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alphabisabolol has a primary antipeptic action depending on dosage which is not caused by an alteration of the phvalue the proteolytic activity of pepsin is reduced by percent through addition of bisabolol in the ratio of the antipeptic action of bisabolol only occurs in case of direct contact in case of a previous con... | 56 | substrate |
a report is given on the recent discovery of outstanding immunological properties in ba ncyanoethyleneurea having a low molecular mass m experiments in ds CS bearing wistar rats have shown that ba at a dosage of only about percent ld mg kg and negligible lethality percent results in a REC rate of percent without hyperg... | 24|49|68|113|137|172 | carcinosarcoma|recovery|reference|recovery|after|plaque |
the virostatic compound nndiethyloxotetradecylimidazolidinylethylpiperazinecarboxamidehydrochloride was analyzed as to its effect on the induction of tryptophanpyrrolase and tyrosineaminotransferase in rat liver the basic activity of the enzymes was not influenced by the substance either in normal or in adrenalectomize... | 55 | substrate |
rmi rmi and rmi are newly synthetized nrdibenzobfoxepinylnmethylpiperazinemaleates which show interesting psychopharmacologic effects this work contains the results of a study performed with these three EDC in order to demonstrate their neuropsycholeptic activity in comparison with chloropromazine cpz and chlordiazepox... | 25|82|127|182|222 | compounds|compounds|inhibitory|lethal doses|catecholamines |
a doubleblind study with intraindividual comparisons was carried out to investigate the effects of mg of ralphahydroxyisopropylalphahtropanium bromidetropate sch mg sch mg OX mg oxazepam and PL with p.o. in randomized sequence on gastric juice volume amount of acid concentration and ph values in healthy volunteers the ... | 22|26|28|77|90|144|158|203 | oxazepam|placebo|oral administration|pentagastrin|evaluation|oxazepam|oxazepam|preparations |
stroma from either normal or pnhlike CRC is capable of inhibiting to some extent lysis in the sucrose test and enhancing lysis in the acidifiedserum test the same opposing effects are displayed by the exclusion peaks from sephadex g obtained from each stroma preparation suggesting that the same factor could be responsi... | 6|82|84|107 | red cells|serum|activated|classical |
the effect of the L1 metabolite of aspirin namely salicylic acid upon the PP pathway ppp of normal and gpddeficient red cells has been studied salicylic acid was shown to inhibit this pathway in proportion to the amount present at any concentration of this substance there was greater inhibition of the ppp in gpddeficie... | 4|13 | major|pentose phosphate |
in one experiment the effect on rumen ph of feeding with restricted amounts of whole or pelleted barley was studied with whole barley there was little variation in rumen ph associated with FF time but with pelleted barley the ph decreased from about before FF to about h after feeding the rate of disappearance of dried ... | 32|44|76|135 | feeding|feeding|after|live weight |
the presence of at least two ionizable AS center groups has been detected by a T0 of the effect of ph upon catalysis of hydrolysis of lalanylbetanaphthylamide by human liver alanine aminopeptidase and upon the inhibition of hydrolysis by inhibitors and substrate analogs octanoic acid octylamine and peptide inhibitors h... | 7|15|63|137|199|247|265 | active|study|active|substrate|substrate|active|amino acid |
the reaction of glutamate dehydrogenase and glutamate gl with nad and nadp has been studied with stoppedflow techniques the enzyme was in all experiments present in excess of the coenzyme the results indicate that the ternary complex enadphkg is present as an intermediate in the formation of the stable complex enadphgl... | 113|203|209|250 | stable|assay|binding|glutamate |
choline acetyltransferase ec catalyzes the biosynthesis of acetylcholine according to the following chemical equation acetylcoa choline in equilibrium to acetylcholine coa in addition to nervous tissue primate placenta is the only other animal source which contains appreciable acetylcholine and its biosynthetic enzyme ... | 44 | caudate |
increasing concentrations of chloride were found to increase the resolution between two visible absorbance spectral transitions associated with acidification of ferricytochrome c analysis of a variety of spectral and viscosity measurements indicates that protonation of a single group having an apparent pk of and an int... | 81 | displacement |
