'Dear White People' Set To Debut In Series Format On Netflix
One of 2014's breakthrough films is heading to Netflix in a major way. Dear White People will be turned into a 30-minute series on the streaming conglomerate, which is set to premiere in 2017, The Hol…
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One of 2014's breakthrough films is heading to Netflix in a major way. Dear White People will be turned into a 30-minute series on the streaming conglomerate, which is set to premiere in 2017, The Hollywood Reporter reveals.
The reel will be carved into a 10-episode comedy program that'll still remain true to the premise of the movie. In a statement published on THR, the reel's director/writer Justin Simien shared his elation with this news.
"During the film's release, I had the pleasure to speak with hundreds of students and faculty across a variety of college campuses dealing with these very issues in real time," he said. "I'm so grateful to have this platform — not only to give a voice to those too often unheard in our culture, but to also tell great stories from new points of views. From Day 1, Lionsgate has been remarkably supportive of the vision for the show, and working with Netflix is every bit as harmonious as I'd imagined it would be. Bringing this show to such a vibrant platform is an honor I don't take lightly."
This "Dear White People" Video Is Funny And Offensive At The Same Damn Time
Dear White People reportedly raked in $4.4 million stateside at the box office, serving as a springboard to promote the conversation of race in America, especially in our higher education spaces. The movie starred Tessa Thompson, Teyonah Parris, Dennis Haysbert and Tyler James Williams.


The DOJ and DHS subpoenaed Peloton over treadmill injury reporting
August 27, 2021 by Injury Law
On Tuesday, Peloton revealed the upcoming launch of its entry-level Tread tool. The news came ahead of an unsatisfactory revenues report and after recalls of both of its treadmill products. Today, the linked physical fitness firm noted in a declaring with the SEC that it has actually been subpoenaed by both the U.S. Department of Justice and Department of Homeland Protection.
Both subpoenas are part of examinations around the method the firm reported injuries from its treadmills. It's seemingly another indicator that, despite the return of one of its 2 Tread products to market, the larger ramifications are much from over for the business.
Peloton composes in the declaring:
Injuries suffered by Members or their friends and family participants, or others who use or purchase our Connected Health and fitness Products, can subject us to regulatory procedures and also litigation by administration companies and exclusive litigants brought against us, that regardless of their values, might harm our credibility, divert management's attention from our procedures as well as lead to significant legal costs as well as other expenses. For example, we are presently subject to a CPSC investigation and various other litigation related to injuries endured by Members and others who use or purchase the Footstep+, and we have reporting responsibilities to security regulators in all territories where we offer Connected Fitness Products, where reporting may cause additional governing examinations.
The business decreased to comment further on the investigations.
Peloton was, notably, at odds with the U.S. Customer Product Security Compensation (CPSC)'s first caution to stop using its treadmill items after a mishap with the Footstep+ led to a kid's death. At the time, Peloton stated it was "bothered" by the reporting and insisted that "there is no reason to quit making use of the Footstep+, as long as all warnings as well as security instructions are adhered to." In May, CEO John Foley apologized for the pushback and also consented to work with the CPSC on a recall.
The Compensation pointed out more than 70 events in all, noting, "a six-year-old kid recently died after being pulled under the back of the treadmill. Furthermore, Peloton has obtained 72 records of adult individuals, children, pets and/or things being drawn under the back of the treadmill, including 29 reports of injuries to youngsters such as 2nd- and third-degree abrasions, busted bones, and also lacerations."
The more affordable Tread model, at the same time, was at the center of different problem wherein the item's touchscreen could separate as well as trigger injury during use. The new version of the device includes a reinforced screen. The remembers affected around 125,000 Footstep+ systems as well as more than 5,500 Footsteps, which remained in early launch.


Turkey, Texas: Restored Phillips 66 Gas Station
Restored with non-working old pumps and signage. This was the first Phillips 66 station in Texas; it opened on July 27, 1928.
Hwy. 86, Turkey, TX
Main St. and 5th St.
RA Rates:
Worth a Detour
Visitor Tips and News About Restored Phillips 66 Gas Station
Phillips 66 Gas Station and Bob Wills Tour Bus
Would absolutely stop there again They have Bob Wills and the Playboys' old tour bus! He's the king of Western Swing.
[Greg, 07/28/2020]
Restored Phillips 66 Gas Station
You can buy the station, the bus, and an adjacent like-decorated small building. They all have "For Sale" signs in their windows. Local restaurant across the street has great food and for real tamales with awesome sauce - Galvan's Restaurant.
[Kathy & Ron - On W X N, 06/08/2016]
Bob Wills Bus at Phillips 66
This is supposedly a "fully restored" Phillips 66 gas station. We were sadly disappointed. It is in some stage of restoration, but far from what we had hoped for. The building is closed and the locals slow down and look at you if you're out milling around. The one bright spot was the Bob Wills tour bus. It's kind of out of the way and wasn't really worth it to us, but if you do go then also go down the road to Bob's Oil Well in Matador.
[Black Beard, 07/27/2012]
Bob Wills is long gone, but his music (and tour bus) lives on.
You'd expect to find a restored gas station somewhere on Route 66 but this one is is on Hwy 86/Main St. in Turkey Tx.
Bob Wills Monument, Turkey, TX - < 1 mi.
Patriotic Midway Drive-In, Quitaque, TX - 5 mi.
Bob's Oil Well, Matador, TX - 27 mi.
Tower Service Station and U-Drop Inn, Shamrock, TX - 68 mi.


Massively explains Warhammer Online to the dedicated WoW player
Assassin's Creed sells 2.5 million copies
Posted Dec 13th 2007 5:30PM by Richard Mitchell
Ubisoft has announced that Assassin's Creed has sold over 2.5 million copies worldwide on Xbox 360 and PS3. The game vastly outperformed the company's expectations, and Ubisoft further announced that the game is "the fastest-selling new video game intellectual property ever in the U.S." Not too shabby. On the heels of the good news, Ubisoft has raised its sales outlook to €840 million ($1.2 billion). Furthermore, the company expects to sell at least 5 million more units in 2007-08 (up 2 million from earlier estimates). It was also revealed that three Ubisoft titles, Tom Clancy's EndWar, Brothers in Arms: Hell's Highway, and Far Cry 2 have been delayed until Ubisoft's fiscal year 2008, which begins in April (the games were previously scheduled to release in early 2008). Finally, the Ubisoft will unveil more details on its incoming lineup of games and will disclose sales figures for the third quarter 2007-08 on January 23, 2008.
Tags: assassins-creed, business, ubisoft
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12-13-2007 @ 5:44PM
BobTheMonkey said...
Stabby Time!
pierce said...
what, no "it prints money!" photoshop? come on. fanboys: get to it.
Slestak said...
This just in: Gamestop stores have purchased 2.5 million used copies of Assassin's Creed from disappointed gamers who could barely keep their eyes open after playing the game.
haha nope. big sellers don't work that way. remember the original halo, and how long that took to come down in price. Gears is the same way.
Chris McDannold said...
They sure got mine, and within a week of release to boot. In my opinion, I totally wasted US$60 on AC - awesome game world, horrid mechanics, mountains of untapped potential, and the worst story I have encountered in a long time.
I hear you, Chris -- it's one of the most gorgeous game worlds I've ever seen. Too bad that the bulk of the gameplay is straight up last-gen. Not to mention the story has bored me to tears. What a dissapointment.
I don't care what Penny Arcade says about the post-credits payoff after you complete the game. Unless it's a naked hot lady fighting force battling a werewolf/ninja army with lasers in space, I'll be heading directly to Gamestop and telling them to put it in their computers to NOT allow me to reserve AC2.
mattclarkie said...
I was so disapointed by the game. I logged over 30 hours playing it, and towards the end I was just waiting for it to end, only doing the bare minimum.
It is beautiful, but the controls were so sluggish, and the number of times I was killed because my sword refused to draw, no matter how many times I pulled LT or pushed the D-Pad. I also kept getting stuck on ledges, Crackdown worked so much better. And towards the end of the game the framerate really dropped, and I fell through walls all the time.
One good thing is I got 815 AP first run through without really trying, if you are an APW then you will love it. Although the AP are very glitchy, I unlocked some when I shouldn't have.
The end was disappointing, it didn't have one, just wait for the sequel, no ending at all.
I don't trade in games, but if I did, let's say I wouldn't be replaying this title.
Bravo6 said...
Sweet, I should be able to get the game dirt cheap soon then.
akatsuki said...
Yeah, Ubisoft had better really take the criticism to heart if they really want a franchise out of this, I don't know too many people who are itching to buy a sequel...
Larry *not allowed to say cheevo* said...
I thought the game was fun has hell. I really enjoyed it. I'm sad that I can't go back and play it again... flag hunting aside, which I don't really want to do. They should release some DLC with more assassinations or something.
And I want my money back.
12-13-2007 @ 11:09PM
Urza said...
I want my money back too.. heck, I want the wad Jade stole too. Nah.. she deserved it. :P
In the end, Ubisoft pimped Jade to cover up the fact that what they were showing us was the whole game.. over and over and over again.
Anticrawl said...
Atleast that one trailer had nifty music. I'll still rent it eventually, but I'm not gonna go check unless I already happen to be there.
Farcry 2 though, man bring on the new hotness.
12-14-2007 @ 9:39AM
cornfed said...
I gave mine away to my nephew after 1 day, super boring, felt very unfulfilled after an assassination, like i did all that nonsense just for that.... I followed this game while it was being developed and hoped that it would be good,.... very disappointing. I wish ubi would have had the balls to release a playable demo on xbox live so i could have saved $60 bucks. My nephew didnt like it as well and sold it to gs after about a week.
12-14-2007 @ 10:00AM
Pops said...
They should change the name of this website from XBox360fanboy to Xbox360whingeboy in honour of nearly every comment thread.
Boss Tempo said...
Agreed. At least the flaming on Joystiq is somewhat entertaining - this site has turned into a real cryfest.
Knight Marquise said...
Huh..you must not read PS3 fanboy then. Every article is a sorry attempt at discreditting MS, pumping Sony up, are trying to do some form of comparison with the 360, and ending with, see...see...it's as good as the 360 and worth every penny. Teh P0w3r of teh C3ll lives on in their fanbot minds. That web site is a cry fest. AC is simply a dissappointment.
strangebrew said...
