import anndata as ad import pandas as pd import numpy as np def build_generated_anndata( embeddings: np.ndarray, # shape: (N, D) condition_id: np.ndarray, # shape: (N, 2) pert_col: str = "perturbation", # first perturbation column name pert_col2: str = "perturbation_2", # second perturbation (if combo) combo_col: str = "pert_combo", # combined label ) -> ad.AnnData: """ Construct AnnData from model-generated embeddings and condition IDs. """ N = embeddings.shape[0] if condition_id.shape[0] != N: raise ValueError("condition_id and embeddings must have same first dimension.") # obs: per-cell annotation obs = pd.DataFrame({ pert_col: condition_id[:, 0], pert_col2: condition_id[:, 1], combo_col: [f"{a}_{b}" for a, b in condition_id], }, index=[f"cell_{i}" for i in range(N)]) # construct AnnData adata = ad.AnnData( X=embeddings, # could also store in obsm obs=obs ) # also store embedding explicitly for plotting adata.obsm["embedding"] = embeddings return adata