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0 | 30,760,312 | Conclusions SC therapy is effective for PAH in pre clinical studies .
These results may help to st and ardise pre clinical animal studies and provide a theoretical basis for clinical trial design in the future . | Background Despite significant progress in drug treatment , the prognosis of patients with advanced pulmonary arterial hypertension ( PAH ) remains extremely poor .
Many pre clinical studies have reported the efficacy of stem cell ( SC ) therapy for PAH ; however , this approach remains controversial .
The aim of this ... | Although transplantation of adult bone marrow mesenchymal stem cells ( BM-MSCs ) holds promise in the treatment for pulmonary arterial hypertension ( PAH ) , the poor survival and differentiation potential of adult BM-MSCs have limited their therapeutic efficiency . Here , we compared the therapeutic efficacy of human ... |
1 | 19,588,356 | There was a trend for endothelin receptor antagonists to reduce mortality ( OR 0.48 ; 95 % CI 0.21 to 1.09 ) , and limited data suggest that endothelin receptor antagonists improve Borg dyspnoea score and cardiopulmonary haemodynamics in symptomatic patients .
Hepatic toxicity was not common , and endothelin receptor a... | BACKGROUND Pulmonary arterial hypertension is a devastating disease , which leads to right heart failure and premature death .
Recent evidence suggests that endothelin receptor antagonists may be promising drugs in the treatment of pulmonary arterial hypertension .
OBJECTIVES To evaluate the efficacy of endothelin rece... | BACKGROUND Primary pulmonary hypertension is a progressive disease for which no treatment has been shown in a prospect i ve , r and omized trial to improve survival . METHODS We conducted a 12-week prospect i ve , r and omized , multicenter open trial comparing the effects of the continuous intravenous infusion of epop... |
2 | 23,893,797 | This present meta- analysis suggests that statin pretreatment might be effective in improving myocardial perfusion in STEMI patients | BACKGROUND To achieve sufficient myocardial perfusion in ST-segment elevation myocardial infa rct ion ( STEMI ) patients receiving primary percutaneous coronary intervention ( PPCI ) , many adjunctive therapies have been proposed .
Previous trials have reported variances in myocardial perfusion improvement for statin p... | BACKGROUND Although improved epicardial blood flow ( as assessed with either TIMI flow grade s or TIMI frame count ) has been related to reduced mortality after administration of thrombolytic drugs , the relationship of myocardial perfusion ( as assessed on the coronary arteriogram ) to mortality has not been examined ... |
3 | 27,167,891 | In conclusion , there is a lack of evidence of effectiveness for most waterpipe interventions . | Waterpipe tobacco smoking is growing in popularity despite adverse health effects among users .
We systematic ally review ed the literature , search ing MEDLINE , EMBASE and Web of Science , for interventions targeting prevention and cessation of waterpipe tobacco smoking . | INTRODUCTION We explored the differential effect of cessation interventions ( behavioral support sessions with [ BSS+ ] and without [ BSS ] bupropion ) between hookah and cigarette smokers . METHODS We reanalyzed the data from a major cluster-r and omized controlled trial , ASSIST ( Action to Stop Smoking In Suspected ... |
4 | 28,753,768 | Several PROMs have been identified to evaluate sexual function in neurologic patients .
Strong evidence was found only for the Multiple Sclerosis Intimacy and Sexuality Question naire-15 and Multiple Sclerosis Intimacy and Sexuality Question naire-19 for patients with MS , although evidence was lacking for certain meas... | CONTEXT Impaired sexual function has a significant effect on quality of life .
Various patient-reported outcome measures ( PROMs ) are available to evaluate sexual function .
The quality of the PROMs to be used for neurologic patients remains unknown .
OBJECTIVE To systematic ally review which vali date d PROMs are ava... | INTRODUCTION Cultural sensitivities tend to limit assessment s of sexual dysfunction ( SD ) in Parkinson 's disease ( PD ) . OBJECTIVE To assess the validity and reliability of the Thai translation ( ASEX-Thai ) of the Arizona Sexual Experiences Scale ( ASEX ) . METHOD The validity and reliability of ASEX-Thai were ass... |
5 | 24,417,824 | Preoperative carbohydrate drinks significantly improved insulin resistance and indices of patient comfort following surgery , especially hunger , thirst , malaise , anxiety and nausea .
No definite conclusions could be made regarding preservation of muscle mass .
Following ingestion of carbohydrate drinks , no adverse ... | INTRODUCTION Surgical stress in the presence of fasting worsens the catabolic state , causes insulin resistance and may delay recovery .
Carbohydrate rich drinks given preoperatively may ameliorate these deleterious effects .
A systematic review was undertaken to analyse the effect of preoperative carbohydrate loading ... | The effect on gastric pH and volume of 0 , 6 and 10 ml · kg−1 , of apple juice given 2.5 hours before surgery to children aged five to ten years was investigated in this prospect i ve , r and omized , single-blind study . Gastric contents were aspirated after induction of anaesthesia , and the volume measured . The pH ... |
6 | 28,416,626 | Conclusions — In observational studies , reinstitution of anticoagulation after ICH was associated with a lower risk of thromboembolic complications and a similar risk of ICH recurrence . | Background and Purpose — The safety and efficacy of restarting anticoagulation therapy after intracranial hemorrhage ( ICH ) remain unclear .
We performed a systematic review and meta- analysis to summarize the associations of anticoagulation resumption with the subsequent risk of ICH recurrence and thromboembolism . | Background : For patients who survive intracerebral haemorrhage ( ICH ) during treatment with oral anticoagulation ( OAC ) , the balance between the benefits and risks of restarting OAC is unclear . The decision to restart OAC or to start antiplatelet therapy in these patients therefore poses a dilemma for all physici... |
7 | 25,767,129 | This meta- analysis found no evidence of an increased risk of suicide or attempted suicide , suicidal ideation , depression , or death with varenicline .
These findings provide some reassurance for users and prescribers regarding the neuropsychiatric safety of varenicline .
There was evidence that varenicline was assoc... | OBJECTIVE To determine the risk of neuropsychiatric adverse events associated with use of varenicline compared with placebo in r and omised controlled trials . | Abstract Alcohol and nicotine dependence are common in schizophrenia . Varenicline is effective in smoking cessation and has also been shown to decrease alcohol consumption in smokers . The present pilot study assessed the safety and effectiveness of varenicline for treatment of concurrent nicotine and alcohol depende... |
8 | 26,949,760 | Overall , the 5-year complication rates were low .
The most frequent complications were secondary caries , endodontic problems , ceramic fractures , ceramic chipping , and loss of retention .
CONCLUSION This systematic review showed that all-ceramic restorations fabricated using the correct clinical protocol have an ... | OBJECTIVE The purpose of this systematic review was to compare the survival and complication rates of all-ceramic restorations after a minimum follow-up time of 5 years . | This study prospect ively evaluated the clinical performance of computer-assisted design and computer-assisted manufacturing (CAD/CAM)-generated In-Ceram Alumina core crowns in Japanese patients for up to 5 years . A total of 101 In-Ceram crowns with aluminium copings fabricated using the GN-I system were placed in Jap... |
9 | 21,474,812 | Because of insufficient method ological quality of most prognostic studies , the predictive value of many clinical determinants for outcome of ADL remains unclear . | BACKGROUND AND PURPOSE Knowledge about robust and unbiased factors that predict outcome of activities of daily living ( ADL ) is paramount in stroke management .
This review investigates the method ological quality of prognostic studies in the early poststroke phase for final ADL to identify variables that are predicti... | Background and Purpose — Several prognostic factors have been identified for outcome after stroke . However , there is a need for empirically derived models that can predict outcome and assist in medical management during rehabilitation . To be useful , these models should take into account early changes in recovery an... |
10 | 25,299,481 | There are likely to be considerable collateral benefits of ITN roll out on cutaneous leishmaniasis where this disease is co-endemic with malaria .
Nonetheless , it is clear that insecticide-treated material s such as ITNs have the potential to reduce pathogen transmission and morbidity from VBDs where vectors enter hou... | INTRODUCTION Insecticide-treated nets ( ITNs ) are one of the main interventions used for malaria control .
However , these nets may also be effective against other vector borne diseases ( VBDs ) .
We conducted a systematic review and meta- analysis to estimate the efficacy of ITNs , insecticide-treated curtains ( ITCs... | Visceral leishmaniasis ( VL ) is a deadly vector-borne disease that causes an estimated 500 000 new cases a year . In India , Nepal and Bangladesh , VL is caused by Leishmania donovani , which is transmitted from man to man by the s and fly Phlebotomus argentipes . In 2005 , these three countries signed a memor and um ... |
11 | 25,506,813 | We did not pool data for other outcomes due to either heterogeneity in outcome measures or differing interventions .There was no evidence that glycerine gel dressings or breast shells with lanolin significantly improved nipple pain .
However , this beneficial effect was not maintained after six to seven days of treatme... | BACKGROUND Leading health authorities all recommend exclusive breastfeeding to six months ' postpartum .
While most women initiate breastfeeding , many discontinue due to difficulties encountered rather than maternal choice .
One common breastfeeding difficulty is painful nipples .
Research has identified poor infant p... | Background A small , non-blinded , RCT ( r and omised controlled trial ) had reported that oral antibiotics reduced the incidence of mastitis in lactating women with Staphylococcus aureus ( S. aureus)- colonized cracked nipples . We aim ed to replicate the study with a more rigorous design and adequate sample size . Me... |
12 | 25,947,646 | VEGF-A level is a reasonable c and i date biomarker for bevacizumab in the treatment of breast cancer . | Abstract Bevacizumab may improve outcomes of patients with breast cancer , but the absence of an established biomarker hampers patient selection and research ers ´ ability to demonstrate a clear survival benefit .
