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10. 1001/jamacardio. 2016. 2750 | 2,017 | JAMA cardiology | Potential Strategies to Address the Major Clinical Hurdles Facing Stem Cell Regenerative Therapy for Cardiovascular Disease: A Review | Importance While progress continues to be made in the field of stem cell regenerative medicine for the treatment of cardiovascular disease, significant barriers to clinical translation still exist that have thwarted the delivery of cell therapy to the bedside. Objective The purpose of this review is to summarize the ma... | No full text available |
10. 1001/jamanetworkopen. 2021. 22607 | 2,021 | JAMA Network Open | Effect of a Novel Macrophage-Regulating Drug on Wound Healing in Patients With Diabetic Foot Ulcers | Key Points Question Can the topical application of ON101 cream demonstrate a superior therapeutic benefit in wound healing among patients with diabetic foot ulcers (DFUs) compared with standard care? Findings In this randomized phase 3 clinical trial of 236 patients with DFUs, topical application of ON101 with gauze im... | Introduction Approximately 80% of lower limb amputations are preceded by chronic diabetic foot ulcers (DFUs), resulting in a heavy burden of medical care and expenditure. 1, 2 The current treatment for DFUs in clinical practice focuses primarily on local wound care, including debridement, off-loading, infection control... |
10. 1001/jamaophthalmol. 2013. 4319 | 2,013 | JAMA ophthalmology | Accelerated | Purpose To design patterned, transparent silk films with fast degradation rates for the purpose of tissue engineering corneal stroma, Methods β-sheet (crystalline) content of silk films was decreased significantly by using a short water annealing time. Additionally, a protocol combining short water annealing time with ... | No full text available |
10. 1001/jamaoto. 2013. 5669 | 2,015 | JAMA otolaryngology-- head & neck surgery | Defining the critical-sized defect in a rat segmental mandibulectomy model | Importance Advances in tissue engineering offer potential alternatives to current mandibular reconstructive techniques; however, prior to clinical translation of this technology, a relevant animal model must be used to validate possible interventions. Objective This study aims to establish the critical-sized segmental ... | No full text available |
10. 1002/0471143030. cb2309s61 | 2,014 | Current protocols in cell biology / editorial board, Juan S. Bonifacino. . . [et al. ] | Expanding Mouse Ventricular Cardiomyocytes through GSK-3 Inhibition | Controlled proliferation of cardiac myocytes remains a major limitation in cell biology and one of the main underlying hurdles for true modern regenerative medicine. Here we provide a technique to robustly expand early fetal-derived mouse ventricular cardiomyocytes on a platform usable for high-throughput molecular scr... | No full text available |
10. 1002/1873-3468. 12285 | 2,016 | Febs Letters | Inherited heart disease – what can we expect from the second decade of human i | Induced pluripotent stem cells (i PSC s) were first generated 10 years ago. Their ability to differentiate into any somatic cell type of the body including cardiomyocytes has already made them a valuable resource for modelling cardiac disease and drug screening. Initially human i PSC s were used mostly to model known d... | Abbreviations ALPK3, alpha kinase 3 ARVC, arrhythmogenic right ventricular cardiomyopathy CMs, cardiomyocytes DCM, dilated cardiomyopathy HCM, familial hypertrophic cardiomyopathy hiPSC, human iPSC hPSC, human pluripotent stem cell iPSCs, induced pluripotent stem cells LQTS, long‐QT syndrome RBM20, RNA‐binding motif pr... |
10. 1002/1873-3468. 12559 | 2,017 | Febs Letters | Identifying niche‐mediated regulatory factors of stem cell phenotypic state: a systems biology approach | Understanding how the cellular niche controls the stem cell phenotype is often hampered due to the complexity of variegated niche composition, its dynamics, and nonlinear stem cell–niche interactions. Here, we propose a systems biology view that considers stem cell–niche interactions as a many‐body problem amenable to ... | Abbreviations MS, multiple sclerosis PCST, Prize Collecting Steiner Tree; NSC, neural stem cell Stem cells are indispensable for maintaining tissue homeostasis due to their unique ability to generate more specialized cell types in a well‐coordinated manner depending on the organismal needs. This function depends crucia... |
10. 1002/1878-0261. 12323 | 2,018 | Molecular Oncology | A combined tissue‐engineered/ | Patient‐tailored therapy based on tumor drivers is promising for lung cancer treatment. For this, we combined in vitro tissue models with in silico analyses. Using individual cell lines with specific mutations, we demonstrate a generic and rapid stratification pipeline for targeted tumor therapy. We improve in vitro mo... | Abbreviations 17AAG 17‐ N ‐allylamino‐17‐demethoxygeldanamycin 2D two‐dimensional 3D three‐dimensional ADME absorption, distribution, metabolism, excretion AICAR 5‐aminoimidazole‐4‐carboxamide ribonucleotide BioVaSc ® Biological Vascularized Scaffold COSMIC Catalogue Of Somatic Mutations In Cancer DRPs differentially r... |
10. 1002/1878-0261. 13037 | 2,021 | Molecular Oncology | Lineage‐specific mechanisms and drivers of breast cancer chemoresistance revealed by 3D biomimetic culture | To improve the success rate of current preclinical drug trials, there is a growing need for more complex and relevant models that can help predict clinical resistance to anticancer agents. Here, we present a three‐dimensional (3D) technology, based on biomimetic collagen scaffolds, that enables the modeling of the tumo... | Abbreviations ABC ATP‐binding cassette Ct threshold cycle DEGs differentially expressed genes ECMs extracellular matrices mTORC1 mammalian target of rapamycin complex 1 SEM scanning electron microscopy 1 Introduction Drug resistance is the major cause of treatment failure in cancer patients, ultimately leading to the d... |
10. 1002/2211-5463. 12250 | 2,017 | FEBS Open Bio | Role of the TGF‐β pathway in dedifferentiation of human mature adipocytes | Dedifferentiation of adipocytes contributes to the generation of a proliferative cell population that could be useful in cellular therapy or tissue engineering. Adipocytes can dedifferentiate into precursor cells to acquire a fibroblast‐like phenotype using ceiling culture, in which the buoyancy of fat cells is exploit... | Abbreviations COL1A1 collagen type I alpha 1 COL1A2 collagen type I alpha 2 COL6A3 collagen type 6 alpha 3 DFAT dedifferentiated ECM extracellular matrix KRH Krebs–Ringer‐Henseleit OM omental SC subcutaneous SVF stromal–vascular fraction TGF‐β transforming growth factor beta Adipose tissue contains connective tissue ma... |
10. 1002/2211-5463. 12317 | 2,017 | FEBS Open Bio | Coculture of endothelial progenitor cells and mesenchymal stem cells enhanced their proliferation and angiogenesis through | The beneficial effects of combined use of mesenchymal stem cells ( MSC s) and endothelial progenitor cells ( EPC s) on tissue repair and regeneration after injury have been demonstrated, but the underlying mechanism remains incompletely understood. This study aimed to investigate the effects of direct contact coculture... | Abbreviations 2D two‐dimensional 3D three‐dimensional AM adipogenic medium ECs endothelial cells EPCs endothelial progenitor cells FACS fluorescence‐activated cell sorting FITC fluorescein isothiocyanate HBMECs human brain microvascular endothelial cells hEPCs human bone marrow‐derived EPCs HLA‐DR human leukocyte antig... |
