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4a5a8940cfaed4c9cfd066173390b1dc | A randomized Phase III trial demonstrated noninferiority of APF530 500 mg SC ( granisetron 10 mg ) to intravenous palonosetron 0.25 mg in preventing CINV in patients receiving MEC or HEC in acute ( 0 - 24 hours ) and delayed ( 24 - 120 hours ) settings , with activity over 120 hours . | [
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] | [] | Biochronomer™ technology and the development of APF530, a sustained release formulation of granisetron. granisetron and other 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are first-line agents for preventing chemotherapy-induced nausea and vomiting (CINV). Current treatment guidelines prefer the longer-actin... | https://pubmed.ncbi.nlm.nih.gov/27186139/ | ### Instruction:
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ef4fb4cd54c88e22cd1b882061876c8d | Classical NSAIDs are still the most logical choice for agents that will slow the progression or delay the onset of AD and other neurodegenerative diseases despite failures of naproxen , celecoxib and rofecoxib in AD clinical trials . | [
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"start": 2... | [] | Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Inflammation is characteristic of a broad spectrum of neurodegenerative diseases. These include Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases, amyotrophic lateral sclerosis, a... | https://pubmed.ncbi.nlm.nih.gov/15974901/ | ### Instruction:
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f3c31f04fdf5a6a559c0fd215a4ebe4c | Between 1987 and 2003 , patients 18 years old were given adjuvant chemotherapy consisting of one of two ' paediatric ' regimens ( depending on the time of presentation ) and craniospinal local-boost radiotherapy : regimen A ( n = 12 ) , vincristine ( VCR ) , intrathecal and/or intravenous methotrexate and conventional ... | [
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Survival of adults treated for medulloblastoma using paediatric protocols. We ... |
7c1b48c4fded5536004f52b2f9c14572 | The US Food and Drug Administration ( FDA ) recommends that " concomitant use of drugs that inhibit CYP2C19 ( e.g. , omeprazole ) should be discouraged . " As the presence of PPIs and clopidogrel in plasma is short lived , separation by 12 - 20 h should in theory prevent competitive inhibition of CYP metabolism and min... | [
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7639b3ca6251f63f76d161da9c24f217 | Long-term overall- and progression-free survival after pentostatin , cyclophosphamide and rituximab therapy for indolent non-Hodgkin lymphoma . | [
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Long-term overall- and progression-free survival after pentostatin , cyclophos... |
70e681adca9791cf2e10d9bd14f4c430 | Once-weekly isoniazid and rifapentine for 3 months is a treatment option in persons with human immunodeficiency virus and latent tuberculosis infection . | [
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Cytokine-Mediated Systemic Adverse Drug Reactions in a Drug-Drug Interaction S... |
5e01b68299caff14016a31896c325af2 | We investigated the effects of these inhibitors on other anticancer drugs including docetaxel , vinblastine , doxorubicin , 10-Hydroxycamptothecin ( 10-HCPT ) and cisplatin and find that both inhibitors induces DU145-TxR cells to be more sensitive only to the microtubule-targeting drugs ( paclitaxel , docetaxel and vin... | [
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960105c5f66a50001d208fdbe4f96ccb | Group B : From January , 1976 to December , 1980 , 55 evaluable patients participated in a consecutive study that added Adriamycin ( doxorubicin ) and cyclophosphamide to the former induction regimen . | [
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] | [] | Comparison of two consecutive trials for treatment of childhood non-Hodgkin's lymphoma. Two consecutive trials for the treatment of childhood non-Hodgkin's lymphoma were evaluated, carried out by the same cooperative groups. Group A: From June, 1973 to December, 1975, 50 evaluable patients under 16 years of age partici... | https://pubmed.ncbi.nlm.nih.gov/6388820/ | ### Instruction:
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Comparison of two consecutive trials for treatment of childhood non-Hodgkin's ... |
db3dec1a94dc53bf5435039c482e060c | When given in repeated doses from 6 h on , 50 g followed by 12.5 g at 6-h intervals , charcoal shortened the serum half-life of amitriptyline by 20 % and that of nortriptyline by 35 % ( p less than 0.05 ) . | [
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Pharmacokinetics of amitriptyline influenced by oral charcoal and urine pH. Th... |
db0e74273491043a8d918e7ddae08e7d | The median overall survival time was 22.7 months in the docetaxel arm and 22.4 months in the paclitaxel arm . | [