Rented it and I want my money back for that. Horribly repeatitive game. I gave it to a co-worker for the rest of my rental period because it got old really fast.
I wanted to give this a fair shake, especially after reading Tycho's defense of the game. But I've been reading a lot of lostgarden.com lately, and I realized that I usually keep playing games to uncover and master new game mechanics, not for the theme/plot/story. Tycho basically admitted that within an hour or two you'll have full understanding of all the mechanics the game is ever going to offer, and you should stay for the story. Unfortunately, that doesn't cut it for me.
I hate to say, but I'm going to go back to RE4:Wii now. I have a bigger, badder shotgun to buy ;-)
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Hindu Scriptures and the Last Messenger
October 24, 2017 0 Muhammad
In this video, a little boy and a young girl talked in the Hindi language about the Last and Final Messenger of Allah (peace be upon him) in Hindu scriptures as well as Sanskrit scriptures emphasizing that the religion of Islam is the only way acceptable by Allah the Almighty. And it is the system of life that was approved by Allah (Glory be to Him) as the final divine message. That is why all previous messages and revelations foretold clearly the advent of the Prophet Muhammad (peace be upon him), including Hinduism. However, those scriptures are not on their pure nature, rather, they were subtracted, added and altered, still many prophesies about the Prophet Muhammad are present in those distorted scriptures.
We can ask those Hindu brothers who believe in the scriptures; why do you not believe in the Antim Ishdut (the Last Messenger) who was predicted by your own scriptures?
Juwairia Shams begins her speech with the praise of Allah and the salutation on the Prophet Muhammad (peace be upon him).
She points out that the truth always is plain and intuitive that does not need evidence or proof, though sometimes we could not understand or some people try to deviate from the truth.
It is also evident that Vedas, Upanishads and Puranas have predicted of the Last and Final Messenger, the Prophet Muhammad (peace be upon Him) by his qualities and descriptions that coincided with the characteristics of the Prophet. The scholars have presented on this subject such manifest proofs that illuminated the whole truth. Allah the Almighty has appointed him as the guide for the entire humanity. The Glorious Qur'an says:
And We have not sent you except comprehensively to mankind as a bringer of good tidings and a warner. But most of the people do not know. (Saba' 34:28)
In Hinduism, the Vedas are the final authority for Hindus, the study of Vedas shows a word used frequently that is narāśaṃsa that means an individual who is to be praised or who is praiseworthy. It is noteworthy that the Arabic word Muhammad means a man who is praiseworthy. The history is a witness that no one in the entire Hindu history was praised by the people and Lord as the Prophet Muhammad (peace be upon Him) was praised. Furthermore, the Veda refers to a camel-riding Rishi, whose chariot touches the heaven. Perhaps, this description refers to the riding animal of the prophet Muhammad (peace be upon him) when he ascended to the seven heavens in Mi`araj, which called Buraq.
Juwairia Shams mentioned many quotes from the Purans referring to the famous Hindu scholar Dr. Vedprkash Upadhay who regarded the Prophet Muhammad as the Kalki Avtar.
I hope you will enjoy this video enlightening your heart and mind by this beautiful speech. We pray for those who produced this attractive talk.
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निमंत्रण पत्र
सैय्यद मेराज रब्बानी
पादरियों ने अपनाया इस्लाम
मुहम्मद चाँद
प्रिय पैग़म्बर सल्लल्लाहु अलैहि व सल्लम की संगत में 40 सभाएँ
आदिल बिन अली अश्शद्दी
हिस्नुल मुस्लिम
सईद बिन अली बिन वहफ अल-क़हतानी
नबी सल्लल्लाहु अलैहि व सल्लम की नमाज़ का तरीक़ा


Uniform Education
Call us on +44(0)203 794 8988
Overseas Candidates
Candidate and School Policies
Candidate & School Polices
Job Title: Physics Teacher
Location: Croydon, Surrey
Start Date: Sept 2019
REF: PHYCROY_1554472885
Contact Name: Richard Brittain
Contact Email: richardb@uniformeducation.co.uk
My School client based in Croydon is seeking to appoint an inspirational and dynamic teacher of Physics Specialist to work with members of the successful Science department for a permanent position to start in September 2019. The ideal candidate will a strong history of teaching Physics up to KS5 and will support the school's vision and strategic objectives.
September 2019 Permanent Vacancy
Physics Teacher KS3-KS5
Ofsted rated Outstanding School, Croydon
Excellent Resources and Facilities
Strong SLT, supportive environment
Uniform Education are proud to be exclusively partnering with a truly outstanding Ofsted 11-18 Girls Secondary school in the borough of Croydon in their recruitment for an exceptional teacher of Physics to start in September 2019.
My client School is recognised as one of the top non-selective secondary schools in the country. It is consistently oversubscribed and has received four 'Outstanding' Ofsted and four 'Outstanding'
Diocesan reports. The School is rightly very proud of its' academic achievement which is due to hard work, focus and dedication to the School's ethos and is endorsed by pupils and staff alike. This School holds specialist status within Science.
It can offer:
A strong commitment to professional development
A working environment focused on Teaching and Learning and raising standards for all
The opportunity to work in a team where the individual skills, enthusiasm and hard work will be appreciated
The opportunity to work within the largest cosmopolitan centre outside of Central London, undergoing substantial redevelopment, growth and change
A school that invests in enrichment and extra-curricular activities
In return it seeks to appoint a dynamic and well qualified Teacher of Physics who is able to teach across the age and ability range to A - level and provide evidence of successful teaching strategies and excellent organisational skills. The successful candidate will be an engaging, dynamic and a confident educator who will be able to inspire the students. The Head is looking for a highly qualified and enthusiastic Physicist who is able to teach across the 11-18 age range, be passionate about Physics and committed to improving teaching and learning. The successful applicant must have proven experience in their subject, good interpersonal and presentation skills, be forward thinking, receptive to change and able to work under pressure.
The Science department in this popular and successful 11-18 girls' Comprehensive school consists of 5 full-time staff. The Department enjoys excellent accommodation with interactive whiteboards in every classroom and priority access to one of the school's computer rooms. Students begin studying for GCSE in Year 9. The department operates as a close-knit team, with all staff agreeing to their contribution towards formulating policy and supporting the importance of Science in the curriculum.
If you match the above criteria and this sounds the kind of School environment you would enjoy working in, Croydon is a suitable location and you are a Teacher of Physics that is currently fulfilling that role or looking for a new challenge school in a highly prestigious school then please get in touch today to have your CV immediately reviewed.
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Corey Irwin Published: November 15, 2022
A previously unreleased scene from the comedy classic Planes, Trains and Automobiles has been released in anticipation of the film's upcoming 35th anniversary.
In the clip, Del Griffith (John Candy) and Neal Page (Steve Martin) are seated together on a packed flight. Del begins offering unwanted parts of Neal's meal to the third man in their row (veteran character actor Bill Erwin). The only thing Neal wants to hang onto is his brownie, that is until a neighboring woman's hair ruins the desert. Naturally, Neal in annoyed by the situation, but Del remains upbeat regardless.
Watch the newly unearthed scene below.
Originally released on Nov. 25, 1987, Planes, Trains and Automobiles chronicled the unlikely pairing of uptight ad exec Neal and affable shower-curtain salesman Del as they try to make it from New York to Chicago in time for Thanksgiving. The film, written and directed by John Hughes, became a box office success and remains a holiday classic more than three decades after its release.
Though the movie clocked in at just over 90-minutes, an original cut was more than three hours in length. Much of the abandoned footage will be included on the film's upcoming 4K Ultra HD 35th anniversary release.
In addition to the original version, the package includes a bonus "Lost Luggage" Blu-ray Disc, featuring more than an hour of never-before-seen footage. A look behind the making of Planes, Trains and Automobiles and the two-part documentary John Hughes: Life Moves Pretty Fast will also be included.
The new rerelease of Planes, Trains and Automobiles arrives Nov. 22.
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Terrified Circus Bear Lunges Into Screaming Audience
He just couldn't take it anymore.
By Sarah V Schweig
Published on 5/31/2017 at 11:34 AM
A video has just surfaced that shows how sad and dangerous forcing wild animals to perform in circuses can be.
The footage, shot during a Circus on Ice show in Bila Tserkva, Ukraine, shows a large bear lying on his back on the ground before his trainer. Dozens of spectators are just a few feet away. And it only takes a second for things to go terribly wrong.
YouTube/Моя Київщина: Офіційний канал
It appears that the bear is following his trainer's orders when he is lying down, but suddenly he lunges up and breaks away from his trainer, jumping toward the crowd. Children's screams can be heard immediately, and the footage cuts away as chaos takes hold of the audience.
A few seconds later, the bear jumps back onto the stage and sprints across to the other side, and the footage cuts away again, as the spectator filming the video starts running away with the crowd, out of the arena and into the open air outside.
The screen goes dark, but the screams and cries of a child can still be heard for another minute.
Scared Little Dog Is So Full Of Joy Now — And Looking For A Family
According to reports, several people were injured — it's not yet clear whether the bear attacked anyone or whether people were hurt fleeing the circus tent.
"The frightening incident captured on video that showed a bear lunging towards the audience at a Ukraine circus is a reminder that bears, elephants, tigers and other captive wildlife abused by circuses are powerful and unpredictable animals, and their use in traveling shows puts the public at risk," Debbie Leahy, manager of captive wildlife protection for the Humane Society of the United States (HSUS), told The Dodo.
The incident occurred just days after one of the most famous and established circuses, Ringling Bros. and Barnum & Bailey Circus, performed its last show ever. While the shuttering of Ringling Bros. appeared to be an emblem of progress for wild animals forced to perform, the last performance was tempered by news that Ringling Bros. still isn't planning to let some of its animals retire, since it is applying for a permit to send many of its tigers to a circus in Germany.
It is unclear what will happen to the bear, now that he may be considered dangerous. The circus reportedly reimbursed audience members for tickets and damaged possessions.