10. 1002/2211-5463. 12634 | 2,019 | FEBS Open Bio | Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through | Oxidative stress and abnormal osteocyte apoptosis are often related to dysregulation of bone turnover and chronic bone loss, and so fruit and vegetables with high antioxidant potential may play an important role in the prevention and/or management of osteoporosis. Osteocytes are the main regulators of bone remodelling.... | Abbreviations Ac‐p53 acetylated‐p53 BB blueberry BE blueberry dry extract BJ blueberry juice ERK1/2 extracellular signal‐regulated kinase 1/2 FBS fetal bovine serum H 2 DCFDA 2′, 7′‐dichlorodihydrofluorescein diacetate JNK c‐Jun N‐terminal kinase MSC marrow mesenchymal stromal cell MTT 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, ... |
10. 1002/2211-5463. 12792 | 2,020 | FEBS Open Bio | All‐trans retinoic acid and human salivary histatin‐1 promote the spreading and osteogenic activities of pre‐osteoblasts | Cell‐based bone tissue engineering techniques utilize both osteogenic cells and biomedical materials, and have emerged as a promising approach for large‐volume bone repair. The success of such techniques is highly dependent on cell adhesion, spreading, and osteogenic activities. In this study, we investigated the effec... | Abbreviations ALP alkaline phosphatase ATRA all‐trans retinoic acid FAK focal adhesion kinase Fmoc fluorenylmethoxycarbonyl Hst1 histatin‐1 LVBD large‐volume bone defects pNPP p ‐nitrophenyl phosphate RXR retinoid X receptor Large‐volume bone defects (LVBD) may severely influence aesthetics and musculoskeletal function... |
10. 1002/2211-5463. 12937 | 2,020 | FEBS Open Bio | Hyperoside ameliorates periodontitis in rats by promoting osteogenic differentiation of BMSCs via activation of the NF‐κB pathway | Hyperoside has been reported to possess anti‐inflammatory properties. Here, we confirmed that hyperoside exhibits potential therapeutic properties against periodontitis via promotion of proliferation and osteogenic differentiation of rat bone mesenchymal stem cells through activation of the NF‐κB signaling pathway. The... | Abbreviations ALP alkaline phosphatase BMSC bone mesenchymal stem cell CCK‐8 Cell Counting Kit‐8 HGF human gingival fibroblast IL‐17 interleukin‐17 LPS lipopolysaccharide NF‐κB nuclear factor‐κB rBMSC rat bone mesenchymal stem cell SD Sprague Dawley TNF‐α tumor necrosis factor‐α Periodontitis is one of the most common ... |
10. 1002/2211-5463. 13002 | 2,020 | FEBS Open Bio | Platelet lysate induces chondrogenic differentiation of umbilical cord‐derived mesenchymal stem cells by regulating the lncRNA H19/miR‐29b‐3p/SOX9 axis | H19 expression is induced in platelet lysate‐stimulated human umbilical cord‐derived mesenchymal stem cells (hUCMSCs), and H19 acts as a sponge of miR‐29b‐3p to up‐regulate the expression of the master chondrocyte transcription factor SRY‐related high‐mobility‐group box 9, thereby promoting platelet lysate‐induced chon... | Abbreviations hUCMSC human umbilical cord‐derived mesenchymal stem cell lncRNA long noncoding RNA MSC mesenchymal stem cell Mut mutated NC negative control OA osteoarthritis PL platelet lysate PRP platelet‐rich plasma qRT‐PCR quantitative real‐time PCR ROCR regulator of chondrogenesis RNA SOX9 SRY‐related high‐mobility... |
10. 1002/2211-5463. 13043 | 2,020 | FEBS Open Bio | miR‐196b‐5p inhibits proliferation of Wharton's jelly umbilical cord stem cells | Human umbilical cord mesenchymal stem cells can be obtained from different parts of the umbilical cord, including Wharton's jelly. Transplantation of Wharton's jelly umbilical cord stem cells (WJCMSCs) is a promising strategy for the treatment of various diseases. However, the molecular mechanisms underlying the prolif... | Abbreviations BMMSC bone marrow mesenchymal stem cell CDK cyclin‐dependent kinase CFSE (CFDA‐SE) 5, 6‐carboxyfluorescein diacetate, succinimidyl ester GAPDH glyceraldehyde‐3 phosphate dehydrogenase iPSC induced pluripotent stem cell MSC mesenchymal stem cell qRT‐PCR quantitative RT‐PCR SA‐β‐gal senescence‐associated β‐... |
10. 1002/2211-5463. 13119 | 2,021 | FEBS Open Bio | The role of biotechnology in the transition from plastics to bioplastics: an opportunity to reconnect global growth with sustainability | Building new value chains, through the valorization of biomass components for the development of innovative bio‐based products (BBPs) aimed at specific market sectors, will accelerate the transition from traditional production technologies to the concept of biorefineries. Recent studies aimed at mapping the most releva... | Abbreviations BBPs bio‐based products CE circular economy LVHV low‐volume high‐value Introduction Over the last 150 years, the industrial system has been uniquely driven by a linear model, which is based on the production of goods starting from fossil raw materials, their commercialization, their use, and final disposa... |
10. 1002/2211-5463. 13336 | 2,021 | FEBS Open Bio | null | Dental pulp tissue engineering is a promising alternative treatment for pulpitis and periapical periodontitis, and dental pulp stem cells (DPSCs) are considered to be the gold standard for dental seed cell research. Periapical lesions harbor mesenchymal stem cells with the capacity for self‐renewal and multilineage dif... | Abbreviations ALP alkaline phosphatase CCK‐8 Cell Counting Kit‐8 CFU‐F colony‐forming units‐fibroblasts DMEM Dulbecco’s modified Eagle’s medium DMP1 dentin matrix protein 1 DPSCs dental pulp stem cells DSPP dentin sialophosphoprotein GDNF glial cell line‐derived neurotrophic factor HGF hepatocyte growth factor HLA‐G hu... |
10. 1002/2211-5463. 13352 | 2,021 | FEBS Open Bio | Bone marrow‐mesenchymal stem cell‐derived extracellular vesicles affect proliferation and apoptosis of leukemia cells | Mesenchymal stem cells (MSCs) have been proposed to have potential for tissue engineering and cell therapy due to their multilineage differentiation potential and ability to secrete numerous paracrine factors, including extracellular vesicles (EVs). Increasing evidence has demonstrated that MSC‐derived EVs (MSC‐EVs) ar... | Abbreviations BAX BCL2‐associated X apoptosis regulator BCL2 apoptosis regulator BID BH3 interacting domain death agonist CCNE2 cyclin E2 FAS Fas cell surface death receptor GAPDH glyceraldehyde‐3‐phosphate dehydrogenase P21 cyclin‐dependent kinase inhibitor 1A (CDKN1A) P53 tumor protein p53 PUMA p53 upregulated modula... |
10. 1002/2211-5463. 13615 | 2,023 | FEBS Open Bio | Bone marrow mesenchymal stem cell‐derived exosomes reduce insulin resistance and obesity in mice via the | Obesity is a common chronic metabolic disease that induces chronic systemic inflammation in the body, eventually leading to related complications such as insulin resistance (IR), type 2 diabetes mellitus, and metabolic syndromes such as cardiovascular disease. Exosomes transfer bioactive substances to neighboring or di... | Abbreviations BMSC bone marrow mesenchymal stem cell BMSC‐Exos bone marrow mesenchymal stem cell‐derived exosomes FABP4 fatty acid‐binding protein 4 FFA free fatty acid GLUT4 glucose transporter protein 4 GTT glucose tolerance tests H&E hematoxylin and eosin HFD high‐fat diet IL‐6 interleukin‐6 IR insulin resistance IT... |
