltration after chemotherapy.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). HER2 positivity of left.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). Right. Breast cancers as detected by IHC.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). Monosomy of chromosome 17 of left.


Human epidermal growth factor receptor 2 (HER2) expression detected by immunohistochemistry (IHC) (100x magnification) and fluorescence in situ hybridization (FISH) (400x magnification). Right. Breast cancers detected by FISH.


CT scan of the chest from Day 2 of the 1st hospitalization, showing diffuse ground-glass attenuation and consolidation of the lungs with lower lobe predominance.


CT chest from Day 1 of 2nd admission showing airspace opacities with cavitation.


CT neck image from Day 1 of 2nd admission showing filling defect in R internal jugular vein (denoted by arrow), suggestive of septic thrombophlebitis and Lemierre Syndrome in the setting of Fusobacterium necrophorum bacteremia.


Dual tracer positron emission tomography and computed tomography scan (18F-fluorodeoxyglucose positron emission tomography and computed tomography and 68Ga-DOTATATE positron emission tomography and computed tomography) showing both somatostatin receptor expressing and fluorodeoxyglucose avid hypodense liver lesions, largest in segment IVa and IVb measuring 6.6 x 5.0 cm with SUVmax (18F-fluorodeoxyglucose)-21.3 (panel A) and SUVmax (68Ga-DOTATATE)-33 (panel B).


Dual tracer positron emission tomography and computed tomography evaluation (18F-fluorodeoxyglucose and 68Ga-DOTATATE) demonstrates the progression of disease with fluorodeoxyglucose avid lesions of the lower third part of the esophagus (now measuring approximately 4.5 cm), multiple hypodense liver lesions (largest measuring 7.2 cm x 7 cm), multiple abdominal enlarged lymph nodes (largest perigastric lymph node measuring 4.1 cm x 2.9 cm) all showing more avidity on 18F fluorodeoxyglucose scan (panel A) compared to 68Ga-DOTATATE positron emission tomography and computed tomography (panel B).


(B) Interphase FISH analysis of case 2 using the dual-color BCL3 probe. FISH results demonstrated two intact red/green fusion signals, and 2 red and 2 green split signals, which indicated BCL3 gene break-apart. (Yellow arrows pointed to split signals of the rearranged gene).


Kidney biopsy showing a glomerulus with cellular crescent formation (H & E stain; 400x).


Kidney biopsy showing interstitial infiltrate of atypical lymphocytes (H & E stain; 100x).


Hypermucoviscous Klebsiella pneumoniae colonies with positive string test.


Bronchoscopy and ultrasound imaging of an abscess. (A,B) Right middle and left lower bronchoscopy, respectively.


Bronchoscopy and ultrasound imaging of an abscess. (C) Ultrasound imaging of an abscess in the left upper arm.


Timeline with relevant data from the case in our hospital; curves of body temperature and leukocyte counts. The arrows below indicate major events. Blue line shows body temperature values. Orange line shows leukocyte counts. TMP-SMX, trimethoprim-sulfamethoxazole; mNGS, metagenomic next-generation sequencing.


The present patient, a 29-year-old female.


Duodenal biopsies. (A) Hematoxylin and eosin staining shows normal duodenal mucosa without villous atrophy.


Duodenal biopsies. (B) CgA immunostaining of the duodenal biopsy shows complete loss of EE cells.


Duodenal biopsies. (C) Normal control duodenal mucosa immunostained with CgA, showing EE cell distribution in the crypt epithelium.


Duodenal biopsies. (D) Repeated biopsy shows normal immunostained CgA duodenal mucosa.


Extra-orally the swellings appeared ovoid in shape, with well-defined borders.


The orthopantamograph revealed multiple impacted teeth in the mandilble (red arrows) with multiloculated osteolytic lesions involving mandible and maxilla (blue arrows).


3-Dimensional computed tomography scan showing multiloculated cystic lesions affecting the body and rami of the mandible (blue arrows) and maxilla with raised orbital floor (red arrows).


Microscopy revealed highly cellular stroma consisting of plenty of multinucleated giant cells (black arrow). The cellular stroma consists of spindle cell fibroblasts with vesicular nuclei arranged in fascicles (blue arrow).


Surgical specimen showing decorticated and curetted material along with impacted teeth.


Two-year postoperative follow-up photograph with acceptable esthetics.


Craniocaudal.


Mediolateral. Radiographs of the right elbow. Note the smoothly marginated bony proliferation arising from the craniodistolateral humerus. Post-contrast transverse computed tomographic image of the right distal humerus.


Three-dimensional reformatted CT imaged displayed in a bone window.


Lateromedial post-contrast transverse computed tomographic image of the right distal humerus. Note the lobular mineral proliferation arising from the craniodistolateral humeral metaphyseal cortex and lack of underlying humeral bone lysis.


Left lateral thoracic radiograph (E): 5mm rounded nodule within the dorsal third intercostal space (white arrow).


Transverse lung window.


Dorsal reformatted bone window. CT showing the pulmonary nodule within the right cranial lung lobe (black and white arrows).