the properties of the functional CG in a protein can be used as builtinprobes of the structure of the protein we have developed a general procedure whereby the ionization constant and chemical reactivity of solitary PET groups in proteins may be determined the method may be applied to the side chain of histidine tyrosi... | 5|35|98|257 | groups|functional|after|reactivity |
primary amines react with pentanedione at ph to form enamines nalkylaminopentenones the latter compounds readily regenerate the primary amine at low ph or on treatment with hydroxylamine guanidine and substituted guanidines react with pentanedione to form nsubstituted aminodimethylpyrimidines at a rate which is lower b... | 95|164|183 | arginine|arginine|change |
a purification procedure is reported for obtaining bovine liver DHF reductase in high yield and amounts of mg a key step in the procedure is the use of an affinity gel prepared by coupling pteroylllysine to sepharose the purified reductase has a TPS activity of about unitsmg and is homogeneous as judged by analytical u... | 9|42|70|100|206 | dihydrofolate|specific|degradation|antiserum|dihydrofolate |
dihydrofolate reductase has been purified fold to apparent homogeneity from a trimethoprimresistant strain of escherichia coli rt using a procedure that includes methotrexate affinity column chromatography determinations of the molecular weight of the enzyme based on its amino acid composition sedimentation velocity an... | 71|106|118|130|156|182 | gel filtration|electrophoresis|dihydrofolate|organic cations|substrate|dihydrofolate |
ionization effects on the binding of the potential TS analogues phosphoglycolate and phosphoglycolohydroxamate appear to be attributable to the changing state of ionization of the ligands themselves therefore it is unnecessary to postulate the additional involvement of an ionizing residue at the active site of trioseph... | 8|129 | transition state|active |
kinetic analyses of monoanion inhibition and cl nuclear magnetic resonance at mhz were employed to study monoanion interactions with the zinc metalloenzyme renal dipeptidase the enzymecatalyzed hydrolysis of glycyldehydrophenylalanine exhibited competitive inhibition when the reaction rate was determined in the presenc... | 100|155|161|254|258|301|325 | effective|inhibitory|line|line|line|line|relaxation |
the nearultraviolet circular dichroism cd of three homogeneous antitype iii pneumococcal antibodies in the absence and the presence of the specific hexasaccharide ligand was studied in addition recombinations and hybridizations of h and l chains derived from two of these antibodies were carried out and the cd spectra o... | 166 | heterologous |
the circular polarization of luminescence cpl emitted by tryptophan residues was used as a sensitive probe for measuring ligandinduced structural changes in a homogeneous type iii pneumococcal antibody a series of oligosaccharide ligands of increasing size derived from type iii polysaccharide by partial acid hydrolysis... | 248 | polysaccharide antigen |
the PET role of the bacillus stearothermophilus s ribosomal protein bl probably rat to the escherichia coli protein l was examined by chemical modification the complex bls rna was photooxidized in the presence of rose bengal and the modified protein incorporated by reconstitution into s ribosomal subunits containing al... | 1|12|60|90|120|146|169|180 | functional|homologous|functional|functional|subunit|subunit|active|sites |
the localization of the previously postulated interface recognition site irs in porcine pancreatic phospholipase a required for a specific interaction between the enzyme and organized lipidwater interfaces was investigated by ultraviolet difference spectroscopy by measurements of the intrinsic fluorescence of the uniqu... | 56|67|137 | substrate|sequence|alkaline |
the action of snake venom phospholipases a in IN human erythrocytes was investigated in detail the basis phospholipase from agkistrodon halys blomhifii was found to induce both hydrolysis of membrane phospholipids and total cell hemolysis under certain experimental conditions the hydrolytic action of the basic enzyme w... | 8|131|288 | intact|glucose|erythrocyte membranes |
the spontaneous inactivation of yeast G3P dehydrogenase was found to fit a simple twostate MM at ph and degrees the first step is a relatively rapid dissociation of the tetramer to dimers with the equilibrium largely in favor of the tetramer in the absence of nad the dimer inactivates irreversibly the apoenzyme is quit... | 5|14|103|105|127|157|172|214|221 | glyceraldehydephosphate|model|binding|reactivity|groups|after|equilibrium dialysis|subunit|binding |
the kinetics of the phinduced dissociation of the x mol wt hemoglobin from lumbricus terrestris the earthworm have been studied in a lightscattering stoppedflow apparatus the ligand dependent dissociation data were fit well by a simple sequential model the data for co and oxyhemoglobin are consistent with hb leads to h... | 172|237 | stable|activation energies |
