abstract string | rna_related int64 |
|---|---|
haematopoietic stem cells (hscs) possess unique physiological adaptations to sustain blood cell production and cope with stress responses throughout life. to maintain these adaptations, hscs rely on maintaining a tightly controlled protein translation rate. however, the mechanism of how hscs regulate protein translatio... | 1 |
the outcome of respiratory virus infection is determined by a complex interplay of viral and host factors. some potentially important host factors for the antiviral response, whose functions remain largely unexplored, are long non-coding rnas (lncrnas). here we systematically inferred the regulatory functions of host l... | 1 |
lung adenocarcinoma (luad) is the most frequent histological subtype of lung cancer, which is the most common malignant tumor and the main cause of cancer-related mortality globally. recent reports revealed that long non-coding rna (lncrna) of metastasis-associated lung adenocarcinoma transcript 1 (malat1) plays a cruc... | 1 |
background synthetic double-stranded rna poly(i:c) is a useful immune adjuvant and exhibits direct antitumor effects against several types of cancers. in this study, we elucidated the mechanisms underlying the effects induced in poly(i:c)-transfected human renal cell carcinoma (rcc) cells. results in contrast to the la... | 0 |
biologists are required to integrate large amounts of data to construct a working model of the system under investigation. this model is often informal and stored mentally or textually, making it prone to contain undetected inconsistencies, inaccuracies, or even contradictions, not much less than a representation in fr... | 0 |
growth hormone (gh) is a key regulatory factor in animal growth, development and metabolism. based on the expression level of the gh receptor, the chicken liver is a major target organ of gh, but the biological effects of gh on the chicken liver are not fully understood. in this work we identified mrnas and mirnas that... | 1 |
riboregulation stands for rna-based control of gene expression. in bacteria, small non-coding rnas (srnas) are a major class of riboregulatory elements, most of which act at the post-transcriptional level by base-pairing target mrna genes. the rna chaperone hfq facilitates antisense interactions between target mrnas an... | 1 |
the epigenetic writer lysine-specific demethylase 1 (lsd1) is aberrantly upregulated in many cancer types and its overexpression correlates with poor survival and tumor progression. in this study, we analysed lsd1 function in non-small cell lung cancer adenocarcinomas. expression profiling of 182 cases of lung adenocar... | 0 |
gene regulation shapes the evolution of phenotypic diversity. we investigated the evolution of liver promoters and enhancers in six primate species using chip-seq (h3k27ac and h3k4me1) to profile cis -regulatory elements (cres) and using rna-seq to characterize gene expression in the same individuals. to quantify regul... | 0 |
glioblastoma multiforme (gbm) is the most malignant brain tumor with limited therapeutic options. temozolomide (tmz) is a novel cytotoxic agent used as first-line chemotherapy for gbm, however, some individual cells can't be isolated for surgical resection and show treatment-resistance, thus inducing poor prognosis. by... | 1 |
curcumin, a natural product derived from the plant curcuma longa , has been found to have anti-inflammatory, antineoplastic and antifibrosis effects. it has been reported that curcumin attenuates allergic airway inflammation in mice through inhibiting nf-κb and its downstream transcription factor gata3. it also has bee... | 0 |
plasma exosomal micrornas (mirnas) are considered as valid circulating biomarkers for cancer diagnosis and prognosis. quantitative real-time polymerase chain reaction (qrt-pcr), the most commonly used technique to assess circulating mirna levels, requires a normalization step involving uniformly expressed endogenous mi... | 1 |
bacterial hfq-associated small regulatory rnas (srnas) parallel animal micrornas in their ability to control multiple target mrnas. the small non-coding mica rna represses the expression of several genes, including major outer membrane proteins such as omp a, tsx and ecn b. in this study, we have characterised the rna ... | 1 |
iron (fe) deficiency directly affects crop growth and development, ultimately resulting in reduced crop yield and quality. recently, long non-coding rnas (lncrnas) have been demonstrated to play critical regulatory roles in a multitude of pathways across numerous species. however, systematic screening of lncrnas respon... | 1 |
background a major goal of the field of systems biology is to translate genome-wide profiling data (e.g., mrnas, mirnas) into interpretable functional networks. however, employing a systems biology approach to better understand the complexities underlying drug resistance phenotypes in cancer continues to represent a si... | 1 |
grain production of rice ( oryza sativa l.) is a top priority in ensuring food security for human beings. one of the approaches to increase yield is to delay leaf senescence and to extend the available time for photosynthesis. micrornas (mirnas) are key regulators of aging and cellular senescence in eukaryotes. here, t... | 1 |