Its putative target , circulating VEGF-A , emerged as the main c and i date and we sought to identify the ... | PURPOSE This r and omized , open-label phase II study compared the efficacy of sunitinib monotherapy with that of single-agent st and ard-of-care ( SOC ) chemotherapy in patients with previously treated advanced triple-negative breast cancer ( TNBC ) . METHODS Patients with advanced TNBC , relapsed after anthracycline-... |
13 | 24,895,945 | There were no clear effects on bleeding , shivering or length of stay in post-anaesthetic care for either comparison .
No other adverse effects were reported .
There is no clear benefit of extra thermal insulation compared with st and ard care .
Forced air warming does seem to maintain core temperature better than extr... | BACKGROUND Inadvertent perioperative hypothermia occurs because of interference with normal temperature regulation by anaesthetic drugs and exposure of skin for prolonged periods .
A number of different interventions have been proposed to maintain body temperature by reducing heat loss .
Thermal insulation , such as ex... | We have investigated the role of aluminized metal foil ( space blanket , UN 320 ) , used pre-emptively , in post-anaesthetic shivering and patients ' subjective perception of cold after general anaesthesia of short duration . Sixty-eight ASA I and II patients undergoing orthopaedic and plastic surgery on the peripheri... |
14 | 22,513,917 | None of the RCTs with altered WBRT dose-fractionation schemes as compared to st and ard ( 3000 cGy in 10 daily fractions or 2000 cGy in 4 or 5 daily fractions ) found a benefit in terms of overall survival , neurologic function , or symptom control .
Radiosurgery boost with WBRT may improve local disease control in sel... | BACKGROUND Brain metastases represent a significant healthcare problem .
It is estimated that 20 % to 40 % of patients with cancer will develop metastatic cancer to the brain during the course of their illness .
The burden of brain metastases impacts on quality and length of survival .
Presenting symptoms include heada... | BACKGROUND To determine the protective effects of memantine on cognitive function in patients receiving whole-brain radiotherapy ( WBRT ) . METHODS Adult patients with brain metastases received WBRT and were r and omized to receive placebo or memantine ( 20 mg/d ) , within 3 days of initiating radiotherapy for 24 week... |
15 | 26,901,389 | This is not yet the case for off-pump surgery | BACKGROUND Reports from animal studies indicate that volatile anaesthetics protect the myocardium against the effects of acute ischaemia – reperfusion injury by reducing infa rct size .
This cardioprotective effect in the clinical setting of coronary artery bypass graft ( CABG ) surgery , where the heart is subjected t... | BACKGROUND Recent clinical and experimental data indicate that volatile anaesthetics may precondition myocardium against ischaemia and infa rct ion . The present clinical trial was design ed to verify the cardioprotective effects of desflurane in patients undergoing elective coronary artery bypass surgery . It was hypo... |
16 | 31,688,792 | Weight-based and high fixed-dose chemoprophylaxis regimens achieved target anti-Xa concentrations more frequently than st and ard fixed-dose regimens but were not associated with a reduction in VTE .
Additionally , high fixed-dose approaches are associated with increased bleeding complications . | BACKGROUND Venous thromboembolism ( VTE ) continues to be a devastating source of morbidity and mortality in obese patients who suffer traumatic injuries or obese surgery patients .
High incidence rates in VTE despite adherence to prevention protocol s have stirred interest in new dosing regimens .
The purpose of this ... | BACKGROUND Prophylaxis for venous thromboembolism is routinely performed for all patients undergoing bariatric surgery . However , there is disagreement regarding the optimal dosing and duration of anticoagulant therapy . Furthermore , there is little data regarding the incidence of asymptomatic deep venous thrombosis ... |
17 | 32,140,829 | LET could lead to worse anterior instability than with ALL reconstruction when these two approaches were combined with single-bundle ACL reconstruction .
However , rotational stability and patient-reported outcomes were similar between the techniques | Anterolateral augmentation procedures can be divided into traditional lateral extra-articular tenodesis ( LET ) and modern anterolateral ligament ( ALL ) reconstruction .
Nevertheless , no studies have compared the clinical results between LET and ALL reconstruction , when combined with intra-articular ACL reconstructi... | Background : The individual kinematic roles of the anterolateral ligament ( ALL ) and the distal iliotibial b and Kaplan fibers in the setting of anterior cruciate ligament ( ACL ) deficiency require further clarification . This will improve underst and ing of their potential contribution to residual anterolateral rota... |
18 | 15,836,553 | : Several interventions have been developed to improve health for people with low literacy . | Abstract OBJECTIVE : To perform a systematic review of interventions design ed to improve health outcomes for persons with low literacy skills . | PURPOSE A comprehensive worksite health promotion program design ed to reduce risk factors for cardiovascular disease among 4000 city of Birmingham employees was used to develop and implement a tailored antihypertensive educational intervention . The mean age of the underlying population was 36 years , 89 % were blue-... |
19 | 28,176,333 | Subgroup analyses by parity ( primiparae versus multiparae ) and by surgical method ( midline versus mediolateral episiotomy ) did not identify any modifying effects .
One trial examined selective episiotomy compared with routine episiotomy in women where an operative vaginal delivery was intended in 175 women , and di... | Background Some clinicians believe that routine episiotomy , a surgical cut of the vagina and perineum , will prevent serious tears during childbirth .
On the other h and , an episiotomy guarantees perineal trauma and sutures .
Objectives To assess the effects on mother and baby of a policy of selective episiotomy ( ' ... | OBJECTIVE : To compare the outcomes of the current practice of liberally or routinely employing episiotomy to prevent perineal tears and pelvic floor relaxation ( control group ) to a policy of restricting episiotomy use to specific fetal and maternal indications ( experimental group ) . DESIGN : A r and omized control... |
20 | 29,245,998 | Blood lactate was significantly reduced in the levosimendan group while there was no difference in MAP , CI , norepinephrine dose and length of ICU stay .
Conclusions Findings from this meta- analysis demonstrated that levosimendan treatment may not reduce mortality in patients with septic shock . | Object Several studies have investigated a survival benefit for levosimendan treatment in patients with septic shock .
However , data are conflicting .
We conducted a meta- analysis to evaluate the effect of levosimendan treatment on mortality in patients with septic shock . | BACKGROUND Levosimendan is a calcium-sensitizing drug with inotropic and other properties that may improve outcomes in patients with sepsis . METHODS We conducted a double-blind , r and omized clinical trial to investigate whether levosimendan reduces the severity of organ dysfunction in adults with sepsis . Patients w... |
21 | 27,861,583 | No effects of mHealth app interventions were found on blood pressure , serum lipids , or weight .
Smartphone apps offered moderate benefits for T2DM self-management . | BACKGROUND Mobile health interventions ( mHealth ) based on smartphone applications ( apps ) are promising tools to help improve diabetes care and self-management ; however , more evidence on the efficacy of mHealth in diabetes care is needed .
The objective of this study was to conduct a systematic review and meta- an... | OBJECTIVE This study was design ed to evaluate the impact of a teleassistance system on the metabolic control of type 2 diabetes patients . RESEARCH DESIGN AND METHODS We conducted a 1-year controlled parallel-group trial comparing patients r and omized ( 1 ) to an intervention group , assigned to a teleassistance syst... |
22 | 28,835,875 | A significantly higher 30-day and 1-year mortality was revealed in nonoperatively treated hip fracture patients .
No data were found examining (HR)QOL and costs . | Introduction : Increasing numbers of patients with hip fractures also have advanced comorbidities .
A majority are treated surgically .
However , a significantly increasing percentage of medically unfit patients with unacceptably high risk of perioperative death are treated nonoperatively .
Important questions about pa... | Background Research ers are increasingly investigating the potential for ordinal tasks such as ranking and discrete choice experiments to estimate QALY health state values . However , the assumptions of r and om utility theory , which underpin the statistical models used to provide these estimates , have received insuf... |
23 | 22,133,697 | Ziprasidone exposure was increased when the medication was administered with food , irrespective of fat content .
The findings from this meta- analysis and review suggest that ziprasidone 120 - 160 mg/d is a less effective treatment for psychotic disorders compared with olanzapine and risperidone , but that the low lev... | BACKGROUND Among atypical antipsychotics , ziprasidone exhibits a unique clinical profile .
However , prescription rates for this medication remain among the lowest of all atypical antipsychotics .
OBJECTIVE The present meta- analysis examined premature study discontinuation ( PSD ) and dose-response associated with zi... | STUDY OBJECTIVE To evaluate the influence of a high-fat meal on the pharmacokinetics and pharmacodynamics of the novel atypical antipsychotic drug ziprasidone . DESIGN Open , r and omized , three-way crossover study . SETTING University-based research facility . SUBJECTS Eight healthy male volunteers . INTERVENTIONS Zi... |
24 | 16,628,439 | MRI has equivalent sensitivity and specificity to ultrasound for diagnosis of DVT , but has been evaluated in many fewer studies , using a variety of different techniques | Magnetic resonance imaging ( MRI ) may be used to diagnose deep vein thrombosis ( DVT ) in patients for whom ultrasound examination is inappropriate or unfeasible .
We undertook a systematic review of the literature and meta- analysis to estimate the diagnostic accuracy of MRI for DVT . | We performed a prospect i ve , blinded study to assess and compare the values of preoperative contrast venography and magnetic resonance venography in the detection of deep venous thrombosis in the thigh and pelvis of forty-five consecutive patients who had a displaced acetabular fracture . The magnetic resonance venog... |
25 | 16,279,145 | Conclusions This study demonstrates that investigators evaluating aprotinin were not adequately citing previous research , result ing in a large number of RCTs being conducted to address efficacy questions that prior trials had already definitively answered . | Background Aprotinin is a serine protease inhibitor used to limit perioperative bleeding and reduce the need for donated blood transfusions during cardiac surgery .
