id stringlengths 8 11 | text stringlengths 6.72k 79k | reference-summary stringlengths 265 2.23k | source stringlengths 9 10 |
|---|---|---|---|
pubmed-1 | anxiety affects quality of life in those living with parkinson's disease (pd) more so than overall cognitive status, motor deficits, apathy, and depression [13]. although anxiety and depression are often related and coexist in pd patients, recent research suggests that anxiety rather than depression is the most promine... | research on the implications of anxiety in parkinson's disease (pd) has been neglected despite its prevalence in nearly 50% of patients and its negative impact on quality of life. previous reports have noted that neuropsychiatric symptoms impair cognitive performance in pd patients; however, to date, no study has direc... | PMC5075302 |
pubmed-2 | small non-coding rnas are transcribed into mrna but remain untranslated in eukaryotic cells. they include sirna (small interfering rna), mirna (microrna), pirna (piwi-interacting rna) and snorna (small nucleolar rna). mirnas are a class of multifunctional singled-stranded small rna which are ~20 nt in length and regul... | small non-coding rnas include sirna, mirna, pirna and snorna. the involvement of mirnas in the regulation of mammary gland tumorigenesis has been widely studied while the role for other small non-coding rnas remains unclear. here we summarize the involvement of mirna in breast cancer onset and progression through regul... | PMC3309138 |
pubmed-3 | ohss is a serious complication of ovulation induction, occurring in 1-10% of in vitro fertilization patients (rizk and aboulghar, 1991; brinsden et al., 1995). this iatrogenic condition has a spectrum of clinical and laboratory manifestations ranging from mild to severe, even life-threatening conditions (rizk et al.,... | objective: to evaluate the efficacy and safety of outpatient management of severe ovarian hyperstimulation syndrome (ohss) requiring placement of a pigtail catheter. methods: retrospective analysis of thirty-three consecutive patients who underwent in-vitro fertilization (2003-2009) and developed severe/critical ohss... | PMC4086000 |
pubmed-4 | the family is the cornerstone of human social support network and its presence is essential in everyone s life. changes inevitably occur in families with illness and hospitalization of a family member. in other words, among the sources of stress for families are accidents leading to hospitalization particularly intensi... | background: since the family is a social system, the impairment in each of its component members may disrupt the entire family system. one of the stress sources for families is accidents leading to hospitalization particularly in the intensive care unit (icu). in many cases, the families needs in patient care are not m... | PMC3702150 |
pubmed-5 | rising levels of obesity are becoming a worldwide phenomenon and are increasingly identified as a health problem across the globe [14]. higher weight has been associated with adverse health indicators and outcomes, including cardiovascular disease [512], stroke [5, 13], cognitive and functional decline [1418], metaboli... | excess weight has generally been associated with adverse health outcomes; however, the link between overweight and health outcomes may vary with socioeconomic, cultural, and epidemiological conditions. we examine associations of weight with indicators of biological risk in three nationally representative populations: t... | PMC3679767 |
pubmed-6 | many studies have not been reported in literature for lumbar discectomy by destandau endospine system. we report a series of 300 patients operated for lumbar dissectomy by destandau endospine system. a total of 300 patients suffering from lumbar disc herniations were operated between january 2002 and december 2008. tec... | background: posterior endoscopic discectomy is an established method for treatment of lumbar disc herniation. many studies have not been reported in literature for lumbar discectomy by destandau endospine system. we report a series of 300 patients operated for lumbar dissectomy by destandau endospine system. materials ... | PMC3270611 |
pubmed-7 | squamous cell carcinoma of the head and neck (hnscc) is a heterogeneous disease that includes tumors arising from the mucosal epithelial surface of the oral cavity, oropharynx, hypopharynx, and larynx. although these tumors originate within different anatomic sites within the upper aerodigestive tract, they are histolo... | molecular therapeutics for treating epidermal growth factor receptor-(egfr-) expressing cancers are a specific method for treating cancers compared to general cell loss with standard cytotoxic therapeutics. however, the finding that resistance to such therapy is common in clinical trials now dampens the initial enthu... | PMC3135278 |
pubmed-8 | global and regional left ventricular (lv) functions are well-known indicators of cardiac disease. quantitative values of ventricular volumes and of myocardial mass are independent predictors of morbidity and mortality in patients with coronary artery disease. classically, echo has been used to evaluate lv volume and fu... | background: coronary computed tomography angiography (ccta) is a frequently performed examination for coronary artery disease. when performed with retrospective gating, there is an opportunity to derive functional parameters of left ventricle utilizing automated software. complementary information, if validated with es... | PMC5353405 |
pubmed-9 | moraxella catarrhalis is a gram-negative, aerobic diplococcus human mucosal pathogen which causes middle ear infections in infants and children [13], and it is one of the three major causes of otitis media along with streptococcus pneumonia and haemophilus influenzae. although moraxella catarrhalis is frequently found... | a bioassay-guided fractionation of methanol extract of aristolochia bracteolata whole plant was carried out in order to evaluate its antimicrobial activity and to identify the active compounds in this extract. antibacterial and antifungal activities of methanol extract against gram-positive, gram-negative, and fungal s... | PMC4745564 |
pubmed-10 | anti-neutrophil cytoplasmic antibodies (ancas) correlate well with a wide spectrum of vasculitis manifestations, including wegener's granulomatosis, microscopic polyangiitis, and churg-strauss syndrome, all of which are commonly referred to as anca-associated vasculitis (1). several infections, particularly infective e... | we herein report an unusual case of an infected descending aortic pseudoaneurysm with luminal pathognomonic oscillating vegetation with serological findings and clinical features mimicking anti-proteinase 3-antineutrophil cytoplasmic antibody-associated vasculitis. the positive blood cultures and imaging findings, incl... | PMC5216144 |
pubmed-11 | neonatal diabetes mellitus (ndm) presenting within the first 6 months of life includes permanent neonatal diabetes mellitus (pndm), which require lifelong therapy, and transient neonatal diabetes mellitus (tndm) where the condition shows remission during infancy but relapses in adolescence. almost all cases of neonatal... | permanent neonatal diabetes mellitus refers to diabetes that occurs before the age of 6 months and persists through life. it is a rare disorder affecting one in 0.2-0.5 million live births. mutations in the gene kcnj11, encoding the subunit kir6.2, and abcc8, encoding sur1 of the atp-sensitive potassium (katp) channel,... | PMC4573445 |
pubmed-12 | radiocontrast-induced nephropathy (rin) can lead to acute renal failure (arf), which may require dialysis therapy. arf increases treatment cost due to sepsis, hemorrhage, respiratory failure, and a long hospitalization.[13] rin is an important cause of hospital-acquired arf and is responsible for 12% of cases. renal me... | radiocontrast administration is an important cause of acute renal failure. in this study, compared the plasma creatinine levels with spot urine il-18 levels following radiocontrast administration. twenty patients (11 males, 9 females) underwent radiocontrast diagnostic and therapeutic-enhanced examinations. the rin meh... | PMC3459524 |