10. 1002/2211-5463. 13650 | 2,024 | FEBS Open Bio | Endothelial cell‐derived extracellular vesicles induce pro‐angiogenic responses in mesenchymal stem cells | Angiogenesis is a central component of vital biological processes such as wound healing, tissue nourishment, and development. Therefore, angiogenic activities are precisely maintained with secreted factors such as angiopoietin‐1 (Ang1), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF). As a... | Abbreviations AFM atomic force microscopy Ang1 Angiopoietin‐1 ATPS aqueous two‐phase system CANX calnexin DMEM Dulbecco's Modified Eagle's Medium FAME fatty acid methyl ester FBS fetal bovine serum FGF fibroblast growth factor Flk‐1 VEGF receptor 2 Flt‐1 VEGF receptor 1 GC–MS gas chromatography–mass spectrometry GO Gen... |
10. 1002/acm2. 12489 | 2,018 | Journal of Applied Clinical Medical Physics | A dosimetric study on the use of 3D‐printed customized boluses in photon therapy: A hydrogel and silica gel study | Abstract Purpose The aim of the study was to compare the dose differences between two kinds of materials (silica gel and hydrogel) used to prepare boluses based on three‐dimensional (3D) printing technologies and commercial bolus in head phantoms simulating nose, ear, and parotid gland radiotherapy. Methods and materia... | 1 INTRODUCTION In the radiotherapy of skin carcinomas, parotid gland carcinomas, or chest wall after mastectomy in breast carcinomas, there is a deficiency in the dose of the skin or superficial tissue due to the dose build‐up effect of the high energy X (γ) ray. The bolus can effectively improve the skin dose from 10%... |
10. 1002/adbi. 201700056 | 2,017 | Advanced biosystems | Proangiogenic Activity of Endometrial Epithelial and Stromal Cells in Response to Estradiol in Gelatin Hydrogels | Biomaterial vascularization remains a major focus in the field of tissue engineering. Biomaterial culture of endometrial cells is described as a platform to inform the design of proangiogenic biomaterials. The endometrium undergoes rapid growth and shedding of dense vascular networks during each menstrual cycle mediate... | No full text available |
10. 1002/adbi. 201700083 | 2,018 | Advanced biosystems | Embedded Spheroids as Models of the Cancer Microenvironment | To more accurately study the complex mechanisms behind cancer invasion, progression, and response to treatment, researchers require models that replicate both the multicellular nature and 3D stromal environment present in an in vivo tumor. Multicellular aggregates (i. e. , spheroids) embedded in an extracellular matrix... | No full text available |
10. 1002/adbi. 201800101 | 2,018 | Advanced biosystems | Stereolithographic 4D Bioprinting of Multiresponsive Architectures for Neural Engineering | 4D printing represents one of the most advanced fabrication techniques for prospective applications in tissue engineering, biomedical devices, and soft robotics, among others. In this study, a novel multiresponsive architecture is developed through stereolithography-based 4D printing, where a universal concept of stres... | No full text available |
10. 1002/adbi. 201900089 | 2,019 | Advanced biosystems | Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs | Controlled delivery of cytokines and growth factors has been an area of intense research interest for molecular and cellular bioengineering, immunotherapy, and regenerative medicine. In this study, we show that primary human lung fibroblasts chemically induced to senescence (cell cycle arrest) can act as a living sourc... | No full text available |
10. 1002/adbi. 201900137 | 2,020 | Advanced biosystems | Decorating 3D Printed Scaffolds with Electrospun Nanofiber Segments for Tissue Engineering | Repairing large tissue defects often represents a great challenge in clinics due to issues regarding lack of donors, mismatched sizes, irregular shapes, and immune rejection. Three-dimensional (3D) printed scaffolds are attractive for growing cells and producing tissue constructs because of the intricate control over p... | No full text available |
10. 1002/adbi. 202000046 | 2,020 | Advanced biosystems | Elastic Biomaterial Scaffold with Spatially Varying Adhesive Design | In order to secure biomaterials to tissue surfaces, sutures or glues are commonly used. Of interest is the development of a biomaterial patch for applications in tissue engineering and regeneration that incorporates an adhesive component to simplify patch application and ensure sufficient adhesion. A separate region de... | No full text available |
10. 1002/adbi. 202000133 | 2,021 | Advanced biosystems | Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions | Tissue-engineered models continue to experience challenges in delivering structural specificity, nutrient delivery, and heterogenous cellular components, especially for organ-systems that require functional inputs/outputs and have high metabolic requirements, such as the heart. While soft lithography has provided a mea... | No full text available |
10. 1002/adbi. 202000168 | 2,021 | Advanced biology | Engineering Advanced In Vitro Models of Systemic Sclerosis for Drug Discovery and Development | Systemic sclerosis (SSc) is a complex multisystem disease with the highest case-specific mortality among all autoimmune rheumatic diseases, yet without any available curative therapy. Therefore, the development of novel therapeutic antifibrotic strategies that effectively decrease skin and organ fibrosis is needed. Exi... | 1. Introduction Systemic sclerosis (SSc; also termed scleroderma) is an autoimmune disease that is characterized by the distinctive pathogenetic triad of microvascular dysfunction, dysregulation of innate and adaptive immunity, and generalized fibrosis in multiple organs. [ 1 ] SSc has the highest case-specific mortali... |
10. 1002/adbi. 202000624 | 2,021 | Advanced Biology | In Vitro Models for Studying Respiratory Host–Pathogen Interactions | Abstract Respiratory diseases and lower respiratory tract infections are among the leading cause of death worldwide and, especially given the recent severe acute respiratory syndrome coronavirus‐2 pandemic, are of high and prevalent socio‐economic importance. In vitro models, which accurately represent the lung microen... | 1 Introduction Respiratory diseases are among the leading causes of death worldwide, [ 1 ] with more than 1 billion people suffering from long standing respiratory illness. [ 2 ] Among others, the most common conditions include asthma, [ 3, 4 ] chronic obstructive pulmonary disorder (COPD), [ 5 ] and idiopathic pulmona... |
10. 1002/adbi. 202200267 | 2,023 | Advanced biology | Bioengineering and Clinical Translation of Human Lung and its Components | Clinical lung transplantation has rapidly established itself as the gold standard of treatment for end-stage lung diseases in a restricted group of patients since the first successful lung transplant occurred. Although significant progress has been made in lung transplantation, there are still numerous obstacles in the... | No full text available |
10. 1002/adem. 201800166 | 2,018 | Advanced engineering materials | Mechanical Properties of Graphene Foam and Graphene Foam – Tissue Composites | Graphene foam (GF), a 3-dimensional derivative of graphene, has received much attention recently for applications in tissue engineering due to its unique mechanical, electrical, and thermal properties. Although GF is an appealing material for cartilage tissue engineering, the mechanical properties of GF – tissue compos... | No full text available |
