prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of OSTC in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | OSTC | cell proliferation | Neuroblastoma Cell Line | Gene: OSTC (oligosaccharyltransferase complex non-catalytic subunit)
Type: protein-coding
Summary: Predicted to contribute to dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase ... |
Does Knockout of NAA15 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | NAA15 | cell proliferation | Monocytic Leukemia Cell Line | Gene: NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit)
Type: protein-coding
Summary: N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino grou... |
Does Knockout of PCDHB4 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | PCDHB4 | cell proliferation | Colonic Cancer Cell Line | Gene: PCDHB4 (protocadherin beta 4)
Type: protein-coding
Summary: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell recept... |
Does Knockout of HCCS in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | HCCS | cell proliferation | Colonic Cancer Cell Line | Gene: HCCS (holocytochrome c synthase)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the sa... |
Does Knockout of TIMELESS in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | TIMELESS | cell proliferation | Gastric Cancer Cell Line | Gene: TIMELESS (timeless circadian regulator)
Type: protein-coding
Summary: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The en... |
Does Knockout of HMGCL in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | HMGCL | cell proliferation | Melanoma Cell Line | Gene: HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene a... |
Does Knockout of UBR5 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | UBR5 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: UBR5 (ubiquitin protein ligase E3 component n-recognin 5)
Type: protein-coding
Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific prote... |
Does Knockout of TERF1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | TERF1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: TERF1 (telomeric repeat binding factor 1)
Type: protein-coding
Summary: This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in ci... |
Does Knockout of KRTAP5-7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | KRTAP5-7 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: KRTAP5-7 (keratin associated protein 5-7)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: Q6L... |
Does Knockout of KRT39 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | KRT39 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: KRT39 (keratin 39)
Type: protein-coding
Summary: This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along ... |
Does Knockout of RPS13 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | RPS13 | cell proliferation | Gastric Cancer Cell Line | Gene: RPS13 (ribosomal protein S13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of TSPYL5 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | TSPYL5 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: TSPYL5 (TSPY like 5)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity and histone binding activity. Involved in several processes, including cellular response to gamma radiation; positive regulation of protein kinase B signaling; and positive regulation of protein ubiqu... |
Does Knockout of MED4 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | MED4 | cell proliferation | Neuroblastoma Cell Line | Gene: MED4 (mediator complex subunit 4)
Type: protein-coding
Summary: This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encod... |
Does Knockout of COL4A4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | COL4A4 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: COL4A4 (collagen type IV alpha 4 chain)
Type: protein-coding
Summary: This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other m... |
Does Knockout of TET2 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | TET2 | cell proliferation | Glioblastoma Cell Line | Gene: TET2 (tet methylcytosine dioxygenase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been ass... |
Does Knockout of SLC39A12 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | SLC39A12 | response to chemicals | Glioblastoma Cell Line | Gene: SLC39A12 (solute carrier family 39 member 12)
Type: protein-coding
Summary: Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation.... |
Does Knockout of WDR17 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | WDR17 | cell proliferation | Gastric Cancer Cell Line | Gene: WDR17 (WD repeat domain 17)
Type: protein-coding
Summary: This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided... |
Does Knockout of NEK8 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | NEK8 | cell proliferation | Gastric Cancer Cell Line | Gene: NEK8 (NIMA related kinase 8)
Type: protein-coding
Summary: This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in th... |
Does Knockout of JAGN1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | JAGN1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: JAGN1 (jagunal vesicle mediated transporter 1)
Type: protein-coding
Summary: The protein encoded by this gene is a transmembrane protein. It functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Mutations in this gene result in severe congenital neu... |
Does Knockout of RSPH10B in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | RSPH10B | response to chemicals | Glioblastoma Cell Line | Gene: RSPH10B (radial spoke head 10 homolog B)
Type: protein-coding
Summary: Predicted to enable kinase activity. Located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: 9+2 motile cilium, cell projection, cilium, cytoplasm, cytoskeleton, motile ciliu... |
Does Knockout of ANAPC13 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | ANAPC13 | cell proliferation | Ovarian Cancer Cell Line | Gene: ANAPC13 (anaphase promoting complex subunit 13)