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] | [] | A phase II randomized study of two taxanes and cisplatin for metastatic breast cancer after anthracycline: a final analysis. The purpose of the study is to compare two taxanes/cisplatin combinations for metastatic breast cancer in terms of time to disease progression, response rates and toxicity. ### methods Between Ap... | https://pubmed.ncbi.nlm.nih.gov/17172351/ | ### Instruction:
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A phase II randomized study of two taxanes and cisplatin for metastatic breast... |
faf0c9f77be3f3da48e14be921b759f0 | We hypothesized that Aurora A kinase ( AK ) contributes to castrate resistance in prostate cancer ( PCa ) and that inhibiting AK with alisertib can resensitize PCa cells to androgen receptor ( AR ) inhibitor abiraterone . | [
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A Phase I/II Study of the Investigational Drug Alisertib in Combination With A... |
64be1cf1b7842c1f1e561a1885ffcb34 | Tanespimycin plus trastuzumab is well tolerated and has antitumor activity in patients with HER-2 + breast cancer whose tumors have progressed during treatment with trastuzumab . | [
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Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and acti... |
259fcb11e8020d04ee63f8e43cb90c7a | It contains data on prophylaxis with mefloquine ( n = 48,264 ) , with chloroquine ( 6,752 ) , with chloroquine plus proguanil ( 19,727 ) , and with no prophylaxis ( 3,871 ) . | [
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Tolerability and Effectiveness of Malaria Chemoprophylaxis with Mefloquine or ... |
dd0068d9fba06a8e7c381728dd8e1029 | We hypothesized that the brain damage mitigating effect of mild hypothermia after cardiac arrest can be enhanced with thiopental loading , and even more so with the further addition of phenytoin and methylprednisolone . | [
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138ed4d659b783b0815a4433b59d0cff | Caspase-independent mechanisms , mainly based on increased oxidative stress , result from 2-methoxyestradiol , Artesunate , ascorbic acid , Dihydroartemisinin , Evodiamine , b-AP15 , VLX1570 , Erw-ASNase , and TAK-242 . | [
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5edd6b7bf1ec8e231328a5a83f5b82ae | This was a multi-center randomized , two-armed , double-blinded phase II study comparing cediranib plus gefitinib versus cediranib plus placebo in subjects with first relapse/first progression of glioblastoma following surgery and chemoradiotherapy . | [
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Multi-Center Randomized Phase II Study Comparing Cediranib plus Gefitinib with... |
aef35abee464e3a0075caeb3d70926f6 | This study aims to compare the biological , molecular , pharmacological , and clinical characteristics of these three treatment modalities for SARS-COV-2 infections , Chloroquine and Hydroxychloroquine , Convalescent Plasma , and Remdesivir . | [
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Biological, molecular and pharmacological characteristics of chloroquine, hydr... |
be6dfc402b0da5cb965fc0a6da145866 | Patients received a mean ( ±standard deviation ) of 8.8 ± 4.9 intravitreal bevacizumab injections prior to the switch to intravitreal ranibizumab . | [
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] | [] | Diabetic macular edema treated with ranibizumab following bevacizumab failure in Israel (DERBI study). To evaluate the outcome of second-line intravitreal ranibizumab treatment in eyes with diabetic macular edema having persistent edema following initial therapy with intravitreal bevacizumab. ### Methods Diabetic macul... | https://pubmed.ncbi.nlm.nih.gov/29916263/ | ### Instruction:
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Diabetic macular edema treated with ranibizumab following bevacizumab failure ... |
0a53b483acefa9c81b17bd994c27ddfd | Combinations of penicillin and streptomycin and penicillin and amikacin were synergistic only against those strains that were not highly resistant to streptomycin and kanamycin , respectively . | [
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7d64d6b1c7e8c6d3edc29168ad6c4477 | Treatment with a combination chemotherapeutic regimen consisting of cyclophosphamide , vincristine , and dacarbazine for malignant paraganglioma with hepatic metastasis is reported . | [
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Combination chemotherapy for malignant paraganglioma. Treatment with a combin... |
498f31d903df63cf2f948946a8ee5018 | The aim of this study was to evaluate the in vitro effect of single antibiotic ( ciprofloxacin , ceftazidime , or ampicillin ) treatment on adherence of Escherichia coli and Enterococcus to plastic stents . | [