background therapeutic interventions that optimize angiogenic activities may reduce rates of end-stage kidney disease, critical limb ischemia, and lower extremity amputations in individuals with diabetic kidney disease (dkd). infusion of autologous mesenchymal stromal cells (msc) is a promising novel therapy to rejuven... | 1 |
obesity is associated with metabolic perturbations including liver and adipose tissue inflammation, insulin resistance, and type 2 diabetes. omega-6 fatty acids (ω6) promote and omega-3 fatty acids (ω3) reduce inflammation as they can be metabolized to pro- and anti-inflammatory eicosanoids, respectively. 12/15-lipoxyg... | 0 |
abstract respiratory syncytial virus (rsv) is the most common viral cause of severe lower respiratory tract illness in infants and children. the virus replicates in polarized epithelial cells in the airway and, to a lesser extent, infects airway antigen-presenting cells, such as dendritic cells (dcs). rsv possesses a n... | 1 |
background rna sequencing technologies reveal that bacteria express rna molecules other than mrna, rrna or trna. during the last years genome-wide bacterial transcriptomes have been shown to comprise intergenic rna, antisense rna, and untranslated regions, all capable of performing diverse regulatory functions. results... | 1 |
the molecular mechanism that regulates epicardial development has yet to be understood. in this study, we explored the function of cdx1, a caudal -related family member, in epicardial epithelial-to-mesenchymal transition (emt) and in the migration and the differentiation of epicardium-derived progenitors into vascular ... | 0 |
background: this study examined the metformin (mf) and/or chitosan stabilized selenium nanoparticles (ch-senps) efficacy to alleviate the male reproductive function impairment in a high-fat diet feed with low-dose streptozotocin (hfd/stz) induced type 2 diabetes mellitus (t2dm) diabetic rat model. methods: control non-... | 0 |
ketamine has become a popular recreational drug due to its neuronal anesthesia effect and low price. the process of learning and memory is part of the distinctive high-level neural activities in animals. we investigated the effects of subanesthetic and anesthetic doses of ketamine on the learning and memory-related sig... | 0 |
the specialized protein synthesis functions of the cytosol and endoplasmic reticulum compartments are conferred by the signal recognition particle (srp) pathway, which directs the cotranslational trafficking of signal sequence-encoding mrnas from the cytosol to the endoplasmic reticulum (er). although subcellular mrna ... | 0 |
circular rnas (circrnas) comprise a novel class of widespread non-coding rnas that may regulate gene expression in eukaryotes. however, the characterization and function of circrnas remain elusive in human cancer, including oral squamous cell carcinoma (oscc). in this study, the expression level of circpvt1 in oscc was... | 1 |
background the vast majority of lncrnas have low expression abundance, which greatly limits their functional range and impact. as a high expression abundance lncrna, fgd5-as1’s non-cerna biological function in cancer is unclear. methods rna-seq studies and chromatin immunoprecipitation (chip) assays were performed to i... | 1 |
one of the main causes of female infertility is a deregulated antral follicular atresia, a process of which the underlying molecular mechanisms are largely unknown. our objective was therefore to characterize the complex transcriptome changes in porcine granulosa cells of healthy antral (ha) and advanced antral atretic... | 0 |
facioscapulohumeral muscular dystrophy (fshd) is linked to abnormal derepression of the transcription activator dux4. this effect is localized to a low percentage of cells, requiring single-cell analysis. however, single-cell/nucleus rna-seq cannot fully capture the transcriptome of multinucleated large myotubes. to ci... | 0 |
micrornas (mirnas) are key regulators of gene expression at the post-transcription level. the present study specifically explored and compared the mirna expression profiles of f. gigantica and f. hepatica using an integrated sequencing and bioinformatics platform and quantitative real-time pcr. nineteen and 16 mirna ca... | 1 |
aims endothelial progenitor cells (epcs) are capable of proliferating and differentiating into mature endothelial cells, and they have been considered as potential candidates for coronary heart disease therapy. however, the transition of epcs to mesenchymal cells is not fully understood. this study aimed to explore the... | 1 |
noncoding rnas are integral to a wide range of biological processes, including translation, gene regulation, host-pathogen interactions and environmental sensing. while genomics is now a mature field, our capacity to identify noncoding rna elements in bacterial and archaeal genomes is hampered by the difficulty of de n... | 1 |