"This tragic case highlights the fact that wild animals should not be used in circuses," a spokesperson from Four Paws International told The Dodo in a statement. "The cramped conditions, constant changes of location, loud noises, flashing lights and intermittent feeding can all lead to behavioral disturbances and illness."
The inherently unnatural conditions of a circus strip animals of their natural behaviors and socialization with their own kind, according to Four Paws. "In stark contrast to behavior in the wild, no bear would be performing the actions we see in circuses today," Four Paws said. "These sorts of 'stunts' are always the result of questionable and usually brutal methods of training based on dominance and in the worst cases, violence."
Four Paws runs five bear sanctuaries across Europe for bears rescued from abuse and neglect, as more and more people realize how painful it is to keep bears locked up in cages. "We aim to make private ownership of bears obsolete and to stop bears from being exploited for entertainment purposes such as in circuses," Four Paws said. "It is our hope that these tragic events will no longer happen because bears, and other wild animals, will no longer be put in these unnatural situations."
Leahy added: "These cruel and demeaning spectacles are quickly becoming a thing of the past as more and more circuses close and a growing number of communities are banning wild animal acts."
But for the exhausted circus bear who snapped during the performance on Friday, the change just didn't come fast enough.
To stand up for animals forced to perform in circuses, you can pledge never to buy a ticket to an animal show and share this story with your friends and family. You can also speak out against circuses coming to your region, or donate to help bears rescued by Four Paws International.


Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice
George G. Schweitzer, Sara L. Collier, Zhouji Chen, Kyle S. McCommis, Sara K. Pittman, Jun Yoshino, Scot J. Matkovich, Fong Fu Hsu, Roman Chrast, James M. Eaton, Thurl E. Harris, Conrad C. Weihl, Brian N. Finck
Center of Regenerative Medicine
Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)
Division of Endocrinology, Metabolism & Lipid Research
Division of Neuromuscular Medicine
Division of Geriatrics & Nutritional Science
DBBS - Molecular Cell Biology
DBBS - Neurosciences
Lipin 1 regulates glycerolipid homeostasis by acting as a phosphatidic acid phosphohydrolase (PAP) enzyme in the triglyceride-synthesis pathway and by regulating transcription factor activity. Mutations in human lipin 1 are a common cause of recurrent rhabdomyolysis in children. Mice with constitutive whole-body lipin 1 deficiency have been used to examine mechanisms connecting lipin 1 deficiency to myocyte injury. However, that mouse model is confounded by lipodystrophy not phenocopied in people. Herein, 2 muscle-specific mouse models were studied: 1) Lpin1 exon 3 and 4 deletion, resulting in a hypomorphic protein without PAP activity, but which preserved transcriptional coregulatory function; and 2) Lpin1 exon 7 deletion, resulting in total protein loss. In both models, skeletal muscles exhibited a chronic myopathy with ongoing muscle fiber necrosis and regeneration and accumulation of phosphatidic acid and, paradoxically, diacylglycerol. Additionally, lipin 1-deficient mice had abundant, but abnormal, mitochondria likely because of impaired autophagy. Finally, these mice exhibited increased plasma creatine kinase following exhaustive exercise when unfed. These data suggest that mice lacking lipin 1-mediated PAP activity in skeletal muscle may serve as a model for determining the mechanisms by which lipin 1 deficiency leads to myocyte injury and for testing potential therapeutic approaches.
https://doi.org/10.1096/fj.201800361R
Diacylglycerol
LPIN1
Triacylglycerol
10.1096/fj.201800361R
Dive into the research topics of 'Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice'. Together they form a unique fingerprint.
lipine Medicine & Life Sciences 100%
Phosphatidate Phosphatase Medicine & Life Sciences 92%
Phosphatidic Acid Chemical Compounds 73%
Muscular Diseases Medicine & Life Sciences 62%
Muscles Medicine & Life Sciences 34%
Glycerolipid Chemical Compounds 21%
Creatine Chemical Compounds 18%
Muscle Cells Medicine & Life Sciences 15%
Schweitzer, G. G., Collier, S. L., Chen, Z., McCommis, K. S., Pittman, S. K., Yoshino, J., Matkovich, S. J., Hsu, F. F., Chrast, R., Eaton, J. M., Harris, T. E., Weihl, C. C., & Finck, B. N. (2019). Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice. FASEB Journal, 33(1), 652-667. https://doi.org/10.1096/fj.201800361R
Schweitzer, George G. ; Collier, Sara L. ; Chen, Zhouji et al. / Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice. In: FASEB Journal. 2019 ; Vol. 33, No. 1. pp. 652-667.
@article{cd90f77c9ea94458b8fe2efb854e0127,
title = "Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice",
abstract = "Lipin 1 regulates glycerolipid homeostasis by acting as a phosphatidic acid phosphohydrolase (PAP) enzyme in the triglyceride-synthesis pathway and by regulating transcription factor activity. Mutations in human lipin 1 are a common cause of recurrent rhabdomyolysis in children. Mice with constitutive whole-body lipin 1 deficiency have been used to examine mechanisms connecting lipin 1 deficiency to myocyte injury. However, that mouse model is confounded by lipodystrophy not phenocopied in people. Herein, 2 muscle-specific mouse models were studied: 1) Lpin1 exon 3 and 4 deletion, resulting in a hypomorphic protein without PAP activity, but which preserved transcriptional coregulatory function; and 2) Lpin1 exon 7 deletion, resulting in total protein loss. In both models, skeletal muscles exhibited a chronic myopathy with ongoing muscle fiber necrosis and regeneration and accumulation of phosphatidic acid and, paradoxically, diacylglycerol. Additionally, lipin 1-deficient mice had abundant, but abnormal, mitochondria likely because of impaired autophagy. Finally, these mice exhibited increased plasma creatine kinase following exhaustive exercise when unfed. These data suggest that mice lacking lipin 1-mediated PAP activity in skeletal muscle may serve as a model for determining the mechanisms by which lipin 1 deficiency leads to myocyte injury and for testing potential therapeutic approaches.",
keywords = "Autophagy, Diacylglycerol, LPIN1, Rhabdomyolysis, Triacylglycerol",
author = "Schweitzer, {George G.} and Collier, {Sara L.} and Zhouji Chen and McCommis, {Kyle S.} and Pittman, {Sara K.} and Jun Yoshino and Matkovich, {Scot J.} and Hsu, {Fong Fu} and Roman Chrast and Eaton, {James M.} and Harris, {Thurl E.} and Weihl, {Conrad C.} and Finck, {Brian N.}",
note = "Funding Information: The authors thank Dr. Alan Pestronk and Dr. Abhinav Diwan for technical assistance in interpreting histology, and Dennis J. Dietzen for determining plasma creatine kinase (all from Washington University). This work was supported by U.S. National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK078187 and NIH National Heart, Lung, and Blood Institute Grant R01 HL119225 (to B.N.F.). G.G.S. was supported by NIH National Heart, Lung, and Blood Institute Grants T32 HL007275, T32 HL007081, and the Washington University Institute of Clinical and Translational Sciences NIH Grant UL1 TR000448, Subaward KL2 TR000450, from the National Center for Advancing Translational Sciences (NCATS). K.S.M. was supported by NIH National Institute of Diabetes and Digestive and Kidney Diseases Grant T32-DK007120. J.Y. was supported by Washington University Institute of Clinical and Translational Sciences NIH Grant UL1 TR000448, Subaward KL2 TR000450. T.E.H. and J.M.E. were supported by NIH National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK101946. C.C.W. and S.K.P were supported by NIH National Institute on Aging Grant R01 AG031867. This work was also supported by the cores of the Washington University Nutrition Obesity Research Center (Grant P30 DK56341), Diabetes Research Center (DRC) (Grant P30 DK020579), the Metabolomics Facility at Washington University (Grant P30 DK056341), and the Washington University NIH National Institute of General Medical Sciences Biomedical Mass Spectrometry Resource (Grant P41 GM103422) to F.-F.H.; the Washington University Genome Technology Access Center in the Department of Genetics (Grant P30 CA91842); and the Department of Pathology DRC Electron Microscopy Facility (Grant P60 DK020579). The authors declare no conflicts of interest. Publisher Copyright: {\textcopyright} FASEB.",
doi = "10.1096/fj.201800361R",
Schweitzer, GG, Collier, SL, Chen, Z, McCommis, KS, Pittman, SK, Yoshino, J, Matkovich, SJ, Hsu, FF, Chrast, R, Eaton, JM, Harris, TE, Weihl, CC & Finck, BN 2019, 'Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice', FASEB Journal, vol. 33, no. 1, pp. 652-667. https://doi.org/10.1096/fj.201800361R
Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice. / Schweitzer, George G.; Collier, Sara L.; Chen, Zhouji et al.
In: FASEB Journal, Vol. 33, No. 1, 01.2019, p. 652-667.
T1 - Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice
AU - Schweitzer, George G.
AU - Collier, Sara L.
AU - Chen, Zhouji
AU - McCommis, Kyle S.
AU - Pittman, Sara K.
AU - Yoshino, Jun
AU - Matkovich, Scot J.
AU - Hsu, Fong Fu
AU - Chrast, Roman
AU - Eaton, James M.
AU - Harris, Thurl E.
AU - Weihl, Conrad C.
AU - Finck, Brian N.
N1 - Funding Information: The authors thank Dr. Alan Pestronk and Dr. Abhinav Diwan for technical assistance in interpreting histology, and Dennis J. Dietzen for determining plasma creatine kinase (all from Washington University). This work was supported by U.S. National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK078187 and NIH National Heart, Lung, and Blood Institute Grant R01 HL119225 (to B.N.F.). G.G.S. was supported by NIH National Heart, Lung, and Blood Institute Grants T32 HL007275, T32 HL007081, and the Washington University Institute of Clinical and Translational Sciences NIH Grant UL1 TR000448, Subaward KL2 TR000450, from the National Center for Advancing Translational Sciences (NCATS). K.S.M. was supported by NIH National Institute of Diabetes and Digestive and Kidney Diseases Grant T32-DK007120. J.Y. was supported by Washington University Institute of Clinical and Translational Sciences NIH Grant UL1 TR000448, Subaward KL2 TR000450. T.E.H. and J.M.E. were supported by NIH National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK101946. C.C.W. and S.K.P were supported by NIH National Institute on Aging Grant R01 AG031867. This work was also supported by the cores of the Washington University Nutrition Obesity Research Center (Grant P30 DK56341), Diabetes Research Center (DRC) (Grant P30 DK020579), the Metabolomics Facility at Washington University (Grant P30 DK056341), and the Washington University NIH National Institute of General Medical Sciences Biomedical Mass Spectrometry Resource (Grant P41 GM103422) to F.-F.H.; the Washington University Genome Technology Access Center in the Department of Genetics (Grant P30 CA91842); and the Department of Pathology DRC Electron Microscopy Facility (Grant P60 DK020579). The authors declare no conflicts of interest. Publisher Copyright: © FASEB.
