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An approach to quantify the dependence of economy on resource efficiency: A case study in Beijing-Tianjin-Hebei region of north China. The improvements of resource efficiency are crucial for economic development of a city. Currently, the variations of utilization efficiency of ecological resources have been studied muc...
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Experiences of care coordination among older adults in the United States: Evidence from the Health and Retirement Study. The goal of this study was to examine variation in patient experiences and perceptions of care coordination across sociodemographic and health factors.
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Natural Products for the Treatment of Neurodegenerative Diseases. Neurodegenerative diseases are a heterogeneous group of disorders characterized by the progressive degeneration of the structure and function of the central nervous system or peripheral nervous system. Alzheimer's Disease (AD), Parkinson's Disease (PD) a...
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Mechanical dyssynchrony and diastolic dysfunction are common in LVH: a pilot correlation study using Doppler echocardiography and CZT gated-SPECT MPI. Hypertrophic cardiomyopathy (HCM) is an often under-diagnosed cause of left ventricular hypertrophy (LVH). It affects 1/500 of the population, is the most commonly inher...
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Removal of methylene blue via bioinspired catecholamine/starch superadsorbent and the efficiency prediction by response surface methodology and artificial neural network-particle swarm optimization. This paper demonstrates coupling of the artificial neural network (ANN) technique with the particle swarm optimization (P...
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Engaging Patients in Decision-Making and Behavior Change to Promote Prevention. Effectively engaging patients in their care is essential to improve health outcomes, improve satisfaction with the care experience, reduce costs, and even benefit the clinician experience. This chapter will address the topic of patient enga...
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New data about the 21st Century Identified Skeletal Collection (University of Coimbra, Portugal). After the publication of the first article in 2014, 21st Century Identified Skeletal Collection, housed in the Laboratory of Forensic Anthropology, Department of Life Sciences at the University of Coimbra, Portugal, has be...
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Considerable variability in antibiotic use among US children's hospitals in 2017-2018. To characterize the prevalence of and seasonal and regional variation in inpatient antibiotic use among hospitalized US children in 2017-2018.
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[Effects of microbial fertilizer on soil improvement and fruit quality of kiwifruit in old orchard.]. The continuous cropping obstacles caused by the increase of kiwifruit planting period resulted in imbalance of soil microbial community structure, and decrease of soil enzyme activity and physicochemical indicators, wh...
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Differential effects of working memory load on priming and recognition of real images. Several studies have explored the effects of divided attention on priming, but little is known about the impact of working memory load on implicit visual memory. The aim of this study was to determine whether there are differential e...
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What strategies do desk-based workers choose to reduce sitting time and how well do they work? Findings from a cluster randomised controlled trial. Large amounts of sitting at work have been identified as an emerging occupational health risk, and findings from intervention trials have been reported. However, few such r...
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Household Food Insecurity in Early Adolescence and Risk of Subsequent Behavior Problems: Does a Connection Persist Over Time? Household food insecurity is common among U.S. families, and adolescents are almost twice as likely as school-aged children to be food insecure. However, little is known about how household food...
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Influence of Divalent Counterions on the Dynamics in DNA as Probed by Using a Minor-Groove Binder. DNA dynamics, to which water, counterions, and DNA motions contribute, is a topic of considerable interest because it is closely related to the efficiency of biological functions performed by it. Simulation studies and ex...
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The case of encephalitis in a COVID-19 pediatric patient. The COVID-19 pandemic, induced by the worldwide spreading of the SARS-CoV-2, is well known for its clinical picture consistent with respiratory symptoms. If pulmonary complications are the most common manifestation of the disease, neurological problems are also ...
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Effects of selected rehabilitative exercises on external rotator muscles and trapezius muscles of masonry workers. Masonry workers engaged in occupational work-activities have high risk of shoulder injury that often develops to functional loss and disability. Rehabilitative exercises (REs) have potential for slowing th...
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Skin concerns in patients with trisomy 21 (Down syndrome): A Mayo Clinic 22-year retrospective review. Trisomy 21 has known associated clinical phenotypes, including skin and soft tissue concerns. However, the overall prevalence and types of findings are largely unclear.
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Arthroscopic and Endoscopic Treatment of Proximal Rectus Femoris Avulsion. Proximal rectus femoris avulsion (PRFA) is an uncommon injury that is poorly reported in the literature. Historically, these injuries have been treated nonoperatively or with open techniques. This is the first study showing endoscopic treatment ...