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In vitro evaluation of antibiotic prophylaxis in the prevention of biliary ste... |
717f8a8c20069d19d917002e078901ef | Paclitaxel and docetaxel as single agents have yielded overall response rates of 7 % to 56 % , depending on whether the patients have received prior chemotherapy for metastatic disease . | [
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] | [] | Current and future perspectives in advanced bladder cancer: is there a new standard? The methotrexate/vinblastine/doxorubicin/cisplatin (MVAC) regimen has been the standard treatment in patients with locally advanced and metastatic urothelial cancer for the past 15 years. The minimal or moderate survival benefit-depend... | https://pubmed.ncbi.nlm.nih.gov/11894002/ | ### Instruction:
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Current and future perspectives in advanced bladder cancer: is there a new sta... |
a963d46b799a8ea638850359444188f9 | The most effective treatment regimens for advanced nonseminomatous testicular tumors employ vinblastine , CDDP and bleomycin and adjunctive surgery . | [
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[Preoperative chemotherapy of testicular cancer and Wilm's tumor]. Of the vari... |
773651170795da523779ad0a4d8fdd24 | 27 patients suffering from disseminated carcinoma of the breast with at least two visceral metastases , and two had become resistant to conventional chemotherpy and hormones , received a combination of , in the present trial , vincristine followed by cyclophosphamide with 5-fluoro-uracil . | [
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[Chemotherapeutic combinations of mutually potentializing drugs. 1-Application... |
8a164fc8cdf186bd07aed353d735c00b | We previously demonstrated that the combination of oral estramustine ( 15 mg/kg/day ) and oral etoposide ( 50 mg/m2/day ) is effective first-line therapy for the treatment of hormone refractory prostate cancer . | [
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3065e65032c8537a0d4a53be07e8519a | Therapy consisted of bendamustine ( 70 mg/m(2 ) ) for 2 consecutive days every 28 days , and ofatumumab 300 mg on day 1 and 1000 mg on day 8 during the first cycle , and 1000 mg on day 1 subsequently . | [
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Bendamustine in combination with ofatumumab in relapsed or refractory chronic ... |
304fb876f9dfa960295aef5a6099c04b | All consecutive patients with advanced BTC received the GEMOX regimen in a setting outside a study : gemcitabine 1,000 mg/m(2 ) on day 1 , and oxaliplatin 100 mg/m(2 ) on day 2 , treatment repeated every 2 weeks until progression or unacceptable toxicity . | [
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Experience of gemcitabine plus oxaliplatin chemotherapy in patients with advan... |
70bd47165d708bee82beff55a73c29fc | Recent randomized controlled trials ( RCT ) have failed to demonstrate the efficacy of widely used therapies , such as rituximab plus intravenous immunoglobulin or proteasome inhibition ( bortezomib ) , reinforcing a great need for new therapeutic concepts . | [
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Clazakizumab in late antibody-mediated rejection: study protocol of a randomiz... |
42c1681f652cf35adf1ced53b97516f8 | The aim of this study was to find an experimental model of a donor-recipient rat strain combination that , under triple drug immunosuppressive treatment ( methylprednisolone , cyclosporine , and azathioprine ) , would develop chronic rejection within a few weeks . | [
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An experimental model of chronic renal allograft rejection in the rat using tr... |
373bedaa15b826ea4c469e0ce2643608 | In FOLL05 trial , R-CHOP was compared with R-CVP ( cyclophosphamide , vincristine , prednisone ) and R-FM ( fludarabine , mitoxantrone ) . | [
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] | Rituximab and new regimens for indolent lymphoma: a brief update from 2012 ASCO Annual Meeting. Indolent lymphoma (IL), the second most common lymphoma, remains incurable with chemotherapy alone. While R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) remains the standard frontline regimen for ... | https://pubmed.ncbi.nlm.nih.gov/22913602/ | ### Instruction:
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Rituximab and new regimens for indolent lymphoma: a brief update from 2012 ASC... |
a4a83ba48665f39aac03658bbacb486b | All patients underwent 3 cycles of neoadjuvant gemcitabine , paclitaxel , and capecitabine . | [
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Direct percutaneous transhepatic portomesenteric venous stenting in management... |
509f0b830dc248843856cc659af95634 | The aim of the present investigation was to study and characterize the effect of voriconazole on the fungicidal activity of amphotericin B. | [