pubmed-13 | according to the u.s. national institutes of health, up to 80% of human bacterial infections involve biofilm-associated microorganisms 1. among these, implant-related infections do still have a tremendous impact in orthopaedics and trauma 2, with high social and economic costs 3, 4, posing challenging diagnostic and th... | living in biofilms is probably the most common condition for bacteria and fungi and biofilm-related infections account for the majority of bacterial infectious diseases worldwide.among others biofilm-related infections, those associated with implanted biomaterials have an enormous and still largely underestimated impac... | PMC5423572 |
pubmed-14 | in 2011, who declared combat drug resistance: no action today, no cure tomorrow.. in recent years presently, antimicrobial resistance (amr) poses a major threat to patient's treatment as it leads to increased morbidity and mortality, increased hospital stay, and severe economic loss to the patient and nation [3, 4]. t... | background and objective. antimicrobial resistance is now a major challenge to clinicians for treating patients. hence, this short term study was undertaken to detect the incidence of multidrug-resistant (mdr), extensively drug-resistant (xdr), and pandrug-resistant (pdr) bacterial isolates in a tertiary care hospital... | PMC4749793 |
pubmed-15 | the majority of women with menorrhagia, postcoital bleeding, intermenstrual bleeding, or postmenopausal bleeding ultimately undergo diagnostic hysteroscopy with endometrial sampling as part of their assessment, particularly if symptoms persist or pelvic imaging suggests a uterine abnormality. dilatation and curettage (... | aims. our aim is to compare the adequacy and diagnostic yield of samples obtained by the endometrial explora sampler i-mx120 with endometrial specimens obtained by conventional dilatation and curettage (d&c). methods. a total of 1270 endometrial samples were received in the histopathology laboratories at the king khal... | PMC4334055 |
pubmed-16 | the geological and (palaeo-)biological evolution of lowland amazonia during neogene and quaternary times remains fascinating since the early days of natural sciences (for summaries of research history see e.g., loczy, 1963 and wesselingh, 2008). many, but partly highly controversial models have been introduced to expla... | in miocene times a vast wetland existed in western amazonia. whereas the general development of this amazing ecosystem is well established, many questions remain open on sedimentary environments, stratigraphical correlations as well as its palaeogeographical configuration. several outcrops located in a barely studied r... | PMC4599590 |
pubmed-17 | with increasing availability, widened indications, and technical refinements of computed tomography (ct) and magnetic resonance imaging (mri), the number of incidentally discovered adrenal lesions, such as adrenal incidentalomas and incidental adrenal enlargement, is increasing. in a recent study by tang et al., among ... | aim. to investigate incidental adrenal enlargement clinical characteristics and functional status and analyze functional lesion risk factors. materials and methods. this retrospective study included 578 patients with adrenal imaging features showing enlargement. incidental adrenal enlargement cases (78) were considere... | PMC4369954 |
pubmed-18 | pursuing the goal of improved health literacy requires more alliances between health and education sectors to improve literacy levels in the population. it is important for health educators to know about knowledge transfer to meet their needs in transferring their knowledge to public. knowledge transfer, which means th... | objectivethe purpose of this study is to propose an innovative method of knowledge transfer that aims to improve health literacy about pediatric infectious diseases prevention in families. children have an appreciable role in this scheme. methodsthis study is a before and after trial that has been conducted in hamedan ... | PMC3533150 |
pubmed-19 | septic arthritis of the shoulder is uncommon in adults. it is a surgical emergency as joint destruction occurs rapidly and can lead to significant morbidity and mortality. a 43 years old male came to our outpatient department with complaints of pain and stiffness of his left shoulder. on examination, his shoulder movem... | introduction: septic arthritis of the shoulder is uncommon in adults. it is a surgical emergency as joint destruction occurs rapidly and can lead to significant morbidity and mortality. accurate diagnosis can be particularly challenging in patients with underlying liver disease. mri is a useful adjunct in early detecti... | PMC5040566 |
pubmed-20 | split-liver transplantation (slt) is an attractive alternative procedure to expand the donor pool in patients waiting for liver transplantation. the standard split-liver procedure for a child and an adult (adult/pediatric split liver ttransplantation, a/p slt), by splitting segment ii-iii for pediatric recipient an... | biliary complications continue to be a major cause of morbidity after split-liver transplantation (slt). in this report we describe an uncommon late biliary complication. one year after slt the patient showed an intrahepatic bile dicy dilatation with severe cholangitis episodes. the segmentary bile duct of hepatic segm... | PMC2809321 |
pubmed-21 | ribonucleotide reductase (rr) inhibitors have been studied as radiation sensitizers for over 30 years in both the lab and the clinic. the first of these, hydroxyurea, has been studied in both cervical and head and neck cancers, among others. although initially promising, many of the clinical trials produced negative r... | ribonucleotide reductase (rr), the rate limiting enzyme in the synthesis and repair of dna, has been studied as a target for inhibition in the treatment of cancer for many years. while some researchers have focused on rr inhibitors as chemotherapeutic agents, particularly in hematologic malignancies, some of the most p... | PMC3356024 |
pubmed-22 | the value of the ketogenic diet (kd) has been recognized in the treatment of epilepsy, although the exact mechanisms by which it exerts its effect remain an enigma. they seem to be different from those of regular antiepileptic medications (aeds), and discovering what they are may lead to its use in clinical situations ... | although the ketogenic diet (kd) has been widely accepted as a legitimate and successful therapy for epilepsy and other neurological disorders, its mechanism of action remains an enigma. the use of the kd causes major metabolic changes. the most significant of them seems to be the situation of chronic ketosis, but ther... | PMC3420518 |
pubmed-23 | the endotracheal tube (ett) should be placed at the optimal level to avoid inadvertent complication. if the ett is too deep, it increases the risk of unintended single lung ventilation. on the other hand, if the ett is too shallow, it may cause vocal cord injury by the ett balloon or accidental extubation. there are ma... | abstractendotracheal tube (ett) should be placed at the optimal level to avoid single lung ventilation or accidental extubation. this study was performed to estimate the mid-tracheal level by using surface anatomical landmarks in adult patients.neck computed tomography images of 329 adult patients between the ages of 1... | PMC5371447 |
pubmed-24 | thyroid cancer is the most common endocrine neoplasia which accounts for about 1% of human cancers. mtc originates from calcitonin-producing cells (c-cells) of the thyroid gland and accounts for 35% of thyroid cancers. mtc is relatively slow-growing tumor but, if metastasized or relapsed, it becomes very aggressive cau... | medullary thyroid carcinoma (mtc), which originates from thyroid parafollicular c cells, accounts for 3 to 5% of thyroid malignancies. mtc occurs either sporadically or in an inherited autosomal dominant manner. hereditary mtc occurs as a familial mtc or as a part of multiple endocrine neoplasia (men) type 2a and b syn... | PMC4803041 |
pubmed-25 | neurosurgery is characterized by the delicate balance between surgical success and potential for devastating side effects. thanks to multiple technological improvements, the morbidity of neurosurgical interventions has substantially decreased over the last decades, allowing for the resection of previously inoperable le... | current neuronavigation systems can not adapt to changing intraoperative conditions over time. to overcome this limitation, we present an experimental end-to-end system capable of updating 3d preoperative images in the presence of brain shift and successive resections. the heart of our system is a nonrigid registration... | PMC3263624 |