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Is feyerabendian philosophy relevant for scientific knowledge development in nursing? To revitalize nursing science, there is a need for a new approach to guide nurse scientists in addressing complex problems in health care. By applying theoretical concepts from a revolutionary philosopher of science, Paul K. Feyeraben...
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Recognition method of construction conflict based on driver's eye movement. Drivers eye movement data in simulated construction conflicts at different speeds were collected and analyzed to find the relationship between the drivers' eye movement and the construction conflict. On the basis of the relationship between the...
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Pterins as diagnostic markers of exercise-induced stress: a systematic review. To evaluate pterins as diagnostic biomarkers of exercise-induced stress.
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Changes in socio-economic level and their impact on nutritional status: a follow-up study among young Chilean adults. To verify the association between changes in socio-economic level (SEL) and nutritional status of Chilean adults over a 10-year period.
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A comprehensive review on freshness of fish and assessment: Analytical methods and recent innovations. Fish, a highly nutritious, containing a good amount of protein and fatty acids, has TMA and TVB-N present as major factors responsible for quality deterioration during storage and maintaining of fish freshness. Freshn...
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A High-Fat High-Fructose Diet Dysregulates the Homeostatic Crosstalk Between Gut Microbiome, Metabolome, and Immunity in an Experimental Model of Obesity. Ample evidence supports the prominent role of gut-liver axis in perpetuating pathological networks of high-fat high-fructose (HFF) diet induced metabolic disorders, ...
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Student evaluations of teaching (SET): implications for medical education in psychiatry and an approach to evaluating SET and student performance. We present reflections on student evaluation of teaching (SET) in the context of recent higher educational research that assesses SET, as well as concurrent and/or subsequen...
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Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform. Current drug development techniques are expensive and inefficient, partially due to the use of preclinical models that do not accurately recapitulate in vivo drug efficacy and cytotoxicity. To addr...
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Signaling-to-chromatin pathways in the immune system. Complex organisms are able to respond to diverse environmental cues by rapidly inducing specific transcriptional programs comprising a few dozen genes among thousands. The highly complex environment within the nucleus-a crowded milieu containing large genomes tightl...
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Improved efficacy and safety of low-dose oxaliplatin/pegylated liposomal doxorubicin/S-1 regimen in advanced gastric cancer: a cohort study. Dose-limiting neurotoxicity is the major side effect caused by oxaliplatin treatment. Optimization of oxaliplatin-containing chemotherapeutic regimens may potentially benefit adva...
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Anatomic study of fibrous structures attached to the volar ulnar corner of the radius: implications in the volar rim fracture. This study aimed to clarify the bone and soft tissue morphological features at the volar ulnar corner of the radius. Micro-computed tomography, macroscopic and histological analyses were conduc...
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The effect of speed limit reductions in urban areas on cyclists' injuries in collisions with cars. Objective: Impact speed is one of the most important factors explaining the severity of injuries to cyclists when they collide with passenger cars. To reduce injury severity (especially for vulnerable road users), since 2...
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Surgery Versus Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for Large Polyps: Making Sense of When to Use Which Approach. Endoscopic resection for large colorectal lesion is effective and cost-saving than surgery. Piecemeal resections are often effective if applied meticulously but endoscopic su...
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Correlation between osteoarthritis of the atlantoaxial facet joint and a high-riding vertebral artery. A high-riding vertebral artery (HRVA) is an intraosseous anomaly that narrows the trajectory for C2 pedicle screws. The prevalence of a HRVA is high in patients who need surgery at the craniovertebral junction, but re...
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Esophageal Button Battery in the Pediatric Population: Experience from a Tertiary Care Center. To highlight different patterns of clinical presentation, share authors' experience in the management of children following button battery ingestion and their outcomes.
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Versatility of buccinator flaps for the treatment of palatal defects: a series of cases. The buccinator flap is currently one of the best techniques for the reconstruction of defects in the oral cavity and other sites. Reconstruction of the palate is a major challenge because of the functional consequences of the excis...
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Nanoparticle-mediated histotripsy (NMH) using perfluorohexane 'nanocones'. Nanoparticle-mediated histotripsy (NMH) is an ultrasound treatment strategy that combines acoustically sensitive nanoparticles with histotripsy. Previous NMH studies using perfluorocarbon (PFC) nanodroplets (ND's), ~200 nm in diameter, demonstra...