N2 - Lipin 1 regulates glycerolipid homeostasis by acting as a phosphatidic acid phosphohydrolase (PAP) enzyme in the triglyceride-synthesis pathway and by regulating transcription factor activity. Mutations in human lipin 1 are a common cause of recurrent rhabdomyolysis in children. Mice with constitutive whole-body lipin 1 deficiency have been used to examine mechanisms connecting lipin 1 deficiency to myocyte injury. However, that mouse model is confounded by lipodystrophy not phenocopied in people. Herein, 2 muscle-specific mouse models were studied: 1) Lpin1 exon 3 and 4 deletion, resulting in a hypomorphic protein without PAP activity, but which preserved transcriptional coregulatory function; and 2) Lpin1 exon 7 deletion, resulting in total protein loss. In both models, skeletal muscles exhibited a chronic myopathy with ongoing muscle fiber necrosis and regeneration and accumulation of phosphatidic acid and, paradoxically, diacylglycerol. Additionally, lipin 1-deficient mice had abundant, but abnormal, mitochondria likely because of impaired autophagy. Finally, these mice exhibited increased plasma creatine kinase following exhaustive exercise when unfed. These data suggest that mice lacking lipin 1-mediated PAP activity in skeletal muscle may serve as a model for determining the mechanisms by which lipin 1 deficiency leads to myocyte injury and for testing potential therapeutic approaches.
AB - Lipin 1 regulates glycerolipid homeostasis by acting as a phosphatidic acid phosphohydrolase (PAP) enzyme in the triglyceride-synthesis pathway and by regulating transcription factor activity. Mutations in human lipin 1 are a common cause of recurrent rhabdomyolysis in children. Mice with constitutive whole-body lipin 1 deficiency have been used to examine mechanisms connecting lipin 1 deficiency to myocyte injury. However, that mouse model is confounded by lipodystrophy not phenocopied in people. Herein, 2 muscle-specific mouse models were studied: 1) Lpin1 exon 3 and 4 deletion, resulting in a hypomorphic protein without PAP activity, but which preserved transcriptional coregulatory function; and 2) Lpin1 exon 7 deletion, resulting in total protein loss. In both models, skeletal muscles exhibited a chronic myopathy with ongoing muscle fiber necrosis and regeneration and accumulation of phosphatidic acid and, paradoxically, diacylglycerol. Additionally, lipin 1-deficient mice had abundant, but abnormal, mitochondria likely because of impaired autophagy. Finally, these mice exhibited increased plasma creatine kinase following exhaustive exercise when unfed. These data suggest that mice lacking lipin 1-mediated PAP activity in skeletal muscle may serve as a model for determining the mechanisms by which lipin 1 deficiency leads to myocyte injury and for testing potential therapeutic approaches.
KW - Autophagy
KW - Diacylglycerol
KW - LPIN1
KW - Rhabdomyolysis
KW - Triacylglycerol
U2 - 10.1096/fj.201800361R
DO - 10.1096/fj.201800361R
Schweitzer GG, Collier SL, Chen Z, McCommis KS, Pittman SK, Yoshino J et al. Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice. FASEB Journal. 2019 Jan;33(1):652-667. doi: 10.1096/fj.201800361R


Gaebelein's Annotated Bible
Hampton's Commentary
Haldane on Romans and Hebrews
Owen on Hebrews
Newell's Commentary
1. The priesthood of Melchisedec in contrast with the Levitical priesthood (Hebrews 7:1-58.7.19 )
2. The holy and heavenly priesthood of Christ (Hebrews 7:20-58.7.28 )
Hebrews 7:1-58.7.19
The interrupted argument concerning the priesthood of Christ is now resumed. It connects with Hebrews 5:10 . There we find Melchisedec mentioned for the first time, and here the historical Melchisedec is first of all described. The record is given in Genesis 14:18-1.14.20 . He met Abraham, who returned from the smiting of the Kings, and blessed him. Abraham gave him the tenth of all. His name means "King of Righteousness"; but he was also King of Salem, that is, "King of Peace." First righteousness and peace after-ward. This is God's order--not peace and righteousness, but righteousness and peace. It is so spiritually for the believer; it will be so in millennial times when "righteousness and peace will kiss each other."
Who was Melchisedec? Some have said he was Shem and not a few maintain that he was the Lord Himself, one of the theophanies, a pre-incarnation manifestation of the Son of God. The latter view is certainly wrong, for Scripture states that Melchisedec is "made like unto the Son of God", that is, he is a pattern, a similitude of Him; Melchisedec was therefore not the Lord Himself. It is vain to speculate on the identity of this King-Priest, for the Holy Spirit on purpose does not mention who he was. When we read, "Without father, without mother, without descent, having neither beginning of days nor end of life," it does not mean that Melchisedec had no father and no mother, etc. But it means that Scripture gives no record of these facts; Moses being divinely guided in omitting it all in the book of Genesis, and thus making Melchisedec appear as a man without father and mother, without descent, having no beginning and end of days, who has a priesthood invested in himself. And this for the purpose of furnishing a type of our Lord as the royal priest.
Melchisedec foreshadows fully the millennial glory of the Lord Jesus Christ. See Zechariah 6:9-38.6.13 . He will receive His own throne and be a priest upon that throne. Significantly he appeared suddenly when Abraham was returning from smiting the allied kings. (Genesis 14:1-1.14.24 gives the record of the first war of the Bible.) And then he blessed Abraham and made known to him God as the Most-High (the millennial name of God), the possessor of heaven and earth. Even so the true Melchisedec will some day appear, and after the smiting of the kings (the battle of Armageddon, Revelation 16:14-66.16.16 ; Revelation 19:19 ) will begin His glorious rule. Nor must it be overlooked that Melchisedec brought to Abraham bread and wine, the blessed emblems of the great sacrificial work of the true Melchisedec, which points us, who are by faith the children of Abraham, to the blessed memorial feast, in which His love and grace, as well as glory, are remembered. Christ is therefore now for His own the Priest after the order of Melchisedec; the full display of His Melchisedec priesthood arrives in the day of His coming glory.
The chief object of bringing forward the person of Melchisedec and his connection with Abraham is, to show first, the superiority of Melchisedec to Levi and his priesthood as better and higher than the Levitical priesthood. Abraham gave him the tenth part of all the spoil. The whole Levitical priesthood was then not in existence, inasmuch as Levi, unborn, was in the loins of Abraham; in Abraham, Levi, therefore, gave tithes to Melchisedec. Melchisedec, as priest, blessed the father of the nation, and therefore he was greater than Abraham, for "without controversy, the less is blessed of the greater." The priesthood of Melchisedec was therefore superior to that of the sons of Levi, the Aaronic priesthood.
After this argument another one is introduced. The question is concerning the Levitical priesthood, if it could give perfection. The one hundred and tenth psalm announced the coming of a priest after the order of Melchisedec and therefore superior to Aaron. If then perfection were by the Levitical priesthood, what need was there that this other priest of a higher order than Aaron should arise? Because perfection was not by that earthly priesthood, nor by the law, therefore this better priest had to come to bring the needed perfection and that necessitated a change of the law also. "The law, doubtless, was good; but separation still existed between man and God. The law made nothing perfect. God was ever perfect, and human perfection was required; all must be according to what divine perfection required of man. But sin was there, and the law was consequently without power (save to condemn); its ceremonies and ordinances were but figures, and a heavy yoke. Even that which temporarily relieved the conscience brought sin to mind and never made the conscience perfect towards God. They were still at a distance from Him. Grace brings the soul to God, who is known in love and in a righteousness which is for us."--J.N.D.
The law in all its ordinances was a witness of imperfection, though it foreshadowed the good things to come. The law was therefore not to abide. With the cessation of the Levitical priesthood the entire law-covenant would terminate. And He of whom these things are spoken (the Lord Jesus Christ) "pertaineth to another tribe, of which no one hath given attendance at the altar (as priest). For it is certain that our Lord sprang out of Judah; of which tribe Moses spake nothing concerning priesthood." His coming, therefore, has taken from the tribe of Levi the honor and set aside their priesthood. And He who sprang out of Judah, the priest after the similitude of Melchisedec (combining priesthood and royalty) hath been made, not after a law of fleshly commandment, but after the power of an indissoluble life. His priesthood is not a thing of time and change, a fleshly priesthood like Aaron's but it is a priesthood in the power of an indissoluble life. He has passed through death, and now in heaven, not on earth, He is the Melchisedec priest, who has no end of days, who lives eternally.
Then follows a conclusion, a summing up of the whole argument. In the stated fact that the Lord Jesus Christ is a priest forever after the order of Melchisedec, "There is a setting aside of the commandment going before (the law and its ordinances) on account of weakness and unprofitableness (for the law made nothing perfect) and the bringing in of a better hope through which we draw near to God." The law is then set aside on account of its weakness and unprofitableness, for it could not perfect anything. All the priestly ordinances and ministrations could not make atonement, nor could bring nigh unto God. It was all imperfection. Yet perfection and bringing His children nigh unto Himself is God's gracious and eternal purpose. And God has accomplished this now in the person of His ever blessed Son, the priest after the order of Melchisedec. This is the bringing in of a better hope; by Him we draw near unto God. This truth is more fully developed later.