background most existing tools for detecting next-generation sequencing-based splicing events focus on generic splicing events. consequently, special types of non-canonical splicing events of short mrna regions (ire1α targeted) have not yet been thoroughly addressed at a genome-wide level using bioinformatics approache... | 0 |
background gastric intestinal metaplasia (im) is considered a precancerous lesion, and bile acids (ba) play a critical role in the induction of im. ectopic expression of hnf4α was observed in a ba-induced im cell model. however, the mechanisms underlying the upregulation of the protein in im cells remains to be elucida... | 1 |
recent studies have indicated that long non-coding rnas play crucial roles in numerous cancers, including thyroid cancer, while their function in the mechanism of thyroid cancer 131 i resistance has not been elucidated to date. the present study identified a functional long non-coding rna, slc6a9-5:2, which was involve... | 1 |
microvesicles (mvs) play an important role in intercellular communication by carrying mrnas, micrornas (mirnas), non-coding rnas, proteins, and dna from cell to cell. to our knowledge, this is the first report of delivery of a therapeutic mrna/protein via mvs for treatment of cancer. we first generated genetically engi... | 1 |
pheochromocytomas (pc) and paragangliomas (pg) are rare neuroendocrine tumors associated with autonomic nerves. here we use single-nuclei rna-seq and bulk-tissue gene-expression data to characterize the cellular composition of pcpg and normal adrenal tissues, refine tumor gene-expression subtypes and make clinical and ... | 0 |
aim stomach adenocarcinoma (stad) is a common malignancy worldwide. this study aimed to identify the aberrantly expressed long non-coding rnas (lncrnas) in stad. results total of 74 delncrnas and 449 demrnas were identified in stad compared with paired non-tumor tissues. the delncrna/demrna co-expression network was co... | 1 |
background to study the role of microrna (mirna) in the regulation of chinese hamster ovary (cho) cell growth, qpcr, microarray and quantitative lc-ms/ms analysis were utilised for simultaneous expression profiling of mirna, mrna and protein. the sample set under investigation consisted of clones with variable cellular... | 1 |
a gene for the hfq protein is present in the majority of sequenced bacterial genomes. its characteristic hexameric ring-like core structure is formed by the highly conserved n-terminal regions. in contrast, the c-terminal forms an extension, which varies in length, lacks homology, and is predicted to be unstructured. i... | 0 |
salix matsudana koidz. is a deciduous, rapidly growing, and drought resistant tree and is one of the most widely distributed and commonly cultivated willow species in china. currently little transcriptomic and small rnaomic data are available to reveal the genes involve in the stress resistant in s. matsudana. here, we... | 1 |
caulobacter crescentus undergoes an asymmetric cell division controlled by a genetic circuit that cycles in space and time. we provide a universal strategy for defining the coding potential of bacterial genomes by applying ribosome profiling, rna-seq, global 5′-race, and liquid chromatography coupled with tandem mass s... | 0 |
long noncoding rnas (lncrnas) are important regulators of transcription; however, their involvement in protein translation is not well known. here we explored whether the lncrna gas5 is associated with translation initiation machinery and regulates translation. gas5 was enriched with eukaryotic translation initiation f... | 1 |
background long non-coding rnas (lncrnas) regulate embryonic development and cell fate decision in various ways, such as modulation of chromatin modification and post-transcription regulation of gene expression. however, the profiles and roles of lncrnas in early mammalian development have not yet been demonstrated. he... | 1 |
identifying master regulators of biological processes and mapping their downstream gene networks are key challenges in systems biology. we developed a computational method, called iregulon, to reverse-engineer the transcriptional regulatory network underlying a co-expressed gene set using cis -regulatory sequence analy... | 0 |
puberty is a complex physiological event by which animals mature into an adult capable of sexual reproduction. in order to enhance our understanding of the genes and regulatory pathways and networks involved in puberty, we characterized the transcriptome of five reproductive tissues (i.e. hypothalamus, pituitary gland,... | 0 |
background allograft inflammatory factor 1 (aif-1) is a putative obesity gene. our aim was to examine the expression of aif-1 in human white adipose tissue (wat) in relation to obesity and metabolic phenotypes in women. methods wat secretion of aif-1 was determined in subcutaneous adipose tissue pieces in vitro by elis... | 0 |
epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. intriguingly, p73 displays a very specific localization to basal epithelial cells in human tissues, while p63 is expressed in both basal and diff... | 0 |