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Characterization of the inhibitory effect of voriconazole on the fungicidal ac... |
f9f7d99cac5550bbc464785cf3e3db64 | Dual Therapy with Aspirin and Cilostazol May Improve Platelet Aggregation in Noncardioembolic Stroke Patients : A Pilot Study . | [
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Dual Therapy with Aspirin and Cilostazol May Improve Platelet Aggregation in N... |
d9bc9e760dfd975a2703bfd8e7ef700e | Gemcitabine and vinorelbine have shown activity in the first-line setting . | [
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4dfb347a107d0cb265cbec52dc05280d | The combination of tenofovir disoproxil fumarate ( TDF ) plus emtricitabine ( FTC ) is used extensively to treat HIV infection and also has potent activity against hepatitis B virus ( HBV ) infection . | [
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Efficacy and tolerance of a combination of tenofovir disoproxil fumarate plus ... |
c9947a148118a7c7c0374ef9e7f3a915 | HRQOL was better in Japanese postmenopausal women treated with tamoxifen than those treated with exemestane or anastrozole . | [
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Health-related quality of life, psychological distress, and adverse events in ... |
250ab0e4ff2d5694d10eb236713fe562 | This was driven by the relative advantage of weight loss compared with rosiglitazone , glimepiride , and insulin glargine , and administration frequency compared with exenatide . | [
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Willingness to pay for diabetes drug therapy in type 2 diabetes patients: base... |
8cc636e27faf0c1e91489ed1d054c255 | Pegylated liposomal doxorubicin plus cyclophosphamide followed by paclitaxel as primary chemotherapy in elderly or cardiotoxicity-prone patients with high-risk breast cancer : results of the phase II CAPRICE study . | [
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e062362953dea1901bad45908e5e5566 | We randomly assigned 410 women with advanced ovarian cancer and residual masses larger than 1 cm after initial surgery to receive cisplatin ( 75 mg per square meter of body-surface area ) with either cyclophosphamide ( 750 mg per square meter ) or paclitaxel ( 135 mg per square meter over 24 hours ) . | [
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967ea702edc061a8a1b8b17a2d779d8c | We now present the long-term follow-up findings of a randomized phase III study on the addition of six cycles of procarbazine , lomustine , and vincristine ( PCV ) chemotherapy to radiotherapy ( RT ) . | [
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8c229f9bee992965dc0cac147088ce6d | A phase II clinical trial was conducted to evaluate the efficacy and toxicity of vinorelbine plus gemcitabine in very old patients with inoperable ( stage IIIb or IV ) NSCLC . | [
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aca79bc0aba0854bf6e69d6468578862 | Despite the absence of strong data , entecavir and telbivudine seem to be the preferred options for nucleoside analogue-naive CHB patients with chronic kidney disease , depending on viraemia and severity of renal dysfunction . | [
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bddb579070955f889fea255e42d919f5 | Results from clinical trials evaluating agents such as ixabepilone , albumin-bound paclitaxel , capecitabine , vinorelbine , pemetrexed , and irinotecan are presented . | [
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1a4b7002c34da6a84d3592bc7bc47325 | The clinical studies provide evidence that combined fluticasone/formoterol is more efficacious than fluticasone or formoterol given alone , and provides similar improvements in lung function to fluticasone ( Flixotide ( ® ) ) and formoterol ( Foradil ( ® ) ) administered concurrently . | [
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b34f763241f46b224f71b6494c6b2fb8 | Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen : a TransATAC study . | [
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a8312c2cee1d08090d323d2c0b611d9e | When novel DMARDs were used as monotherapies , greater ACR20/50/70 responses were observed with tocilizumab than with anti-tumor necrosis factor agents ( aTNF ) or tofacitinib . | [
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Comparative Efficacy of Novel DMARDs as Monotherapy and in Combination with Me... |
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0702354a47fff4da19d07a1467671915 | The experimental protocol was as follows : ( 1 ) at time zero , intravenous infusion of ritodrine was begun ; ( 2 ) at 120 min , 2 % lidocaine was given epidurally to achieve a sensory level of at least T6 ; and ( 3 ) at 135 min , an intravenous bolus of either ephedrine , phenylephrine , or normal saline-control was g... | [