the reduction of metmyoglobin by the ironii complex of transdiaminocyclohexanennnntetraacetate fecdta has been investigated the equilibrium constant measured spectrophotometrically is with a resulting reduction potential of v for mb the rate constant for the reduction is m sec with a deltah of kcal m and deltas of eu b... | 60 | reactivity |
the purification of axonal membranes of crustaceans was followed by measuring enrichment in htetrodotoxin IB capacity and in na katpase activity a characteristic of these membranes is their high content of lipids and their low content of protein as compared to other types of plasmatic CM the axonal membrane contains my... | 14|45|112|116|181|235|309|325 | binding|membranes|binding|membranes|binding|electrophysiological|membranes|functioning |
a new procedure is described for selecting nitrogenasederepressed mutants based on the method of brenchley et al brenchley je prival mj and magasanik b j biol chem for isolating histidaseconstitutive mutants of a nonnfixing bacterium nitrogenase levels of the new mutants in the presence of nh were as high as of the nit... | 60|82 | biochemical|glutamate |
the superoxide anion radical o reacts with ferricytochrome c to form ferrocytochrome c no intermediate complexes are observable no reaction could be detected between o and ferrocytochrome c at degrees c the rate constant for the reaction at ph to is m s and as the ph increases above the rate constant steadily decreases... | 63|139 | heart|energy |
after a mus laser flash a mus phase in the decay of delayed fluorescence is visible under a variety of circumstances in spinach chloroplasts and subchloroplast particles EC in photosystem ii prepared by means of digitonin the level of this phase is high in the case of inhibition of oxygen evolution at the donor side of... | 27|84|89 | enriched|oxidized|photosystem |
photosystem ii reaction center components have been studied in small system ii particles prepared with digitonin upon illumination the reduction of the primary acceptor was indicated by absorbance changes due to the reduction of a PQ to the semiquinone anion and by a small blue shifts of absorption bands near nm c and ... | 35|55|64|80 | plastoquinone|semiquinone|preparations|oxidized form |
crude extracts and partially purified enzyme preparations from potato tubers catalyse at ph the conversion of linoleic acid hydroperoxides to a range of oxygenated fatty acid derivatives d and lhydroperoxide isomers are converted at similar rates to equivalent isomeric products the major products from the hydroperoxide... | 98 | sulphydryl |
microsomal PA phosphohydrolase phosphatidate phosphatase ec was solubilized and fractionated to yield at least two distinct enzymatically active fractions one denoted fa was nonspecific had a relatively high km for phosphatidic acid and was insensitive to inhibition by diacylglycerol the second fraction fb was specific... | 1 | phosphatidate |
rabbit liver microsomal S9 fortified with mm nadph effectively promote hydroxylation of betah or callochenodeoxycholic acid or alphaalphahalphacholestanealphaalphadiol to their respective alphahydroxyl derivatives in yields of about or in min minor amounts of other products are formed from the diol the requirements for... | 3|46|53|75 | preparations|liver|liver|substrate |
properties of the phenobarbital induced cytoplasmic aldehyde dehydrogenase ec have been studied in rat liver fold higher C2 were seen in the cytoplasmic activities after phenobarbital treatment in reactor compared to nonreactor animals with high concentrations of acetaldehyde mm and propionaldehyde mm no difference was... | 17|180|184 | levels|diethylstilbestrol|enzyme activity |
the hydrolysis of pnitrophenyl phosphate by wheat germ acid phosphatase orthophosphoric monoester phosphohydrolase ec has been investigated in mixtures of AQ buffers with AC dioxane and acetonitrile the enzyme was either in free solution or immobilized on a pellicular support which consisted of a porous carbonaceous la... | 20|23|58|93|127 | aqueous|acetone|acetone|aqueous|aqueous |
a strain of bacillus sp bacillus r produces a protease and a carbohydrolase both of which have the ability to lyse rhizopus cell walls of the enzymes the carbohydrolase has been purified to an ultracentrifugally and electrophoretically homogeneous state and identified as a chitosanase the enzyme was active on glycol ch... | 73 | active |