R and omized controlled trials of aprotinin evaluating its effect on the outcome of perioperative transfusion have been published since 1987 , and systemat... | Background —Extracorporeal circulation induces a systemic inflammatory response , which may adversely affect organ function . One manifestation of this response is increased fibrinolysis . Antifibrinolytic drugs such as aprotinin and & egr;-aminocaproic acid have been effective in reducing fibrinolysis and blood loss a... |
26 | 19,561,291 | The published data suggest that nonanthracycline alternatives are less toxic than anthracycline-containing regimens and equally , if not more , efficacious . | Anthracycline regimens have been the mainstay of adjuvant care in breast cancer for > 20 years .
A growing body of clinical experience has uncovered an unacceptable rate of significant cardiac and leukomogenic toxicities . | PURPOSE This study was design ed to determine whether increasing the dose of doxorubicin in or adding paclitaxel to a st and ard adjuvant chemotherapy regimen for breast cancer patients would prolong time to recurrence and survival . PATIENTS AND METHODS After surgical treatment , 3,121 women with operable breast cance... |
27 | 27,880,972 | The effects of IFNs-beta and GA in the treatment of people with RRMS , including clinical ( e.g. people with relapse , risk to progression ) and MRI ( Gd-enhancing lesions ) measures , seem to be similar or to show only small differences .
When MRI lesion load accrual is considered , the effect of the two treatments di... | BACKGROUND Interferons-beta ( IFNs-beta ) and glatiramer acetate ( GA ) were the first two disease-modifying therapies ( DMTs ) approved 20 years ago for the treatment of multiple sclerosis ( MS ) .
DMTs ' prescription rates as first or switching therapies and their costs have both increased substantially over the past... | We performed yearly MRI analyses on 327 of the total 372 patients in a multicenter , r and omized , double-blind , placebo-controlled trial of interferon beta-1b ( IFNB ) . Clinical results are presented in the preceding companion paper . Baseline MRI characteristics were the same in all treatment groups . Fifty-two p... |
28 | 29,164,600 | Although we were able to calculate one estimation of DTA in , especially , the prediction of progression from MCI to ADD at four years follow-up , the small number of participants implies imprecision of sensitivity and specificity estimates . | BACKGROUND 18F-florbetaben uptake by brain tissue , measured by positron emission tomography ( PET ) , is accepted by regulatory agencies like the Food and Drug Administration ( FDA ) and the European Medicine Agencies ( EMA ) for assessing amyloid load in people with dementia .
Its added value is mainly demonstrated b... | Of 57 individuals diagnosed with Alzheimer 's disease ( AD ) in a phase III study , 13 ( 23 % ) had amyloid-β ( Aβ ) levels on postmortem histopathology that did not explain the dementia . Based on postmortem histopathology , a wide range of different non-AD conditions was identified , including frontotemporal dementi... |
29 | 16,263,889 | Since exercise training confers substantial physiologic and clinical benefits and activity levels are inversely proportional to cardiovascular mortality ( 9 ) , it is not surprising that trials of exercise programs found positive effects on survival . | Cardiovascular disease remains the most common cause of office visits , hospitalizations , and death in the United States : More than 13 million Americans have documented coronary artery disease ( CAD ) , and costs for CAD are expected to exceed $ 393 billion in 2005 ( 1 ) .
Control of the CAD epidemic requires a multi... | Of 22 r and omized trials of rehabilitation with exercise after myocardial infa rct ion ( MI ) , one trial had results that achieved conventional statistical significance . To determine whether or not these studies , in the aggregate , show a significant benefit of rehabilitation after myocardial infa rct ion , we per... |
30 | 30,519,579 | Most review s including children and adolescents with compromised bone mass showed an improvement of BMD at lower limbs , lumbar spine , and whole body .
In conclusion , WBV interventions seem to help children and adolescents with compromised bone mass to increase their BMD , but these improvements are limited in postm... | Whole-body vibration ( WBV ) intervention studies and review s have been increasing lately .
However , the results regarding its effects on bone tissue in different population s are still inconclusive .
The goal of this overview was to summarize systematic review s assessing the effects of WBV training on bone paramete... | BACKGROUND Although data from studies in animals demonstrated beneficial effects of whole-body vibration ( WBV ) therapy on bone , clinical trials in postmenopausal women showed conflicting results . OBJECTIVE To determine whether WBV improves bone density and structure . DESIGN A 12-month , single-center , superiority... |
31 | 31,190,844 | Conclusion : Lymphodepletion regimen may play a crucial role in predicting the prognosis of patients with hematological malignancies .
Lymphodepletion patients had better progression-free survival than those who did not | Purpose : Chimeric Antigen Receptor T(CAR-T ) cell therapy is an immunotherapy approach used in treating cancer which has seen rapid development over the decades .
It becomes the preferred treatment choice after patients have failed conventional chemotherapy . | We conducted a clinical trial to assess adoptive transfer of T cells genetically modified to express an anti-CD19 chimeric Ag receptor ( CAR ) . Our clinical protocol consisted of chemotherapy followed by an infusion of anti-CD19-CAR-transduced T cells and a course of IL-2 . Six of the 8 patients treated on our protoc... |
32 | 31,166,007 | Findings demonstrated a benefit of behavioural support in addition to pharmacotherapy .
There is high-certainty evidence that providing behavioural support in person or via telephone for people using pharmacotherapy to stop smoking increases quit rates .
Subgroup analysis suggests that the incremental benefit from more... | BACKGROUND Pharmacotherapies for smoking cessation increase the likelihood of achieving abstinence in a quit attempt .
It is plausible that providing support , or , if support is offered , offering more intensive support or support including particular components may increase abstinence further .
OBJECTIVES To evaluate... | Tobacco use is the single most important preventable cause of death in military personnel . The purpose of this r and omized clinical trial was to evaluate the effectiveness of two behavioral interventions when added to nicotine-replacement therapy on smoking cessation . The sample of 512 included 52 % active duty mil... |
33 | 23,998,622 | RESULTS The incorporation of nystatin ( in general , 500 000 units ) into tissue conditioners to prevent the onset of the disease and immersion in sodium hypochlorite for disinfection were the methods most often described in this systematic review , and both methods were able to prevent or inhibit C and ida colonizatio... | STATEMENT OF PROBLEM Denture liners are well known for their poor physical properties that favor the accumulation of plaque and colonization by C and ida species , which can irritate the oral tissues and lead to denture stomatitis .
PURPOSE A systematic review was conducted to determine the feasibility of a prevention ... | This study investigated the C. albicans adhesion to cold- and heat-polymerized soft lining material s that were initially incubated in two different artificial body fluids , namely saliva and nasal secretion , and examined the surface roughness the material s ( cold and heat polymerized soft liner ) tested in vitro . ... |
34 | 32,352,165 | There is no evidence to support the use of low-dose aspirin or other NSAIDs of any class ( celecoxib , rofecoxib or naproxen ) for the prevention of dementia , but there was evidence of harm . | BACKGROUND Dementia is a worldwide concern .
Its global prevalence is increasing .
At present , there is no medication licensed to prevent or delay the onset of dementia .
Inflammation has been suggested as a key factor in dementia pathogenesis .
Therefore , medications with anti-inflammatory properties could be benefi... | Objective To examine whether observed differences in dementia rates between black and white older people living in the community could be explained by measures of socioeconomic status ( income , financial adequacy , education , and literacy ) and health related factors . Design Prospect i ve cohort study . Setting Gene... |
35 | 24,633,141 | The ALT-mortality association was inconsistent and seems particularly susceptible to age after synthesizing the previous prospect i ve studies .
In terms of the age , ALT activity was more valuable in predicting mortality in the older population ; extremely low ALT levels indicated a higher all-cause , CV-related , and... | OBJECTIVE Controversy exists in using alanine aminotransferase ( ALT ) activity for predicting long-term survival .
Therefore , this research study investigated the association between ALT activity and mortality through a systematic review and meta- analysis of previous prospect i ve studies . | Serum biochemical liver tests ( LTs ) ( ALT , AST , GGT ) and platelet counts are often used to screen for chronic liver disease . Population ‐based data on abnormal LTs in Mediterranean areas are lacking . The prevalence and etiology of abnormal LTs were assessed from 2002 to 2003 in a 1 in 5 systematic r and om sampl... |
36 | 28,973,656 | Conclusions and Relevance Our study provides more precise data on the incidence of endocrine dysfunctions among patients receiving ICI regimens .
Patients on combination therapy are at increased risk of thyroid dysfunction and hypophysitis | Importance If not promptly recognized , endocrine dysfunction can be life threatening .
The incidence and risk of developing such adverse events ( AEs ) following the use of immune checkpoint inhibitor ( ICI ) regimens are unknown .
Objective To compare the incidence and risk of endocrine AEs following treatment with U... | PURPOSE Programmed death-1 ( PD-1 ) , an inhibitory receptor expressed on activated T cells , may suppress antitumor immunity . This phase I study sought to determine the safety and tolerability of anti-PD-1 blockade in patients with treatment-refractory solid tumors and to preliminarily assess antitumor activity , pha... |
37 | 27,249,419 | There was fairly consistent evidence for the cost-effectiveness/favorable cost-benefit of removing indoor lead to prevent lead poisoning and sequelae , and retrofitting insulation to prevent lung disease .
But the value of assessing and improving home safety and providing smoke alarms to prevent injuries was more mixed... | Background Housing improvements have considerable potential for improving health .
So does the provision of insecticide-treated bednets for malaria prevention .