abstract the upsurge of multidrug-resistant infections has rendered tuberculosis the principal cause of death among infectious diseases. a clonal outbreak multidrug-resistant triggering strain of mycobacterium tuberculosis was identified in kanchanaburi province, labelled “mkr superspreader,” which was found to subsequ... | 0 |
background mica/b are major ligands for nk cell activating receptor nkg2d and previous studies showed that the serum level of soluble mica (smica) is an independent prognostic factor for advanced human hepatocellular carcinoma. however, the correlation between cellular mica/b expression pattern and human hepatocellular... | 0 |
long non-coding rna (lncrna) is a large class of gene transcripts with regulatory functions discovered in recent years. many more are expected to be revealed with accumulation of rna-seq data from diverse types of normal and diseased tissues. however, discovering novel lncrnas and accurately quantifying known lncrnas i... | 1 |
background recent studies have focused on the diagnostic and prognostic significance of cd24 and cd44 expression in human cancers. this study aimed to explore changes in cd44 and cd24 expression levels in patients with gastric cancer and to assess their prognostic values. methods cd44 and cd24 expression levels were in... | 0 |
obesity, a characteristic of metabolic syndrome, is also associated with chronic inflammation and the development of autoimmune diseases. however, the relationship between obesity and autoimmune diseases remains to be investigated in depth. here, we compared hepatic gene expression profiles among high-fat diet (hfd) mi... | 0 |
escherichia coli endoribonuclease e has a major influence on gene expression. it is essential for the maturation of ribosomal and transfer rna as well as the rapid degradation of messenger rna. the latter ensures that translation closely follows programming at the level of transcription. recently, one of the hallmarks ... | 0 |
background rna sequencing (rna-seq) has revolutionized the detection of transcriptomic signatures due to its high-throughput sequencing ability. therefore, genomic annotations on different animal species have been rapidly updated using information from tissue-enriched novel transcripts and novel exons. results 34 putat... | 0 |
telomerase rnas (ters) are highly divergent between species, varying in size and sequence composition. here, we identify a candidate for the telomerase rna component of leishmania genus, which includes species that cause leishmaniasis, a neglected tropical disease. merging a thorough computational screening combined wi... | 1 |
localized mrna translation is thought to play a key role in synaptic plasticity, but the identity of the transcripts and the molecular mechanism underlying their function are still poorly understood. here, we show that syncrip, a regulator of localized translation in the drosophila oocyte and a component of mammalian n... | 0 |
vascular calcification is associated with significant cardiovascular morbidity and mortality, and has been demonstrated as an actively regulated process resembling bone formation. oxidized low density lipoprotein (ox-ldl) has been identified as a regulatory factor involved in calcification of vascular smooth muscle cel... | 0 |
abstract epithelial–mesenchymal transition (emt) has been a subject of intense scrutiny as it facilitates metastasis and alters drug sensitivity. although emt-regulatory roles for numerous mirnas and transcription factors are known, their functions can be difficult to disentangle, in part due to the difficulty in ident... | 1 |
humanity is in the midst of the coronavirus disease 2019 (covid-19) pandemic, and vaccines—including mrna vaccines—have been developed at an unprecedented speed. it is necessary to develop guidelines for vaccination for people undergoing treatment with assisted reproductive technology (art) and for pregnancy-related si... | 0 |
abstract bacterial small noncoding rnas (srnas) play posttranscriptional regulatory roles in cellular responses to changing environmental cues and in adaptation to harsh conditions. generally, the rna-binding protein hfq helps srnas associate with target mrnas to modulate their translation and to modify global rna pool... | 1 |
background stevia ( stevia rebaudiana ) is an important medicinal plant that yields diterpenoid steviol glycosides (sgs). sgs are currently used in the preparation of medicines, food products and neutraceuticals because of its sweetening property (zero calories and about 300 times sweeter than sugar). recently, some pr... | 0 |
piezo1 is a mechanosensitive cation channel with widespread physiological importance; however, its role in the heart is poorly understood. cardiac fibroblasts help preserve myocardial integrity and play a key role in regulating its repair and remodeling following stress or injury. here we investigated piezo1 expression... | 0 |
we present a network framework for analyzing multi-level regulation in higher eukaryotes based on systematic integration of various high-throughput datasets. the network, namely the integrated regulatory network, consists of three major types of regulation: tf→gene, tf→mirna and mirna→gene. we identified the target gen... | 1 |