pubmed-26 | acquired angioedema (aae), an acquired deficiency of c1esterase inhibitor, is a medically treatable condition which can cause severe abdominal pain mimicking an acute surgical abdomen. this disorder is strongly associated with chronic lymphocytic leukemia (cll) and other indolent lymphoplasmacytic disorders. we describ... | introductionacquired angioedema (aae), an acquired deficiency of c1esterase inhibitor, is a medically treatable condition which can cause severe abdominal pain mimicking an acute surgical abdomen. this disorder is strongly associated with chronic lymphocytic leukemia (cll) and other indolent lymphoplasmacytic disorders... | PMC3220812 |
pubmed-27 | a 68-year-old woman visited the clinic with the chief complaints of pain, swelling, and a warm sensation in her left thigh for over 2 days prior to her visit. the patient also complained about a warm sensation during the nighttime but body temperature was normal when measured in the clinic. she had undergone a left bip... | a 68-year-old woman who suffered from polycythemia vera presented at our clinic with the chief complaints of pain, swelling, and a warm sensation in her left thigh. she had undergone a left bipolar hemiarthroplasty following a hip fracture 24 days prior to this presentation. her erythrocyte sedimentation rate and c-rea... | PMC4971116 |
pubmed-28 | brachial plexus surgery using the da vinci surgical robot is a new procedure. to evaluate the advantages and the restrictions of the technique, a cadaveric study of supraclavicular and axillary approaches was conducted. we found that the axillary approach was useful and advantageous for lower roots, particularly for th... | brachial plexus surgery using the da vinci surgical robot is a new procedure. although the supraclavicular approach is a well known described and used procedure for robotic surgery, axillary approach was unknown for brachial plexus surgery. a cadaveric study was planned to evaluate the robotic axillary approach for bra... | PMC4130329 |
pubmed-29 | gastric cancer is the second most frequent neoplasm of the alimentary tract after the large intestine. 5,103 people in poland were affected by it in 2008. the case-to-death ratio of around 1 indicates unfavourable prognosis as to recovery from this disease [1, 2]. this poor result is determined by the fact that it is r... | the typical symptoms of advanced cancer of the stomach are well known in clinical practice. the presented case concerns a patient with symptoms of left-sided renal colic, caused by a malignant tumour involving the ureter, which was diagnosed with a ct scan. the multifocal process, involving the stomach, two parts of th... | PMC3687400 |
pubmed-30 | eosinophilic gastritis is an extremely rare disease that is characterized by eosinophilic infiltration of the various layers of the gastrointestinal tract in the absence of any definite causes of eosinophilia. patients with eosinophilic gastritis have diverse symptoms, including abdominal pain, emesis, abdominal disten... | eosinophilic gastroenteritis is very rare disorder that is characterized by eosinophilic infiltration of the gastrointestinal tract in the absence of any definite causes of eosinophilia. it is associated with various clinical gastrointestinal manifestations, and depends on the involved layer and site. we report a case ... | PMC4676670 |
pubmed-31 | the skin is the largest organ of the body and protects the organism against external physical, chemical, and biological insults such as wounding, uvb radiation, and microorganisms. this major barrier resides in the upper layers of the epidermis (for review see segre, 2006). the epidermis is the upper part of the skin t... | caspase-14 is a unique member of the evolutionarily conserved family of cysteinyl aspartate specific proteinases, which are mainly involved in inflammation and apoptosis. however, recent evidence also implicates these proteases in proliferation and differentiation. although most caspases are ubiquitously expressed, ca... | PMC2234247 |
pubmed-32 | kelch-like ech-associated protein 1 (keap1)-nuclear factor e2-related factor 2 (nrf2) is a major cellular pathway that protect normal cells against oxidative and xenobiotic damage.1 nrf2 is an essential transcription factor for antioxidant and detoxification genes and is crucial for the chemopreventive effect of variou... | nuclear factor e2-related factor 2 (nrf2) is a transcription factor that upregulates expression of a battery of genes to combat oxidative and electrophilic stress. modification of kelch-like ech-associated protein 1 (keap1) by reactive oxygen species stabilizes nrf2 by escaping from degradation. nrf2 then binds to anti... | PMC4204167 |
pubmed-33 | sepsis is the major cause of death in the intensive care unit. despite improvement of antibiotics treatment and supportive techniques, the mortality of septic shock increases to approximately 60%., it not only helps doctors to make an early diagnosis of sepsis, but also predicts outcomes. there have been some biomarker... | objective. to investigate the prognostic significance of serum soluble triggering receptor expressed on myeloid cells-1 (strem-1), procalcitonin (pct), n-terminal probrain natriuretic peptide (nt-pro-bnp), c-reactive protein (crp), cytokines, and clinical severity scores in patients with sepsis. methods. a total of 10... | PMC3941582 |
pubmed-34 | worksites in glass and metal works, foundries, rolling mills, in the vicinity of hardening furnaces, rotary kilns in the cement industry, high-temperature laboratory furnaces, as well as firefighting, are associated, in addition to common mechanical hazards (e.g., due to splashes of molten metals and slag), sparks and ... | the paper analyses the selected optical parameters of protective optic filters used for protection of the eyes against hazardous radiation within the visible (vis) and near infrared (nir) spectrum range. the indexes characterizing transmission and reflection of optic radiation incident on the filter are compared. as it... | PMC4960498 |
pubmed-35 | the synthetic modification of proteins enables the construction of biomolecular hybrids that can be used to study protein function, deliver potent therapeutics to cellular targets, and build new materials. the synthesis of these constructs requires a suite of chemoselective bioconjugation reactions that proceed unde... | the synthetic modification of proteins plays an important role in chemical biology and biomaterials science. these fields provide a constant need for chemical tools that can introduce new functionality in specific locations on protein surfaces. in this work, an oxidative strategy is demonstrated for the efficient ... | PMC4353012 |
pubmed-36 | alcohol withdrawal syndrome (aws) is characterized by varied symptoms that range from mild to severe intensity depending on several factors including the quantity, frequency and duration of alcohol intake, and the number of prior withdrawal episodes, as well as individual differences in the vulnerability [14]. symptom... | objective. to identify the underlying factor structure of alcohol withdrawal syndrome, as measured with ciwa-ar. methods. exploratory factor analysis was conducted on the items of ciwa-ar. on 201 alcohol-dependent male patients seeking treatment for alcohol withdrawal at 36 hours of abstinence. results. a three-factor... | PMC4006624 |
pubmed-37 | choroid plexus papilloma (cpp) is a rare benign tumor accounting for 0.5% of all intracranial tumors that is more common in childhood, consisting of 1.5 to 6.4% of pediatric intracranial tumors.1 2 the majority of cpps occur during the first 2 years of life, with 12.5 to 20% (10 to 12%) reported in infants under 1 y... | choroid plexus papilloma is a rare benign tumor accounting for 0.5% of all intracranial tumors. the majority of choroid plexus papillomas occur during the first 2 years of life in the ventricular system. moreover, dense calcification of the tumor is uncommon. we report an adult case of densely calcified, atypical choro... | PMC3836973 |