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f9b1f1a93c415dc0e29c0a8bed13dc1c | compared to busulfan and cyclophosphamide as conditioning regimen for allogeneic stem cell transplant from matched siblings and unrelated donors for acute myeloid leukemia . | [
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compared to busulfan and cyclophosphamide as conditioning regimen for allogene... |
dc747d23089de0920b9129198f64388e | Posttransplant immunosuppression to prevent graft-versus-host disease ( GVHD ) consisted of cyclosporine and prednisone ( CSA/PSE ) . | [
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f76446fad47e58f6c8cbe3add6b8bde7 | Tadalafil 20 mg was preferred to sildenafil 50 mg for the initiation of ED therapy in this study population . | [
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9f6a5691861df15334acb4b555ed7ee0 | Either 5-fluorouracil ( 5-FU ) and leucovorin for 6 months or 5-FU and levamisole for 12 months are currently considered standard adjuvant treatment for stage III colorectal cancer . | [
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7ac7f5459159308e28b92b4bf1bdf281 | Codelivery of sorafenib and curcumin by directed self-assembled nanoparticles enhances therapeutic effect on hepatocellular carcinoma . | [
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Codelivery of sorafenib and curcumin by directed self-assembled nanoparticles ... |
975254697195819e20dfd94a71918e9a | Single treatment of closantel plus albendazole mixture reduced egg counts in camels by 100 % , 100 % , 98 % and 77 % for Haemonchus longistipes , Ascaris spp . , Monezia expansa and Fasciola hepatica , respectively . | [
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a810b68cf7ccc6138320048a4167e583 | In contrast to patients receiving lidocaine , older patients receiving tetracaine experienced significantly less overall pain and discomfort , unpleasant taste , and dyspnea . | [
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A prospective, randomized, double-blind study comparing the efficacy of topica... |
8426f8e8f60a6c637801b577610e05d9 | Second-line chemotherapy was also ineffective ; therefore , the bevacizumab and irinotecan were given after a third gross-total resection of the tumor . | [
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Long-term efficacy of bevacizumab and irinotecan in recurrent pediatric gliobl... |
532c3c76c61f8d9eb020f295bd8cbfc8 | In unselected patients with advanced HCC immunotherapeutics , namely the programmed cell death-1 ( PD-1 ) antibodies , nivolumab and pembrolizumab have shown promising efficacy in therapy-naïve , as well as pre-treated patients with advanced HCC . | [
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Recent developments with immunotherapy for hepatocellular carcinoma. Immunothe... |
fa1e8b298a512fc856c1e81df55911b0 | Treatment with rapamycin and paclitaxel resulted in decreased phosphorylation of S6 and 4E-BP1 , two critical downstream targets of the mTOR pathway . | [
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Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells th... |
d49e128f648e789ddc390d1f87e75031 | Conversely , the IMbrave150 trial recently showed that , among patients with previously untreated unresectable HCC , treatment with atezolizumab plus bevacizumab resulted in significantly longer overall survival and progression-free survival compared to sorafenib monotherapy . | [
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Biochemical predictors of response to immune checkpoint inhibitors in unresect... |
400a1eae25bec51f7399dce5efbc4014 | Evaluation of tamoxifen plus letrozole with assessment of pharmacokinetic interaction in postmenopausal women with metastatic breast cancer . | [
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Evaluation of tamoxifen plus letrozole with assessment of pharmacokinetic inte... |
0a4bbd89b0116fe38b5aa37d3710db43 | Moreover , the BCR/ABL1 inhibitors nilotinib and ponatinib were found to decrease STAT5 activity and CD25 expression in KU812 cells and primary CML LSCs . | [
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Identification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Ce... |
4f3b59fab506326763dc670b527a345f | The EVERLAR study reports prospective data of somatostatin analogue in combination with everolimus in nonfunctioning gastrointestinal neuroendocrine tumors suggesting meaningful activity and favorable toxicity profile that supports drug combination in this setting . | [
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### Input:
Phase II Study of Everolimus and Octreotide LAR in Patients with Nonfunctionin... |
90bfe4266085a7725c0b30a40fca9cc6 | Synergism between anti-HER2 monoclonal antibody ( trastuzumab ) and paclitaxel has been shown in vitro and in vivo . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Phase II study of weekly paclitaxel and trastuzumab in anthracycline- and taxa... |