The thin, mineralized rim with a soft tissue center is evident on the enlarged transverse CT image displayed in a bone window (H).


Transverse.


Dorsal. Plane CT images in a bone window of the right elbow from repeat CT scan 217 days after completion of SBRT. Note that the soft tissue portions of the mass are more mineralized and the humeral cortex remains intact.


Macroscopic view of the 2.0-cm subcutaneous tumor on the right elbow.


A-c Cell morphology of the primary and recurrent tumors. A; The primary tumor showed irregularly arranged collagen fibers mixed with scattered proliferating fibroblast.


B; The first recurrent tumor, composed of slimmer spindle cells.


C; The second recurrent tumor, composed of slimmer spindle cells. Cells in the recurrent tumors were more monomorphic and showed higher cellularity.


D-f Immunostaining for Ki-67. The Ki-67 labeling index of the primary tumor was 2% ,that of the first.


Second recurrent tumors 10.


7% , respectively.


Skin colored, lobulated mass over the tip and dorsum of nose.


T1 MRI axial images show the stability of the colloid cyst within the third ventricle, followed by regression images were acquired in July 2015.


August 2017.


August 2019 The cyst measured 5 mm initially and at follow-up scans 2 years later, and 2.5-3 mm at his follow-up scan in 2019. The 2019 scan also shows hyperintense signal in the cyst, suggesting colloid cyst involution.


Mutation analysis and identification of the c.1858+1G>T mutation of the CSF1R gene. (A) Sequence chromatograms from parts of the CSF1R gene of this case. It displays a splice-site mutation (c.1858+1G>T) in intron 13 of CSF1R.


Mutation analysis and identification of the c.1858+1G>T mutation of the CSF1R gene. (B) Pedigree of the family studied in this report. The affected individuals are indicated with filled squares and circles. The proband is indicated with an arrow. A plus sign indicates that DNA was examined for the CSF1R sequencing analysis.


Histopathology of affected lymph node of case 1 (A,B): Patchy circumscribed areas with eosinophilic fibrinoid necrosis in the paracortex and cortex and absence of granulocytes in the areas of necrosis are shown. A variety of cells surround the necrotic area, and a large number of apoptotic cell fragments exist outside the cells.


Diagnosis of Legionella pneumophila infection using mNGS. (A) The majority of reads mapped to the L. Pneumophila genome with coverage of 28.12.


Diagnosis of Legionella pneumophila infection using mNGS. (B) The majority of reads mapped to the L. Pneumophila genome with coverage of 13.35.


(A,B) Gram stain of bronchoalveolar lavage fluid (BALF) with arrows indicating Legionella pneumophila, magnification x1,000.


(D) Gram stain of L. Pneumophila colonies (magnification x1,000).


Patient's hair at diagnosis of Crohn's disease.


Patient's hair one year after treatment.


Control abdominal CT showing left adrenal gland metastasis.


Comparison of cross-sectional chest CT images obtained from the patient at different time points. A1-4 October 5th, 2020: The day of admission; B1-4 Eighth day after admission on October 13th, 2020; C1-4 October 22nd, 2020 The day of discharge; D1-4 November 14th, 2020 20 days after discharge; E1-4 February 6th, 2021 Nearly 4 months after discharge.


A flow chart describing the patient diagnosis process.


Photograph of the patient's subcutaneous hemorrhage.


Hess chart (orbital Burkitt lymphoma: an aggressive presentation).


Orbital magnetic resonance imaging of axial.


Coronal. At the first medical examination. White arrows indicate a tumor of the lacrimal gland.


Pathologic examination and tissue immunostaining of the tumor. Hematoxylin, and ,eosin stain (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with CD20 (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with MiB1 (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with CD10 (original magnification x400).


Pathologic examination and tissue immunostaining of the tumor. Staining with Bcl-6 (original magnification x400).


Image of the dilated fundus of the right eye shows an elevated amelanotic yellow-creamy lesion located in the posterior pole (greater diameter of 4 disc diameter [DD]) with focal round pigmented lesion of 1 DD located superotemporally to the optic nerve. There is also a more peripheral amelanotic lesion extending from 6 to 9 o'clock clockwise inferotemporally.


Macular optical coherence tomography (OCT) examination shows the elevated choroidal lesion (*) associated with exudative changes (subretinal fluid [#] and intraretinal cysts [^]).


An ultrasound of the right eye shows diffuse choroidal thickening (*). There is also a small elevated lesion (#) (<2 mm) located at the macula.


The choroid biopsy shows a dense lymphoplasmacytic infiltrate composed of a majority of small lymphocytes with a slightly irregular nucleus, occasional blasts, and a minor component of cells with plasmacytic features, for example, eccentric nuclei and perinuclear halo.


Images from the initial abdominal ultrasound (A) Jejunal ulcerations with gas inclusions (red arrows).


Images from the initial abdominal ultrasound (B) Enlarged jejunal lymph node with gas (red arrows).


Endoscopy (C,D) Colonic mucosa showing marked generalized hyperemia with small (~1 cm diameter) and diffuse colonic circular erosions.


Endoscopy (E) Ileum mucosa with hyperemia and striations.