OS containing terminal nonreducing alpha leads to alpha leads to and alpha leads to linked mannose residues isolated from human and bovine mannosidosis urines were used as substrates to test the specificities of acidic alphamannosidases isolated from human and bovine liver the enzymes released all the alphalinked manno... | 0|67|124 | oligosaccharides|active|substrate |
the characterization and localization of a caatpase atp phosphohydrolase ec in the tooth germ of the porcine fetus are reported this enzyme a microsome fraction is preferentially activated by ca in the presence of mm atp maximal CEA is obtained at mm cacl the maximal rate of atp hydrolysis is approx mumol per h per mg ... | 37|151|172 | enzyme activity|smooth endoplasmic reticulum|layer |
purified skeletal muscle myosin ec has been covalently bound to sepharose b by the cyanogen bromide procedure the resulting complex sepharosemyosin possesses adenosine triphosphatase activity and is relatively stable for long periods of time under optimal binding conditions approximately of the TPS atpase activity of t... | 41|47|50|70|79|83|85|104 | specific|myosin|polyacrylamide gel electrophoresis|heavy chains|agreement|binding|release|myosin |
based on incorporation of radioactively labeled nethylmaleimide the readily reactive thiol groups of isolated myosin ec from fast slow and cardiac muscles could be classified into types all myosins contain thiol thiol and a variable number of thiol groups per molecule both thiol and thiol CG which are essential for SF-... | 45|50|59|65|158|167|176|185 | groups|functioning|heavy chains|variation|light|myosin|myosin|cardiac myosin |
the ph dependencies of the apparent K(m) for oxidized glutathione and the apparent turnover number of yeast glutathione reductase ec have been determined at a fixed concentration of mm nadph in the range ph between ph and both of these parameters are relatively constant the principal effect of low ph on the kinetics of... | 6|63|66|81|130|196 | michaelis constant|substrate|oxidized|binding|serum|oxidized form |
the phosphorylated form of CL glycogen phosphorylase alphaglucan orthophosphate alphaglucosyltransferase ec phosphorylase a is AS and easily measured while the dephosphorylated form phosphorylase b in contrast to the muscle enzyme has been reported to be essentially inactive even in the presence of amp we have purified... | 4|14|99|105|126|130|156|160|217 | liver|active|substrate|binding|liver|active|crude extract|appropriate|after |
two rb EA CS kinases gtpcasein kinase i and gtpcasein kinase ii have been purified and fold respectively studies employing sucrose density gradient centrifugation indicate that kinase i has a molecular weight of about s and kinase ii about s these enzymes can utilize either atp or gtp as the phosphoryl donor among vari... | 1|2|3|63|79|95|114|133|192|206 | rabbit|erythrocyte|casein|casein|serum|casein|active|casein|diphosphoglycerate|casein |
a purification procedure for creatine kinase ec from muscle of the monke muequiv hmg protein per min at degrees c and a yield of approx gkg muscle assuming equilibrium kinetics synergistic binding of substrates at one catalytic site is found for both the forward and back reactions kinetic constants for the binding of e... | 54|160|202 | substrate|enzymesubstrate|substrate |
a technique has been developed to separate and measure kallikrein in a heterogeneous population of rat renal cortical cells in suspension T3 rat kidneys were perfused in situ in anaesthetized rats viable counted cortical cell suspensions were obtained cells were suspended in a sucrosetris buffer containing deoxycholate... | 21 | after |
the electrochemical behaviour of ferricytochrome c metmyoglobin and methemoglobin was studied using dc ac and differential PP polarography and controlled potential electrolysis the three hemoproteins yield dc polarographic steps and peaks in differential pulse polarograms the height of which is proportional to concentr... | 16 | pulse |
theory is presented relating to the binding of an effector to two states of a protein acceptor coexisting in equilibrium the problem is treated in terms of the four possible cases which specify relations between numbers of binding CS and intrinsic binding constants relevant to the acceptor states it is shown that a dis... | 38|114|115|214 | sites|binding|sites|diphosphoglycerate |
human hemoglobin was spin labeled with isothiocanatotetramethylpiperdinooxyl which is known to bind specifically to the nterminal alphaamino CG of proteins and slightly to the reactive sulfhydryl groups electron spin resonance esr analysis indicated a partially resolved fiveline spectrum suggesting that the label was a... | 17|49|61|62|118 | groups|binding|binding|sites|nterminal |