10. 1002/adem. 202000759 | 2,020 | Advanced Engineering Materials | Rapid Fabrication of Sterile Medical Nasopharyngeal Swabs by Stereolithography for Widespread Testing in a Pandemic | The 3D printing of nasopharyngeal swabs during the COVID‐19 pandemic presents a central case of how to efficiently address a break in the global supply chain of medical equipment. Herein a comprehensive study of swab design considerations for mass production by stereolithography is presented. The retention and comfort ... | 1 Introduction The challenge of the local and global supply chain to respond to potential catastrophes is very high, as shown by the Federal Emergency Management Agency (FEMA) Supply Chain Resilience Guide. [ 1 ] Responses to natural disasters, such as hurricanes, have shown that even with historical analyses that pref... |
10. 1002/adem. 202300301 | 2,023 | Advanced engineering materials | Incorporating the Antioxidant Fullerenol into Calcium Phosphate Bone Cements Increases Cellular Osteogenesis without Compromising Physical Cement Characteristics | Herein, fullerenol (Ful), a highly water-soluble derivative of C 60 fullerene with demonstrated antioxidant activity, is incorporated into calcium phosphate cements (CPCs) to enhance their osteogenic ability. CPCs with added carboxymethyl cellulose/gelatin (CMC/Gel) are doped with biocompatible Ful particles at concent... | 1. Introduction Calcium phosphate cements (CPCs) have been extensively used as clinical bone substitutes for over 20 years. CPCs have a similar structure to natural bone and can easily be applied to osseous defects due to their moldability and low-temperature setting reaction. [ 1 - 4 ] They can produce apatite in phys... |
10. 1002/adfm. 201202685 | 2,014 | Advanced functional materials | Charge-Tunable Silk-Tropoelastin Protein Alloys That Control Neuron Cell Responses | Tunable protein composites are important for constructing extracellular matrix mimics of human tissues with control of biochemical, structural, and mechanical properties. Molecular interaction mechanisms between silk fibroin protein and recombinant human tropoelastin, based on charge, are utilized to generate a new gro... | No full text available |
10. 1002/adfm. 201301275 | 2,013 | Advanced functional materials | Iron Oxide-labeled Collagen Scaffolds for Non-invasive MR Imaging in Tissue Engineering | Non-invasive imaging holds significant potential for implementation in tissue engineering. It can e. g. be used to monitor the localization and function of tissue-engineered implants, as well as their resorption and remodelling. Thus far, however, the vast majority of efforts in this area of research have focused on th... | No full text available |
10. 1002/adfm. 201302859 | 2,014 | Advanced functional materials | Multilayered Inorganic Microparticles for Tunable Dual Growth Factor Delivery | There is an increasing need to control the type, quantity, and timing of growth factors released during tissue healing. Sophisticated delivery systems offering the ability to deliver multiple growth factors with independently tunable kinetics are highly desirable. Here, a multilayered, mineral coated micro-particle (MC... | No full text available |
10. 1002/adfm. 201302901 | 2,014 | Advanced functional materials | Arrayed Hollow Channels in Silk-based Scaffolds Provide Functional Outcomes for Engineering Critically-sized Tissue Constructs | In the field of regenerative medicine there is a need for scaffolds that support large, critically-sized tissue formation. Major limitations in reaching this goal are the delivery of oxygen and nutrients throughout the bulk of the engineered tissue as well as host tissue integration and vascularization upon implantatio... | No full text available |
10. 1002/adfm. 201303400 | 2,014 | Advanced functional materials | Deconstructing the Effects of Matrix Elasticity and Geometry in Mesenchymal Stem Cell Lineage Commitment | A wide variety of environmental factors including physical and biochemical signals are responsible for stem cell behavior and function. In particular, matrix elasticity and cell shape have been shown to determine stem cell function, yet little is known about the interplay between how these physical cues control cell di... | No full text available |
10. 1002/adfm. 201303460 | 2,014 | Advanced functional materials | Highly Aligned Nanofibrous Scaffold Derived from Decellularized Human Fibroblasts | Native tissues are endowed with a highly organized nanofibrous extracellular matrix (ECM) that directs cellular distribution and function. The objective of this study is to create a purely natural, uniform, and highly aligned nanofibrous ECM scaffold for potential tissue engineering applications. Synthetic nanogratings... | No full text available |
10. 1002/adfm. 201303547 | 2,014 | Advanced Functional Materials | Synthesis and Characterization of Gelatin-Based Magnetic Hydrogels | A simple preparation of thermoreversible gelatin-based ferrogels in water provides a constant structure defined by the crosslinking degree for gelatin contents between 6 and 18 wt%. The possibility of varying magnetite nanoparticle concentration between 20 and 70 wt% is also reported. Simulation studies hint at the sui... | 1 Introduction Living organisms are able to produce highly sophisticated materials. 1 Biominerals are organic-inorganic hybrid materials abundant in Nature. 1 They are formed under highly controlled conditions, 2 show complex morphologies and are very often hierarchically structured. 3 On each hierarchical level, the o... |
10. 1002/adfm. 201303655 | 2,014 | Advanced functional materials | Composite Living Fibers for Creating Tissue Constructs Using Textile Techniques | The fabrication of cell-laden structures with anisotropic mechanical properties while having a precise control over the distribution of different cell types within the constructs is important for many tissue engineering applications. Automated textile technologies for making fabrics allow simultaneous control over the ... | No full text available |
10. 1002/adfm. 201400274 | 2,015 | Advanced functional materials | Digital Plasmonic Patterning for Localized Tuning of Hydrogel Stiffness | The mechanical properties of the extracellular matrix (ECM) can dictate cell fate in biological systems. In tissue engineering, varying the stiffness of hydrogels—water-swollen polymeric networks that act as ECM substrates—has previously been demonstrated to control cell migration, proliferation, and differentiation. H... | No full text available |
10. 1002/adfm. 201400526 | 2,014 | Advanced functional materials | Highly tunable elastomeric silk biomaterials | Elastomeric, fully degradable and biocompatible biomaterials are rare, with current options presenting significant limitations in terms of ease of functionalization and tunable mechanical and degradation properties. We report a new method for covalently crosslinking tyrosine residues in silk proteins, via horseradish p... | No full text available |
10. 1002/adfm. 201401300 | 2,014 | Advanced functional materials | Layer-by-layer assembly of 3D tissue constructs with functionalized graphene | Carbon-based nanomaterials have been considered as promising candidates to mimic certain structure and function of native extracellular matrix materials for tissue engineering. Significant progress has been made in fabricating carbon nanoparticle-incorporated cell culture substrates, but limited studies have been repor... | No full text available |