71f038d703d77df97e666dc522f17849 | Between September 1998 and December 1999 , we treated 25 patients at risk for post-operative renal dysfunction ( high-risk basiliximab group ) with the new induction regimen and another 33 patients not at risk ( low-risk CsA group ) for renal dysfunction with our standard cyclosporine protocol . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Induction therapy with basiliximab allows delayed initiation of cyclosporine a... |
afb487e5f3a9ba9b35526d05826560e6 | Cardiac events occurred after posaconazole administration , incriminating posaconazole use , alone or in combination with voriconazole , as the culpable agent . | [
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Long QT Syndrome Leading to Multiple Cardiac Arrests After Posaconazole Admini... |
d27c12a579e30cabf1743a89badedece | Prognostic value of expression of Kit67 , p53 , TopoIIa and GSTP1 for curatively resected advanced gastric cancer patients receiving adjuvant paclitaxel plus capecitabine chemotherapy . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Prognostic value of expression of Kit67 , p53 , TopoIIa and GSTP1 for curative... |
8d395c0462d3164578455a4339b29ea1 | The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin ( FL ) . | [
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Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon canc... |
dbe218b8b09950b9c28f7a92e7b5f29d | Effects of ultrasound were similar at baseline and after propranolol but increased after phenylephrine . | [
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Alteration of left ventricular endocardial function by intracavitary high-powe... |
e164b14965950212d9af8afd0dc70c96 | Thirty-four patients ( 4 patients with stage IIIb , 30 patients in stage IV ) , with median age 66 and performance status 0 - 1 , were administered paclitaxel , 175 mg/m(2 ) in a 3-h infusion rate on day 1 and vinorelbine , 25 mg/m(2 ) in a 10-min infusion rate on days 1 , and 8 with G-CSF and EPO support . | [
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A phase II study of non-platinum based chemotherapy with paclitaxel and vinore... |
f34bb0d6ddd6e05d3a7d9a2cac06618f | Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia . | [
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Phase I study of decitabine alone or in combination with valproic acid in acut... |
324a822968415251d1110100374543de | Early discontinuation of clopidogrel results in a transient rebound increase in risk of recurrence in acute coronary syndromes , but there are no published data on any similar rebound effect in patients with TIA or stroke that might inform the design of clinical trials of aspirin and clopidogrel in the acute phase . | [
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### Input:
Low risk of rebound events after a short course of clopidogrel in acute TIA or... |
e168784c0e299ecd1e3b2e48bfe61993 | Patients received docetaxel 35 mg/m(2 ) and irinotecan 60 mg/m(2 ) , intravenously , on Days 1 and 8 , every 21 days , until disease progression . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Docetaxel and irinotecan in recurrent or metastatic head and neck cancer: a ph... |
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Gemcitabine and carboplatin in second-line ovarian cancer. Most patients with... |
457f957cafaf7d707f008bebb67491e7 | Patients were assigned to receive either oxaliplatin ( 100 mg/m(2 ) ) in the SOX arm or docetaxel ( 40 mg/m(2 ) ) in the mDS arm on day 1 of every 3-week cycle . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Low-dosed docetaxel showed equivalent efficacy but improved tolerability compa... |
21f9362aa253d6a8783dfec4552cd563 | Agents in clinical trials for subsets of MDS include luspatercept , antibodies targeting CD33 , isocitrate dehydrogenase inhibitors , deacetylase inhibitors , venetoclax , and immunotherapies designed to overcome immune checkpoint inhibition . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Recent advances in the cellular and molecular understanding of myelodysplastic... |
ebd455680a4ddeb606e9c2b94cd162c3 | Possible differences between enalapril and captopril . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Possible differences between enalapril and captopril . Inhibitors of angiotens... |
e4fd3f4f3543e792ba43e968cecc17af | Exposure of the saphenous veins to imipenem or imipenem combined with amphotericin B had no adverse effects on the viability of the endothelial cells with 12 h exposure . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Effects of antibiotics on the endothelium of fresh and cryopreserved canine sa... |