Therefore we aim ed to conduct up date d systematic review s of health economic analyses in both these intervention domains . | BACKGROUND There has been little rigorous economic analysis of the relationship between asthma and improved housing . AIM To evaluate the cost-effectiveness of installing ventilation systems , and central heating if necessary , in homes of children with ' moderate ' or ' severe ' asthma . DESIGN AND SETTING An incremen... |
38 | 23,276,465 | This pooled analysis confirms that continuing T beyond the first progression continues to be 1 of the effective and preferred choices in HER2 + MBC , failing a ( T-based ) first-line regimen | BACKGROUND In HER2 + MBC , continuing trastuzumab ( T ) after the progression during a first-line T-based regimen , represents 1 of the possible strategies , even if few data from r and omized trials exist in this setting . | Background : Recent UK clinical guidance advises against continuing trastuzumab ( T ) beyond disease progression ( PD ) in the absence of brain metastases in patients with HER-2 positive ( + ve ) advanced breast cancer .We have retrospectively evaluated the outcome of patients with HER-2+ve locally advanced ( LA ) or m... |
39 | 19,370,610 | Adverse events were generally mild to moderate , rarely led to withdrawal , and did not differ in frequency between groups .
A single dose of parecoxib 20 mg or 40 mg provided effective analgesia for 50 to 60 % of those treated compared to about 15 % with placebo , and was well tolerated .
Duration of analgesia was lon... | BACKGROUND Parecoxib was the first COX-2 available for parenteral administration , and may , given intravenously or intramuscularly , offer advantages over oral medication when patients have nausea and vomiting or are unable to swallow , such as in the immediate postoperative period .
OBJECTIVES Assess the efficacy of ... | OBJECTIVE : The aim of this study was to compare the upper GI mucosal effects of i.v . parecoxib sodium with i.v . ketorolac tromethamine and placebo in healthy elderly subjects . METHODS : This was a two-center , double-blind , r and omized , placebo-controlled study . Healthy subjects aged 65–75 yr who were shown at ... |
40 | 22,516,416 | In general , annual citation rate appeared to gradually increase during the first 2 - 3 years after publication before reaching high levels .
However , areas such as quality of life , side effects , and end-of-life care were underrepresented . | High and continuously increasing research activity related to different aspects of pathogenesis , epidemiology , diagnosis and treatment of glioblastoma has been performed between 2006 and 2010 .
Different measures of impact , visibility and quality of published research are available , each with its own pros and cons ... | PURPOSE Alternative dosing schedules of temozolomide may improve survival in patients with newly diagnosed glioblastoma ( GBM ) by increasing the therapeutic index , overcoming common mechanisms of temozolomide resistance , or both . The goal of this r and omized phase II study was to evaluate two different temozolomid... |
41 | 22,385,092 | These elements were distilled into 5 primary categories and conceptually referred to as the 5 Ms : mission-clearly defined policy/st and ards for PAaN ; motivate-providing choices , developmentally appropriate activities , feedback , and encouragement ; manage-structuring and managing the environment for safety , routi... | BACKGROUND After-school programs ( ASPs , 3 pm to 6 pm ) have been called upon to increase the amount of daily physical activity children accumulate and improve the nutritional quality of the snacks served .
To this end , state and national physical activity and nutrition ( PAaN ) policies have been proposed .
Frontlin... | Background Underst and ing the correlates of dietary intake is necessary in order to effectively promote healthy dietary behavior among children and adolescents . A literature review was conducted on the correlates of the following categories of dietary intake in children and adolescents : Fruit , Juice and Vegetable ... |
42 | 23,979,092 | Moderate evidence supports the use of decision support and clinical pharmacy interventions to increase provision of patient self-education/asthma action plans .
Moderate evidence supports use of decision support tools to reduce emergency department visits , and low- grade evidence suggests there is no benefit for this ... | BACKGROUND AND OBJECTIVE : Health care provider adherence to asthma guidelines is poor .
The objective of this study was to assess the effect of interventions to improve health care providers ’ adherence to asthma guidelines on health care process and clinical outcomes . | Abstract Objective : To evaluate the use of a computerised support system for decision making for implementing evidence based clinical guidelines for the management of asthma and angina in adults in primary care . Design : A before and after pragmatic cluster r and omised controlled trial utilising a two by two incompl... |
43 | 22,699,870 | Conclusions CT measurements of emphysema or peripheral airways are significantly related to airflow obstruction in COPD patients .
CT provides a morphological method to investigate airway obstruction in COPD .Key Points• Computed tomography is widely performed in patients with chronic obstructive pulmonary disease ( CO... | Objectives To determine the correlation between CT measurements of emphysema or peripheral airways and airflow obstruction in chronic obstructive pulmonary disease ( COPD ) . | PURPOSE The purpose of this study was to directly and prospect ively compare the capability of dynamic O(2)-enhanced MRI and quantitatively assessed thin-section MDCT to assess smokers ' COPD in a large prospect i ve cohort . MATERIAL S AND METHODS The GOLD criteria for smokers were used to classify 187 smokers into fo... |
44 | 21,898,134 | Conclusions The HADS anxiety subscale performed worse than the total and the depression subscales for both indicators .
Diagnostic accuracy varied widely by threshold but was consistently superior for depression screening than for screening of any mental disorder | Purpose The Hospital Anxiety and Depression Scale ( HADS ) is the most extensively vali date d scale for screening emotional distress in cancer patients .
However , thresholds for clinical decision making vary widely across studies .
A meta- analysis was conducted with the aim of identifying optimal , empirically deriv... | Abstract The psychometric properties of the Italian version of the Hospital Anxiety and Depression Scale and its utility as a screening instrument for anxiety and depression in a non-psychiatric setting were evaluated . The question naire was administered twice to 197 breast cancer patients r and omised in a phase I... |
45 | 26,706,491 | A single oral dose of 2 g of amoxicillin before lower third molar osteotomy surgical extraction significantly decreased the incidence of SSI .
A single dose of 0.8 g of penicillin V before lower third molar osteotomy surgical extraction significantly decreased the incidence of alveolar osteitis | PURPOSE We conducted a systematic review of r and omized controlled trials ( RCTs ) to evaluate the effectiveness of a single dose of preoperative antibiotic administered perorally , intravenously , intramuscularly , or topically for preventing infection and alveolar osteitis in lower third molar surgical extraction ap... | Abstract The use of systemic prophylactic antibiotics in third molar surgery is still a controversial issue . A double-blind study has been conducted with 75 selected patients r and omized into two groups . After exclusions , 68 patients requiring removal of 133 bone impacted m and ibular third molars remained . Surger... |
46 | 21,249,667 | Few studies reported on pain , therefore , at best , there was very low quality evidence of little or no difference in pain relief between the different techniques .
When the working mechanism for pain relief and functional improvement is fusion of the motion segment , there is low quality evidence that iliac crest aut... | BACKGROUND The number of surgical techniques for decompression and solid interbody fusion as treatment for cervical spondylosis has increased rapidly , but the rationale for the choice between different techniques remains unclear .
OBJECTIVES To determine which technique of anterior interbody fusion gives the best clin... | OBJECTIVE After 40 years of experience with anterior cervical operations , whether to fuse is still controversial . This study seeks to answer this question . METHODS In this prospect i ve r and omized study , we operated on 91 patients with single-level cervical root compression using three different methods : 1 ) dis... |
47 | 16,034,931 | This review failed to demonstrate the superiority of atosiban over betamimetics or placebo in terms of tocolytic efficacy or infant outcomes .
A recent Cochrane review suggests that calcium channel blockers ( mainly nifedipine ) are associated with better neonatal outcome and fewer maternal side-effects than betamimeti... | BACKGROUND Preterm birth , defined as birth before 37 completed weeks , is the single most important cause of perinatal mortality and morbidity in high-income countries .
Oxytocin receptor antagonists have been proposed as effective tocolytic agents for women in preterm labour to postpone the birth , with fewer side-ef... | OBJECTIVES To compare the efficacy and safety of nifedipine and ritodrine in preventing preterm labor , and to evaluate maternal side effects and neonatal outcome . STUDY DESIGN Non-blind , r and omized controlled trial RESULTS A r and omized trial of 102 pregnant women with gestational ages under 34 weeks , including ... |
48 | 29,930,519 | Qualitative analyses showed lower volumes of WB , prefrontal regions , temporal lobe , hippocampus , thalamus and cerebellum , and higher volumes of lateral ventricles , amygdala , and putamen in violent vs. non-violent people with schizophrenia .
Conclusions : We review ed evidence for differences in brain volume corr... | Background : Aggression in psychoses is of high clinical importance , and volumetric MRI techniques have been used to explore its structural brain correlates . | The profile of brain structural abnormalities in schizophrenia is still not fully understood , despite decades of research using brain scans . To vali date a prospect i ve meta- analysis approach to analyzing multicenter neuroimaging data , we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy c... |
49 | 30,696,461 | Conclusion RIC was associated with lower myocardial edema levels , myocardial salvage index and incidence of MACCE , while non-significant beneficial effect on infa rct size , TIMI flow grade III or LVEF .
These findings suggest that RIC is a promising adjunctive treatment to PCI for the prevention of reperfusion injur... | Objective This systematic review was design ed to evaluate the efficacy of remote ischemic conditioning ( RIC ) with primary percutaneous coronary intervention ( PCI ) versus primary PCI alone for ST-segment elevation myocardial infa rct ion ( STEMI ) . | OBJECTIVES This study sought to evaluate whether remote ischemic post-conditioning ( RIPC ) could reduce enzymatic infa rct size in patients with anterior ST-segment elevation myocardial infa rct ion undergoing primary percutaneous coronary intervention ( pPCI ) . BACKGROUND Myocardial reperfusion injury may attenuate ... |
50 | 31,425,631 | Radiotherapy for gliomas with a good prognosis may increase the risk of neurocognitive side effects in the long term ; however the magnitude of the risk is uncertain . | BACKGROUND Gliomas are brain tumours arising from glial cells with an annual incidence of 4 to 11 people per 100,000 .