pubmed-38 | multipath signals occur in numerous microwave and rf applications when an unwanted portion of the original transmission propagates along any alternate path and ultimately couples to the receiver distorting the amplitude and phase of the desired signal [14]. if the amplitude of the multipath signal is sufficiently large... | microwave imaging techniques are prone to signal corruption from unwanted multipath signals. near-field systems are especially vulnerable because signals can scatter and reflect from structural objects within or on the boundary of the imaging zone. these issues are further exacerbated when surface waves are generated w... | PMC3332071 |
pubmed-39 | the main cause of treatment failure and death in cancer patients is metastasis the formation of secondary tumors in organs distant from the original neoplastic cell tissue. adjuvant therapy of proven efficacy is not currently available for cancer patients; therefore, the search for new targets of therapeutic reage... | the receptor for advanced glycation end-products (rages) is associated with the malignancy of cancer. a recent study has suggested that glyceraldehyde-derived ages (glycer-ages) enhanced the malignancy of melanoma cells, but glucose-derived ages did not. however, the effects of glycer-ages on other cancer cells remain ... | PMC2902753 |
pubmed-40 | according to numerous estimations, 15% to 29% of patients with cataract have 1.5 diopters (d) of refractive astigmatism.1,2 cataract surgeons usually prefer to treat cataract and correct refractive (spherical and astigmatic) disorders at the time of the surgery. corneal incision (astigmatic keratotomy) and peripheral c... | purpose: to present clinical results of toric intraocular lens (iol) implantation for preexisting astigmatism correction and determine the time of any postoperative rotation. patients and methods: twenty-nine eyes of 19 patients underwent uncomplicated phacoemulsification and were implanted with an acrysof toric iol. ... | PMC2850825 |
pubmed-41 | song is a complex, learned motor skill that involves the precise coordination of vocal and respiratory musculature in order to produce highly stereotyped renditions of a memorized song model. two pathways contributed to this behavior are identified in the songbird forebrain: the motor pathway that is required throughou... | the song of zebra finch is stable in life after it was learned successfully. vocal plasticity is thought to be a motor exploration that can support continuous learning and optimization of performance. the activity of ra, an important pre-motor nucleus in songbird's brain, influences the song directly. this variability ... | PMC3363989 |
pubmed-42 | adolescents in sub-saharan africa face high exposure to human immunodeficiency virus (hiv) infection. despite all efforts to prevent the disease, prevalence estimates in sub-saharan unaids (i.e., the joint united nations programme on hiv and aids) priority countries range from 1.3 to 15.6% among young women and 0.56.5%... | self-report of sexual behavior among adolescents is notoriously inconsistent, yet such measures are commonly used as outcomes for human immunodeficiency virus (hiv) prevention intervention trials. there has been a growing interest in the use of hiv and other sexually transmitted disease biomarkers as more valid measure... | PMC3996329 |
pubmed-43 | nanobiomaterials are characterized by constituent particles and/or surface features less than 100 nm in at least one dimension. starting with photolithography and dry etching in the 1980 's to high-resolution electron beam lithography and other technologies in the 1990 's, nanotechnology allows for making surface... | cell-surface interactions play a crucial role for biomaterial application in orthopaedics. it is evident that not only the chemical composition of solid substances influence cellular adherence, migration, proliferation and differentiation but also the surface topography of a biomaterial. the progressive application ... | PMC2233875 |
pubmed-44 | the success of valproic acid (vpa, 2-propylpentanoic acid), a short branched chain fatty acid, for the therapy of absence seizures, partial seizures, tonic-clonic seizures, bipolar disorder, schizoaffective disorder, social phobias, neuropathic pain and for the prophylaxis and treatment of migraine headaches has spurre... | valproic acid (vpa) has successfully been used in the therapy of a number of conditions including absence seizures, partial seizures, tonic-clonic seizures, bipolar disorder, schizoaffective disorder, social phobias, neuropathic pain and migraine headaches. there is a high rise in number of cases of toxicity due to ove... | PMC4071718 |
pubmed-45 | intramammary infection (mastitis) is the most common reason for the use of antimicrobials in dairy cows. antimicrobials have been used to treat mastitis for more than fifty years, but consensus about the most efficient, safe, and economical treatment is still lacking. the concept of evidence-based medicine has been int... | treatment of mastitis should be based on bacteriological diagnosis and take national and international guidelines on prudent use of antimicrobials into account. in acute mastitis, where bacteriological diagnosis is not available, treatment should be initiated based on herd data and personal experience. rapid bacteriolo... | PMC3339349 |
pubmed-46 | the gram-negative coccobacillus pasteurella multocida is normally found in the oral cavity of dogs and cats. it is a recognised cause of wound infection as a result of bites, licking or scratching. bacteraemia and endocarditis are uncommon complications and, from literature reviews, are found to be associated with prio... | pasteurella multocida is a rare cause of infective endocarditis with only a few cases described. this report involves a 38-year-old penicillin-allergic patient in an immunocompromised state with several co-morbidities. two molecular microbiological techniques, 16s rrna sequencing and matrix-assisted laser desorption/io... | PMC3892627 |
pubmed-47 | genital infection due to chlamydia trachomatis is one of the most prevalent bacterial sexually transmitted infections (stis). according to the who estimates, globally 92 million new cases of c. trachomatis infection occur each year and about two-thirds of these cases occur in the developing world, where diagnostic and ... | reproductive tract infection (rtis)/sexually transmitted infections (stis) are recognized as a major public health problem, particularly due to their relationship with hiv infection. early detection and treatment of chlamydia trachomatis infection (cti) among hiv-infected and hiv-uninfected women may impact heterosexua... | PMC3870114 |
pubmed-48 | hip fracture is a moderate musculoskeletal trauma that mainly affects the older population with comorbid conditions. the number will increase markedly in coming years due to the ageing of the population. comorbidity and the double trauma may dispose them to serious postoperative adverse outcomes and a high mortality do... | hip fracture, a moderate musculoskeletal trauma, is associated with a high postoperative mortality. most patients are elderly, with comorbid conditions and often with heart disease. the objective of this study was to find out if clinical parameters and analyses of specific muscle enzymes could predict three month posto... | PMC3103949 |
pubmed-49 | an infliction in the life expectancy figure of patients with sickle cell disease (scd) occurred around the middle of the 1970s (fig. this minimal increase in life expectancy coincided with my appointment at thomas jefferson university as the associate director of the newly created adult sickle cell center. the number o... | in the 1970s, sickle cell pain was treated with trial and error approach by increasing or decreasing the dose of an opioid or switching from one analgesic to another. this approach was controversial with criticism and doubt about its usefulness. since then, advances in determining the structure of opioid receptors and ... | PMC4817573 |
pubmed-50 | the potential of rnai to silence any gene has made it an attractive therapeutic modality. however, the main obstacle to rnai in the clinic is delivery. to be effective, sirnas must be transported through the body, bind, and be taken up by target cells where they must traverse the plasma membrane and gain access to the ... | due to their ability to knock down the expression of any gene, sirnas have been heralded as ideal candidates for treating a wide variety of diseases, including those involving undruggable targets. however, the therapeutic potential of sirnas remains severely limited by a lack of effective delivery vehicles. recently,... | PMC4754549 |