Hebrews 7:20-58.7.28
An additional argument is given. The priesthood of Christ was established by an oath, while that of Aaron was not. Swearing an oath God said as to Him, who sat down at His own right hand, "The Lord hath sworn, and will not repent, Thou art a priest forever, after the order of Melchisedec." How superior, then, this priesthood! By so much, also, hath Jesus become surety of a better covenant." And furthermore, they were many priests, for they were mortal men and died. But Christ continueth forever and hath the unchangeable priesthood. And this ever-living priest is able to save to the uttermost those that come unto God by Him, seeing that He always liveth to make intercession for them." He saves completely and keeps His own by His priestly, all-powerful intercession, for eternal glory. And what a high priest He is! Such a high priest! Well may His own in holy joy and praise cry out--"Such a high priest!" He is holy, harmless, undefiled, and separate from sinners. "In His official dignity and glory He is made higher than the heavens." And He has no need, day by day, as the earthly high priests, first to offer up sacrifices for His own sins, then for those of the people. This He did once for all when He offered up Himself. What a contrast with the Jewish priests. They were sinners--He, separate from sinners and absolutely holy; they with the many sacrifices, which could accomplish nothing for man--He with the one great sacrifice which has accomplished all. And so He maketh intercession for them who have believed in Him, the many sons He brings to glory. He is holy and heavenly--even so are all His own, saved by grace, holy and partakers of the heavenly calling (Hebrews 3:1 ).
Gaebelein, Arno Clemens. "Commentary on Hebrews 7". "Gaebelein's Annotated Bible". https://www.studylight.org/commentaries/eng/gab/hebrews-7.html. 1913-1922.


I'm Loving Pokémon Sword And Shield's First Expansion So Far
Just a few hours in, I'm already enjoying Pokémon Sword and Shield's Isle of Armor DLC more than the base game. While much smaller in size, it feels more free flowing and open ended. There's a lot to explore, and plenty more Pokémon to catch, including a bunch of my favorites that didn't make the cut the first time around. Isle of Armor is more Pokémon, which is great, but with some neat new tricks, which is even better.
The Isle of Armor DLC, which went live earlier today as the first part of Pokémon Sword and Shield's $30 Expansion Pass, takes you to a new island in the northeastern part of the Galarian region just off the coast of Spikemuth. You can access it as soon as you've reached the Wild Area for the first time, with the level scaling based on whether you've already beaten the main game or not.
Level Scaling
Unfortunately, most of the wild Pokémon you'll face in Isle of Armor max out at level 60, with a few appearing to go up level 80. That's perfect for someone who's just finished the main game, like me, but won't be much of a challenge, or earn as much experience per fight, for players who have been grinding since Sword and Shield came out last year.
Once you arrive you meet a new rival trainer called Klara who you compete with as a student at the island's dojo in order to obtain its treasure. A new gym and more trainer battles are just the start, though. The Isle of Armor is full of mysterious towers to gain entry to, hidden locations to explore, and new Pokémon to collect. There's a main story to follow, but so far it's left me plenty of time to look around and discover things in my own way and at my own pace.
If you don't already have a Bulbasaur or Squirtle to import from another game the owners of Isle of Armor's dojo will give you one of them as a gift.
Screenshot: Nintendo (Kotaku)
Chief among these discoveries is just how many Gen I Pokémon have been packed into this first expansion. It adds over 100 returning Pokémon from earlier games in the series, but especially from the original Red and Blue. The opening areas of Isle of Armor feel like a trip down memory lane to the Safari Zone from those two games, complete with Pinsirs, Tauros, Chanseys, Tangelas, Scythers, Lickatungs, and Kangaskhan. Within half an hour I was able to nab a complete team of six.
But there are also plenty of familiar faces from the rest of the generations, like Marill, Scizor, and Skarmory up through the more recent additions like Magearna, Druddigon, and Dedenne. Not all of them are welcome. One of the first returning Pokémon I ran into was the floating set of keys, Klefki. I didn't know there was a vocal contingent of Klefki fans out there, but, well, Game Freak hears you. For the most part, though, the Isle of Armor Pokédex feels like a good mix of crowd favorites and powerful B-sides I'm interested in giving a second look to.
Then there are the cool new variants on Pokémon from the base game. The Galarian Slowpoke now has a new Galarian Slowbro evolution that's part psychic, part poison, and 100% has a gun arm.
Wailord, meanwhile, finally gets the big-ass version it deserves floating just off the main beach.
It makes for a giant landmark but you can also sail out and battle it yourself if you want. Again, it's the little details like this that are a big part of why I've been having so much fun with Isle of Armor. It feels like the big open Wild Area from the main game but with secrets and fun flourishes hidden throughout.
For example, if you do decide to go out and visit Wailord up close you'd better be prepared to get stalked by Sharpedo, a returning water Pokémon from Gen III. In Sword and Shield though, because of the way the 3D camera works, they're a lot more menacing, usually jetting in from off-screen with only the splash of a fin to let you know they're coming. Repels don't work on them, and while they're easy to kill they're still sort of terrifying.
Gif: CrombieJordan (Reddit)
The Sharpedo-infested waters are worth braving for another reason. One of the best things Isle of Armor does is let you have one of your Pokémon follow you around. It might seem like a small thing, but a bunch of the Pokémon have personalities that only come through when they're walking around behind you.
I thought the Gyarados I've been playing with almost all of the game looked pretty cool flying around on land, but in the water he actually swims. (Which I discovered after swapping out my Venusaur, who does not).
There's also new move tutors, additional Gigantamax Pokémon, and more custom looks for your character and their bike, but for the most part I've been too distracted just wandering around the island and recapturing my favorite older Pokémon. They can also be imported from previous games using Pokémon Home even if you don't buy the Expansion Pass. Isle of Armor feels laid out with enough care, though, that I don't mind hunting for them all over again.
Kotaku staff writer. You can reach him at ethan.gach@kotaku.com
Has the Pokemon community/subreddit counted the triangles in the new models yet?
I hope it's enough for them.


CL: Real Madrid vs PSG Prediction
Prediction, Odds & Betting tips for the Real Madrid vs PSG match.
Football Tips Tips
When: Wednesday, March 9, 2022
Where: Santiago Bernabeu, Madrid, Spain
Real Madrid and PSG meet on Wednesday night in the most interesting and sounding pair of the UEFA Champions League round of 16. The first leg in Paris saw hosts' narrow win, 1-0, which promises a very good battle at Santiago Bernabeu. Besides this clash, the whole world is talking about an alleged agreement between Los Blancos and Kylian Mbappe, which will land the youngster in Madrid next summer. It'll be interesting to see him play after such allegations.
Real Madrid vs PSG Preview
Los Blancos accelerated in the best possible moment, posting three wins in a row and getting ready for the clash with the Saints. The first two rivals weren't some big names, Alaves and Rayo Vallecano, but clean sheets against them surely had a positive impact on the morale in the locker room.
Coming back from a deficit against Real Sociedad and scoring four straight goals for a 4-1 win is another boost for the Spanish powerhouse who didn't lose at home since late September. Back then, Sheriff Tiraspol shocked the world, beating Real 1-2.
Since that upset, Ancelotti's unit had 12 wins and two draws, recording eight clean sheets. In five of the last six games, Real scored two or more goals, and even though they don't play as attractive as before, Los Blancos are efficient as usual.
The French side showed signs of struggle in the past three weeks, losing twice in the domestic championship. At first, Nantes beat the Saints, 3-1 at home, then PSG won at Parc des Princes against St. Etienne, 3-1, before losing in Nice on Saturday night, 1-0.
This was another loss to the same club, following elimination from the French Cup back on January 31. Mbappe was out, yet that can't be an alibi for PSG, who plays slow, dull, and without any creativity.
They have only one victory in the last four road matchups, which is something that frightens their fans. PSG scored two or more goals only twice in the past six outings from Paris.
Real Madrid vs. PSG Possible Lineups
Real Madrid: Courtois; Carvajal, Militao, Nacho, Mendy; Camavinga, Casemiro, Modric; Asensio, Benzema, Vinicius
PSG: Donnarumma; Kehrer, Marquinhos, Kimpembe, Mendes; Verratti, Gueye, Pereira; Mbappe, Messi, Neymar
Real Madrid vs. PSG Head to Head
The first game ended 1-0 for the Parisians, with Mbappe netting in the game's closing moments.
Since 2015, these two powerhouses have met six times in the UEFA Champions League, and the record is on Real's side, three wins, two draws, and a loss. However, they are without a win over this rival in the past three meetings.
Real Madrid vs. PSG Prediction
This is going to be a cautious game, without too much excitement in the opening half. Neither side will draw first, which is why we predict goals in the second half. Our pick would be over 1.5 goals in the second 45 minutes because that will be when all the action goes down.
Our Verdict: Over 1.5 Second Half
Real Madrid vs. PSG Odds


CFR - Code of Federal Regulations Title 21
The information on this page is current as of April 1 2020.
For the most up-to-date version of CFR Title 21, go to the Electronic Code of Federal Regulations (eCFR).
Help | More About 21CFR
[Code of Federal Regulations]
[Title 21, Volume 8]
[Revised as of April 1, 2020]
[CITE: 21CFR814.3]
TITLE 21--FOOD AND DRUGS
CHAPTER I--FOOD AND DRUG ADMINISTRATION
SUBCHAPTER H - MEDICAL DEVICES
PART 814 -- PREMARKET APPROVAL OF MEDICAL DEVICES
Subpart A - General
Sec. 814.3 Definitions.
For the purposes of this part:
(a) Act means the Federal Food, Drug, and Cosmetic Act (sections 201-902, 52 Stat. 1040 et seq., as amended (21 U.S.C. 321-392)).
(b) FDA means the Food and Drug Administration.
(c) IDE means an approved or considered approved investigational device exemption under section 520(g) of the act and parts 812 and 813.
(d) Master file means a reference source that a person submits to FDA. A master file may contain detailed information on a specific manufacturing facility, process, methodology, or component used in the manufacture, processing, or packaging of a medical device.
(e) PMA means any premarket approval application for a class III medical device, including all information submitted with or incorporated by reference therein. "PMA" includes a new drug application for a device under section 520(1) of the act.
(f) PMA amendment means information an applicant submits to FDA to modify a pending PMA or a pending PMA supplement.