In this review we focus on gliomas with low aggressive potential in the short term , i.e. low- grade gliomas .
Most people with low- grade gliomas are treated with surgery and may receive radiotherapy ... | PURPOSE A prospect i ve , open-label phase II study was conducted to determine whether donepezil , a US Food and Drug Administration-approved reversible acetylcholinesterase inhibitor used to treat mild to moderate Alzheimer 's type dementia , improved cognitive functioning , mood , and quality of life ( QOL ) in irrad... |
51 | 25,991,068 | PARP inhibitors appear to improve PFS in women with recurrent platinum-sensitive disease .
Ongoing studies are likely to provide more information about whether the improvement in PFS leads to any change in OS in this subgroup of women with EOC .
More research is needed to determine whether PARP inhibitors have any rol... | BACKGROUND Ovarian cancer is the sixth most common cancer and seventh most common cause of cancer death in women world-wide .
Three-quarters of women present when the disease has spread throughout the abdomen ( stage III or IV ) and treatment consists of a combination of debulking surgery and platinum-based chemotherap... | BACKGROUND Olaparib is a poly(ADP-ribose ) polymerase inhibitor and cediranib is an anti-angiogenic agent with activity against VEGF receptor ( VEGFR ) 1 , VEGFR2 , and VEGFR3 . Both oral agents have antitumour activity in women with recurrent ovarian cancer , and their combination was active and had manageable toxicit... |
52 | 26,834,707 | The data of 14 reports disclosed enhanced antiadhesive and antibiofilm activity by the plant extracts obtained from Vitis vinifera , Pinus spp . ,
Overall , a positive correlation was revealed between herb-based therapies and elimination rates of all types of multispecies oral biofilms .
In that context , integrating o... | Oral diseases such as caries and periodontitis are mainly caused by microbial biofilms .
Antibiotic therapy has reached its limits with regard to antimicrobial resistance , and new therapeutic measures utilizing natural phytochemicals are currently a focus of research .
Hence , this systematic review provides a critica... | UNLABELLED This study determined the changes of calcium concentration in a medium containing teeth/biofilm exposed to Coffea canephora extract ( CCE ) . Enamel fragments were r and omly fixed into two 24-well polystyrene plates containing BHI . Pooled human saliva was added to form biofilm on fragments . Specimens were... |
53 | 26,333,419 | We did not find strong or consistent evidence that quasi-r and omization is associated with selection bias more often than true r and omization .
High risk of bias judgements for quasi-r and omized emergency studies should therefore not be assumed in systematic review s. Clinical heterogeneity across trials within revi... | BACKGROUND Quasi-r and omization might expedite recruitment into trials in emergency care setting s but may also introduce selection bias . | Objective . Birth asphyxia represents a serious problem worldwide , result ing in ∼1 million deaths and an equal number of serious sequelae annually . It is therefore important to develop new and better ways to treat asphyxia . Resuscitation after birth asphyxia traditionally has been carried out with 100 % oxygen , an... |
54 | 20,464,734 | There is some evidence of improvement in metabolic control in people with diabetes , after treating periodontal disease . | BACKGROUND Glycaemic control is a key issue in the care of people with diabetes mellitus ( DM ) .
Some studies have suggested a bidirectional relationship between glycaemic control and periodontal disease .
OBJECTIVES To investigate the relationship between periodontal therapy and glycaemic control in people with diabe... | Purpose This study aim ed to investigate the effects of oral hygiene care by oral professionals on periodontal health in type 2 diabetes mellitus patients . Material s and Methods Diabetic participants were recruited at a university hospital and matched at a 1:1 ratio by age and gender , and r and omly allocated into i... |
55 | 27,998,966 | Conclusions The increased risk of cardiovascular events with AIs relative to tamoxifen is likely the result of cardioprotective effects of the latter . | Background Aromatase inhibitors ( AIs ) have been associated with cardiovascular disease in adjuvant r and omized controlled trials ( RCTs ) comparing these drugs to tamoxifen .
However , it is unclear whether this risk is real or due to cardioprotective effects of tamoxifen .
To address this question , we conducted a ... | Tamoxifen is associated with a reduced risk of coronary heart disease ( CHD ) . However , there are few reports on long-term effects . Using data from a large Swedish r and omized trial of 5 and 2 years of adjuvant tamoxifen in women with early breast cancer , we here present results on morbidity and mortality from car... |
56 | 26,071,276 | Results For dalteparin and tinzaparin , no accumulation was observed .
Enoxaparin , on the other h and , did lead to accumulation in patients with renal insufficiency , although not in patients undergoing renal replacement therapy .
Bemiparin and certoparin also did show accumulation .
Conclusions In this systematic re... | Purpose Although therapeutic dosages of most low-molecular-weight heparins ( LMWHs ) are known to accumulate in patients with renal insufficiency , for the lower prophylactic dosages this has not been clearly proven .
Nevertheless , dose reduction is often recommended .
We conducted a systematic review to investigate w... | The efficacy and safety of a low molecular weight heparin ( LMWH ) given as a single predialysis bolus injection was compared to st and ard heparin ( SH ) administered with a continuous infusion in a r and omized , 6 month , open follow-up study in 70 patients undergoing hemodialysis . No major bleeding or adverse even... |
57 | 23,047,793 | Two broad findings emerged : ( 1 ) disgust appears to be promoting aversion to ( and avoidance of ) CRC screening , and ( 2 ) several known elicitors of disgust are widely apparent in CRC context s. CONCLUSIONS Disgust likely represents a key emotional substrate for avoidance among CRC patients , caregivers , and healt... | BACKGROUND The emotion of disgust appears to promote psychological and behavioral avoidance , a dynamic that has significant implication s in physical and psychological outcomes in colorectal cancer ( CRC ) .
Patients , caregivers , and health professionals alike are all potentially susceptible to responding with disgu... | Delay in follow-up after an abnormal mammogram is associated with advanced disease stage , poorer survival , and increased anxiety . Despite the implementation of many patient navigator programs across the country , there are few published , peer- review ed studies documenting its effectiveness . We tested the effectiv... |
58 | 26,517,779 | Occurrence of adverse events was not significantly different between the treated patients the and controls .
Limited evidence suggests beneficial effects of propranolol after burn injury , and its use seems safe . | BACKGROUND The hypermetabolic state after severe burns is a major problem that can lead to several pathophysiologic changes and produce multiple sequelae .
Adrenergic blockade has been widely used to reverse these changes and improve outcomes in burned patients but has not been rigorously evaluated .
The aim of this sy... | OBJECTIVE To determine whether propranolol and growth hormone ( GH ) have additive effects to combat burn-induced catabolism . SUMMARY BACKGROUND DATA Both GH and propranolol have been attributed anabolic properties after severe trauma and burn . It is conceivable that the two in combination would have additive effects... |
59 | 27,690,702 | Pneumococcal and influenza vaccination comprise one of the most important preventive approaches for CAP in the elderly | INTRODUCTION Community acquired pneumonia ( CAP ) is a major health problem in elderly persons and is associated with high morbidity and mortality .
Areas covered : This article review s the most recent publications relative to CAP in the elderly population , with a focus on epidemiology , prognostic factors , microbia... | Background : An inadequate response to initial empirical treatment of community acquired pneumonia ( CAP ) represents a challenge for clinicians and requires early identification and intervention . A study was undertaken to quantify the incidence of failure of empirical treatment in CAP , to identify risk factors for t... |
60 | 21,339,502 | Conclusions : The Road Sign Recognition , Compass , and TMT B are clinical ly administrable office-based tests that can be used to identify persons with stroke at risk of failing an on-road assessment . | Objective : To identify the best determinants of fitness to drive after stroke , following a systematic review and meta- analysis . | OBJECTIVE To determine the reliability of the road test performed by stroke patients . DESIGN Prospect i ve study of a 6-month predriving evaluation . SETTING Driving safety center in Belgium . PARTICIPANTS Thirty patients with sequelae of stroke . INTERVENTIONS Not applicable . MAIN OUTCOME MEASURES Results of driving... |
61 | 16,625,604 | A small pharmacological effect on clinical histamine dose response was found .
After treatment , leukotriene levels in nasal lavage did not increase in the capsaicin group .
There is insufficient evidence to assess the use of capsaicin in clinical practice | BACKGROUND Allergic rhinitis represents a global health problem .
Non-specific nasal hyperresponsiveness is an important feature of allergic and non-allergic rhinitis .
This phenomenon is believed to result from the effect of allergic inflammation on the sensory nerves that supply the upper airway mucosa .
A pharmacolo... | We have previously shown that capsaicin nasal challenge in subjects with allergic rhinitis produces a dose-dependent increase in the albumin content of nasal lavage fluids . In the present set of studies , we determined whether this observation represents plasma extravasation that is neuronally mediated . To evaluate w... |
62 | 27,930,803 | Hospital readmissions and mortality studies newly included in this up date showed , on average , significantly smaller effects of rehabilitation than were seen in earlier studies .High- quality evidence suggests that pulmonary rehabilitation after an exacerbation improves health-related quality of life .
AUTHORS ' CONC... | BACKGROUND Guidelines have provided positive recommendations for pulmonary rehabilitation after exacerbations of chronic obstructive pulmonary disease ( COPD ) , but recent studies indicate that postexacerbation rehabilitation may not always be effective in patients with unstable COPD .