pubmed-51 | type iii dysbetalipoproteinaemia is a kind of lipid metabolism disorders, caused by apo-e deficiency, which leads to accumulation of chylomicrons and very low density lipoprotein remnants in the plasma.123 lipid metabolism disorders are mostly manifested by xanthomas, which are known as yellowish cholesterol-rich mater... | familial dysbetalipoproteinaemia (fdl) is an inherited disorder in which both cholesterol and triglycerides are elevated in the plasma, pre-disposing the people to coronary artery disease and peripheral vascular disease. the disease is mostly manifested by xanthomas, which have variable forms according to lipid amounts... | PMC3821231 |
pubmed-52 | the national cancer institute (nci) of the united states of america has proposed a reporting system for thyroid fine needle aspiration (fna) cytology, so-called bethesda system, which became an international standard of thyroid cytology [1, 2]. following this recommendation, the uk royal college of pathologists (the uk... | background. the japan thyroid association recently published guidelines for clinical practice for the management of thyroid nodules, which include a diagnostic system for reporting thyroid fine needle aspiration cytology. it is characterized by the subclassification of follicular neoplasms, which is different from oth... | PMC4334867 |
pubmed-53 | plant cells need to maintain the functional integrity of their walls during cell morphogenesis and exposure to biotic/abiotic stress. the available evidence suggests that a dedicated plant cell wall integrity (cwi) maintenance mechanism exists (wolf et al., 2011). while our understanding of the mechanisms regulating st... | plant cell walls provide structural support during development and represent together with the cuticle the first line of defense against biotic and abiotic stress. in recent years, evidence has accumulated that a dedicated plant cell wall integrity (cwi) maintenance mechanism exists. this mechanism monitors and maintai... | PMC3355559 |
pubmed-54 | acute patellar dislocation is a common injury usually associated with a significant traumatic mechanism resulting in lateral displacement. vertical axis rotation following dislocation is a rare variant of this type of injury and can prevent closed reduction in the acute setting. a 32-year old gentleman presented with a... | introduction: acute patellar dislocation is a common injury usually associated with a significant traumatic mechanism resulting in lateral displacement. vertical axis rotation following dislocation is a rare variant of this type of injury and can prevent closed reduction in the acute setting. case presentation: a 32-ye... | PMC4845415 |
pubmed-55 | in recent years, the concept of minimal intervention (mi) has prevailed in dentistry. therefore, the importance of diagnosing caries at an early stage has increased. in conventional procedures, the diagnosis of caries has mainly consisted of visual inspection and tactile assessment with probing. however, lussi report... | the aim of this study was to assess the possibility of digital image analysis of pit-and-fissure discoloration in order to diagnose caries. digital images showing pit-and-fissure discoloration in 100 teeth of 19 patients were analyzed to obtain the fractal dimension (fd) and the proportion of the area of pit-and-fissur... | PMC2836524 |
pubmed-56 | polyarginine peptides are known as one of the widely used classes of cell-penetrating peptides (cpps) and cellular delivery tools. it has been reported that the presence of the guanidine group in the side chain of arginine plays a key role for improved ability of arginine-rich peptides to cross the cell membrane. v... | many of the reported arginine-rich cell-penetrating peptides (cpps) for the enhanced delivery of drugs are linear peptides composed of more than seven arginine residues to retain the cell penetration properties. herein, we synthesized a class of nine polyarginine peptides containing 5 and 6 arginines, namely, r5 a... | PMC4144761 |
pubmed-57 | as of 2014, the worldwide prevalence of type 2 diabetes mellitus (t2 dm) was estimated to be 9% among adults aged 18 years with great impact on mortality, particularly in low- and middle-income countries (lmic) [1, 2]. moreover, globally, approximately 25% to 75% of diabetes cases remain undiagnosed [3, 4], until furth... | objective. to develop and validate a risk score for detecting cases of undiagnosed diabetes in a resource-constrained country. methods. two population-based studies in peruvian population aged 35 years were used in the analysis: the eninbsc survey (n=2,472) and the cronicas cohort study (n=2,945). fasting plasma gluco... | PMC5027039 |
pubmed-58 | atherosclerosis is a coronary heart disease (chd), and is the most common cause of death in the industrialized world. high blood pressure (bp), hypercholesterolemia, diabetes mellitus (dm) and smoking are considered as the major risk factors for the development of atherosclerosis. in addition, increasing age, male sex,... | background: atherosclerosis is a coronary heart disease, andis the most common cause of death in the industrialized world. some studies suggested that atherosclerosis may be triggered by infectious agents, mostly chlamydophila pneumoniae. however, the role of c. pneumoniae in the pathogenesis of coronary atherosclerosi... | PMC3644743 |
pubmed-59 | confrontation with the consequences of diabetes causes a crisis in physical, mental, and spiritual dimensions. sometimes the spiritual crisis can be tremendous. since spiritual health coordinates different aspects of human life, this study aimed to identify the spiritual health of patients with defects caused by diabet... | background: confrontation with the consequences of diabetes causes a crisis in physical, mental, and spiritual dimensions. sometimes the spiritual crisis can be tremendous. since spiritual health coordinates different aspects of human life, this study aimed to identify the spiritual health of patients with defects caus... | PMC3696216 |
pubmed-60 | vitamin d deficiency was once thought to exclusively affect bone metabolism, but now there is ample evidence of its role in many other conditions including metabolic syndrome, autoimmune diseases, and cancer. vitamin d receptors are recognized to be in numerous extraskeletal tissues, such as pancreas and muscle. a syst... | to study the effect of puberty on the relationship between serum 25-hydroxyvitamin d (25(oh)d) and parameters of insulin kinetics in obese asian-indian children. material and methods. the study population included 62 obese asian-indian children and adolescents in the age group of 617 years. blood glucose, serum insulin... | PMC3432876 |
pubmed-61 | a 21-year-old man (height=180 cm, weight=95 kg, body mass index=29.3 kg/m) presented to the outpatient department with a long history of frequent and severe snoring. on physical exam, after a diagnosis of obstructive sleep apnea was made, a bilateral tonsillectomy and uvulopalatopharyngoplasty was planned for treatment... | post-tonsillectomy hemorrhage (pth) is the most frequent complication of tonsillectomy, and occasionally results in a lethal outcome. a 21-year-old man (height 180 cm, weight 95 kg) was scheduled for a bilateral tonsillectomy and uvulopalatopharyngoplasty for treatment of obstructive sleep apnea. he required 5 rounds o... | PMC4121494 |
pubmed-62 | infertility has been recognized as a public health issue worldwide (1) leading to an increasing need to the use of assisted reproductive technologies (art), including in vitro fertilization (ivf). after the first reported case of ivf in 1978(2) art enabled millions of people to have their own children in cases when pre... | human reproduction is a relatively inefficient process and therefore the number of infertile couples is high. assisted reproductive technologies (art) have facilitated the birth of over five million children worldwide. art, however, superimposes its own relative inefficiency on the preexisting inefficiency of normal re... | PMC4975227 |