head and neck cancer is the sixth most common malignancy worldwide, with the relatively low 5-year survival rate, mainly because it is diagnosed at a late stage. infection with hpv is a well known aetiology, which affects the nature of these cancers and patients’ survival. besides, it is considered that the main drivin... | 1 |
shellfish allergy affects 2% of the world’s population and persists for life in most patients. the diagnosis of shellfish allergy, in particular shrimp, is challenging due to the similarity of allergenic proteins from other invertebrates. despite the clinical importance of immunological cross-reactivity among shellfish... | 0 |
radiation induced genomic instability is a well-studied phenomenon, the underlying mechanisms of which are poorly understood. persistent oxidative stress, mitochondrial dysfunction, elevated cytokine levels and epigenetic changes are among the mechanisms invoked in the perpetuation of the phenotype. to determine whethe... | 1 |
rna sequencing (rna-seq) enables characterization and quantification of individual transcriptomes as well as detection of patterns of allelic expression and alternative splicing. current rna-seq protocols depend on high-throughput short-read sequencing of cdna. however, as ongoing advances are rapidly yielding increasi... | 0 |
gene duplication is a widespread phenomenon in genome evolution, and it has been proposed to serve as an engine of evolutionary innovation. in the present study, we performed the first comprehensive analysis of duplicate genes in the bovine genome. a total of 3131 putative duplicated gene pairs were identified, includi... | 0 |
synthetic analogs of the 5′ end of mrna (cap structure) are widely used in molecular studies on mechanisms of cellular processes such as translation, intracellular transport, splicing, and turnover. the best-characterized cap binding protein is translation initiation factor 4e (eif4e). recognition of the mrna cap by ei... | 0 |
studies of various mrnas have revealed that changes in the abundance of transcripts, through mrna degradation, act as a critical step in the control of various biological pathways. similarly, the regulation of non-coding rna (ncrna) levels is also considered to be important for their biological functions; however, far ... | 1 |
insulin resistance (ir) precedes the development of type 2 diabetes (t2d) and increases cardiovascular disease risk. although genome wide association studies (gwas) have uncovered new loci associated with t2d, their contribution to explain the mechanisms leading to decreased insulin sensitivity has been very limited. t... | 0 |
background the application of next-generation sequencing technology to gene expression quantification analysis, namely, rna-sequencing, has transformed the way in which gene expression studies are conducted and analyzed. these advances are of particular interest to researchers studying organisms with missing or incompl... | 0 |
post-transcriptional regulation is regarded as one of the major processes involved in the regulation of gene expression. it is mainly performed by rna binding proteins and micrornas, which target rnas and typically affect their stability. recent efforts from the scientific community have aimed at understanding post-tra... | 1 |
polyamines are involved in the regulation of some trichomonas vaginalis virulence factors such as the transcript, proteolytic activity, and cytotoxicity of tvcp65, a cysteine proteinase (cp) involved in the trichomonal cytotoxicity. in this work, we reported the putrescine effect on tvcp39, other cp that also participa... | 0 |
simple summary optimal reproductive performance on goat farms is an important trait in terms of production and economics. from a genetic perspective, understanding molecular mechanisms through the use of rna-seq technology can help us better understand goat herds. in this study, a whole-transcriptome sequencing approac... | 1 |
background micrornas (mirnas) are a class of small rna molecules that regulate expression of specific mrna targets. they can be released from cells, often encapsulated within extracellular vesicles (evs), and therefore have the potential to mediate intercellular communication. it has been suggested that certain mirnas ... | 1 |
development of the vasculature is a complex, dynamic process orchestrated by a balance of pro and anti-angiogenic signaling pathways. the same signaling pathways are mis-regulated and exploited during pathological angiogenesis in cancer, inflammation and cardiovascular diseases and contribute to disease progression. in... | 1 |
objective here, we assess the usage of high throughput sequencing (hts) in rheumatic research and the availability of public hts data of rheumatic samples. methods we performed a semiautomated literature review on pubmed, consisting of an r-script and manual curation as well as a manual search on the sequence read arch... | 0 |
objective sjögren’s disease (sjd) is an autoimmune disease characterised by inflammatory destruction of exocrine glands. patients with autoantibodies to ro/ssa (sjd ro+ ) exhibit more severe disease. long non-coding rnas (lncrnas) are a functionally diverse class of non-protein-coding rnas whose role in autoimmune dise... | 1 |