OBJECTIVES To assess effects of ... | PURPOSE Acute exacerbations of chronic obstructive pulmonary disease ( AE COPD ) impair health-related quality of life ( HRQL ) . We evaluated the effect of an abbreviated repeat pulmonary rehabilitation ( PR ) program on HRQL after an AE COPD . METHODS Patients who had completed PR were followed for up to 12 months to... |
63 | 24,452,314 | Thrombolysis increases the patency of veins and reduces the incidence of PTS following proximal DVT by a third .
In those who are treated there is a small increased risk of bleeding .
In recent years CDT is the most studied route of administration , and results appear to be similar to systemic administration | BACKGROUND St and ard treatment for deep vein thrombosis aims to reduce immediate complications .
Use of thrombolysis or clot dissolving drugs could reduce the long-term complications of post-thrombotic syndrome ( PTS ) ( pain , swelling , skin discolouration , or venous ulceration ) in the affected leg .
This is the s... | Sequential ascending venographic studies were used to assess the healing of deep venous thrombosis in 50 patients r and omly assigned to streptokinase or heparin therapy . Various degrees of thrombolysis and /or recanalization were demonstrated by venograms performed on the fourth and tenth days of treatment . Late fo... |
64 | 25,695,871 | The low- quality evidence from three small trials with 147 participants does not allow any firm conclusions to be drawn regarding the effectiveness of DMT for depression . | BACKGROUND Depression is a debilitating condition affecting more than 350 million people worldwide ( WHO 2012 ) with a limited number of evidence -based treatments .
Drug treatments may be inappropriate due to side effects and cost , and not everyone can use talking therapies .
There is a need for evidence -based treat... | Dance and movement therapy are consisted of music , easy exercises and sensorial stimulus and provide drugless treatment for the depression on low rates . In this study , it has been aim ed to examine the effect of dance over the depression . A total of 120 healthy male and female conservatory students ranged from 20 a... |
65 | 19,523,038 | The established endothelial-erectile dysfunction connection was thoroughly revised , from basic mechanisms to the clinical importance of endothelial dysfunction assessment as diagnosis for generalized vascular disease . | INTRODUCTION The endothelial monolayer plays a crucial role in the vasodilation and hemodynamic events involved in erection physiology .
Due to its relevant functions , a close link has been established between endothelial integrity and erectile dysfunction ( ED ) .
Endothelial dysfunction is induced by the detrimental... | Men with erectile dysfunction ( ED ) frequently have a disproportionate burden of comorbid vascular disorders including atherosclerotic disease . We investigated whether scheduled tadalafil is better than on-dem and ( OD ) in improving endothelium-dependent vasodilatation of cavernous arteries in men with ED and whethe... |
66 | 32,074,216 | The average HBV-DNA level before treatment was approximately 8 log10 copies/mL. Compared to the onset of antiviral intervention in the third trimester , the beginning of treatment in the second trimester distinctly reduced maternal predelivery HBV-DNA levels .
However , no significant difference in HBV MTCT was found b... | For pregnant women with high viral load , antiviral therapy has been administered in addition to active and passive immune prophylaxis as a crucial adjunctive therapy to interrupt mother-to-child hepatitis B virus ( HBV ) transmission ( MTCT ) .
However , the time of antiviral therapy onset remains controversial .
A sy... | Background To evaluate the efficacy and safety of treating HBV-positive mothers with telbivudine in early and middle pregnancy to prevent mother-to-infant HBV transmission . Methods The subject population comprised pregnant women with chronic hepatitis B ( CHB ; n = 188 ) from January 2013 to June 2015 , with HBV DNA ≥... |
67 | 29,391,004 | There were mixed results for dietary interventions affecting growth and diarrhea outcomes in the post-acute period . | Background Although acute diarrhea often leads to acute dehydration and electrolyte imbalance , children with diarrhea also suffer long term morbidity , including recurrent or prolonged diarrhea , loss of weight , and linear growth faltering .
They are also at increased risk of post-acute mortality .
The objective of t... | Glutamine has been demonstrated to be an important source of fuel for the gut . The purpose of this study was to evaluate the effect of glutamine-supplemented hyperalimentation on gut immune function . Thirty-six female Fischer rats were r and omized into three groups : group 1 ( chow ) was fed rat chow and water ad l... |
68 | 28,689,271 | A systematic review of topic-specific faith-based health programs determined that health outcomes can be improved though faith-based health interventions . | A university research team , in partnership with the Kansas United Method ist Church and a United Method ist philanthropy , facilitated planning and development of a statewide initiative to increase the capacity of laity-led health ministry teams .
The purpose of this paper is to describe the processes utilized to desi... | Background Community-based approaches have been increasing in the effort to raise awareness and early detection for cancer and other chronic disease . However , many times , such interventions are tested in r and omized trials , become evidence -based , and then fail to reach further use in the community . Project HEAL... |
69 | 29,607,494 | Tinnitus and voice alteration were the only adverse events significantly more common in the inhaled antibiotics group .
No significant differences were found in the remaining comparisons with regard to lung function .
Inhaled anti-pseudomonal antibiotic treatment probably improves lung function and reduces exacerbation... | BACKGROUND Inhaled antibiotics are commonly used to treat persistent airway infection with Pseudomonas aeruginosa that contributes to lung damage in people with cystic fibrosis .
Current guidelines recommend inhaled tobramycin for individuals with cystic fibrosis and persistent Pseudomonas aeruginosa infection who are ... | RATIONALE Inhaled tobramycin has been shown to transiently clear Pseudomonas from lower airways in early cystic fibrosis ( CF ) , but does not markedly reduce lung inflammation , a key factor in disease progression . OBJECTIVE Test the hypothesis that systemic antibiotics are more effective than inhaled antibiotics for... |
70 | 28,094,851 | There is no evidence for managing adults , or children who do not have HbSS sickle cell disease .
In children who are at higher risk of stroke and have not had previous long-term transfusions , there is moderate quality evidence that long-term red cell transfusions reduce the risk of stroke , and low quality evidence t... | BACKROUND Sickle cell disease is one of the commonest severe monogenic disorders in the world , due to the inheritance of two abnormal haemoglobin ( beta globin ) genes .
Sickle cell disease can cause severe pain , significant end-organ damage , pulmonary complications , and premature death .
Stroke affects around 10 %... | Noninvasive , quantitative , and accurate assessment of liver iron concentration ( LIC ) by MRI is useful for patients receiving transfusions , but R2 and R2 * MRI techniques have not been systematic ally compared in sickle cell anemia ( SCA ) . We report baseline LIC results from the TWiTCH trial , which compares hydr... |
71 | 21,088,343 | Sivelestat was not associated with decreased mortality , even when including studies published in Japanese language | INTRODUCTION Sivelestat is neutrophil elastase inhibitor , which is widely used in Japan for the treatment of acute lung injury .
However , the clinical efficacy of the medication has not been convincingly demonstrated . | Overwhelming evidence shows the quality of reporting of r and omised controlled trials ( RCTs ) is not optimal . Without transparent reporting , readers can not judge the reliability and validity of trial findings nor extract information for systematic review s. Recent method ological analyses indicate that inadequate ... |
72 | 23,016,739 | Conclusion Country specific pharmacoeconomic analyses are too scarce and inconsistently used to have had a significant influence on the selection of essential medicines in Tanzania . | Background Due to escalating treatment costs , pharmacoeconomic analysis has been assigned a key role in the quest for increased efficiency in re source allocation for drug therapies in high-income countries .
The extent to which pharmacoeconomic analysis is employed in the same role in low-income countries is less wel... | Background Intermittent preventive treatment in infants ( IPTi ) is a new malaria control tool . However , it is uncertain whether IPTi works mainly through chemoprophylaxis or treatment of existing infections . Underst and ing the mechanism is essential for development of replacements for sulfadoxine-pyrimethamine (... |
73 | 15,495,134 | However , the trend was for sclerotherapy to be evaluated as significantly better than surgery at one year ; after one year ( sclerotherapy result ed in worse outcomes ) the benefits with sclerotherapy were less , and by three to five years surgery had better outcomes .
REVIEW ERS ' CONCLUSIONS There was insufficient e... | BACKGROUND Varicose veins are a relatively common condition and account for around 54,000 in-patient hospital episodes per year .
The two most common interventions for varicose veins are surgery and sclerotherapy .
However , there is little comparative data regarding their effectiveness .
OBJECTIVES To identify whether... | PURPOSE Surgical treatment of varicose veins with preservation of the greater saphenous vein ( GSV ) was studied . METHODS Patients with reflux at the saphenofemoral junction and grossly normal GSV were treated with two different surgical techniques : perivalvular b and ing valvuloplasty ( PVBV-A ) of the saphenous val... |
74 | 23,734,989 | Community paramedicine research to date is lacking , but programs in the United Kingdom , Australia , and Canada are perceived to be promising , and one RCT shows that paramedics can safely practice with an exp and ed scope and improve system performance and patient outcomes . | BACKGROUND Paramedics are an important health human re source and are uniquely mobile in most communities across Canada .
In the last dozen years , challenges in the delivery of health care have prompted governments from around the globe to consider exp and ing the role paramedics play in health systems .
Utilizing par... | Objective To evaluate the benefits of paramedic practitioners assessing and , when possible , treating older people in the community after minor injury or illness . Paramedic practitioners have been trained with extended skills to assess , treat , and discharge older patients with minor acute conditions in the communit... |
75 | 26,976,366 | Five studies including a total of 403 participants provided no evidence that fluid optimization strategies improve outcomes for participants undergoing surgery for PFF . | BACKGROUND Proximal femoral fracture ( PFF ) is a common orthopaedic emergency that affects mainly elderly people at high risk of complications .
Advanced methods for managing fluid therapy during treatment for PFF are available , but their role in reducing risk is unclear .