22e4c43526214a50dd7ba189ee96a40d | First-line chemotherapy was either R-CHOP ( rituximab , cyclophosphamide , doxorubicin , vincristine and prednisolone ) or CHOP-like-based regimen . | [
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] | [Primary testicular non-Hodgkin's lymphoma: clinical analysis of 21 cases]. To explore the clinical characteristics and prognosis of patients with primary testicular non-Hodgkin's lymphoma. ### methods The clinical profiles and prognostic factors of 21 cases newly diagnosed as primary testicular non-Hodgkin's lymphoma ... | https://pubmed.ncbi.nlm.nih.gov/24169330/ | ### Instruction:
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[Primary testicular non-Hodgkin's lymphoma: clinical analysis of 21 cases]. To... |
cb3413a04ed145ab2ccfc3b8ba5675d8 | The combination of rituximab with vincristine and 5-day cyclophosphamide is able to produce CR in patients with advanced follicular lymphoma , even in patients resistant to third-generation regimens . | [
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] | Immunochemotherapy with rituximab, vincristine and 5-day cyclophosphamide for heavily pretreated follicular lymphoma. Therapeutic options for relapsed or refractory follicular lymphoma include combination chemotherapy, immunotherapy and, for selected patients, autotransplant. Because of the different mechanisms of acti... | https://pubmed.ncbi.nlm.nih.gov/16006752/ | ### Instruction:
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989e4dbe95c2ec8043f087978dfa8204 | The results showed that lamotrigine did not produce any change in cognitive function , while carbamazepine produced cognitive dysfunction . | [
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] | [] | Effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemical epileptogenesis in rats. The present study assessed the effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemically induced epileptogenesis in rats. Epileptogenes... | https://pubmed.ncbi.nlm.nih.gov/20002063/ | ### Instruction:
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Effect of carbamazepine and lamotrigine on cognitive function and oxidative st... |
b0dcf3e3038370ed524af039d260b6ef | These results confirm that sequential decitabine and carboplatin requires further investigation as a combination treatment for melanoma . | [
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] | Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma. Melanoma has two key features, an over-representation of UV-induced mutations and resistance to DNA damaging chemotherapy agents. Both of these features may result from dysf... | https://pubmed.ncbi.nlm.nih.gov/29373959/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Sequential decitabine and carboplatin treatment increases the DNA repair prote... |
08f60e955a6158992b104ff65ea478bd | [ Rhabdomyosarcoma of the urinary bladder : complete remission induced by vinblastine , cis-platinum , and bleomycin ] . | [
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] | [ Rhabdomyosarcoma of the urinary bladder : complete remission induced by vinblastine , cis-platinum , and bleomycin ] . Combination therapy consisting of vincristine, actinomycin-D, and cyclophosphamide with or without adriamycin is the most common chemotherapy for rhabdomyosarcoma in childhood. But the effective chem... | https://pubmed.ncbi.nlm.nih.gov/6191695/ | ### Instruction:
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[ Rhabdomyosarcoma of the urinary bladder : complete remission induced by vinb... |
a3728ecff22176b9a5c91cf433c52ad7 | Recent comparative studies suggest that atenolol ( 200 mg daily ) , metoprolol ( 200 mg daily ) ; acebutolol ( 400 mg daily ) , oxprenolol ( 160 mg daily ) , nadolol ( 80 mg daily ) and timolol ( 20 mg daily ) produce a beneficial clinical response equal to that seen with propranolol ( 160 mg daily ) . | [
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] | Use of beta-adrenoceptor blocking drugs in hyperthyroidism. There is an increasing use and variety of beta-adrenoceptor blocking agents (beta-blockers) available for the treatment of hyperthyroidism. Recent comparative studies suggest that atenolol ( 200 mg daily ) , metoprolol ( 200 mg daily ) ; acebutolol ( 400 mg da... | https://pubmed.ncbi.nlm.nih.gov/6144501/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Use of beta-adrenoceptor blocking drugs in hyperthyroidism. There is an increa... |
6940b79498c210d4948acbca8b303f0c | All the animals in the placebo group had tumors in each lobe compared with only 43 % each in the dorsolateral ( DLP ) and anterior prostate ( AP ) of the animals treated with raloxifene ( 10 mg/kg/day ) plus nimesulide . | [