understanding the immune responses to sars-cov-2 vaccination is critical to optimizing vaccination strategies for individuals with autoimmune diseases, such as systemic lupus erythematosus (sle). here, we comprehensively analyzed innate and adaptive immune responses in 19 patients with sle receiving a complete 2-dose p... | 0 |
uremic encephalopathy (ue) poses a significant challenge in neurology, leading to the need to investigate the involvement of non-coding rna (ncrna) in its development. this study employed ncrna-seq and rna-seq approaches to identify fundamental ncrnas, specifically circrna and mirna, in the pathogenesis of ue using a m... | 1 |
the torrent of rna-seq data becoming available not only furnishes an overview of the entire transcriptome but also provides tools to focus on specific areas of interest. our focus on the synthesis of ribosomes asked whether the abundance of mrnas encoding ribosomal proteins (rps) matched the equimolar need for the rps ... | 0 |
flagellar synthesis is a highly regulated process in all motile bacteria. in escherichia coli and related species, the transcription factor flhdc is the master regulator of a multi-tiered transcription network. flhdc activates transcription of a number of genes, including some flagellar genes and the gene encoding the ... | 1 |
abstract most common genetic variants associated with disease are located in non-coding regions of the genome. one mechanism by which they function is through altering transcription factor (tf) binding. in this study, we explore how genetic variation is connected to differences in the regulatory landscape of livers fro... | 0 |
background validation of physiologic mirna targets has been met with significant challenges. we employed hits-clip to identify which mirnas participate in liver regeneration, and to identify their target mrnas. results mirna recruitment to the risc is highly dynamic, changing more than five-fold for several mirnas. mir... | 1 |
oomycetes in the class saprolegniomycetidae of the eukaryotic kingdom stramenopila have evolved as severe pathogens of amphibians, crustaceans, fish and insects, resulting in major losses in aquaculture and damage to aquatic ecosystems. we have sequenced the 63 mb genome of the fresh water fish pathogen, saprolegnia pa... | 0 |
background sugarcane is the source of sugar in all tropical and subtropical countries and is becoming increasingly important for bio-based fuels. however, its large (10 gb), polyploid, complex genome has hindered genome based breeding efforts. here we release the largest and most diverse set of sugarcane genome sequenc... | 0 |
background micrornas (mirnas) are a class of small non-coding rnas that regulate gene expression by targeting mrnas for translation repression or mrna degradation. although many mirnas have been discovered and studied in human and mouse, few studies focused on porcine mirnas, especially in genome wide. results here, we... | 1 |
the spike protein in sars-cov-2 (sars-2-s) interacts with the human ace2 receptor to gain entry into a cell to initiate infection. both pfizer/biontech’s bnt162b2 and moderna’s mrna-1273 vaccine candidates are based on stabilized mrna encoding prefusion sars-2-s that can be produced after the mrna is delivered into the... | 0 |
eukaryotic genomes are pervasively transcribed and only a small portion of the transcribed sequences belongs to protein coding genes. high-throughput sequencing technology contributed to consolidate this perspective, allowing the identification of numerous noncoding rnas with key roles in biological processes. long non... | 1 |
ewing sarcoma is driven by fusion proteins containing a low-complexity (lc) domain that is intrinsically disordered and a powerful transcriptional regulator. the most common fusion protein found in ewing sarcoma, ews-fli1, takes its lc domain from the rna-binding protein ewsr1 (ewing sarcoma rna-binding protein 1) and ... | 0 |
background micrornas (mirnas) are noncoding rnas that direct post-transcriptional regulation of protein coding genes. recent studies have shown mirnas are important for controlling many biological processes, including nervous system development, and are highly conserved across species. given their importance, computati... | 1 |
significance aberrant lncrna expression is responsible for cancer progression and metastasis, positioning lncrnas not only as biomarkers but also as promising therapeutic targets for curing cancer. a number of lncrnas have been reported in escc but their mechanistic roles largely remain unknown. wnt signaling pathways ... | 1 |
nocardithiocin is a thiopeptide compound isolated from the opportunistic pathogen nocardia pseudobrasiliensis. it shows a strong activity against acid-fast bacteria and is also active against rifampicin-resistant mycobacterium tuberculosis. here, we report the identification of the nocardithiocin gene cluster in n. pse... | 0 |
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