10. 1002/adfm. 201500875 | 2,016 | Advanced functional materials | Protein Corona Influences Cell–Biomaterial Interactions in Nanostructured Tissue Engineering Scaffolds | Biomaterials are extensively used to restore damaged tissues, in the forms of implants (e. g. tissue engineered scaffolds) or biomedical devices (e. g. pacemakers). Once in contact with the physiological environment, nanostructured biomaterials undergo modifications as a result of endogenous proteins binding to their s... | No full text available |
10. 1002/adfm. 201501277 | 2,015 | Advanced Functional Materials | Modular and Versatile Spatial Functionalization of Tissue Engineering Scaffolds through Fiber‐Initiated Controlled Radical Polymerization | Native tissues are typically heterogeneous and hierarchically organized, and generating scaffolds that can mimic these properties is critical for tissue engineering applications. By uniquely combining controlled radical polymerization (CRP), end‐functionalization of polymers, and advanced electrospinning techniques, a ... | 1 Introduction The ability to design surface properties of scaffolds to direct cell and protein binding is key in tissue engineering (TE) and regenerative medicine. Following injury or scaffold implantation there are many scenarios where cell ingrowth or protein fouling onto a tissue or scaffold surface may lead to und... |
10. 1002/adfm. 201504160 | 2,016 | Advanced functional materials | Silk Biomaterials with Vascularization Capacity | Functional vascularization is critical for the clinical regeneration of complex tissues such as kidney, liver or bone. The immobilization or delivery of growth factors has been explored to improve vascularization capacity of tissue engineered constructs, however, the use of growth factors has inherent problems such as ... | No full text available |
10. 1002/adfm. 201605352 | 2,018 | Advanced functional materials | Gold Nanocomposite Bioink for Printing 3D Cardiac Constructs | Bioprinting is the most convenient microfabrication method to create biomimetic three-dimensional (3D) cardiac tissue constructs, which can be used to regenerate damaged tissue and provide platforms for drug screening. However, existing bioinks, which are usually composed of polymeric biomaterials, are poorly conductiv... | No full text available |
10. 1002/adfm. 201606273 | 2,019 | Advanced functional materials | Self-assembled Hydrogel Fiber Bundles from Oppositely Charged Polyelectrolytes Mimic Micro-/nanoscale Hierarchy of Collagen | Fiber bundles are present in many tissues throughout the body. In most cases, collagen subunits spontaneously self-assemble into a fibrilar structure that provides ductility to bone and constitutes the basis of muscle contraction. Translating these natural architectural features into a biomimetic scaffold still remains... | No full text available |
10. 1002/adfm. 201606614 | 2,019 | Advanced functional materials | Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation | Biomimetic materials with biomechanical properties resembling those of native tissues while providing an environment for cell growth and tissue formation, are vital for tissue engineering (TE). Mechanical anisotropy is an important property of native cardiovascular tissues and directly influences tissue function. This ... | No full text available |
10. 1002/adfm. 201701183 | 2,020 | Advanced functional materials | Engineered Axonal Tracts as “Living Electrodes” for Synaptic-Based Modulation of Neural Circuitry | Brain-computer interface and neuromodulation strategies relying on penetrating non-organic electrodes/optrodes are limited by an inflammatory foreign body response that ultimately diminishes performance. A novel “biohybrid” strategy is advanced, whereby living neurons, biomaterials, and microelectrode/optical technolog... | No full text available |
10. 1002/adfm. 201701713 | 2,023 | Advanced functional materials | Tissue-Engineered Peripheral Nerve Interfaces | Research on neural interfaces has historically concentrated on development of systems for the brain; however, there is increasing interest in peripheral nerve interfaces (PNIs) that could provide benefit when peripheral nerve function is compromised, such as for amputees. Efforts focus on designing scalable and high-pe... | No full text available |
10. 1002/adfm. 201705563 | 2,018 | Advanced functional materials | Integration of Phase-Change Materials with Electrospun Fibers for Promoting Neurite Outgrowth under Controlled Release | We report a temperature-regulated system for the controlled release of nerve growth factor (NGF) to promote neurite outgrowth. The system is based upon microparticles fabricated using coaxial electrospray, with the outer solution containing a phase-change material (PCM) and the inner solution encompassing payload(s). W... | No full text available |
10. 1002/adfm. 201706046 | 2,018 | Advanced functional materials | Bioorthogonal Strategies for Engineering Extracellular Matrices | Hydrogels are commonly used as engineered extracellular matrix (ECM) mimics in applications ranging from tissue engineering to in vitro disease models. Ideal mechanisms used to crosslink ECM-mimicking hydrogels do not interfere with the biology of the system. However, most common hydrogel crosslinking chemistries exhib... | No full text available |
10. 1002/adfm. 201707107 | 2,018 | Advanced functional materials | Functionally Graded, Bone- and Tendon-Like Polyurethane for Rotator Cuff Repair | Critical considerations in engineering biomaterials for rotator cuff repair include bone-tendon-like mechanical properties to support physiological loading and biophysicochemical attributes that stabilize the repair site over the long-term. In this study, UV-crosslinkable polyurethane based on quadrol (Q), hexamethylen... | No full text available |
10. 1002/adfm. 201800618 | 2,018 | Advanced functional materials | Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction | An auxetic conductive cardiac patch (AuxCP) for the treatment of myocardial infarction (MI) is introduced. The auxetic design gives the patch a negative Poisson’s ratio, providing it with the ability to conform to the demanding mechanics of the heart. The conductivity allows the patch to interface with electroresponsiv... | 1 Introduction Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. [ 1 ] Biomaterials and regenerative therapies represent exciting possible solutions. [ 2 – 8 ] Herein, we investigate a new biomaterial design for cardiac patches to treat myocardial infarction (MI), one of the large... |
10. 1002/adfm. 201801850 | 2,020 | Advanced functional materials | 3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds | A bioengineered spinal cord is fabricated via extrusion-based multi-material 3D bioprinting, in which clusters of induced pluripotent stem cell (iPSC)-derived spinal neuronal progenitor cells (sNPCs) and oligodendrocyte progenitor cells (OPCs) are placed in precise positions within 3D printed biocompatible scaffolds du... | No full text available |