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Properties of natural rubber reinforced with cellulose nanofibers based on fiber diameter distribution as estimated by differential centrifugal sedimentation. Cellulose nanofibers (CNFs) with different degrees of fibrillation are prepared by the mechanical fibrillation of kraft pulp using wet disk milling, and dispersi...
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[Stress Echocardiography in the Assessment of Long-Term Outcomes After Percutaneous Coronary Intervention in Patients With Stable Coronary Heart Disease]. To study the possibilities of stress echocardiography (EchoCG) in the assessment of clinical state of patients after percutaneous coronary intervention (PCI).
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Characterization of Thrombospondin Type 1 Repeat in Haliotis diversicolor and Its Possible Role in Osteoinduction. Thrombospondin repeats (TSR) are important peptide domains present in the sequences of many extracellular and transmembrane proteins with which a variety of ligands interact. In this study, we characterize...
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Knockdown of LncRNA MALAT1 contributes to cell apoptosis via regulating NF-κB/CD80 axis in neonatal respiratory distress syndrome. Neonatal respiratory distress syndrome (NRDS) is a leading cause of morbidity in premature newborns and is a common reason for admission to the neonatal intensive care unit (NICU). Recent s...
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Biomarkers to Predict Cardiovascular Death. This article reviews biomarkers that have been shown to identify subjects at increased risk for cardiovascular death within the general population, in those with established coronary artery disease, and in those with heart failure. Use of biomarkers for risk stratification fo...
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[DICER1 mutated, solid/trabecular thyroid papillary carcinoma in an 11-year-old child]. We report the case of an 11-year-old patient diagnosed with a solid variant of papillary thyroid carcinoma. Papillary thyroid carcinoma (PTC) is the most common thyroid cancer, representing 80-90% of all newly diagnosed thyroid canc...
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Unusual mechanical processing of sounds at the apex of the Guinea pig cochlea. One of the tenets of mammalian auditory physiology is that the frequency selectivity at the cochlear base decreases as a function of stimulus level. Changes in frequency selectivity have been shown to be accompanied by changes in response ph...
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Lymphoscintigraphy of Chylous Anomalies: Chylothorax, Chyloperitoneum, Chyluria, and Lymphangiomatosis-15-Year Experience in a Pediatric Setting and Review of the Literature. In the pediatric setting, lymphoscintigraphy is used mostly for the evaluation of lymphedema. Only a few cases of chylous anomalies and lymphatic...
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Expanding Palliative Medicine across Care Settings: One Health System Experience. The success of our hospital-based Palliative Care program stimulated requests to duplicate the program across the health system continuum of care.
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Kinesio Taping in Dysphonic Patients. Kinesio taping (KT) is a method of elastic bandaging that produces a biomechanical effect on the organism. This study aims to evaluate its use in dysphonic patients tratment, as integrated part of speech therapy.
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Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate. Non-coding mutations may drive cancer development. Statistical detection of non-coding driver regions is challenged by a varying mutation rate and uncertainty of functional impact. Here, we develop a ...
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A worldwide epidemiological database for COVID-19 at fine-grained spatial resolution. This database provides the daily time-series of COVID-19 cases, deaths, recovered people, tests, vaccinations, and hospitalizations, for more than 230 countries, 760 regions, and 12,000 lower-level administrative divisions. The geogra...
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Value of CT to detect radiographically occult injuries of the proximal femur in elderly patients after low-energy trauma: determination of non-inferiority margins of CT in comparison with MRI. To determine the margins of non-inferiority of the sensitivity of CT and the sample size needed to test the non-inferiority of ...
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Mapping Risk of Malaria as a Function of Anthropic and Environmental Conditions in Sussundenga Village, Mozambique. Mozambique is a country in Southern Africa with around 30 million inhabitants. Malaria is the leading cause of mortality in the country. According to the WHO, Mozambique has the third highest number of ma...
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Effects of ethnicity on proximal femoral intramedullary nail protrusion-a 3D computer graphical analysis. Antegrade nailing of proximal femur or femoral shaft fractures is a proven treatment with good to excellent results. Nonetheless, clinical evidence from Asia indicates that proximal femur nails can be too proud at ...
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Physician death by suicide in the United States: 2012-2016. Reports of incidence of physician suicide in the United States (US) are outdated. The aims of this research were to assess incidence, methods, and associated risk factors of physicians compared to non-physicians in the general US population. Retrospective suic...