the erythrocruorin of the leech haemopis grandis possessed an sw of s at neutral ph its isoelectric point at ph and exhibited a slightly sigmoid oxygenation curve with n approximately and p mm at ph a minimum molecular weight of per heme group was determined from the iron and heme contents and weight respectively the s... | 70|132 | polyacrylamide gel electrophoresis in sodium dodecyl sulfate|subunit |
the contractile proteins from arterial smooth muscle are highly soluble and can be extracted at i however they can be precipitated by a prolonged dialysis at ph to give an actomyosin with a high although variable actinmyosin ratio the sedimentation behavior of this actomyosin at high ionic strength was examined as a CF... | 52|88|172 | function|actomyosin|myosin |
the activities of hybrid dimers of alkaline phosphatase containing two chemically modified subunits have been investigated one hybrid species was prepared by dissociation and reconstitution of a mixture of two variants produced by chemical modification of the native enzyme with succinic anhydride and tetranitromethane ... | 104|106 | alkaline|function |
fragments of isolated rat liver plasma membrane possess a ribonuclease activity which at ph in the presence of mm edta can digest polyuridylic acid polyu and polycytidylic acid polyc but not polyadenylic acid polya and polyguanylic acid polyg under these conditions the membrane preparation does not degrade native or de... | 84|112|139|165 | groups|substrate|uridine|trinucleotide |
the na kactivated mgdependent atpase from rabbit kidney outer medulla was prepared in a partially inactivated soluble form depleted of endogenous phospholipids using deoxycholate this preparation was reactivated to fold by sonicated liposomes of phosphatidylserine but not by nonsonicated phosphatidylserine liposomes or... | 51 | preparations |
a preparation of atpase from the CM of micrococcus lysodeikticus solubilized and more than pure showed two main bands in analytical polyacrylamide gel PACE they did not correspond to isoenzymes because one band could be converted into the other by exposure to a mildly ALP ph value the conversion was paralleled by chang... | 6|23|44|76|78|164 | membranes|electrophoresis|alkaline|polyacrylamide gel electrophoresis|large|alkaline |
the helix to coil transition of polylglutamic acid was investigated in and m aqueous potassium chloride solutions by use of potentiometric titration and circular dichroism measurement polymer concentration dependence of the transition was observed in the range from to monomole in m kg solution the polymer concentration... | 72 | polymer |
experiments were conducted on cats under nembutal anesthesia a study was made of PP activity of bulbar respiratory neurons EA of the diaphragm and of the IC muscles po pco ph arterial blood oxygen saturation were determined in combined action of hypoxia and hypercapnia when hypoxic gaseous mixture was given for respira... | 13|19|26|98|131 | pulse|electrical activity|intercostal|development|pulse |
experiments were conducted on male rats a study was made of the content of nicotinamide coenzymes in the liver and myocardium hours after the administration of ml of dichloroethane into the stomach in parallel with disturbance of the morphological structure of the CL and of the myocardium increase in the activity of al... | 42|59 | liver|serum |
chronic experiments were conducted on rats and rabbits a study was made of the effect of carbidine on the CS defence reflexes in stimulation of the mesencephalic part of the reticular formation carbidine prevented the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of t... | 19|50 | conditioned|reticular |
it was shown in acute experiments on rats that one hour after an intraperitoneal injection of theophylline mgkg there was a decrease in the nad nadp content by a tendency to a fall of nadh nadph was expressed and the total nicotinamide coferment level was reduced a tendency to decrease nad nadp and the total pyridine n... | 99 | oxidized |
drinking water supplies of rural communities in georgetown county south carolina were randomly selected for sample collection the analysis showed that most of the waters were slightly acidic low but acceptable concentrations of chloride copper fluoride sodium cadmium nitrate and phosphate were found a few water samples... | 70|122 | arsenic|quality |
this T0 has investigated the relationship between duodenogastric reflux gastritis and certain PS months T3 three operations for uncomplicated duodenal ulcer the operations studied were proximal gastric vagotomy pgv cases TV and pyloroplasty tvp cases and TV and antrectomy tva cases duodenogastric reflux was assessed bo... | 1|12|14|30|36|76|99|138|169 | study|symptoms|after|truncal vagotomy|truncal vagotomy|symptoms|superficial gastritis|operation|intact |
