DOI stringlengths 13 47 | Year int64 2.01k 2.02k | Journal stringlengths 3 170 | Title stringlengths 1 281 ⌀ | Abstract stringlengths 14 62.9k ⌀ | Full Text stringlengths 22 5M |
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10. 1001/jamacardio. 2016. 2750 | 2,017 | JAMA cardiology | Potential Strategies to Address the Major Clinical Hurdles Facing Stem Cell Regenerative Therapy for Cardiovascular Disease: A Review | Importance While progress continues to be made in the field of stem cell regenerative medicine for the treatment of cardiovascular disease, significant barriers to clinical translation still exist that have thwarted the delivery of cell therapy to the bedside. Objective The purpose of this review is to summarize the ma... | No full text available |
10. 1001/jamanetworkopen. 2021. 22607 | 2,021 | JAMA Network Open | Effect of a Novel Macrophage-Regulating Drug on Wound Healing in Patients With Diabetic Foot Ulcers | Key Points Question Can the topical application of ON101 cream demonstrate a superior therapeutic benefit in wound healing among patients with diabetic foot ulcers (DFUs) compared with standard care? Findings In this randomized phase 3 clinical trial of 236 patients with DFUs, topical application of ON101 with gauze im... | Introduction Approximately 80% of lower limb amputations are preceded by chronic diabetic foot ulcers (DFUs), resulting in a heavy burden of medical care and expenditure. 1, 2 The current treatment for DFUs in clinical practice focuses primarily on local wound care, including debridement, off-loading, infection control... |
10. 1001/jamaophthalmol. 2013. 4319 | 2,013 | JAMA ophthalmology | Accelerated | Purpose To design patterned, transparent silk films with fast degradation rates for the purpose of tissue engineering corneal stroma, Methods β-sheet (crystalline) content of silk films was decreased significantly by using a short water annealing time. Additionally, a protocol combining short water annealing time with ... | No full text available |
10. 1001/jamaoto. 2013. 5669 | 2,015 | JAMA otolaryngology-- head & neck surgery | Defining the critical-sized defect in a rat segmental mandibulectomy model | Importance Advances in tissue engineering offer potential alternatives to current mandibular reconstructive techniques; however, prior to clinical translation of this technology, a relevant animal model must be used to validate possible interventions. Objective This study aims to establish the critical-sized segmental ... | No full text available |
10. 1002/0471143030. cb2309s61 | 2,014 | Current protocols in cell biology / editorial board, Juan S. Bonifacino. . . [et al. ] | Expanding Mouse Ventricular Cardiomyocytes through GSK-3 Inhibition | Controlled proliferation of cardiac myocytes remains a major limitation in cell biology and one of the main underlying hurdles for true modern regenerative medicine. Here we provide a technique to robustly expand early fetal-derived mouse ventricular cardiomyocytes on a platform usable for high-throughput molecular scr... | No full text available |
10. 1002/1873-3468. 12285 | 2,016 | Febs Letters | Inherited heart disease – what can we expect from the second decade of human i | Induced pluripotent stem cells (i PSC s) were first generated 10 years ago. Their ability to differentiate into any somatic cell type of the body including cardiomyocytes has already made them a valuable resource for modelling cardiac disease and drug screening. Initially human i PSC s were used mostly to model known d... | Abbreviations ALPK3, alpha kinase 3 ARVC, arrhythmogenic right ventricular cardiomyopathy CMs, cardiomyocytes DCM, dilated cardiomyopathy HCM, familial hypertrophic cardiomyopathy hiPSC, human iPSC hPSC, human pluripotent stem cell iPSCs, induced pluripotent stem cells LQTS, long‐QT syndrome RBM20, RNA‐binding motif pr... |
10. 1002/1873-3468. 12559 | 2,017 | Febs Letters | Identifying niche‐mediated regulatory factors of stem cell phenotypic state: a systems biology approach | Understanding how the cellular niche controls the stem cell phenotype is often hampered due to the complexity of variegated niche composition, its dynamics, and nonlinear stem cell–niche interactions. Here, we propose a systems biology view that considers stem cell–niche interactions as a many‐body problem amenable to ... | Abbreviations MS, multiple sclerosis PCST, Prize Collecting Steiner Tree; NSC, neural stem cell Stem cells are indispensable for maintaining tissue homeostasis due to their unique ability to generate more specialized cell types in a well‐coordinated manner depending on the organismal needs. This function depends crucia... |
10. 1002/1878-0261. 12323 | 2,018 | Molecular Oncology | A combined tissue‐engineered/ | Patient‐tailored therapy based on tumor drivers is promising for lung cancer treatment. For this, we combined in vitro tissue models with in silico analyses. Using individual cell lines with specific mutations, we demonstrate a generic and rapid stratification pipeline for targeted tumor therapy. We improve in vitro mo... | Abbreviations 17AAG 17‐ N ‐allylamino‐17‐demethoxygeldanamycin 2D two‐dimensional 3D three‐dimensional ADME absorption, distribution, metabolism, excretion AICAR 5‐aminoimidazole‐4‐carboxamide ribonucleotide BioVaSc ® Biological Vascularized Scaffold COSMIC Catalogue Of Somatic Mutations In Cancer DRPs differentially r... |
10. 1002/1878-0261. 13037 | 2,021 | Molecular Oncology | "Lineage‐specific mechanisms and drivers of breast cancer chemoresistance revealed by 3D biomimeti(...TRUNCATED) | "To improve the success rate of current preclinical drug trials, there is a growing need for more co(...TRUNCATED) | "Abbreviations ABC ATP‐binding cassette Ct threshold cycle DEGs differentially expressed genes ECM(...TRUNCATED) |
10. 1002/2211-5463. 12250 | 2,017 | FEBS Open Bio | Role of the TGF‐β pathway in dedifferentiation of human mature adipocytes | "Dedifferentiation of adipocytes contributes to the generation of a proliferative cell population th(...TRUNCATED) | "Abbreviations COL1A1 collagen type I alpha 1 COL1A2 collagen type I alpha 2 COL6A3 collagen type 6 (...TRUNCATED) |
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