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[Habitat suitability index of larval Japanese Halfbeak (Hyporhamphus sajori) in Bohai Sea based on geographically weighted regression.]. To investigate the early supplementary processes of fishre sources in the Bohai Sea, the geographically weighted regression (GWR) was introduced to the habitat suitability index (HSI)...
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The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity. Synaptic vesicle (SV) release probability ( P r ) is a key presynaptic determinant of synaptic strength established by cell-intrinsic properties and further refined by plasticity. To characterize mec...
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Lung Cancer Screening Eligibility and Utilization Among Transgender Patients: An Analysis of the 2017-2018 United States Behavioral Risk Factor Surveillance System Survey. Transgender and gender diverse (TGD) persons disproportionately face many health disparities including a higher risk of lung cancer. Lung cancer scr...
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Wastewater treatment nexus: Carbon nanomaterials towards potential aquatic ecotoxicity. Carbon nanomaterials (CNMs) provide an effective solution and a novel advancement for wastewater treatment. In this review, a total of 3823 bibliographic records derived from recent 10 years are visualized based on scientometric ana...
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Skill acquisition is enhanced by reducing trial-to-trial repetition. Developing approaches to improve motor skill learning is of considerable interest across multiple disciplines. Previous research has typically shown that repeating the same action on consecutive trials enhances short-term performance but has detriment...
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Safety and efficacy of plasma exchange via direct femoral vein puncture in autoimmune blistering diseases. Plasma exchange (PE) is performed for patients with autoimmune blistering diseases by using multiple vascular access routes. We retrospectively examined the safety and the efficacy of PE using direct femoral vein ...
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Tolerance induction in hemophilia: innovation and accomplishments. Hemophilia is an X-linked blood coagulation genetic disorder, which can cause significant disability. Replacement therapy for coagulation factor VIII (hemophilia A) or factor IX (hemophilia B) may result in the development of high-affinity alloantibodie...
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[Influence of Pre-existing Cognitive Impairment on Rehabilitation Outcomes in Patients with Cerebral Infarction]. The present study determined the effects of pre-existing cognitive impairment (PreCI) on the rehabilitation outcomes in patients with cerebral infarction.
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Associations between school lunch consumption and urinary phthalate metabolite concentrations in US children and adolescents: Results from NHANES 2003-2014. Diet is a major route of phthalate exposure in humans due to use in food packaging materials. School lunches may be an important contributor to phthalate exposure ...
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Transcriptional Pausing as a Mediator of Bacterial Gene Regulation. Cellular life depends on transcription of DNA by RNA polymerase to express genetic information. RNA polymerase has evolved not just to read information from DNA and write it to RNA but also to sense and process information from the cellular and extrace...
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Pediatric oropharyngeal microbiome: Mapping in chronic tonsillitis and tonsillar hypertrophy. Aim of our study was to map the adenotonsillar lymphoid tissues' microbiome identifying its potential etiopathogenetic role in children affected by chronic tonsillitis or tonsillar hypertrophy with Obstructive Sleep Apnea Synd...
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Acute embolisms in multiple arterial districts following Ad26.COV2-S vaccine. A case of multiple arterial thrombosis/embolisms in a 74-year-old Caucasian man with no other cardiovascular risk factors who received Ad26.COV2-S vaccine 16 days before is reported. The unusual presentation required a longer diagnostic worku...
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Evidence-informed vaccination decision-making in countries: Progress, challenges and opportunities. Countries face an increasingly complex vaccination landscape. As well as ever-changing infectious disease epidemiology, the number and diversity of vaccine-preventable diseases, vaccine products, and vaccine technologies...
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MicroRNA-200c suppresses tumor metastasis in oral squamous carcinoma by inhibiting epithelial-mesenchymal transition. To examine the potential mechanisms implicating miR-200c and epithelial-mesenchymal transition (EMT) in oral squamous carcinoma (OSC).
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Ventricular geometry-regularized QRSd predicts cardiac resynchronization therapy response: machine learning from crosstalk between electrocardiography and echocardiography. Up to one-third of patients selected by current guidelines do not respond to cardiac resynchronization therapy (CRT), the aim of this study was to ...
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Mandibular incisor alignment in untreated subjects compared with long-term changes after orthodontic treatment with or without retainers. The aim of this work was to analyze the dental and skeletal changes in patients treated with fixed orthodontic appliances with or without retention appliances, and to compare the cha...