a new haemoglobin with increased oxygen affinity beta ef lysine leads to threonine hb rahere was found during the investigation of a patient who was found to have a raised haemoglobin concentration after a routine blood count the substitution affects one of the 2,3-DPG IB sites resulting in an increased affinity for ox... | 43|44|78|118 | diphosphoglycerate|binding|electrophoresis|plasma volume |
the actions of glycine gaba alphaalanine betaalanine and taurine were studied by intracellular recordings from lumbar MNs of the isolated spinal cord of the frog all amino acids tested produced a reduction in the amplitude of postsynaptic potentials a blockade of the antidromic action potential and an increase of Gm fu... | 16|49|70|103|113 | motoneurons|membrane conductance|inhibitory|picrotoxin|inhibitory |
crude synaptosomal fractions p derived from guineapig cerebral SC were incubated in the presence of mm kcl in a krebsglucose medium torpedo marmorata electric organs were stimulated electrically in vivo at pulsessec for min by electrodes placed on the electric lobe SVs were isolated from each source and the phospholipi... | 8|41|123|137|176|217|252 | cortex|synaptic vesicles|electric organ|crude synaptosomal|cerebral|synaptic vesicles|after |
the effects of acidbase changes on cardiac output during diethyl ether anaesthesia were studied in mongrel dogs prepared by surgically implanting a plastic encased nonferrous core EM probe on the ascending aorta the findings are metabolic acidaemia produced only slight decrease in cardiac output but a more marked fall ... | 26|68 | electromagnetic|output |
many eyes donated for use in corneal grafting are rejected because of signs of autolysis in the donor material the purpose of this experimental study was to determine whether hydrocortisone acting as a lysosome membrane stabilizer could prevent or retard autolysis of the corneas under storage and if so what was the mos... | 58|86 | rabbit|after |
mock cerebrospinal fluid ph or dinitrophenol dnp mg was injected into the subarachnoid space of the ventral brain stem of exteriorized fetal sheep changes in ph on the ventral surface of the medulla did not stimulate respiratory efforts or induce significant cardiovascular changes the respiratory response to dnp inject... | 62|134|135 | peripheral|secondary|change |
axenic washed conidia of fusarium solani f sp phaseoli aspergillus flavus and verticillium alboatrum were placed on washed difco purified agar discs along with an inorganic salt solution containing various levels of carbon and nitrogen substrates these discs were exposed to volatiles from six soils ph fusarium solani m... | 102 | amino acid |
earlier work showed that escherichia coli contains at least two enzymes which reduce NF and other nitrofuran derivatives one of these enzymes is lacking in some nitrofurazoneresistant mutant strains we now report that there are three separable nitrofuran reductases in this organism reductase i mol wt approximately inse... | 13|141 | nitrofurazone|nitrofurazone |
the mixture of PSs in the gelling component of agar agarose is hydrolyzed to dgalactose and anhydrolgalactose by a series of hydrolytic enzymes obtained from pseudomonas atlantica the final degradative step in the pathway of agarose decomposition is the hydrolysis of the alphalinkage in the dissaccharide neoagarobiose ... | 3 | polysaccharides |
significant differences in amylase betaglucosidase and phosphatase activities were observed among four phytophthora cinnamomi isolates grown in nutrientamended sterilized soil for days amylase ph optima for the four isolates were within a relatively narrow range at ph each isolate was within of its peak activity isolat... | 83|118 | activities|activities |
an intracellular invertase was induced in cultures of clostridium pasteurianum utilizing sucrose as its carbon source for growth this enzyme synthesis could be repressed by the addition of fructose of a sucrosegrowing culture in contrast invertase activity was not affected by the addition of glucose to sucrosegrowing c... | 89|100|136 | sucrose|invertase|groups |
the adenosinetriphosphatase atpase ec activity in azotobacter vinelandii concentrates in the membranous r fraction that is directly associated with azotobacter electron transport CF sonically disrupted azotobacter cells were examined for distribution of atpase activity and the highest specific activity and activity uni... | 22|93|96|258|291 | function|assay|maximal activity|assay|functional |
within km of a zinc zn smelter in palmerton PA near the lehigh water gap up to zn by weight has been measured in the o horizon of the soil and up to zn in the a horizon the total numbers of bacteria actinomycetes and fungi measured by dilution plate counts were greatly reduced in the most severely zncontaminated soils ... | 9 | pennsylvania |