Type: protein-coding
Summary: This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The en... |
Does Knockout of RGS14 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | RGS14 | cell proliferation | Melanoma Cell Line | Gene: RGS14 (regulator of G protein signaling 14)
Type: protein-coding
Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity o... |
Does Knockout of RELT in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | RELT | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: RELT (RELT TNF receptor)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor ... |
Does Knockout of SRRD in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | SRRD | cell proliferation | Monocytic Leukemia Cell Line | Gene: SRRD (SRR1 domain containing)
Type: protein-coding
Summary: Predicted to be involved in microtubule-based process; regulation of circadian rhythm; and regulation of heme biosynthetic process. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of PDCD7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | PDCD7 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PDCD7 (programmed cell death 7)
Type: protein-coding
Summary: This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provid... |
Does Knockout of PYURF in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | PYURF | response to chemicals | Monocytic Leukemia Cell Line | Gene: PYURF (PIGY upstream open reading frame)
Type: protein-coding
Summary: The product of this gene, which is well-conserved, is encoded by the same bicistronic transcript that encodes phosphatidylinositol glycan anchor biosynthesis, class Y, but the two proteins are unrelated. This gene represents th... |
Does Knockout of GGPS1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | GGPS1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: GGPS1 (geranylgeranyl diphosphate synthase 1)
Type: protein-coding
Summary: This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl dip... |
Does Knockout of CLRN1 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | CLRN1 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: CLRN1 (clarin 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The encoded protein may be important in development and homeosta... |
Does Knockout of APOA4 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | APOA4 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: APOA4 (apolipoprotein A4)
Type: protein-coding
Summary: Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processin... |
Does Knockout of GTF2H3 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | GTF2H3 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: GTF2H3 (general transcription factor IIH subunit 3)
Type: protein-coding
Summary: This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA p... |
Does Knockout of TREML4 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | TREML4 | cell proliferation | Endometrial Cancer Cell Line | Gene: TREML4 (triggering receptor expressed on myeloid cells like 4)
Type: protein-coding
Summary: Predicted to enable signaling receptor activity. Involved in positive regulation of toll-like receptor 7 signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell ... |
Does Knockout of FAM25G in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | FAM25G | response to virus | Cervical Adenocarcinoma Cell Line | Gene: FAM25G (family with sequence similarity 25 member G)
Type: protein-coding
Summary: family with sequence similarity 25 member G
Gene Ontology:
Pathways:
UniProt: B3EWG5, B3EWG3, B3EWG6
Entrez ID: 100133093 |
Does Knockout of RPL28 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | RPL28 | cell proliferation | Breast Cancer Cell Line | Gene: RPL28 (ribosomal protein L28)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of HBM in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | HBM | response to virus | Cervical Adenocarcinoma Cell Line | Gene: HBM (hemoglobin subunit mu)
Type: protein-coding
Summary: The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. This gene has an ORF encoding a 141 aa polypeptide which is... |
Does Knockout of RTCB in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | RTCB | cell proliferation | Multiple Myeloma Cell Line | Gene: RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Type: protein-coding
Summary: Enables RNA ligase (ATP) activity and vinculin binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Located in cytosol and nucleoplasm. Part of tRNA-splicing ligase complex. [provide... |
Does Knockout of KRTAP5-1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | KRTAP5-1 | cell proliferation | Endometrial Cancer Cell Line | Gene: KRTAP5-1 (keratin associated protein 5-1)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization, Vitamin D Receptor P... |
Does Knockout of HNRNPL in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | HNRNPL | cell proliferation | Mammary Gland Tumor Cell Line | Gene: HNRNPL (heterogeneous nuclear ribonucleoprotein L)
Type: protein-coding
Summary: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotei... |
Does Knockout of PCDHGC4 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | PCDHGC4 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: PCDHGC4 (protocadherin gamma subfamily C, 4)
Type: protein-coding
Summary: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanis... |
Does Knockout of NDUFA8 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | NDUFA8 | cell proliferation | Gastric Cancer Cell Line | Gene: NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It p... |
Does Knockout of SNIP1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | SNIP1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: SNIP1 (Smad nuclear interacting protein 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transfor... |