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] | Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by raloxifene, an antiestrogen with anti-androgen action, but not nimesulide, a selective cyclooxygenase-2 inhibitor. The chemopreventive efficacies of raloxifene and nimesulide, an anti-estrogen but with anti-androgen action and a cycloox... | https://pubmed.ncbi.nlm.nih.gov/15731164/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic ra... |
c68e463583257ffddef0e7d4b4325724 | Overdose of dolutegravir in combination with tenofovir disaproxil fumarate/emtricitabine in suicide attempt in a 21-year old patient . | [
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] | [] | Overdose of dolutegravir in combination with tenofovir disaproxil fumarate/emtricitabine in suicide attempt in a 21-year old patient . A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravi... | https://pubmed.ncbi.nlm.nih.gov/26045712/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Overdose of dolutegravir in combination with tenofovir disaproxil fumarate/emt... |
e464e3850c3026b2c1eb5be706e579ad | Abiraterone acetate and prednisone in the pre- and post-docetaxel setting for metastatic castration-resistant prostate cancer : a mono-institutional experience focused on cardiovascular events and their impact on clinical outcomes . | [
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] | Abiraterone acetate and prednisone in the pre- and post-docetaxel setting for metastatic castration-resistant prostate cancer : a mono-institutional experience focused on cardiovascular events and their impact on clinical outcomes . The aim of this work was to to evaluate the incidence and risk factors of adverse event... | https://pubmed.ncbi.nlm.nih.gov/29383035/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Abiraterone acetate and prednisone in the pre- and post-docetaxel setting for ... |
9e60e1297fe1d1a7991c6c60ce881374 | Nivolumab plus ipilimumab combined therapy is among the most effective therapies for advanced melanoma . | [
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] | Increased serum CCL26 level is a potential biomarker for the effectiveness of anti-PD1 antibodies in patients with advanced melanoma. Nivolumab plus ipilimumab combined therapy is among the most effective therapies for advanced melanoma . However, this therapy is also associated with a high frequency of immune-related... | https://pubmed.ncbi.nlm.nih.gov/32658051/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Increased serum CCL26 level is a potential biomarker for the effectiveness of ... |
615fe37e6e298fc0bc25eabe90123940 | Cells that were sequentially exposed to rapamycin and topotecan had significantly higher levels of cleaved caspase-8 , -3 , and PARP compared to those treated with topotecan alone . | [
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] | Rapamycin-topotecan combination exhibited enhanced antitumor efficacy compared to topotecan used alone in cisplatin-resistant ovarian cancer cells. The present study aimed to investigate the antitumor efficacy of combination of topotecan with rapamycin, a mTOR inhibitor, in cisplatin-resistant ovarian cancer cells A278... | https://pubmed.ncbi.nlm.nih.gov/26278147/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Rapamycin-topotecan combination exhibited enhanced antitumor efficacy compared... |
cc4118b0a9d2cafa211a84e7363516a0 | No cross-resistance was found with conventional drugs , being PNU-159548 active also in cells resistant to doxorubicin and with a multidrug resistance phenotype ( associated with MDR1 gene/P-glycoprotein overexpression ) , as well as in cells resistant to methotrexate or to cisplatin . | [
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"start... | [] | 4-Demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548): a promising new candidate for chemotherapeutic treatment of osteosarcoma patients. The effectiveness of the alkycycline 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548, ladirubicin), a new drug with high ... | https://pubmed.ncbi.nlm.nih.gov/16140527/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
4-Demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-1595... |
61e5eaac10e21ebad5a2d5e91724cf19 | Synergistic cytotoxic effects of recombinant human tumor necrosis factor and Etoposide ( VP16 ) or Doxorubicin on A2774 human epithelial ovarian cancer cell line . | [
{
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] | Synergistic cytotoxic effects of recombinant human tumor necrosis factor and Etoposide ( VP16 ) or Doxorubicin on A2774 human epithelial ovarian cancer cell line . Recombinant human tumor necrosis factor (rHuTNF) is a cytokine, with some antitumor activity, released by stimulated monocytes-macrophages. In vivo and in v... | https://pubmed.ncbi.nlm.nih.gov/11576250/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Synergistic cytotoxic effects of recombinant human tumor necrosis factor and E... |
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