10. 1002/adfm. 201906330 | 2,020 | Advanced functional materials | 3D Printed Cartilage-Like Tissue Constructs with Spatially Controlled Mechanical Properties | Developing biomimetic cartilaginous tissues that support locomotion while maintaining chondrogenic behavior is a major challenge in the tissue engineering field. Specifically, while locomotive forces demand tissues with strong mechanical properties, chondrogenesis requires a soft microenvironment. To address this chall... | No full text available |
10. 1002/adfm. 201907102 | 2,023 | Advanced functional materials | Creating Physicochemical Gradients in Modular Microporous Annealed Particle Hydrogels via a Microfluidic Method | Microporous annealed particle (MAP) hydrogels are an attractive platform for engineering biomaterials with controlled heterogeneity. Here, we introduce a microfluidic method to create physicochemical gradients within poly(ethylene glycol) based MAP hydrogels. By combining microfluidic mixing and droplet generator modul... | No full text available |
10. 1002/adfm. 201909553 | 2,020 | Advanced functional materials | Engineering liver microtissues for disease modeling and regenerative medicine | The burden of liver diseases is increasing worldwide, accounting for two million deaths annually. In the past decade, tremendous progress has been made in the basic and translational research of liver tissue engineering. Liver microtissues are small, three-dimensional hepatocyte cultures that recapitulate liver physiol... | No full text available |
10. 1002/adfm. 201909556 | 2,020 | Advanced functional materials | Recent Advances in Smart Biomaterials for the Detection and Treatment of Autoimmune Diseases | Autoimmune diseases are a group of debilitating illnesses that are often idiopathic in nature. The steady rise in the prevalence of these conditions warrants new approaches for diagnosis and treatment. Stimuli-responsive biomaterials also known as “smart”, “intelligent” or “recognitive” biomaterials are widely studied ... | No full text available |
10. 1002/adfm. 201909802 | 2,021 | Advanced functional materials | Metabolic Labeling to Probe the Spatiotemporal Accumulation of Matrix at the Chondrocyte–Hydrogel Interface | Hydrogels are engineered with biochemical and biophysical signals to recreate aspects of the native microenvironment and to control cellular functions such as differentiation and matrix deposition. This deposited matrix accumulates within the pericellular space and likely affects the interactions between encapsulated c... | No full text available |
10. 1002/adfm. 201910250 | 2,020 | Advanced Functional Materials | Bioprinting Neural Systems to Model Central Nervous System Diseases | Abstract To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly hampered by the lack of suitable disease models. Indeed, animal models do not faithfully represent human neurodegenerative processes and human in vitro 2D cell culture systems cannot recapitulate the in vivo complexity of n... | 1 Introduction 1. 1 State of the Art of Neural In Vitro Models Central nervous system (CNS) diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD), involve progressive dysfunction of distinct neuronal populations. Notwithstanding the growing amount of studies on CNS diseases, our understanding of brain... |
10. 1002/adfm. 201910442 | 2,021 | Advanced functional materials | Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers | Engineered tissue models comprise a variety of multiplexed ensembles in which combinations of epithelial, stromal, and immune cells give rise to physiologic function. Engineering spatiotemporal control of cell-cell and cell-matrix interactions within these 3D multicellular tissues would represent a significant advance ... | No full text available |
10. 1002/adfm. 202000543 | 2,020 | Advanced functional materials | Bi-layered Tubular Microfiber Scaffolds as Functional Templates for Engineering Human Intestinal Smooth Muscle Tissue | Designing biomimetic scaffolds with in vivo -like microenvironments using biomaterials is an essential component of successful tissue engineering approaches. The intestinal smooth muscle layers exhibit a complex tubular structure consisting of two concentric muscle layers in which the inner circular layer is orthogonal... | No full text available |
10. 1002/adfm. 202000639 | 2,020 | Advanced Functional Materials | Spatiotemporally Controlled Photoresponsive Hydrogels: Design and Predictive Modeling from Processing through Application | Abstract Photoresponsive hydrogels (PRHs) are soft materials whose mechanical and chemical properties can be tuned spatially and temporally with relative ease. Both photo‐crosslinkable and photodegradable hydrogels find utility in a range of biomedical applications that require tissue‐like properties or programmable re... | No full text available |
10. 1002/adfm. 202000893 | 2,021 | Advanced functional materials | A Chemically Defined Hydrogel for Human Liver Organoid Culture | End-stage liver diseases are an increasing health burden, and liver transplantations are currently the only curative treatment option. Due to a lack of donor livers, alternative treatments are urgently needed. Human liver organoids are very promising for regenerative medicine; however, organoids are currently cultured ... | 1 Introduction The liver is the largest internal organ in the body and is responsible for crucial metabolic functions. Upon acute damage, the liver has a great regenerative capacity and can restore up to 70% of its mass. [ 1 ] However, injury caused by chronic diseases such as viral infections or alcoholic fatty liver ... |
10. 1002/adfm. 202003710 | 2,020 | Advanced functional materials | An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering | The unique electrochemical properties of the conductive polymer poly(3, 4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability hav... | 1 Introduction To investigate fundamental questions in human brain development and disease, tissue engineering approaches have employed 3D polymer based biomaterial scaffolds as guidance cues to grow 3D neuronal cultures in conditions resembling the in vivo environment. [ 1 – 5 ] Yet, fully recapitulating all functiona... |
10. 1002/adfm. 202005010 | 2,020 | Advanced functional materials | Reversible Functionalization of Clickable Polyacrylamide Gels with Protein and Graft Copolymers | Modular strategies to fabricate gels with tailorable chemical functionalities are relevant to applications spanning from biomedicine to analytical chemistry. Here, the properties of clickable poly(acrylamide-co-propargyl acrylate) (pAPA) hydrogels are modified via sequential in-gel copper-catalyzed azide-alkyne cycload... | No full text available |
10. 1002/adfm. 202006796 | 2,020 | Advanced functional materials | Bone-on-a-chip: microfluidic technologies and microphysiologic models of bone tissue | Bone is an active organ that continuously undergoes an orchestrated process of remodeling throughout life. Bone tissue is uniquely capable of adapting to loading, hormonal, and other changes happening in the body, as well as repairing bone that becomes damaged to maintain tissue integrity. On the other hand, diseases s... | No full text available |
10. 1002/adfm. 202006967 | 2,020 | Advanced functional materials | Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics | Additive manufacturing (AM) allows the fabrication of customized bone scaffolds in terms of shape, pore size, material type and mechanical properties. Combined with the possibility to obtain a precise 3D image of the bone defects using computed tomography or magnetic resonance imaging, it is now possible to manufacture... | No full text available |