Does Knockout of MYBBP1A in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | MYBBP1A | cell proliferation | Breast Cancer Cell Line | Gene: MYBBP1A (MYB binding protein 1a)
Type: protein-coding
Summary: This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including... |
Does Knockout of RPL36 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | RPL36 | cell proliferation | Medulloblastoma Cell Line | Gene: RPL36 (ribosomal protein L36)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of COL11A1 in Cancer Cell Line causally result in cell proliferation? | 0 | 193 | Knockout | COL11A1 | cell proliferation | Cancer Cell Line | Gene: COL11A1 (collagen type XI alpha 1 chain)
Type: protein-coding
Summary: This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in ... |
Does Knockout of PKM in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | PKM | cell proliferation | Medulloblastoma Cell Line | Gene: PKM (pyruvate kinase M1/2)
Type: protein-coding
Summary: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to inter... |
Does Knockout of MBD3L3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | MBD3L3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: MBD3L3 (methyl-CpG binding domain protein 3 like 3)
Type: protein-coding
Summary: Predicted to enable methyl-CpG binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of transcription by RNA polymerase II. Predicted t... |
Does Knockout of AMBN in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | AMBN | cell proliferation | Cancer Cell Line | Gene: AMBN (ameloblastin)
Type: protein-coding
Summary: This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mut... |
Does Knockout of SRSF10 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | SRSF10 | cell proliferation | Multiple Myeloma Cell Line | Gene: SRSF10 (serine and arginine rich splicing factor 10)
Type: protein-coding
Summary: This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motif... |
Does Knockout of PPP2CA in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | PPP2CA | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PPP2CA (protein phosphatase 2 catalytic subunit alpha)
Type: protein-coding
Summary: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists o... |
Does Knockout of RPL17 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | RPL17 | cell proliferation | Monocytic Leukemia Cell Line | Gene: RPL17 (ribosomal protein L17)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of LIMK2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | LIMK2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: LIMK2 (LIM domain kinase 2)
Type: protein-coding
Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to D... |
Does Knockout of FZR1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | FZR1 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: FZR1 (fizzy and cell division cycle 20 related 1)
Type: protein-coding
Summary: Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in anaphase-promoting complex-dependent catabolic process; mitotic G2 DNA damage checkpoint signaling; a... |
Does Knockout of HMGA1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | HMGA1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: HMGA1 (high mobility group AT-hook 1)
Type: protein-coding
Summary: This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially bi... |
Does Knockout of ASCC3 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | ASCC3 | cell proliferation | Gastric Cancer Cell Line | Gene: ASCC3 (activating signal cointegrator 1 complex subunit 3)
Type: protein-coding
Summary: This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal ... |
Does Knockout of SEPHS2 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | SEPHS2 | cell proliferation | T-lymphoma cell line | Gene: SEPHS2 (selenophosphate synthetase 2)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into ... |
Does Knockout of ZNF713 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | ZNF713 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: ZNF713 (zinc finger protein 713)
Type: protein-coding
Summary: The protein encoded by this gene contains C2H2 zinc finger domains. In some individuals, a CGG-repeat expansion from 5-22 repeats to 68-450 repeats has been identified in the first intron of this gene. This mutation is thought to effec... |
Does Knockout of SS18L2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | SS18L2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SS18L2 (SS18 like 2)
Type: protein-coding
Summary: Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused i... |
Does Knockout of TIMMDC1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | TIMMDC1 | cell proliferation | Gastric Cancer Cell Line | Gene: TIMMDC1 (translocase of inner mitochondrial membrane domain containing 1)
Type: protein-coding
Summary: Located in mitochondrion and nucleoplasm. Implicated in nuclear type mitochondrial complex I deficiency 31. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membr... |
Does Knockout of INCENP in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | INCENP | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: INCENP (inner centromere protein)
Type: protein-coding
Summary: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive pro... |
Does Knockout of ST7L in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | ST7L | response to chemicals | Glioblastoma Cell Line | Gene: ST7L (suppression of tumorigenicity 7 like)
Type: protein-coding
Summary: This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted... |
Does Knockout of UTP20 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | UTP20 | cell proliferation | Medulloblastoma Cell Line | Gene: UTP20 (UTP20 small subunit processome component)
Type: protein-coding
Summary: UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009].