the effect of feeding a relatively lowprotein diet containing dab for weeks on the activity of dabazoreductase nitroreductase pnitrobenzoic acid noxidase nndimethylaniline ndemethylase dab cytochrome p nadphcytochrome c reductase betaglucuronidase and arylsulphatase a were studied rapid decreases occurred in the activi... | 82|159|180|251 | cb|activities|feeding|pretreatment |
the system involved in the reduction of dibromopropyl aminophenylazolbenzoic acid B6 an agent designed for treating primary CL cell cancer has been demonstrated to be localised mainly in the x g supernatant fraction of rat liver TH it is also present in other organs particularly in the SP dabazoreductase as shown previ... | 10|17|36|47|101|116|168 | cb|liver|homogenate|spleen|dihydrofolate|pretreatment|cb |
subcutaneous or IA injections of mg of hgcl g body weight markedly depressed hepatic fatty acid synthetase activity of chicks at h postinjection the depression occurred despite the fact that the chicks continued to eat up until the time they were killed under these same conditions the hepatic activity of acetylcoa carb... | 2|81|110|117|143|195 | intraabdominal|highly purified|enzyme activity|fatty acid synthetase|complete|fatty acid synthetase |
we have observed a high and significant mortality in SH rats compared to normotensive and hypotensive controls in the fifth generation the hypertensive rats exhibited a high frequency of cerebral haemorrhage and periarteritis nodosa | 9 | spontaneously hypertensive |
the influence of the sympathetic nervous system on the cerebral circulatory response to graded reductions in mean arterial blood pressure was studied in anesthetized baboons cerebral blood flow was measured by the xe clearance method and arterial blood pressure was decreased by controlled hemorrhage in normal baboons t... | 67|108|119|151|173|181 | cerebral|cerebral|cerebral|cerebral|hemorrhagic hypotension|cerebral |
an isolated perfused canine lung preparation in which determinants of vascular caliber could be individually controlled was developed the relation of pulmonary arterial pa A-V pv and alveolar pa pressures was such that pa greater than pa greater than pv throughout the whole lung the addition of isoprenaline to the perf... | 24|113|135|175 | venous|arterial blood gas|lactic acidosis|lactic acidosis |
the interaction of chemoreflex and pulmonary inflation reflex control of the coronary circulation was examined in conscious dogs by comparing the responses to chemoreflex stimulation intracarotid injection of nicotine when ventilation was allowed to increase with those when ventilation was controlled the responses were... | 58|63|81|130|134|144|209 | heart|administered|coronary flow|after|cholinergic|carotid sinus|identical |
the rate of coronary blood flow was varied in isolated working rat heart preparations to determine its influence on the rate of glocose utilization tissue highenergy phosphates and intracellular ph a reduction in coronary blood flow resulted in a reduction in oxygen consumption an accelerated rate of glusoe utilization... | 75|92|113 | peak systolic pressure|levels|ventricular |
the mechanisms of glycolytic inhibition in ICM myocardium were investigated in the isolated perfused rat heart glycolysis was inhibited at the level of G3P dehydrogenase the major factors that accounted for the glycolytic inhibition in the ischemic heart compared with the anoxic heart appeared to be higher tissue level... | 6|23|172 | ischemic|glyceraldehydephosphate|major |
this study compared the contractile performance of a canine RA atrial trabecula with that of a macroscopically indistinguishable trabecula isolated from the RVA the heart was removed from nine mongrel puppies weighing kg and placed in krebsringers bicarbonate solution the bathing solution contained only mmoles of ca an... | 9|22|87|106|168|247 | right|right ventricular apex|developed tension|right|ventricular|right |
the LDH of sera from patients suffering myocardial infarction and of sera from patients with hepatocellular damage was assayed under optimal conditions using pyruvate alphaoxobutyrate hydroxypyruvate and glyoxylate as substrates activity was also measured with lactate as substrate at different ph values the ratios of a... | 1|49 | lactate dehydrogenase activity|assay |
we describe a simple rapid fluorometric assay for separate quantitative analysis of procainamide and nacetylprocainamide in mixtures the effective lenear range fluorescence vs concentration in serum is to mgliter regardless of the ratio by weight of the two drugs from to analytical recoveries by the extraction method u... | 60 | variation |