OBJECTIVES To compare the safety and effecti... | BACKGROUND Some observational studies suggest that the use of pulmonary-artery catheters to guide therapy is associated with increased mortality . METHODS We performed a r and omized trial comparing goal -directed therapy guided by a pulmonary-artery catheter with st and ard care without the use of a pulmonary-artery c... |
76 | 26,718,881 | Although the data are limited , radioisotopes seem to reduce pain with a rapid onset of action and duration of response of 1 to 3 months .
The evidence that bisphosphonates or denosumab reduce or prevent pain in patients with NSCLC and bone metastases or that they have an influence on QoL is very weak .
Radioisotopes c... | Bone metastases are common in patients with non-small cell lung cancer ( NSCLC ) , often causing pain and a decrease in quality of life ( QoL ) .
The effect of bone-targeted agents is evaluated by reduction in skeletal-related events in which neither pain nor QoL are included .
Radioisotopes can be administered for mor... | OBJECTIVE To evaluate the measurement of Samarium-153 ethylenediaminetetramethylene phosphonic acid ( (153)Sm-EDTMP ) bone uptake rate using whole-body scintigraphy and analyze the relationship between bone uptake rate and therapeutic effect . METHODS Sixty-six patients with painful bony metastases from prostate ( n = ... |
77 | 27,693,295 | Intervention strength was positively correlated with reporting of positive anthropometric outcomes for physical activity , diet , and combined interventions , and parent engagement components increased the strength of these relationships .
Study quality was modestly related to percent successful healthy eating outcomes... | TIME AND PLACE OF STUDY 2010 - 2015 ; INTERNATIONAL : Given the high levels of obesity in young children , numbers of children in out-of-home care , and data suggesting a link between early care and education ( ECE ) participation and overweight/obesity , obesity prevention in ECE setting s is critical .
As the field h... | Background Many unhealthy dietary and physical activity habits that foster the development of obesity are established by the age of five . Presently , approximately 70 percent of children in the United States are currently enrolled in early childcare facilities , making this an ideal setting to implement and evaluate c... |
78 | 28,323,240 | The most common measures for motor performances were the maximum strength of the trunk flexors and extensors and the endurance and fatigability of the trunk extensors .
The meta-analyses demonstrated no negative effect by the continuous use of an LSO for 1 - 6 months .
However , the quality of evidence ranged from low ... | BACKGROUND CONTEXT Lumbosacral orthosis ( LSO ) is prescribed by general practitioners for the management of low back pain .
It may be speculated that continuous use of an LSO for a prolonged period reduces mechanical loading to the trunk muscle in daily living and results in impairments of the trunk muscle .
PURPOSE ... | BACKGROUND AND PURPOSE An active strategy was developed for the implementation of the clinical guidelines on physical therapy for patients with low back pain . The effect of this strategy on patients ' physical functioning , coping strategy , and beliefs regarding their low back pain was studied . SUBJECTS One hundred ... |
79 | 21,975,779 | AUTHORS ' CONCLUSIONS There is limited evidence which supports the use of compensatory scanning training for patients with visual field defects ( and possibly co-existing visual neglect ) to improve scanning and reading outcomes .
There is insufficient evidence to reach a conclusion about the impact of compensatory sca... | BACKGROUND Visual field defects are estimated to affect 20 % to 57 % of people who have had a stroke .
Visual field defects can affect functional ability in activities of daily living ( commonly affecting mobility , reading and driving ) , quality of life , ability to participate in rehabilitation , and depression , an... | BACKGROUND The objective of this study was to determine the effect of a visual rehabilitation intervention on visual field defects in a US cohort . Vision Restoration Therapy ( VRT ) consists of a specific pattern of stimulation that is directed at the border of the blind field . METHODS This retrospective study evalu... |
80 | 29,868,912 | Store environment interventions showed mixed effects .
Education-only interventions appeared effective in simulated environments but not in real stores .
Available data suggested that effects of economic interventions did not differ by socioeconomic status , whereas for other interventions impact was variable .
In our ... | Background Diet is an important determinant of health , and food purchasing is a key antecedent to consumption .
Objective We set out to evaluate the effectiveness of grocery store interventions to change food purchasing , and to examine whether effectiveness varied based on intervention components , setting , or socio... | Objective Small food store interventions show promise to increase healthy food access in under-re source d areas . However , none have tested the impact of price discounts on healthy food supply and dem and . We tested the impact of store-directed price discounts and communications strategies , separately and combined ... |
81 | 29,911,392 | Conclusions : Despite a statistically significant reduction of myocardial damage in STEMI patients , the magnitude of the reduction was small and a significant impact on clinical events is unlikely .
With respect to elective percutaneous coronary intervention , remote ischaemic conditioning had no influence on myocardi... | Background : The efficacy of remote ischaemic conditioning in clinical trials of ST-segment elevation myocardial infa rct ion ( STEMI ) or elective percutaneous coronary intervention is controversial .
We aim ed to systematic ally review and meta-analyse whether remote ischaemic conditioning reduces myocardial damage i... | Remote ischemic preconditioning reduces myocardial infa rct ion ( MI ) in animal models . We tested the hypothesis that the systemic protection thus induced is effective when ischemic preconditioning is administered during ischemia ( PerC ) and before reperfusion and examined the role of the K(+)-dependent ATP ( K(ATP ... |
82 | 30,854,085 | The incidence of some high grade ( ≥ 3 ) AEs increased , such as hemorrhage , hypertension and neutropenia .
Conclusions : Our study demonstrated that regimens with VEGFR-TKIs combined with chemotherapy improved PFS , ORR and DCR in patients with advanced NSCLC , but had no impact on OS .
VEGFR-TKIs induced more frequ... | Introduction : To estimate the efficacy and safety of vascular endothelial growth factor receptor tyrosine kinase inhibitors ( VEGFR-TKIs ) in combination with chemotherapy for patients with advanced non-small cell lung cancer ( NSCLC ) . | PURPOSE This trial evaluated the efficacy and safety of sorafenib plus gemcitabine/cisplatin in chemotherapy-naive patients with unresectable stage IIIB to IV nonsquamous non-small-cell lung cancer ( NSCLC ) . PATIENTS AND METHODS Between February 2007 and March 2009 , 904 patients were r and omly assigned to daily sor... |
83 | 31,757,061 | However , significant within-group effects for change from baseline were prevalent , suggesting that high inter-individual variability precluded significant treatment effects .
Berry consumption in general appears to cause a fluctuation in the pools of small molecule metabolites already present at baseline , rather tha... | Diets rich in berries provide health benefits , however , the contribution of berry phytochemicals to the human metabolome is largely unknown .
The present study aim ed to establish the impact of berry phytochemicals on the human metabolome .
A “ systematic review strategy ” was utilized to characterize the phytochemic... | BACKGROUND There are very limited data regarding the effects of blueberry flavonoid intake on vascular function in healthy humans . OBJECTIVES We investigated the impact of blueberry flavonoid intake on endothelial function in healthy men and assessed potential mechanisms of action by the assessment of circulating meta... |
84 | 31,888,534 | Hepatic portal hemodynamic parameters were improved in statin users for a short-term response .
Statin seemed not to decrease the risk of esophageal variceal bleeding and spontaneous bacterial peritonitis .
However , statin was proved to decrease the risk of hepatic encephalopathy and ascites .
Incidence of drug relat... | Background Statin has been more and more widely used in chronic liver disease , however , existed studies have attained contradictory results .
According to the present study , we aim ed to test the efficacy and safety of statin via a meta- analysis . | Background : Portal hypertension is one of the most frequent complications of cirrhosis . β-adrenergic blockers , with or without organic nitrates , are currently used as hypotensive agents . Statins such as simvastatin seem to be safe for patients with chronic liver diseases and exert multiple pleiotropic actions . Th... |
85 | 28,807,143 | Lifestyle interventions appear effective for treating overweight and obesity among people with serious mental illness .
Interventions of ≥12-months duration compared to ≤6-months duration appear to achieve more consistent outcomes , though effect sizes are similar for both shorter and longer duration interventions | OBJECTIVE To conduct a systematic review and meta- analysis to estimate effects of lifestyle intervention participation on weight reduction among overweight and obese adults with serious mental illness . | Abstract Depressive symptoms have debilitating effects on the physical health and functioning of people with serious mental illness . We examined change in depressive symptoms among overweight and obese adults with serious mental illness ( n = 343 ) using data combined from two r and omized trials comparing the 12-mont... |
86 | 29,153,114 | All antihypertensives were cost effective compared with no treatment .
ARBs appeared to be more cost effective than CCBs , ACEIs , and β-blockers . | CONTEXT Hypertension affects one third of the U.S. adult population .
Although cost-effectiveness analyses of antihypertensive medicines have been published , a comprehensive systematic review across medicine classes is not available . | Objective : To estimate and compare the cost-effectiveness and safety of nebivolol with sustained-release metoprolol in reducing blood pressure by 1 mm of Hg per day in hypertensive patients . Material s and Methods : This was a prospect i ve , r and omized , open label , observational analysis of cost-effectiveness , ... |
87 | 28,371,888 | Implication s This systematic review summarizes existing tobacco-related curriculum components ( content , intensity , competency evaluation , and barriers ) and training interventions for health-care professionals worldwide and demonstrates that they are associated with positive health-care professional outcomes ( kno... | Introduction The objective of this systematic review was to investigate what education and training characteristics prepares and supports health-care professionals ( HCPs ) in the delivery of competent and effective care to clients who use tobacco-nicotine . | INTRODUCTION Advice can have a small but clinical ly important effect in promoting smoking cessation . Where studied , the rate of delivery has been found to be low . Training has been found to increases this rates , but there is little research on effectiveness in terms of smoking cessation rates . This study aim ed t... |
88 | 25,994,366 | Where data were available there was no evidence of a difference between alginate dressings and alternative treatments in terms of complete wound healing or adverse events .