... |
Does Knockout of TNFSF11 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | TNFSF11 | response to virus | Hepatoma Cell Line | Gene: TNFSF11 (TNF superfamily member 11)
Type: protein-coding
Summary: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentriti... |
Does Activation of USP45 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | USP45 | protein/peptide accumulation | T cell | Gene: USP45 (ubiquitin specific peptidase 45)
Type: protein-coding
Summary: The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase act... |
Does Knockout of IL11 in Cancer Cell Line causally result in cell proliferation? | 0 | 193 | Knockout | IL11 | cell proliferation | Cancer Cell Line | Gene: IL11 (interleukin 11)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130)... |
Does Knockout of MFN2 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | MFN2 | cell proliferation | Ovarian Cancer Cell Line | Gene: MFN2 (mitofusin 2)
Type: protein-coding
Summary: This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell pro... |
Does Knockout of RAB1B in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | RAB1B | response to virus | Cervical Adenocarcinoma Cell Line | Gene: RAB1B (RAB1B, member RAS oncogene family)
Type: protein-coding
Summary: Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is esse... |
Does Knockout of TOPBP1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | TOPBP1 | cell proliferation | Colonic Cancer Cell Line | Gene: TOPBP1 (DNA topoisomerase II binding protein 1)
Type: protein-coding
Summary: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta th... |
Does Knockout of XRCC6 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | XRCC6 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: XRCC6 (X-ray repair cross complementing 6)
Type: protein-coding
Summary: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be... |
Does Knockout of YBEY in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | YBEY | cell proliferation | Ovarian Cancer Cell Line | Gene: YBEY (ybeY metalloendoribonuclease)
Type: protein-coding
Summary: This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple t... |
Does Knockout of COX4I1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | COX4I1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: COX4I1 (cytochrome c oxidase subunit 4I1)
Type: protein-coding
Summary: Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a p... |
Does Knockout of KCTD19 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | KCTD19 | response to virus | Lung Cancer Cell Line | Gene: KCTD19 (potassium channel tetramerization domain containing 19)
Type: protein-coding
Summary: Predicted to be involved in protein homooligomerization. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, male meiotic nuclear division, meiotic cell ... |
Does Activation of SYNGR3 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | SYNGR3 | protein/peptide accumulation | T cell | Gene: SYNGR3 (synaptogyrin 3)
Type: protein-coding
Summary: This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene pro... |
Does Knockout of PSMD8 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | PSMD8 | cell proliferation | Monocytic Leukemia Cell Line | Gene: PSMD8 (proteasome 26S subunit, non-ATPase 8)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings ar... |
Does Knockout of PSTPIP1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | PSTPIP1 | cell proliferation | Melanoma Cell Line | Gene: PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1)
Type: protein-coding
Summary: This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organizat... |
Does Knockout of BRI3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | BRI3 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: BRI3 (brain protein I3)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be located in azurophil granule membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: identical protein binding, protein binding; ... |
Does Knockout of GNPNAT1 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | GNPNAT1 | cell proliferation | Glioblastoma Cell Line | Gene: GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicte... |
Does Knockout of PRSS54 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | PRSS54 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: PRSS54 (serine protease 54)
Type: protein-coding
Summary: This gene encodes a putative serine-type endopeptidase containing the peptidase S1 domain. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: proteolysis; M... |
Does Knockout of ZBTB39 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | ZBTB39 | response to virus | Huh-7 Cell | Gene: ZBTB39 (zinc finger and BTB domain containing 39)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of... |
Does Knockout of ELOC in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | ELOC | cell proliferation | Cancer Cell Line | Gene: ELOC (elongin C)
Type: protein-coding
Summary: This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the poly... |
Does Knockout of SRP19 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | SRP19 | cell proliferation | Medulloblastoma Cell Line | Gene: SRP19 (signal recognition particle 19)
Type: protein-coding
Summary: Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal... |
Does Activation of SCAPER in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | SCAPER | protein/peptide accumulation | T cell | Gene: SCAPER (S-phase cyclin A associated protein in the ER)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: antral ovaria... |
Does Knockout of SUPV3L1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | SUPV3L1 | cell proliferation | Ovarian Cancer Cell Line | Gene: SUPV3L1 (Suv3 like RNA helicase)
Type: protein-coding
Summary: Enables helicase activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including mitochondrial RNA metabolic process; mitochondrion morphogenesis; and positive regulation of mito... |