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CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy. Tisagenlecleucel, a chimeric antigen receptor (CAR) T-cell product targeting CD19 is approved for relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the impact of pretreatment vari...
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BET bromodomains' functions in bone-related pathologies. Throughout life, bones are subjected to the so-called 'bone-remodeling' process, which is a balanced mechanism between the apposition and the resorption of bone. This remodeling process depends on the activities of bone-specialized cells, namely the osteoblasts a...
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Operational Communications: Adapting a Hospital Daily Check-In (DCI) for Expanded Use During Emergency Events. Low-frequency, high-acuity emergency events can and do occur within health care settings. Having a strong sense of daily situational and operational awareness is the first step in responding to any emergency e...
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A Polygenic Risk Score of glutamatergic SNPs associated with schizophrenia predicts attentional behavior and related brain activity in healthy humans. Multiple genetic variations impact on risk for schizophrenia. Recent analyses by the Psychiatric Genomics Consortium (PGC2) identified 128 SNPs genome-wide associated wi...
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Hyperbaric oxygen therapy for the treatment of perianal fistulas in Crohn's disease (HOT-TOPIC): study protocol of a prospective interventional cohort study with one-year follow-up. Perianal fistulizing Crohn's disease (pCD) has a significant impact on patients' health and quality of life. Current treatment options hav...
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Increasing adult vaccinations at a regional supermarket chain pharmacy: A multi-site demonstration project. Millions of American adults do not receive the recommended vaccinations each year. Community pharmacies are well positioned to help fill this gap through easy access and innovative patient-centered interventions....
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A comparative study of remote sensing classification methods for monitoring and assessing desert vegetation using a UAV-based multispectral sensor. Restoration programs require long-term monitoring and assessment of vegetation growth and productivity. Remote sensing technology is considered to be one of the most powerf...
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Significant alteration of liver metabolites by AAV8.Urocortin 2 gene transfer in mice with insulin resistance. Urocortin 2 (Ucn2) is a 38-amino acid peptide of the corticotropin-releasing factor family. Intravenous (IV) delivery of an adeno-associated virus vector serotype 8 encoding Ucn2 (AAV8.Ucn2) increases insulin ...
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Gait-combined transcranial alternating current stimulation modulates cortical control of muscle activities during gait. Non-invasive brain stimulation has been of interest as a therapeutic tool to modulate cortical excitability. However, there is little evidence that oscillatory brain stimulation can modulate the corti...
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Clinical problem solving and social determinants of health: a descriptive study using unannounced standardized patients to directly observe how resident physicians respond to social determinants of health. Objectives While the need to address patients' social determinants of health (SDoH) is widely recognized, less is ...
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Detection and segmentation of morphologically complex eukaryotic cells in fluorescence microscopy images via feature pyramid fusion. Detection and segmentation of macrophage cells in fluorescence microscopy images is a challenging problem, mainly due to crowded cells, variation in shapes, and morphological complexity. ...
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Synergistic effects of combined therapy with transcranial photobiomodulation and enriched environment on depressive- and anxiety-like behaviors in a mice model of noise stress. The development of anxiety and depression due to chronic exposure to noise stress has remained as an unsolved health problem so far. Despite th...
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piR-001773 and piR-017184 promote prostate cancer progression by interacting with PCDH9. Prostate cancer is one of the most common malignancies and the major cause of cancer-related death in men. Increasing evidence has revealed that P-element-induced wimpy (piwi)-interacting RNAs (piRNAs) play an important role in tum...
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[Significance of the expression of proliferating cell nuclear antigen and P53 in the regeneration process of an atrophic parotid gland]. This research aims to further explore the expression and significance of proliferating cell nuclear antigen (PCNA) and P53 in regenerating rat atrophy parotid gland from the gene and ...
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Sex Differences in Rupture Risk and Mortality in Untreated Patients With Intact Abdominal Aortic Aneurysms. Background Studies on intact abdominal aortic aneurysms mainly focus on treated patients, and data on untreated patients are sparse. The objective was to investigate sex differences among untreated patients regar...
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Shared decision making for elective abdominal aortic aneurysm surgery. Decisions on how and when to treat an abdominal aortic aneurysm involve a number of clinicians; interventional radiologists and vascular surgeons assess the technical ability to repair the aneurysm. Patients' fitness and past medical history is asse...
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