pubmed-63 | leaf senescence is the last phase of plant development and a highly coordinated process regulated by a large number of senescence associated genes (sags) (12). leaf senescence can either be naturally induced during development stages, or stimulated by environmental factors including darkness, nutritional deficiency and... | by broad literature survey, we have developed a leaf senescence database (lsd, http://www.eplantsenescence.org/) that contains a total of 1145 senescence associated genes (sags) from 21 species. these sags were retrieved based on genetic, genomic, proteomic, physiological or other experimental evidence, and were classi... | PMC3013730 |
pubmed-64 | female study participants were recruited from participants in a cross-sectional study assessing bmd in young women with type 1 diabetes and age-matched community control subjects (7). cases for the cross-sectional study (baseline) were recruited from a regional tertiary hospital pediatric diabetes center and from endoc... | objective individuals with type 1 diabetes have decreased bone mineral density (bmd), yet the natural history and pathogenesis of osteopenia are unclear. we have previously shown that women with type 1 diabetes (aged 1335 years) have lower bmd than community age-matched nondiabetic control subjects. we here report 2-y... | PMC2518333 |
pubmed-65 | familial adenomatous polyposis account for 1% of colorectal cancers, and provides a model of apc inactivation as an early genetic event for the approximately 80%85% of cancers that develop from sporadic polyps. colorectal cancers arising in patients with familial adenomatous polyposis can be largely prevented by poly... | a few familial adenomatous polyposis studies have focused upon faecal sterols and bile acids but none has analysed the fecal content of fatty acids. we report here findings of an observational study on 29 colectomized familial adenomatous polyposis patients that describe the fecal content of fatty acids, and relate thi... | PMC2967835 |
pubmed-66 | local anesthesia and pain control is one of the most important elements of dentistry, and particularly prosthetic dentistry. according to the american dental association, fear of pain is the most important factor preventing patients from visiting their dentists. different kinds of fear related to previous clinical expe... | objective: the objective of this study was to compare the pain levels on opposite sides of the maxilla at needle insertion during delivery of local anesthetic solution and tooth preparation for both conventional and anterior middle superior alveolar (amsa) technique with the wand computer-controlled local anesthesia ap... | PMC4327666 |
pubmed-67 | chronic obstructive pulmonary disease (copd) is a progressive lung disease which is characterized by airway obstruction and lung parenchyma destruction. patients may experience dyspnoea or shortness of breath, a persistent cough with sputum production, decreased exercise tolerance and decreased quality of life [1, 2]. ... | pulmonary rehabilitation is an effective treatment for people with chronic obstructive pulmonary disease. however, access to these services is limited especially in rural and remote areas. telerehabilitation has the potential to deliver pulmonary rehabilitation programs to these communities. the aim of this study was t... | PMC3462379 |
pubmed-68 | acute mountain sickness (ams) occurs during exposure to high altitude (ha) and is a clinical syndrome characterised by headache, insomnia, malaise, and gastrointestinal symptoms. it is common, developing in 1030% at 25003000 meters and in up to 60% of those ascending to around 4500 meters. it causes significant morb... | acute mountain sickness (ams) is a common clinical challenge at high altitude (ha). a point-of-care biochemical marker for ams could have widespread utility. neutrophil gelatinase-associated lipocalin (ngal) rises in response to renal injury, inflammation and oxidative stress. we investigated whether ngal rises with ha... | PMC3817649 |
pubmed-69 | when deposited on various substrate surfaces, rod-like, -conjugated, small organic molecules are well-known for their tendency to form highly anisotropic crystal shapes, which are frequently called fibers or needles. whereas the epitaxial growth has been studied on various substrates, in particular anisotropic sur... | the morphology and structure of 2,2:6,2-ternaphthalene (nnn) deposited on muscovite mica(001) substrates was investigated by scanning force microscopy (sfm) and specular x-ray diffraction measurements. consistently, both methods reveal the coexistence of needle-like structures with a {111} contact plane and {001} ... | PMC3919176 |
pubmed-70 | a-38-year-old female patient consulted to our emergency outpatient clinic with complaints of fever, sore throat, coughing, shivering, chills, joint, and muscle pain, headache, chest pain continuing for nearly 2 weeks and she was hospitalized to investigate the etiology of fever. physical examination findings were as fo... | adult onset still s disease is a rare systemic inflammatory disorder. at the onset of the disease sore throat, pharyngitis; which does not respond to antibiotics, one or two times peaking febrile episodes, marked salmon-colored rash on the trunk and extremities, arthralgia, arthritis, myalgia, fatigue, loss of appetite... | PMC5175095 |
pubmed-71 | dual-polymerizing resin cements have been extensively used for placement of indirect restorations and posts. the dual-polymerizing materials were developed to compensate for the lack of polymerization in the absence of light and to represent a combination of auto- and light-polymerizing components. in some clinical sit... | objective: the purpose of this study was to evaluate the effects of the viscosities and curing modes on the degree of conversion (dc) of two resin cements. methods:eight experimental groups were evaluated (n=5), according to the dual-cured resin cements (nexus 2/variolink ii), viscosity (low and high) and evaluation ti... | PMC3571514 |
pubmed-72 | pleura is divided into a parietal layer which lines the inner aspect of the chest wall and a visceral layer which covers the interlobar fissures. fluid collection within the pleural cavity can be assessed with clinical and radiological means. when pleural effusion is detected, the characteristics of the fluid (exu... | the aim is to examine whether the changes in pleural fluid interleukin (il)-1, il-2, il-6, and il-8 levels were significant in differential diagnosis of childhood pleural effusions. il-1, il-2, il-6, and il-8 levels in pleural fluids of all 36 patients were measured. the levels of il-1, il-2, il-6, and il-8 in p... | PMC1513055 |
pubmed-73 | literature analysis showed few articles about this complication, but no publication has described the management of open patella fracture around total knee arthroplasty. we report a unique case of an open patellar fracture above a total knee arthroplasty, sustained by a 56-year-old female patient. despite the poor outc... | introduction: periprosthetic patellar fracture after total knee arthroplasty (tka) is a rare complication. their management can be very challenging with unpredictable results. literature analysis showed few articles about this complication, but no publication has described the management of open patella fracture around... | PMC5040584 |
pubmed-74 | hypertension is a common chronic medical condition affecting people in pakistan and the rest of the world. it is an important modifiable risk factor for cardiovascular morbidity and mortality, particularly for stroke (accounting for 51% of all stroke deaths worldwide), ischemic heart disease (45% of all deaths), chroni... | objectives. hypertension, if uncontrolled, can lead to hypertensive crisis. we aim to determine the prevalence of hypertensive crisis, its management, and outcome in patients presenting to a tertiary care center in karachi. methods. this was a cross-sectional study conducted at the aga khan university, karachi, pakist... | PMC4590913 |
pubmed-75 | a basic set of proteins and mrnas are differentially expressed among cell types, temporally and spatially, generating a vast assortment of cell phenotypes and/or activation states within a single tissue. outlining this protein/mrna portrait is thus crucial for understanding not only the uniqueness characterizing cells,... | in the cns, neuroinflammation occurring during pathologies as amyotrophic lateral sclerosis (als) and multiple sclerosis (ms) is the consequence of an intricate interplay orchestrated by various cell phenotypes. among the molecular cues having a role in this process, extracellular nucleotides are responsible for interc... | PMC4142314 |