(g) PMA supplement means a supplemental application to an approved PMA for approval of a change or modification in a class III medical device, including all information submitted with or incorporated by reference therein.
(h) Person includes any individual, partnership, corporation, association, scientific or academic establishment, Government agency, or organizational unit thereof, or any other legal entity.
(i) Statement of material fact means a representation that tends to show that the safety or effectiveness of a device is more probable than it would be in the absence of such a representation. A false affirmation or silence or an omission that would lead a reasonable person to draw a particular conclusion as to the safety or effectiveness of a device also may be a false statement of material fact, even if the statement was not intended by the person making it to be misleading or to have any probative effect.
(j) 30-day PMA supplement means a supplemental application to an approved PMA in accordance with § 814.39(e).
(k) Reasonable probability means that it is more likely than not that an event will occur.
(l) Serious, adverse health consequences means any significant adverse experience, including those which may be either life-threatening or involve permanent or long term injuries, but excluding injuries that are nonlife-threatening and that are temporary and reasonably reversible.
(m) HDE means a premarket approval application submitted pursuant to this subpart seeking a humanitarian device exemption from the effectiveness requirements of sections 514 and 515 of the act as authorized by section 520(m)(2) of the act.
(n) HUD (humanitarian use device ) means a medical device intended to benefit patients in the treatment or diagnosis of a disease or condition that affects or is manifested in not more than 8,000 individuals in the United States per year.
(o) Newly acquired information means data, analyses, or other information not previously submitted to the agency, which may include (but are not limited to) data derived from new clinical studies, reports of adverse events, or new analyses of previously submitted data (e.g., meta-analyses) if the studies, events or analyses reveal risks of a different type or greater severity or frequency than previously included in submissions to FDA.
(p) Human cell, tissue, or cellular or tissue-based product (HCT/P) regulated as a device means an HCT/P as defined in § 1271.3(d) of this chapter that does not meet the criteria in § 1271.10(a) and that is also regulated as a device.
(q) Unique device identifier (UDI) means an identifier that adequately identifies a device through its distribution and use by meeting the requirements of § 830.20 of this chapter. A unique device identifier is composed of:
(1) A device identifier - a mandatory, fixed portion of a UDI that identifies the specific version or model of a device and the labeler of that device; and
(2) A production identifier - a conditional, variable portion of a UDI that identifies one or more of the following when included on the label of the device:
(i) The lot or batch within which a device was manufactured;
(ii) The serial number of a specific device;
(iii) The expiration date of a specific device;
(iv) The date a specific device was manufactured.
(v) For an HCT/P regulated as a device, the distinct identification code required by § 1271.290(c) of this chapter.
(r) Universal product code (UPC) means the product identifier used to identify an item sold at retail in the United States.
(s) Pediatric patients means patients who are 21 years of age or younger (that is, from birth through the twenty-first year of life, up to but not including the twenty-second birthday) at the time of the diagnosis or treatment.
(t) Readily available means available in the public domain through commonly used public resources for conducting biomedical, regulatory, and medical product research.
[51 FR 26364, July 22, 1986, as amended at 61 FR 15190, Apr. 5, 1996; 61 FR 33244, June 26, 1996; 73 FR 49610, Aug. 22, 2008; 78 FR 58821, Sept. 24, 2013; 79 FR 1740, Jan. 10, 2014; 82 FR 26349, June 7, 2017]


How To Become A Chess Master
GM Gserper
Dec 7, 2020, 11:00 AM |
102 | Strategy
For an average beginner, the road to a rating in the range of 1400-1600 is pretty straightforward. Learn as many tactical patterns as possible, get yourself familiar with some basic opening principles, and you are there! Notice, I said that the road is straightforward, but it is not easy at all. Still, if you have desire and determination, it is just a matter of time till you reach this rating level. We already discussed the tools that might help you to achieve this initial goal in this, this and this article.
If you are making a quick progress in chess and your rating raises faster than the price of a bitcoin, congratulations! The good news is, unlike the price of the above-mentioned bitcoin, your rating will never drop to zero. The bad news is, unlike the bitcoin's price, the higher your rating, the more difficult it is to get it higher. I bet you've seen dozens of players in your chess club whose rating permanently stuck somewhere between 1800 and 2000. What should such players do to become a master?
If you attend any big open tournament, you'll see dozens of games opened with the so-called neo London (1.d4 followed by 2.Bf4). It is both funny and sad to see a 1200 player starting his games this way. Ask these players what attracts them to such a sophisticated (I almost used a "b" word, which rhymes with a word "snoring.") opening, and they will proudly answer that it is one of Magnus Carlsen's favorites. Never mind that Carlsen's requirements for any opening that he plays are completely different from what a club player might have in his mind.
Moreover, while the neo-London is a perfectly fine opening, sometimes you can get yourself in trouble by blindly following somebody else's recommendation. A case in point is the following position.
Even if a very strong grandmaster called this position winning for White in a book, it is still a draw. Poor Sam Shankland trusted the book author, and as a result, he resigned in a theoretically drawn position.
One of the most important skills for any chess player is the ability to think critically. You should never accept any statement (including this one) without asking a simple question: "why?" By critically analyzing every single chess variation or a statement made by a strong players, you'll learn to think like them and eventually become one of them!
I would like to share one memorable episode from my childhood where it took years for me to decipher one of Anatoly Karpov's comments that consisted of just three sentences.
Anatoly Karpov, possibly the greatest strategist in chess. | Photo: Dutch National Archive.
In my old article, I already mentioned one of my all-time-favorite chess books. It is a collection of Karpov's best games, which was a part of the famous Soviet "Black Series" about the world's best chess players. The book was translated into English in 1978 as "My Best Games."
You can find the following typical Karpov masterpiece in the book:
In order to understand the depth of Karpov's play, you really need to read his annotations in the book. Here I want to talk about one of them after White's 14th move. Karpov gives the following comment:
"The usual 14.Nd5 Qxd2+ 15.Kxd2 Bxd5 16.Bxd5 gives White a definite spatial advantage. But it is not easy to win this position, if Black plays carefully, refraining from pseudo-active precipitous continuations like 16...b5??. You see, after the exchange of the major pieces, the two bishops versus bishop and knight endgame gives White excellent winning chances thanks to the presence of his opponent's pawn weaknesses on the queenside."
So, Karpov is talking about this variation:
At the age of 10, when I read the book first time, the whole comment was absolutely incomprehensible for me. At that point, I thought that a move deserved a double question mark if it blundered a checkmate or lost at least a minor piece. I just couldn't see why the move 16...b5?? was losing. Again and again, I returned to this comment trying to pick the twelfth world champion's wisdom. It took literally years before I was able to put all the pieces of this jigsaw puzzle together.
Future grandmaster Rustem Dautov, who was the Soviet junior champion at that time, taught me the first lesson. He clearly demonstrated that if Black doesn't play b7-b5, then it is indeed very difficult to win this endgame despite a significant spatial advantage. Black simply has no weaknesses White can attack.
Later I found the following game in an old book about the world championship match Petrosian vs. Spassky. Notice GM Boleslavsky's comment after White's 17th move.
During my game, and especially afterward when I analyzed it with Dautov, who was a big expert on the variation, I learned that had Black played b7-b5 at any point in the endgame, it would have given me good practical chances due to the a2-a4 break. Boleslavsky's comment was just a confirmation of my findings. It is not the b5-pawn that becomes weak after b7-b5, it is the a6-pawn that can get into trouble!
Isaac Boleslavsky. Photo: Wikipedia.
The following game encapsulates the results of my multiyear research. Notice that I played Nc3-d5 only after the move b7-b5 was already played. Then I indeed pushed a2-a4 to break Black's queenside. After that, just as I expected, Black's a6-pawn became very weak. At first it had to move to a5, but eventually all was lost anyway. As a result, White got a passed a4-pawn which decided the game.
It goes without saying that spending years trying to understand the meaning of just one brief Karpov comment is very unusual, but try the following exercise. Find a very good game played by a great player with his own annotations. Then try to understand every single comment. If the player says "White is better," ask yourself, "Why is White is better?". If he says the f4-square becomes weak, try to explain why it is weak to an imaginary student. If you leave no stones unturned in such a game, then you really learned something from it, and then you are on the way to your master title!
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Briscoe Accepts Positon at Grace College
In June, Mooresville High School will say goodbye to our Athletic Director of two years, Chad Briscoe.
Briscoe has accomplished many things as Athletic Director at MHS, including Mooresville's Champions of Character program, a program that recognizes students from all Mooresville schools who display excellency in character, unity and servant leadership. He also oversaw the planning for the Mooresville Sports Complex, a complex that includes the Mooresville Junior League fields, the cross country course, all other Mooresville athletic fields, and the League of Miracles.
"Chad served Mooresville Schools extraordinarily well by consistently living out positive, professional and productive behaviors and habits," Superintendent Brad Lindsay said in a press release.
There were also several firsts in Mooresville Athletics history while Briscoe was Athletic Director, including Mooresville's first All Star in Cross Country, the first Regional qualifier in swimming and the first Sectional title in girls' tennis.
"[Briscoe] has done a wonderful job in the two years that he has been here," Athletic Secretary Marsha Green said. "He has done so many positive things."
Briscoe also oversaw the building of the first school-owned softball field in MHS history. He has also secured a three-year sponsorship from St. Francis hospital for the athletic department and improving the school's tennis courts, baseball field, weight rooms, track and football building, basketball gym, natatorium and soccer field.
Briscoe has accepted a position as athletic director and professor of Sports Management at Grace College in Indiana.
"There are many benefits for my family in returning to the college level," Briscoe said. "I will serve as a professor on campus and I look forward to returning to teaching again."
Briscoe will be missed by the students and staff at MHS. Be sure to wish him luck at Grace College.
"I have grown professionally from my experience at Mooresville and will miss working with the staff, students and coaches that make Mooresville a special place," Briscoe said.
Spring Musical Tonight!