10. 1002/adfm. 202007199 | 2,021 | Advanced functional materials | Engineering new microvascular networks on-chip: ingredients, assembly, and best practices | Tissue engineered grafts show great potential as regenerative implants for diseased or injured tissues within the human body. However, these grafts suffer from poor nutrient perfusion and waste transport, thus decreasing their viability post-transplantation. Graft vascularization is therefore a major area of focus with... | No full text available |
10. 1002/adfm. 202009946 | 2,022 | Advanced functional materials | Single-Cell Microgels for Diagnostics and Therapeutics | Cell encapsulation within hydrogel droplets is transforming what is feasible in multiple fields of biomedical science such as tissue engineering and regenerative medicine, in vitro modeling, and cell-based therapies. Recent advances have allowed researchers to miniaturize material encapsulation complexes down to single... | No full text available |
10. 1002/adfm. 202100015 | 2,021 | Advanced Functional Materials | Development of Fluorine‐Free Tantalum Carbide MXene Hybrid Structure as a Biocompatible Material for Supercapacitor Electrodes | Abstract The application of nontoxic 2D transition‐metal carbides (MXenes) has recently gained ground in bioelectronics. In group‐4 transition metals, tantalum possesses enhanced biological and physical properties compared to other MXene counterparts. However, the application of tantalum carbide for bioelectrodes has n... | 1 Introduction With ongoing rapid development in the area of bioelectronics, small and light weight biocompatible electrodes are in high demand for biomedical implantable devices such as, cardiac pacemakers, neurostimulators, and cochlear implants. [ 1, 2, 3, 4, 5 ] The supercapacitors (SCs) with promising properties, ... |
10. 1002/adfm. 202100850 | 2,021 | Advanced functional materials | Self-Oxygenation of Tissues Orchestrates Full-Thickness Vascularization of Living Implants | Bioengineering of tissues and organs has the potential to generate functional replacement organs. However, achieving the full-thickness vascularization that is required for long-term survival of living implants has remained a grand challenge, especially for clinically sized implants. During the pre-vascular phase, impl... | 1. Introduction The bioengineering of tissues and organs has the potential to deliver functional replacement organs. [ 1, 2 ] However, the creation of viable clinically sized implants has remained a grand challenge. Current tissue engineering strategies, although suitable for the development of small living tissues tha... |
10. 1002/adfm. 202108495 | 2,021 | Advanced Functional Materials | Conversion of 2D MXene to Multi‐Low‐Dimensional GerMXene Superlattice Heterostructure | Abstract Integration of 2D structures into other low‐dimensional materials results in the development of distinct van der Waals heterostructures (vdWHSs) with enhanced properties. However, obtaining 2D–1D–0D vdWHSs of technologically useful next generation materials, transition‐metal carbide MXene and monoelemental Xen... | 1 Introduction Recently, there has been growing interest in the development of van der Waals heterostructures (vdWHSs) for applications in biomedical field, electronics and energy storage. [ 1, 2 ] The strategies to synthesize vdWHSs have not been limited to the 2D nanosheets rather there have been significant efforts ... |
10. 1002/adhm. 201200382 | 2,017 | Advanced healthcare materials | Nanoscale Topography and Chemistry Affect Embryonic Stem Cell Self-Renewal and Early Differentiation | Adherent cells respond to a wide range of substrate cues, including chemistry, topography, hydrophobicity, and surface energy. The cell-substrate interface is therefore an important design parameter in regenerative medicine and tissue engineering applications, where substrate cues are used to influence cell behavior. T... | No full text available |
10. 1002/adhm. 201300063 | 2,014 | Advanced healthcare materials | Combinatorial biomatrix/cell-based therapies for restoration of host tissue architecture and function | This Progress Report reviews recent advances in the utility of extracellular matrix (ECM)-mimic biomaterials in presenting and delivering therapeutic cells to promote tissue healing. This overview gives a brief introduction of different cell types being used in regenerative medicine and tissue engineering while address... | No full text available |
10. 1002/adhm. 201300505 | 2,014 | Advanced healthcare materials | Electrospun PGS: PCL Microfibers Align Human Valvular Interstitial Cells and Provide Tunable Scaffold Anisotropy | Tissue engineered heart valves (TEHV) could be useful in the repair of congenital or acquired valvular diseases due to their potential for growth and remodeling. The development of biomimetic scaffolds is a major challenge in heart valve tissue engineering. One of the most important structural characteristics of mature... | No full text available |
10. 1002/adhm. 201300620 | 2,014 | Advanced healthcare materials | Role of Extracellular Matrix Signaling Cues in Modulating Cell Fate Commitment for Cardiovascular Tissue Engineering | It is generally agreed that engineered cardiovascular tissues require cellular interactions with the local milieu. Within the microenvironment, the extracellular matrix (ECM) is an important support structure that provides dynamic signaling cues in part through its chemical, physical, and mechanical properties. In resp... | No full text available |
10. 1002/adhm. 201300678 | 2,014 | Advanced healthcare materials | Confinement and Deformation of Single Cells and Their Nuclei Inside Size-Adapted Microtubes | No abstract available | The mechanical properties of the microenvironment of cells, like substrate rigidity and topography, have a considerable impact on various aspects of cell fate, such as proliferation, [ 1 – 3 ] apoptosis, [ 4 ] and differentiation. [ 5, 6 ] For example, on 2D predefined adhesion sites, the cells need a minimum area for ... |
10. 1002/adhm. 201400065 | 2,014 | Advanced Healthcare Materials | Assessing Cellular Response to Functionalized α-Helical Peptide Hydrogels | No abstract available | For applications in 2D and 3D cell cultures and tissue engineering, there is a need to develop biocompatible scaffolds that support cell and tissue growth therefore mimicking the biochemical and morphological properties of the natural extracellular matrix (ECM). In order to support cellular growth, the scaffold must pr... |
10. 1002/adhm. 201400095 | 2,014 | Advanced healthcare materials | Biphasic Ferrogels for Triggered Drug and Cell Delivery | Ferrogels are an attractive material for many biomedical applications due to their ability to deliver a wide variety of therapeutic drugs on-demand. However, typical ferrogels have yet to be optimized for use in cell-based therapies, as they possess limited ability to harbor and release viable cells. Previously, we hav... | No full text available |
10. 1002/adhm. 201400277 | 2,015 | Advanced healthcare materials | An Enzyme-sensitive PEG Hydrogel Based on Aggrecan Catabolism for Cartilage Tissue Engineering | A new cartilage-specific degradable hydrogel based on photoclickable thiol-ene PEG hydrogels is presented. The hydrogel crosslinks are composed of the peptide, CRDTEGE-ARGSVIDRC, derived from the aggrecanase-cleavable site in aggrecan. This new hydrogel is evaluated for use in cartilage tissue engineering by encapsulat... | No full text available |