pubmed-76 | acute kidney injury (aki) requiring dialysis is a serious complication in critically ill patients, bringing increased morbidity, mortality, and costs of care [14]. aki requiring dialysis is usually considered the most severe form of kidney injury, and these patients have been conventionally regarded as a relatively ho... | in a multicenter observational cohort of patients-admitted to intensive care units (icu), we assessed whether creatinine elevation prior to dialysis initiation in acute kidney injury (aki-d) further discriminates risk-adjusted mortality. aki-d was categorized into four groups (grp) based on creatinine elevation after i... | PMC3556436 |
pubmed-77 | many previous studies have revealed that parents, especially mothers, of children with developmental disabilities such as intellectual disabilities (ids), developmental delay, and physical and sensory handicaps are more likely to show signs of psychological distress or depressive symptoms and to exhibit lower well-bein... | parents of children with intellectual disabilities and/or physical disabilities are supposed to have an increased risk for parenting stress and psychological distress. we as professional caregivers sometimes experience difficulties in keeping good relations or communicating with the parents. professional workers in 460... | PMC3265212 |
pubmed-78 | in may 2001, 24 cases of s. typhimurium dt160 salmonellosis were reported in the auckland region compared with an average of four sporadic cases each month with this serotype in the previous 7 months. raw and undercooked egg consumption was commonly reported by the first 10 case-patients interviewed. a case-control stu... | an outbreak of human salmonella enterica serotype typhimurium dt160 infection in new zealand was investigated from may to august 2001. handling of dead wild birds, contact with persons with diarrheal illness, and consumption of fast food were associated with infection. contaminated roof-collected rainwater was also det... | PMC2957965 |
pubmed-79 | putting a halt to the rising trend in overweight prevalence has high priority in public health policy all over the developed world. prevention, preferably starting at an early age, is considered as the key strategy to achieve this goal, and considerable effort is put into the design of preventive measures. whereas we... | objective. to prospectively identify behavioral risk factors for childhood overweight and to assess their relevance in high risk sub groups (children of mothers with overweight or low education). methods. in the piama birth cohort (n=3963), questionnaire data were obtained at ages 5 and 7 on screen time, walking or ... | PMC2915806 |
pubmed-80 | the protection of water supplies and water distribution infrastructure such as reservoirs is of great concern for those defending against bioterrorism. the us military is concerned because there exist multiple biological warfare agents (bwas) that could be intentionally introduced into the water supply which could have... | development of a rapid field test is needed capable of determining if field supplies of water are safe to drink by the warfighter during a military operation. the present study sought to assess the effectiveness of handheld assays (hhas) in detecting ricin and staphylococcal enterotoxin b (seb) in water. performance of... | PMC3139884 |
pubmed-81 | with the goal of discovering the genes that contribute to the risk of common diseases, numerous susceptibility loci have been identified using linkage analysis. despite replication of many of these linkages in a second sample, some exceptions include tbc1d1, identified as the gene responsible for the obesity linkage on... | we previously localized type 2 diabetes (t2d) susceptibility genes to five chromosomal regions through a genome-wide linkage scan of t2d and age of diagnosis (aod) in the african american subset of the gennid sample. to follow up these findings, we repeated the linkage and association analysis using genotypes on an add... | PMC3692593 |
pubmed-82 | the circadian system organizes the different biological functions in 24 h, such as sleep/activity, temperature, heart rate, glucose level, cortisol production, and oxidative stress. in mammals, this system is organized by a central clock localized in the suprachiasmatic nucleus of the hypothalamus (scn) and in a series... | the circadian system is a supraphysiological system that modulates different biological functions such as metabolism, sleep-wake, cellular proliferation, and body temperature. different chronodisruptors have been identified, such as shift work, feeding time, long days, and stress. the environmental changes and our mode... | PMC4893437 |
pubmed-83 | cellular adaptation requires biochemical processes including post-translational mechanisms to modify existing proteins. catalyzed by opposing kinases and phosphatases, reversible phosphorylation of serine, threonine, and tyrosine residues is now appreciated as a fundamental regulatory mechanism with the majority of pho... | protein phosphatase 2a- (pp2a-) catalyzed dephosphorylation of target substrate proteins is widespread and critical for cellular function. pp2a is predominantly found as a heterotrimeric complex of a catalytic subunit (c), a scaffolding subunit (a), and one member of 4 families of regulatory subunits (b). substrate spe... | PMC3132988 |
pubmed-84 | dysphagia is the subjective awareness of difficulty in the passage of solids or liquids from the oropharynx to the stomach. dysphagia can be classified into an oropharyngeal or an esophageal location, and it is caused by neuromuscular motility disorders and mechanical obstruction.1) mechanical dysphagia is associated w... | dysphagia aortica is difficulty in swallowing caused by extrinsic compression of the esophagus due to an ectatic, tortuous, or aneurysmatic atherosclerotic thoracic aorta. this condition is very uncommon, and it is usually associated with old age, women with short stature, hypertension, and kyphosis. we report herein a... | PMC2771838 |
pubmed-85 | from now on, molecular study regarding female sexuality has focused on female sexual hormone, like estrogen receptor (er) and er derivatives.12 but flibanserin is an agent of 5-hydroxytryptamin (5-ht) type 1a receptor and an antagonist of 5-ht type 2a and thus a new molecular entity.3 flibanserin was originally develop... | there have been several products developed for male sexual dysfunction. however, developing agents for female sexual dysfunction is lagging behind for various reasons. sildenafil citrate (viagra) and tadalafil (cialis), which have been prescribed for male sexual function disorders, are known to act on vessels.[1] on th... | PMC4854663 |
pubmed-86 | hydroxyapatite biomaterials are materials that are very widely used in several health purposes, including as a source of calcium for the manufacture of toothpaste and as an important material in the formation/bone repair. the chemical properties of hydroxyapatite are bioactive and compatible with the adjacent bone and ... | crab's shells of portunus pelagicus species were used as raw materials for synthesis of hydroxyapatite were used for protection against demineralization of teeth. calcination was conducted to crab's shells of portunus pelagicus at temperature of 1000c for 5 hours. the results of calcination was reacted with (nh4)2hpo4,... | PMC4508471 |
pubmed-87 | brain injury is caused by intrinsic or extrinsic factors and it can result in various disabilities such as motor, sensory, behavioral, or cognitive dysfunction depending on the area of the brain lesion1. cognitive impairment due to brain injury is an important factor affecting patients independent functions and par... | [ purpose] the purpose of this review was to investigate various types of vr programs and their use in cognitive evaluations and interventions for patients with brain injury. [subjects and methods] pubmed, cochrane, and otseeker electronic databases were searched with the search terms. at of 350 titles and abstracts... | PMC4616145 |