AUTHORS ' CONCLUSIONS The relative effects of alginate dressings compared with alternative treatments are unclear . | BACKGROUND Pressure ulcers , also known as bedsores , decubitus ulcers and pressure injuries , are localised areas of injury to the skin or the underlying tissue , or both .
Dressings are widely used to treat pressure ulcers and there are many options to choose from including alginate dressings .
A clear and current ov... | OBJECTIVE To compare the efficacy and tolerability of a new ionic silver alginate matrix ( Askina Calgitrol Ag ) with that of a st and ard silver-free alginate dressing ( Algosteril ) . METHOD Patients with locally infected chronic wounds ( pressure ulcers , venous or mixed aetiology leg ulcers , diabetic foot ulcers )... |
89 | 28,787,448 | There is evidence that the use of certain doses of xylitol may be effective in arresting dental caries in primary dentition .
Chlorhexidine and CPP-ACP may be more effective than a placebo in managing caries in primary dentition , but their effectiveness is borderline when compared with fluoride .
Arginine-containing m... | OBJECTIVE To assess the effect of non-fluoride agents on the prevention of dental caries in primary dentition . | OBJECTIVE The aim of the present study was to determine if a sugarless mint containing CaviStat ( an arginine bicarbonate calcium carbonate complex ) is capable of preventing the development of dental caries in the primary molars and first permanent molars of 10 1/2- to 11-year-old Venezuelan children . METHODS Two-hun... |
90 | 23,435,741 | Conclusion DES for focal infrapopliteal lesions significantly inhibit vascular restenosis and thereby improve primary patency , decrease repeat procedures , improve wound healing , and prolong overall event-free survival | Introduction Drug-eluting stents ( DES ) have been proposed for the treatment of infrapopliteal arterial disease .
We performed a systematic review to provide a qualitative analysis and quantitative data synthesis of r and omized controlled trials ( RCTs ) assessing infrapopliteal DES . | OBJECTIVE To assess 3- and 12-month angiographic restenosis rates and their clinical impact after infrapopliteal angioplasty . DESIGN Prospect i ve multicenter study . MATERIAL S AND METHODS We analyzed 68 critical ischemic limbs ( tissue loss : 58 limbs ) from 63 consecutive patients due to isolated infrapopliteal l... |
91 | 20,393,932 | Cell salvage did not appear to impact adversely on clinical outcomes .
The results suggest cell salvage is efficacious in reducing the need for allogeneic red cell transfusion in adult elective cardiac and orthopaedic surgery .
The use of cell salvage did not appear to impact adversely on clinical outcomes .
As the tri... | BACKGROUND Concerns regarding the safety of transfused blood have prompted reconsideration of the use of allogeneic ( from an unrelated donor ) red blood cell ( RBC ) transfusion , and a range of techniques to minimise transfusion requirements .
OBJECTIVES To examine the evidence for the efficacy of cell salvage in red... | Purpose . To compare the use of a blood salvage and reinfusion system with st and ard allogeneic blood transfusion after total knee arthroplasty — a procedure associated with significant postoperative blood loss . Methods . Between June 2002 and May 2004 , 60 patients undergoing total knee arthroplasty were r and omly... |
92 | 17,943,839 | Lay-led self-management education programmes may lead to small , short-term improvements in participants ' self-efficacy , self-rated health , cognitive symptom management , and frequency of aerobic exercise .
There is currently no evidence to suggest that such programmes improve psychological health , symptoms or heal... | BACKGROUND Lay-led self-management programmes are becoming widespread in the attempt to promote self-care for people with chronic conditions .
OBJECTIVES To assess systematic ally the effectiveness of lay-led self-management programmes for people with chronic conditions . | Abstract Objective This study evaluated the 6-week Chronic Disease Self-Management Program ( CDSMP ) in Hong Kong . Methods A total of 148 subjects with chronic illness were recruited . Subjects were matched on duration of illness and gender , and then r and omly allocated to experimental and comparison groups . The e... |
93 | 17,943,843 | To date there is only a small and heterogeneous body of evidence on the effectiveness of family oriented approaches for bipolar disorder , and it is not yet possible to draw any definite conclusions to support their use as an adjunctive treatment for bipolar disorder . | BACKGROUND Pharmacological treatments are the principal intervention for bipolar disorder .
Alone , however , they are not sufficient to control symptoms and maintain psychosocial functioning .
Adjunctive psychosocial interventions may help to improve the patient 's condition and the course of the illness .
Family inte... | BACKGROUND Levels of expressed emotion ( EE ) in relatives are consistent predictors of relapse among bipolar and other mood disordered patients followed naturalistically . However , few studies have examined whether levels of EE predict the course of illness for patients engaged in psychosocial interventions . METHOD... |
94 | 29,221,929 | Conclusion : Pharmacy technicians are utilized most often to support MTM through assistance in medication reconciliation .
St and ardized training for pharmacy technicians that delineates administrative support from pharmacists ' role of clinical decision making could help pharmacists obtain greater efficiency in MTM d... | Background : Documented barriers to Medication Therapy Management ( MTM ) delivery , such as limited time and inefficient workflow may be overcome by utilizing support staff for administrative services .
However , it is unknown how pharmacy technicians have been historically utilized to assist pharmacists in MTM‐delive... | BACKGROUND The collection of a complete , verified medication history is essential to patient safety . The involvement of clinical pharmacists has been shown to improve the completeness and accuracy of medication histories ; however , to our knowledge , involvement of pharmacy technicians has not been studied . OBJECTI... |
95 | 28,191,983 | Children born at ELBW were reported by parents and teachers to be at significantly greater risk than NBW controls for inattention and hyperactivity , internalizing , and externalizing symptoms .
ELBW children were also at greater risk for conduct and oppositional disorders , autistic symptoms , and social difficulties ... | Although individuals born at extremely low birth weight ( ELBW ; < 1,000 g ) are the most vulnerable of all preterm survivors , their risk for mental health problems across the life span has not been systematic ally review ed .
The primary objective of this systematic review and meta- analysis was to ascertain whether ... | CONTEXT Traditionally , educational attainment , getting a job , living independently , getting married , and parenthood have been considered as markers of successful transition to adulthood . OBJECTIVE To describe and compare the achievement and the age at attainment of the above markers between extremely low-birth-we... |
96 | 31,070,870 | Interactions with robopets were described as having a positive impact on aspects of well-being including loneliness , depression and quality of life by residents and staff , although there was no corresponding statistically significant evidence from meta- analysis for these outcomes .
Not everyone had a positive experi... | BACKGROUND Robopets are small animal-like robots which have the appearance and behavioural characteristics of pets .
OBJECTIVE To bring together the evidence of the experiences of staff , residents and family members of interacting with robopets and the effects of robopets on the health and well-being of older people l... | ABSTRACT Objectives : We undertook a cluster-r and omised controlled trial exploring the effect of a therapeutic companion robot ( PARO ) compared to a look-alike plush toy and usual care on dementia symptoms of long-term care residents . Complementing the reported quantitative outcomes , this paper provides critical ... |
97 | 23,922,214 | Laquinimod had potential benefits in reducing relapse rates and was safe for most patients with RRMS in the short term .
The published study suggests that laquinimod at a dose of 0.6 mg orally administered once daily may be safe and have potential benefits for most patients with RRMS in the short term . | BACKGROUND Multiple sclerosis ( MS ) is a chronic immune-mediated , inflammatory , demyelinating , neurodegenerative disorder of the central nervous system , and it causes major socioeconomic burden for the individual patient and for society .
An inflammatory pathology occurs during the early relapsing stage of MS and ... | Introduction Cerebral atrophy is a compound measure of the neurodegenerative component of multiple sclerosis ( MS ) and a conceivable outcome measure for clinical trials monitoring the effect of neuroprotective agents . In this study , we evaluate the rate of cerebral atrophy in a 6-month period , investigate the predi... |
98 | 25,721,906 | AUTHORS ' CONCLUSIONS There is insufficient evidence of differences in live birth , miscarriage , stillbirth or clinical pregnancy to choose between TLS and conventional incubation . | BACKGROUND Embryo incubation and assessment is a vital step in assisted reproductive technology ( ART ) .
Traditionally , embryo assessment has been achieved by removing embryos from a conventional incubator daily for assessment of quality by an embryologist , under a light microscope .
Over recent years time-lapse sys... | OBJECTIVE To determine if the addition of continuous morphokinetic data improves reproductive outcomes when all embryos are cultured in a closed system . DESIGN Prospect i ve , r and omized , controlled study . SETTING Single academic center . PATIENT(S ) A total of 235 patients undergoing fresh autologous IVF cycles w... |
99 | 31,742,669 | Reports of adverse effects from topical fluoride applications were rare and unlikely to be significant .
AUTHORS ' CONCLUSIONS This review found a low level of certainty that 12,300 ppm F foam applied by a professional every 6 to 8 weeks throughout fixed orthodontic treatment , might be effective in reducing the propor... | BACKGROUND Early dental decay or demineralised lesions ( DLs , also known as white spot lesions ) can appear on teeth during fixed orthodontic ( brace ) treatment .
Fluoride reduces decay in susceptible individuals , including orthodontic patients .
This review compared various forms of topical fluoride to prevent th... | The purpose of this study was to compare the effectiveness of a 1100 ppm fluoride toothpaste used alone , or together with a 0.05 % NaF rinse used once daily or a 0.4 % SnF2 gel applied twice daily , in controlling the decalcification that often accompanies orthodontic treatment . Ninety-five consecutively treated adol... |
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