10. 1002/adhm. 201400458 | 2,015 | Advanced healthcare materials | Spatial Control of Cell Gene Expression by siRNA Gradients in Biodegradable Hydrogels | The extracellular environment exposes cells to numerous biochemical and physical signals that regulate their behavior. Strategies for generating continuous gradients of signals in biomaterials may allow for spatial control and patterning of cell behavior, and ultimately aid in the engineering of complex tissues. Short ... | No full text available |
10. 1002/adhm. 201400695 | 2,015 | Advanced healthcare materials | Development of a cellularly degradable PEG hydrogel to promote articular cartilage extracellular matrix deposition | Healing articular cartilage remains a significant clinical challenge because of its limited self-healing capacity. While delivery of autologous chondrocytes to cartilage defects has received growing interest, combining cell-based therapies with scaffolds that capture aspects of native tissue and promote cell-mediated r... | No full text available |
10. 1002/adhm. 201400724 | 2,015 | Advanced Healthcare Materials | Going Beyond Compromises in Multifunctionality of Biomaterials | No abstract available | Design, synthesis, processing, and testing, or perhaps better altogether exploration, of biomaterials, which are intended to substitute native tissue, have generally been approached from one of two distinct perspectives ( Figure 1 A). Researchers with a background in chemistry or biology have been inspired by the natur... |
10. 1002/adhm. 201400760 | 2,015 | Advanced healthcare materials | Biomaterials for Bone Regenerative Engineering | Strategies for bone tissue regeneration have been continuously evolving for the last 25 years since the introduction of the “tissue engineering” concept. The convergence of the life, physical, and engineering sciences has brought in several advanced technologies available to tissue engineers and scientists. This result... | No full text available |
10. 1002/adhm. 201400762 | 2,015 | Advanced Healthcare Materials | Generation and Assessment of Functional Biomaterial Scaffolds for Applications in Cardiovascular Tissue Engineering and Regenerative Medicine | Current clinically applicable tissue and organ replacement therapies are limited in the field of cardiovascular regenerative medicine. The available options do not regenerate damaged tissues and organs, and, in the majority of the cases, show insufficient restoration of tissue function. To date, anticoagulant drug‐free... | 1 Introduction Cardiovascular diseases (CVDs) such as coronary heart disease, rheumatic heart disease, congenital heart disease, myocardial infarction (MI) and strokes remain the number one cause of death in western countries. Despite the development of new therapies and the approach of risk‐reducing strategies to prev... |
10. 1002/adhm. 201400781 | 2,015 | Advanced healthcare materials | Fabricated elastin | The mechanical stability, elasticity, inherent bioactivity, and self-assembly properties of elastin make it a highly attractive candidate for the fabrication of versatile biomaterials. The ability to engineer specific peptide sequences derived from elastin allows for precise control of these physicochemical and organiz... | No full text available |
10. 1002/adhm. 201500005 | 2,015 | Advanced healthcare materials | Photocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering | Natural hydrogels are promising scaffolds to engineer epidermis. Currently, natural hydrogels used to support epidermal regeneration are mainly collagen- or gelatin-based, which mimic the natural dermal extracellular matrix (ECM) but often suffer from insufficient and uncontrollable mechanical and degradation propertie... | No full text available |
10. 1002/adhm. 201500168 | 2,015 | Advanced healthcare materials | 3D Printing of Scaffolds for Tissue Regeneration Applications | The current need for organ and tissue replacement, repair and regeneration for patients is continually growing such that supply is not meeting the high demand primarily due to a paucity of donors as well as biocompatibility issues that lead to immune rejection of the transplant. In an effort to overcome these drawbacks... | No full text available |
10. 1002/adhm. 201500197 | 2,015 | Advanced Healthcare Materials | Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory | No abstract available | Collagen scaffolds are biological templates for the regeneration of damaged or diseased tissues. Since cell invasion into these porous scaffolds is vital for healthy tissue regeneration, the characteristics that influence cellular response must be accounted for in scaffold design. For instance, characterization of mean... |
10. 1002/adhm. 201500236 | 2,015 | Advanced healthcare materials | ECM-Based Biohybrid Materials for Engineering Compliant, Matrix-Dense Tissues | An ideal tissue engineering scaffold should not only promote, but take an active role in, constructive remodeling and formation of site appropriate tissue. ECM-derived proteins provide unmatched cellular recognition, and therefore influence cellular response towards predicted remodeling behaviors. Materials built with ... | No full text available |
10. 1002/adhm. 201500304 | 2,015 | Advanced healthcare materials | Temporally Tunable, Enzymatically-responsive Delivery of Pro-angiogenic Peptides from Poly(ethylene glycol) Hydrogels | Pro-angiogenic drugs hold great potential to promote reperfusion of ischemic tissues and in tissue engineering applications, but efficacy is limited by poor targeting and short half-lives. Methods to control release duration or provide enzymatically-responsive drug delivery have independently improved drug efficacy. Ho... | No full text available |
10. 1002/adhm. 201500411 | 2,016 | Advanced healthcare materials | Recombinant Resilin-based Bioelastomers for Regenerative Medicine Applications | The superior elasticity, excellent resilience at high-frequency, and hydrophilic capacity of natural resilin have motivated investigations of recombinant resilin-based biomaterials as a new class of bio-elastomers in the engineering of mechanically active tissues. Accordingly, we report here the comprehensive character... | No full text available |
10. 1002/adhm. 201500517 | 2,016 | Advanced healthcare materials | Textile Technologies and Tissue Engineering: A Path Towards Organ Weaving | Textile technologies have recently attracted great attention as potential biofabrication tools for engineering tissue constructs. Using current textile technologies, fibrous structures can be designed and engineered to attain the required properties that are demanded by different tissue engineering applications. Severa... | No full text available |
10. 1002/adhm. 201500531 | 2,015 | Advanced healthcare materials | Hierarchical Nanofibrous Microspheres with Controlled Growth Factor Delivery for Bone Regeneration | The integration of controlled growth factor delivery and biomimetic architecture into a microsphere is a challenging but attractive strategy for developing new injectable biomaterials for tissue engineering. In this work, we developed a unique hierarchical nanosphere-encapsulated-in-microsphere scaffolding system for b... | No full text available |
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