in this method blood is collected in ammonium heparinized microhematocrit tubes and lactate is directly determined in the plasma separated within min from the erythrocytes lactate is assayed by mixing mul of sample with nad and lactate dehydrogenase in trishydroxymethylaminomethane Hz buffer the rate of increase in abs... | 40 | hydrazine |
highvoltage paper PACE of small samples of serum and urine at ph resolves basic and acidic amino acids and separates them from the NAA for separation and ID of the neutral amino acids the appropriate area of the electrophoretogram is cut out sewn onto a second sheet of paper and rerun at ph by this method amino acids a... | 2|23|27|80|84 | electrophoresis|neutral amino acids|identification|staining|amino acid |
a simple highly sensitive and reproducible method for the assay of gammaglutamyl transpeptidase ec activity is introduced using gammaglutamylpnitroanilide as a ATP and glycylglycine as an acceptor in gl of polyoxyethylene nonylphenol SS transpeptidase activity was assayed in healthy adults the normal mean value being m... | 21|32 | substrate|serum |
there are different types of renal hypertension hypertension due to parenchymal renal disease renovascular hypertension hypertension due to urological disease hypertension of endstage renal disease treatment has to considerabove allthe possibility of TPS medical or surgical procedures that may cause the underlying cond... | 32 | specific |
some effects of sodium salicylate upon anaerobic glycolysis have been studied in normal human erythrocytes incubated for up to h at degrees c in autologous sera both glucose consumption and lactate production were stimulated by concentrations of salicylate up to mmoll but at the highest concentration used mmoll an init... | 50 | stimulus |
we measured the minute ventilation and arterial blood catecholamine concentrations in four normal men standing and at two C2 of moderate treadmill exercise breathing oxygen or air minute ventilation was significantly higher during hypoxic exercise than during normoxic exercise at an oxygen uptake of mlmin arterial plas... | 18|64 | levels|plasma noradrenaline |
clinical impressions about the problem of defibrillation during states of acidbase imbalance and hypoxia have been influenced by studies involving the effect of these derangements on the VFT based on body weight energy requirements for defibrillation in normal dogs were compared to requirements in dogs subjected to com... | 27|66|72|74 | ventricular fibrillation threshold|study|levels|energy |
a patient with aortitis syndrome had a pleural effusion which subsided but reappeared with an exacerbation of aortitis PS while under antituberculosis treatment the character of the fluid was that of an exudate and the glucose concentration was normal clinical and laboratory features of the case suggest that the effusi... | 18 | symptoms |
the apparent isoelectric points pi in isoelectric focusing if of human pituitary and amniotic fluid prolactin hprl both noniodinated and iodinated were determined unresolved mixtures of PIT hprl isohormones e and f and of at least five isohormones found in amniotic fluid and plasma hprl exhibit an average pi value of t... | 26|66|74|119 | pituitary|after|major|major |
the feasibility of using isoelectric focusing for the separation of primate pituitary growth hormone from prolactin and for the characterization of polymorphic forms of these hormones was explored in a ph gradient extracts of both human and cynomolgus monkey pituitaries were each resolved into growth hormone components... | 135|211 | pituitary|preparations |
certain climatic and edaphic conformations in the bavarian subalpine mountains and in the alps favor above all the development of a land utilization system and farm structures similar to those in the northern part of scandinavia in the years of the highest environmental contamination up to the present we established in... | 95 | feeding |
both udpglucuronyltransferase gt and betaglucuronidase betag were assayed in untreated liver microsomes optimum assay conditions were established with rat CL microsomes using pnitrophenol pnp and its glucuronide pnpga at the ph optima of gt and betag the MICs of the two enzymes were compared using microsomes from rats ... | 19|37|59|101|130|184 | liver|activities|substrate|identical|functional|liver |
SS CL and renal gammaglutamyl transpeptidase ggt activities were studied in four groups of rabbits controls rabbits with obstructive extrahepatic cholestasis rabbits with obstructive anuria and animals with combined obstructive extrahepatic cholestasis and obstructive anuria SS ggt was essentially increased in rabbits ... | 0|1|35|131 | serum|liver|serum|serum |
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