Does Knockout of MIR3164 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | MIR3164 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: MIR3164 (microRNA 3164)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of ATL2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | ATL2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ATL2 (atlastin GTPase 2)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in Golgi organization; endoplasmic reticulum tubular network membrane organization; and protein homooligomerization. Located in endoplasmic reticulum tubular network membrane. Is integral co... |
Does Knockout of UBA5 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | UBA5 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: UBA5 (ubiquitin like modifier activating enzyme 5)
Type: protein-coding
Summary: This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy ... |
Does Knockout of FEM1A in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | FEM1A | cell proliferation | T-lymphoma cell line | Gene: FEM1A (fem-1 homolog A)
Type: protein-coding
Summary: Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule... |
Does Knockout of NOL12 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | NOL12 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: NOL12 (nucleolar protein 12)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, identical protein binding, protein binding, rRNA binding, single... |
Does Knockout of SPTSSB in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | SPTSSB | cell proliferation | Neuroblastoma Cell Line | Gene: SPTSSB (serine palmitoyltransferase small subunit B)
Type: protein-coding
Summary: Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA prefe... |
Does Knockout of PHF12 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | PHF12 | cell proliferation | Medulloblastoma Cell Line | Gene: PHF12 (PHD finger protein 12)
Type: protein-coding
Summary: Enables phosphatidylinositol binding activity and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. L... |
Does Knockout of ACTR10 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | ACTR10 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: ACTR10 (actin related protein 10)
Type: protein-coding
Summary: Predicted to be involved in retrograde axonal transport of mitochondrion. Predicted to be located in cytosol; extracellular region; and secretory granule. Predicted to be part of dynactin complex. [provided by Alliance of Genome Resou... |
Does Activation of MPST in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | MPST | response to virus | Hepatoma Cell Line | Gene: MPST (mercaptopyruvate sulfurtransferase)
Type: protein-coding
Summary: This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in... |
Does Knockout of PUS7L in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | PUS7L | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: PUS7L (pseudouridine synthase 7 like)
Type: protein-coding
Summary: Predicted to enable pseudouridine synthase activity. Predicted to be involved in pseudouridine synthesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA modi... |
Does Knockout of F13A1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | F13A1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: F13A1 (coagulation factor XIII A chain)
Type: protein-coding
Summary: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B s... |
Does Knockout of C8orf34 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | C8orf34 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: C8orf34 (chromosome 8 open reading frame 34)
Type: protein-coding
Summary: This gene encodes a protein that is related to the cyclic AMP dependent protein kinase regulators. Naturally occurring mutations in this gene are associated with an increased risk for severe toxicities, such as diarrhea and... |
Does Knockout of GRAMD1B in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | GRAMD1B | cell proliferation | Gastric Cancer Cell Line | Gene: GRAMD1B (GRAM domain containing 1B)
Type: protein-coding
Summary: Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol and cholesterol homeostasis. Located in endoplasmic ret... |
Does Knockout of ATP6V0B in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | ATP6V0B | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ATP6V0B (ATPase H+ transporting V0 subunit b)
Type: protein-coding
Summary: This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied pro... |
Does Knockout of SSB in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | SSB | cell proliferation | Astrocytoma Cell Line | Gene: SSB (small RNA binding exonuclease protection factor La)
Type: protein-coding
Summary: The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processin... |
Does Knockout of CEP55 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | CEP55 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: CEP55 (centrosomal protein 55)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Acts upstream of or within mitotic cytokinesis. Located in Flemming body; centrio... |
Does Knockout of ARAP2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | ARAP2 | cell proliferation | Melanoma Cell Line | Gene: ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2)
Type: protein-coding
Summary: The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 G... |
Does Knockout of MRPL55 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | MRPL55 | cell proliferation | Neuroblastoma Cell Line | Gene: MRPL55 (mitochondrial ribosomal protein L55)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of DNAI1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | DNAI1 | cell proliferation | Endometrial Cancer Cell Line | Gene: DNAI1 (dynein axonemal intermediate chain 1)
Type: protein-coding
Summary: This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in ... |
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