pubmed-88 | coronary artery disease (cad) is a major public health problem worldwide and the single largest cause of mortality in the united states, responsible for one of every six deaths (aha heart disease and stroke statistics, 2010). cad is caused by atherosclerosis, which is an inflammatory disease that involves multiple cell... | coronary artery disease (cad) is the largest killer of males and females in the united states. there is a need to develop innovative diagnostic markers for this disease. micrornas (mirnas) are a class of noncoding rnas that posttranscriptionally regulate the expression of genes involved in important cellular processes,... | PMC3137987 |
pubmed-89 | among eusocial insects, paper wasps (hymenoptera: vespidae: polistinae) are notable for the diversity of their nest architecture (jeanne, 1975; wenzel, 1991). many swarm-founding polistine wasps, including most species of the neotropical tribe epiponini, construct envelopes around their brood combs. comparative and exp... | the swarm-founding wasp polybia emaciata is unusual among eusocial vespidae because it uses mud, rather than wood pulp, as its primary nest construction material. polybia emaciata nests are more durable than similarly sized paper nests. we tested the hypothesis that the defensive behavior of this wasp may have been mod... | PMC355903 |
pubmed-90 | human gliomas represent 50% to 60% of all intracranial tumors. according to the world health organization (who) guidelines, gliomas are histologically classified into four grades: pilocytic astrocytoma (grade i), low-grade diffuse astrocytoma (grade ii), anaplastic astrocytoma (grade iii), and glioblastoma multiforme (... | aim. to examine the expression of n-methylpurine-dna glycosylase (mpg) gene and protein in glioma samples with different who grades and its association with patients ' survival. methods. immunohistochemistry assay, quantitative real-time pcr and western blot analysis were carried out to investigate the expression ... | PMC3303893 |
pubmed-91 | the prevalence of overweight and obesity among children and adolescents has widely increased worldwide [1, 2], making it one of the most common chronic disorders in this age group and in adulthood. the use of body mass index (bmi) for age to define being overweight and obese in children and adolescents is well establ... | objective. to review the extant literature on the prevalence of overweight and obesity in adolescents (1019 years old) of both sexes. design. the search was carried out using medline and scopus considering articles published from the establishment of the databanks until june 7, 2012. data on the prevalence of childre... | PMC3901970 |
pubmed-92 | sacubitril/valsartan is a combination of a neprilysin inhibitor and an angiotensin ii receptor blocker, indicated to decrease the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure.a patient previously stable on atorvastatin developed severe rhabdomyolysis and an ... | a 63-year-old woman previously stable on a regimen of atorvastatin 40 mg daily, carvedilol 25 mg twice daily, digoxin 0.125 mg daily, furosemide 40 mg daily, spironolactone 25 mg daily, rivaroxaban 15 mg daily, and enalapril 20 mg twice daily for heart failure developed rhabdomyolysis 26 days after enalapril wa... | PMC5089965 |
pubmed-93 | isolated involvement of the appendix in crohn's disease is reported to be 0.2% to 1.8%, and is usually associated with ileocaecal crohn's disease in 25% of ileal and 50% of caecal disease. while appendicitis in a patient who was previously diagnosed to have ileocaecal crohn's may be managed with appendicectomy and ileo... | context: isolated involvement of the appendix in crohn's disease is reported to be 0.2% to 1.8%, and is usually associated with ileocaecal crohn's disease in 25% of ileal and 50% of caecal disease. while appendicitis in a patient who was previously diagnosed to have ileocaecal crohn's may be managed with appendicectomy... | PMC3354430 |
pubmed-94 | the random sample comprises 267 caucasian preadolescents (121 girls, 146 boys) and 330 caucasian adolescents (164 girls, 166 boys) of a population belonging to the swedish part of the european youth heart study (eyhs). the eyhs is a cross-sectional school-based study of risk factors for future cardiovascular disease am... | backgroundbody height is a classic polygenic trait. about 80%90% of height is inherited and 10%20% owed to environmental factors, of which the most important ones are nutrition and diseases in preadolescents and adolescents. objectivethe aim of this study was to explore potential relations between the lct (lactase) c>t... | PMC3169089 |
pubmed-95 | primary hyperparathyroidism (php) is a hypercalcemic disease stemming from an abnormal increase in parathyroid hormone (pth) secretion by one or more parathyroid glands. the hallmark of this condition is the presence of high levels of calcium and high or inappropriate levels of pth. primary hyperparathyroidism is more ... | introduction. primary hyperparathyroidism (php) is characteristically determined by high levels of calcium and high or inappropriate levels of parathyroid hormone (pth). technological advances have dramatically changed the surgical technique over the years once intraoperative parathyroid hormone (iopth) assay had allo... | PMC3317101 |
pubmed-96 | although enhanced cardiovascular reactivity is generally associated with future development of hypertension and other cardiovascular events [15], there are studies that have failed to show any relationship between reactivity to stress and future elevation of blood pressure [1, 612]. emerging evidence suggest that some ... | although several studies have shown that enhanced cardiovascular reactivity can predict hypertension development in african americans, these findings have not been consistent among all studies examining reactivity and hypertension susceptibility. this inconsistency may be explained by the influence of anxiety (state an... | PMC3259484 |
pubmed-97 | in order to prevent and control microbial proliferation in industrial settings, cleaning and disinfection plans are applied on a regular basis [1, 2]. in food processing plants, the control of microbial contamination generally involves clean-in-place (cip) procedures which consist of running alternated cycles of deterg... | standard cleaning processes may not remove all the soiling typically found in food industry, such as carbohydrates, fats, or proteins. contaminants have a high impact in disinfection as their presence may reduce the activity of disinfectants. the influence of alginic acid, bovine serum albumin, yeast extract, and humic... | PMC4745498 |
pubmed-98 | social scientists who explore factors mediating and moderating the relationships between social stressors and mental health, including drinking outcomes, have highlighted modes of coping [1, 2]. these studies have explored behaviors which protect people from being psychologically harmed and cognitive appraisals which... | research derived from the stress paradigm suggests that certain types of coping (e.g., problem-focused coping instead of behavioral disengagement) are protective against problem-related drinking to deal with social stressors. going beyond the typical focus in the coping literature, we hypothesize that stressors engende... | PMC4180206 |
pubmed-99 | the development of titanium fixtures has brought several benefits for the rehabilitation of edentulous patients. when biological and mechanical principles are respected, this treatment modality may successfully restore the functional and esthetic impairments caused by tooth loss3. in spite of the significant evolution ... | several authors still consider the mechanical problems of fracture and component loosening as the main causes of failure of implant-supported restorations. the purpose of this in vitro study was to compare the preload of three types of screw for transmucosal abutment attachment used in single implant-supported prosthes... | PMC4327281 |
pubmed-100 | colorectal adenocarcinoma is the fourth most frequently diagnosed malignancy in korea, accounting for 12% of newly diagnosed cancer cases. according to the ministry of health and welfare, the incidence of colorectal cancer has increased in both males and females during the past 2 decades. although surgery is potentiall... | purposefluoropyrimidine-based combination chemotherapy, in combination with either oxaliplatin or irinotecan, has demonstrated efficacy and tolerability in treatment of advanced colorectal cancer (acc). materials and methodsbetween january 2006 and december 2007, a total of 478 acc patients were treated with combinatio... | PMC3138923 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.