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Women's Twenty20 Matches played on St Kilda Cricket Ground, Melbourne (54)
20th November 2009 Australian Women's Twenty20 Cup 2009/10 Victoria Women v Queensland Women wtt180
30th January 2011 Australian Women's Twenty20 Cup 2010/11 Victoria Women v South Australia Women wtt559
4th January 2013 Australian Women's Twenty20 Cup 2012/13 Victoria Women v New South Wales Women wtt1117
22nd January 2013 New Zealand Women in Australia 2012/13 1st Twenty20 Australia Women v New Zealand Women wtt1126
22nd January 2013 New Zealand Women in Australia 2012/13 2nd Twenty20 Australia Women v New Zealand Women wtt1127
24th January 2013 New Zealand Women in Australia 2012/13 3rd Twenty20 Australia Women v New Zealand Women wtt1128
6th December 2013 Australian Women's Twenty20 Cup 2013/14 Victoria Women v Tasmania Women wtt1420
2nd January 2014 Australian Women's Twenty20 Cup 2013/14 Victoria Women v Queensland Women wtt1434
4th January 2014 Australian Women's Twenty20 Cup 2013/14 Victoria Women v Queensland Women wtt1437
10th October 2014 Australian Women's Twenty20 Cup 2014/15 Victoria Women v South Australia Women wtt1702
28th November 2014 Australian Women's Twenty20 Cup 2014/15 Victoria Women v Western Australia Women wtt1731
3rd January 2015 Australian Women's Twenty20 Cup 2014/15 Victoria Women v New South Wales Women wtt1765
5th December 2015 Women's Big Bash League 2015/16 Melbourne Stars Women v Brisbane Heat Women wtt2099
8th January 2016 Women's Big Bash League 2015/16 Melbourne Renegades Women v Sydney Sixers Women wtt2211
8th January 2016 Women's Big Bash League 2015/16 Melbourne Stars Women v Adelaide Strikers Women wtt2212
9th January 2016 Women's Big Bash League 2015/16 Adelaide Strikers Women v Sydney Sixers Women wtt2215
10th January 2016 Women's Big Bash League 2015/16 Melbourne Renegades Women v Sydney Sixers Women wtt2216
10th January 2016 Women's Big Bash League 2015/16 Melbourne Stars Women v Adelaide Strikers Women wtt2217
1st December 2018 Women's Big Bash League 2018/19 Hobart Hurricanes Women v Perth Scorchers Women wtt3460
1st December 2018 Women's Big Bash League 2018/19 Melbourne Stars Women v Sydney Sixers Women wtt3461
2nd December 2018 Women's Big Bash League 2018/19 Adelaide Strikers Women v Brisbane Heat Women wtt3462
2nd December 2018 Women's Big Bash League 2018/19 Melbourne Renegades Women v Sydney Thunder Women wtt3463
8th December 2018 Women's Big Bash League 2018/19 Melbourne Renegades Women v Adelaide Strikers Women wtt3468
12th January 2019 Women's Big Bash League 2018/19 Melbourne Renegades Women v Hobart Hurricanes Women wtt3529
19th October 2019 Rebel Women's Big Bash League 2019/20 Melbourne Stars Women v Hobart Hurricanes Women wtt4196
23rd October 2019 Rebel Women's Big Bash League 2019/20 Melbourne Renegades Women v Perth Scorchers Women wtt4230
9th November 2019 Rebel Women's Big Bash League 2019/20 Melbourne Renegades Women v Hobart Hurricanes Women wtt4297
10th November 2019 Rebel Women's Big Bash League 2019/20 Melbourne Renegades Women v Hobart Hurricanes Women wtt4300
13th November 2019 Rebel Women's Big Bash League 2019/20 Melbourne Stars Women v Brisbane Heat Women wtt4309
20th November 2019 Rebel Women's Big Bash League 2019/20 Melbourne Renegades Women v Brisbane Heat Women wtt4320
20th November 2019 Rebel Women's Big Bash League 2019/20 Melbourne Stars Women v Perth Scorchers Women wtt4323
30th November 2019 Rebel Women's Big Bash League 2019/20 Melbourne Renegades Women v Melbourne Stars Women wtt4344
1st December 2019 Rebel Women's Big Bash League 2019/20 Melbourne Renegades Women v Sydney Thunder Women wtt4347
1st December 2019 Rebel Women's Big Bash League 2019/20 Melbourne Stars Women v Brisbane Heat Women wtt4350
7th February 2020 Australia Tri-Nation Women's T20 Series 2019/20 England Women v India Women wtt4460
8th February 2020 Australia Tri-Nation Women's T20 Series 2019/20 Australia Women v India Women wtt4462
9th February 2020 Australia Tri-Nation Women's T20 Series 2019/20 Australia Women v England Women wtt4465
12th February 2020 Australia Tri-Nation Women's T20 Series 2019/20 Final Australia Women v India Women wtt4469
27th February 2020 ICC Women's Twenty20 World Cup 2019/20 Group A India Women v New Zealand Women wtt4481
29th February 2020 ICC Women's Twenty20 World Cup 2019/20 Group A Bangladesh Women v New Zealand Women wtt4485
29th February 2020 ICC Women's Twenty20 World Cup 2019/20 Group A India Women v Sri Lanka Women wtt4486
2nd March 2020 ICC Women's Twenty20 World Cup 2019/20 Group A Australia Women v New Zealand Women wtt4493
2nd March 2020 ICC Women's Twenty20 World Cup 2019/20 Group A Bangladesh Women v Sri Lanka Women wtt4492
10th November 2022 Weber Women's Big Bash League 2022/23 Melbourne Renegades Women v Sydney Sixers Women wtt5875
12th November 2022 Weber Women's Big Bash League 2022/23 Melbourne Renegades Women v Perth Scorchers Women wtt5881
12th November 2022 Weber Women's Big Bash League 2022/23 Melbourne Stars Women v Sydney Sixers Women wtt5882
13th November 2022 Weber Women's Big Bash League 2022/23 Melbourne Renegades Women v Melbourne Stars Women wtt5892
13th November 2022 Weber Women's Big Bash League 2022/23 Perth Scorchers Women v Sydney Sixers Women wtt5891


Apple Kills MacBook Pro. Long Live the New MacBook Pro.
Chuong Nguyen
Apple has not been shy to kill off aging technologies that are on their way out, and it's repeating that this year with the late 2013 release of the new MacBook Pro notebooks. Optical drives, hard drive storage, and low resolution display are all on their way out.
In the recent past, Apple had offered two series of "Pro" notebooks, but now Apple is standardizing on a singular MacBook Pro branding rather than maintaining a separate MacBook Pro with legacy technologies and a MacBook Pro with Retina Display line that is slimmer and eschews the legacy ports. Now, with the new MacBook Pro, Apple is merging both lines into a single product brand.
The new MacBook Pro carries with it a lot of similarities with the older Retina Display cousin, including the Retina Display resolution screen. And now, Apple has killed off the optical drive on the MacBook Pro, a nod to the death of CD and DVD storage as consumers are moving towards the cloud for storage, backup, and even for consumption of content thanks to stores like Amazon's Video on Demand, Apple's iTunes, and Netflix among others.
Also resting in peace is the standard optical disc drive. Rather than a standard hard drive, Apple is now using flash-based storage on the MacBook Pro, another feature that was borrowed from the older MacBook Pro with Retina Display of yore. The new MacBook Pro comes with standard flash storage, offering consumers more reliability as flash drives are less prone to failing in harsh conditions and also allow for lighter, thinner notebook designs. Another benefit is that read and write speeds are faster, which is a must for displaying content on the high resolution display while conserving battery power.
And the best part about this year's refresh? Lower prices. Given the rapid improvements and innovation in technology, prices are dropping so Apple is able to deliver more at a more affordable pricing. The drop in pricing between a 13-inch MacBook Pro–with this year's storage upgrades, Retina Display, slimmer and lighter design–will make it hard to choose between the Pro model and the more ultraportable MacBook Air at the same screen size.
Related Topics:AppleMacBookMacBook ProMacBook Pro Retina DisplayRetina Displayultrabook
Kinda kills it for me. I had been waiting for a new pro to replace my aging 17″ pro. Really wanted the 16GB of ram and since I travel a decent drive size, 1TB would be nice.
All the other changes could have been managed. It's a shame they are trying to make laptops and tablets the same. Reason some people see little difference between the MacBook Air and a iPad.
T O
Apple killed it for me, too. I agree with the guest. I am also replacing mine, and 1 TB would be nice. Apple user since '85. Steve Jobs death made Apple start to rot.


Home Health Young adults, in debt, are now facing an economic crisis
Young adults, in debt, are now facing an economic crisis
"Today, I could get a $ 5 order from McDonald's after three hours of waiting," he said.
Mr. Lawson has a 2 year old child and a pregnant woman who is not working. They were ready to eat simple noodles until he visited a food bank and received a bag of potatoes and carrots. He created accounts on all social networks to spread his need for work – any job.
"Give me something to feed my family on," he said. "I don't care what it is. "
While the minority of young adults who have a university degree do as well or better than previous generations when they were in their twenties and early thirties, those who did not attend college – like M. Lawson – doing much worse, according to an Analysis from the Pew Research Center last year.
The inequality between millennials is even more evident when one takes race into account. Young New Brunswick families at all levels of education have lagged behind their white counterparts in the past two decades, according to New America study, in measures such as household wealth and home ownership. property.
"Over time, it becomes more difficult for young families to accumulate wealth," said William R. Emmons, chief economist at the Federal Reserve Household Financial Stability Center in St. Louis. "We thought they might catch up later, but the current situation doesn't give me much reason to believe it will happen. "
These drawbacks are already shaping the long-term prospects of young Americans. They are much less likely to be married, have children, or own a home than Americans of the same age in recent decades.
Ms. Gardner said that she and Mr. Schade ultimately wanted to have a family and a home. But she said, "We are both going to be in debt for a while, and having children is just not possible. "
While there is a chance that the recession will be short, economists assume that the turmoil that has already occurred will have long-term consequences for young households.
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VARG/RTC - Ratnagiri Airport
Somewhere in India
Ratnagiri Airport (IATA: RTC, ICAO: VARG) is a public airport located in Mirjole, Ratnagiri district, in the Konkan division of the state of Maharashtra, India. == History == The airport was built in 1973 by the Public Works Department, Government of India. Its Contract was awarded to and satisfactorily completed by M/s H. K. Chauhan one of the most reputed contractors from Ratnagiri It was transferred to the Maharashtra Industrial Development Corporation(MIDC) for upgradation, expansion and maintenance in 1997.
(Airport Infos by Wikipedia)
Open current view/airport in an external service:
OurAirports.com
Random Airports
This app shows satellite views of random airports. Its aim is to introduce you to the variety of airport structures embedded into the landscape. Parts of the website are heavily inspired by David Schmidt's website chuchichechocha.com.
Click on the satellite image or on the button in the control panel to advance to another randomly selected airport.
Click on the button in the control panel to start auto play mode (every 30 seconds a random airport is loaded); Click on the button to stop the auto play mode.
Click on the button in the control panel to search for a specific airport by ICAO code, IATA code, airport name, or location name.
Click on the button in the control panel to show additional information about the current airport and to open the current view in a variety of external services (e.g. Google Maps).
Click on the button in the control panel to toggle fullscreen mode.
Unlike other mapping websites, it is not possible to change the view by panning it around with the mouse or to change the zoom factor.
Technologies and Data Sources
This app is based on the Google Maps API, which on the one hand provides a powerful programming interface for web-based mapping applications, and on the other hand opens access to high quality satellite imagery for places all over the world.
The backend is realized in Python with the help of the excellent Flask micro framework.
The locations of airports have been imported from the public domain data provided by the aviation enthusiasts at OurAirports.com. The app displays randomly selected airports of the categories 'large_airport','medium_airport' and 'small_airport' for which runway coordinates are available.
Furthermore, the user interface incorporates icons from Font Awesome and fonts from Google Fonts.
This is brought to you by me, Florian Pigorsch. Feel free to contact me via Google+ or mail. The source code of this app can be found at Github.
Random Airports has been featured on several websites including
the AvGeek Weekly Newsletter on 2015/01/16,
the Maps Mania blog on 2015/01/03
Here's a list of 10 random airports:
LIBA - Amendola Air Base
FBSP/PKW - Selebi Phikwe Airport
NTGJ/GMR - Totegegie Airport
K3R9 - Lakeway Airpark
LGPL/JTY - Astypalaia Airport
SKAP/API - Gomez Nino Apiay Air Base
KTIK/TIK - Tinker Air Force Base
VA1H - Ondwa Airport
LR79 - Ianca Air Base
3J6 - Davis Field
This app shows satellite views of random airports. Its aim is to introduce you to the variety of airport structures embedded into the landscape.
Click on the satellite image or on to advance to another randomly selected airport.
Click on start 'auto play' mode (every 30 seconds a random airport is loaded).
Click on to search for a specific airport.
Click on to show infos about the current airport.
Click on to toggle fullscreen mode.
Search for airports
You can search for ICAO-codes (4-letter airport codes, e.g. 'KSFO'), IATA-codes (3-letter airport codes, e.g. 'SFO'), airport and location names (e.g. 'San Francisco').
Search queries containing multiple words and/or non-alphanumeric characters may be problematic - try to keep your query simple (e.g. prefer 'Helsinki' to 'Helsinki Airport')!
Here's a list of 10 randomly selected airports:


Top 5 Moments From January 2022
KLONDIKE, CP Army Headquarters – As the first month of 2022 draws to a close, the CP Army HQ staff team are excited to present the Top 5 Moments from January.
The CP Army HQ staff team recently held an internal vote to decide what we collectively believed to be the 'Top Five Moments' from January 2022. This includes moments that have resulted in a significant impact on the community as a whole, whether that be a war, retirement or scandal.
5. Templars Crowned 1st on Top Ten Armies of January
Written by: DMT
Starting off the list is a recent one, though its significance cannot be understated; The Templars achieved a monthly score of 99 on the first Monthly Top Ten of 2022. The Templars had a dominant January, placing first on every January Top Ten except one. With the next closest army, the Ice Warriors, accumulating a score of 93, the ranking served as proof to the community that the golden knights are the cream of the crop when it comes to all of the major armies in the army world. This also serves as the first time the Templars placed first in the monthly Top Ten, furthering the notion that the current heights for the army are unprecedented.
4. Fire Warriors Leader Pranav Banished Following Attempted Defection
Written by: Max
The Fire Warriors made the headlines several times across January, but the banishment and attempted defection of leader Pranav made it into the top five moments of the entire month. CP Army HQ broke the news and exclusively revealed his undercover mission for moral justice, after coming to blows with the rest of the leadership. Warriors 'Re-creator' Sweater sensationally released a administrative statement exposing the behind-the-scenes happenings within the army, accusing Pranav of attempting to "destroy" the army by encouraging other staff to also defect with him. However, in his interview with CP Army HQ's Max, he revealed a contradicting story to Sweater's narrative. While the Fire Warriors leadership label his actions as betrayal, Pranav has instead stated he was on a moral justice mission. But despite his attempts, the Fire Warriors remained intact and Pranav was banished from the army and stripped of his Hall of Fame award, choosing to reside in the Templars higher command.
3. Yukon Share HTML5 Source Code; CP Army Battleground Development Relaunches
Written by: Myth
Private Servers emergence after the closure of Club Penguin has kept armies alive. While the abrupt shutdown of Adobe Flash sent shockwaves throughout the community, a new private server has emerged, and has shared their source code to better help the community. On January 25th, Yukon announced their finished project, an HTML rendition of the original Club Penguin. With their release of the source code, others can use it to create their own servers. One private server to do so is CPA Battleground, run by Superhero123. With ambitions high, the development of CPA Battleground has resumed due to the release of Yukon's source code.
2. AUSIA Arena Tournament Launches; United Media Form For Media Coverage
Written by: Scorpion Demon
The AUSIA Arena Tournament was the second AUSIA tournament ever organized in the history of Club Penguin armies. It also happens to be the first ever community-run AUSIA tournament. The coverage of the entire event was taken over by United Media, which is a joint collaboration between CP Army HQ and CP Army Network. United Media announced the event to the community on January 19th. The announcement received a lot of praise, as the AUSIA community had been neglected in terms of tournaments ever since December 2020, which saw the Army of CP organize Aces of AUSIA. The tournament successfully completed its first two rounds, and now we have the Top Four Armies of this month facing off against each other in the Semi Finals. The launch of this tournament definitely is one of the biggest moments of January. The fact that the two sides of our community agreed to come together for the sake of this much anticipated event just adds icing to the cake.
1. Templars Lose Empire to Water Vikings After Breaking Treaty Terms
On the 19th of January, a series of server transfers sent shockwaves through the army community. It began with the Templars, who transferred all of their land to close allies, the People's Imperial Confederation. Then- just two minutes later- the Templars declared war on the Water Vikings. This caused quite a stir between the leaders of the Water Vikings and the Templars, as declaring war was strictly prohibited between the two sides because of the Treaty of the Axe and the Sword. Upon noticing the pandemonium occurring in the server transfers channel, the administration began discussing if the move was a violation of the aforementioned treaty. Ultimately, it was agreed upon that the transfer were to be deemed invalid because the Templars transferred with intent to loophole out of the treaty; which goes against the 4th term. This resulted in the golden knights giving up all 34 of their servers to their rivals. Nevertheless, they attempted to declare war upon the Water Vikings again, but the war was deemed invalid because the treaty was still in place. These decisions were met with great disdain from the Templars, who attempted to carry the war over to Club Penguin Army Network, but were rebuked by the administration there as well. Thus, the Templars returned to the CPAHQ map empty handed.
Whether you agree with our listing or not, there is no doubt the month of January has been a very busy one for the community. As we now head into the second month of the new year, what can we expect to occur? And what moments will top our listings at the end of it?
Filed under: Top 5 Moments | Tagged: CP Army HQ, CPAHQ, Top 5 Moments, Top Five Moments
Max is currently serving as Club Penguin Armies Chief Executive Producer. He is known for his positions as a CPA Headquarters Vice Director (2022), ACP Leader (2021), and CP Army Hub Executive Producer (2020). He won 'Best Admin' in the End of Summer Awards 2020, as well as 'Best Editor', 'Top Post' & 'Best Column' in the CPAHQ 2021 Staff Awards.
The content on this page was last updated on February 1st, 2022 (6:09 pm)


Home > News < PA: Man Arrested For Converting to Judaism
PA: Man Arrested For Converting to Judaism
The ITIM organization has approached Prime Minister Binyamin Netanyahu, Interior Minister Aryeh Deri and the Defense Ministry's Civil Administration, chief Brigadier General Rasan Alian, with a request to assist an Arab convert to Judaism who is being imprisoned in Ramallah • Full Story
Yossi
25th of Tishri, 5780 - October 24, 2019
The ITIM organization has approached Prime Minister Binyamin Netanyahu, Interior Minister Aryeh Deri and the Defense Ministry's Civil Administration, chief Brigadier General Brigadier General Rasan Alian, with a request to assist an Arab convert to Judaism who is being imprisoned in Ramallah.
D., a Palestinian Authority resident, was jailed after converting in a rabbinical court and becoming a Jew.
He went through the conversion process with the late Rabbi Nissim Karelitz, and managed to complete the conversion process but had not yet received the conversion certificate when he was kidnapped by the Palestinian Authority police. He has been in jail for 15 days and has reportedly been subject to torture.
"A former resident of Hevron who converted at Rabbi Nissim Karelitz's Beit Din in Bnei Brak. It was also reported that he had received violent injures, including the burning of his hands and feet," wrote ITIM director attorney Elad Kaplan.
He added, "Concern for the safety of Jews who are in trouble and captivity is not only a moral duty but also a constitutional duty, enshrined in the provisions of Basic Law: Israel – the nation-state of the Jewish people. When the basic liberty of a Jew is denied due to his Jewishness and his joining the Jewish people, the duty of the State of Israel to act and protect his life, well-being and rights."
"It should be noted that this week Rabbi Nissim Karelitz, who according to the publications conducted the conversion, passed away. Rabbi Karelitz spent much of his life assisting converts and meticulously adhering to the command "And the convert you shall not vex or oppress." There is no doubt that the rabbi's will is to assist every Jew who is in captivity and to prevent injury to the converts of the Jewish people. Please hear the voice of our brother's cry."
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