id stringlengths 5 32 | document_id stringlengths 5 32 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
19-norandrostenedione_ddi | 19-norandrostenedione_ddi | [
{
"id": "19-norandrostenedione_ddi__text",
"type": "abstract",
"text": [
"No drug, nutritional supplement, food or herb interactions have yet been reported."
],
"offsets": [
[
0,
82
]
]
}
] | [] | [] | [] | [] |
Abarelix_ddi | Abarelix_ddi | [
{
"id": "Abarelix_ddi__text",
"type": "abstract",
"text": [
"No formal drug/drug interaction studies with Plenaxis were performed. Cytochrome P-450 is not known to be involved in the metabolism of Plenaxis. Plenaxis is highly bound to plasma proteins (96 to 99%). Laboratory Tests Response to Plena... | [
{
"id": "Abarelix_ddi_T1",
"type": "BRAND",
"offsets": [
[
45,
53
]
],
"text": [
"Plenaxis"
],
"normalized": []
},
{
"id": "Abarelix_ddi_T2",
"type": "BRAND",
"offsets": [
[
136,
144
]
],
"text": [
... | [] | [] | [] |
Abatacept_ddi | Abatacept_ddi | [
{
"id": "Abatacept_ddi__text",
"type": "abstract",
"text": [
"Formal drug interaction studies have not been conducted with ORENCIA. Population pharmacokinetic analyses revealed that MTX, NSAIDs, corticosteroids, and TNF blocking agents did not influence abatacept clearance. The majority of patient... | [
{
"id": "Abatacept_ddi_T1",
"type": "BRAND",
"offsets": [
[
61,
68
]
],
"text": [
"ORENCIA"
],
"normalized": []
},
{
"id": "Abatacept_ddi_T2",
"type": "DRUG",
"offsets": [
[
120,
123
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Abatacept_ddi_T19",
"arg2_id": "Abatacept_ddi_T20",
"id": "Abatacept_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Abatacept_ddi_T22",
"arg2_id": "Abatacept_ddi_T23",
"id": "Abatacept_ddi_R2",
"type": "ADVISE",
"normalized": []
},
{
"a... |
Abciximab_ddi | Abciximab_ddi | [
{
"id": "Abciximab_ddi__text",
"type": "abstract",
"text": [
"Formal drug interaction studies with Abciximab have not been conducted. Abciximab has been administered to patients with ischemic heart disease treated concomitantly with a broad range of medications used in the treatment of angina myoc... | [
{
"id": "Abciximab_ddi_T1",
"type": "DRUG",
"offsets": [
[
37,
46
]
],
"text": [
"Abciximab"
],
"normalized": []
},
{
"id": "Abciximab_ddi_T2",
"type": "DRUG",
"offsets": [
[
72,
81
]
],
"text": [
... | [] | [] | [] |
Acamprosate_ddi | Acamprosate_ddi | [
{
"id": "Acamprosate_ddi__text",
"type": "abstract",
"text": [
"The concomitant intake of alcohol and Acamprosate does not affect the pharmacokinetics of either alcohol or acamprosate. Pharmacokinetic studies indicate that administration of disulfiram or diazepam does not affect the pharmacokineti... | [
{
"id": "Acamprosate_ddi_T1",
"type": "DRUG",
"offsets": [
[
26,
33
]
],
"text": [
"alcohol"
],
"normalized": []
},
{
"id": "Acamprosate_ddi_T2",
"type": "DRUG",
"offsets": [
[
38,
49
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Acamprosate_ddi_T8",
"arg2_id": "Acamprosate_ddi_T9",
"id": "Acamprosate_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Acamprosate_ddi_T20",
"arg2_id": "Acamprosate_ddi_T21",
"id": "Acamprosate_ddi_R2",
"type": "EFFECT",
"normalized": []
... |
Acarbose_ddi | Acarbose_ddi | [
{
"id": "Acarbose_ddi__text",
"type": "abstract",
"text": [
"Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoi... | [
{
"id": "Acarbose_ddi_T1",
"type": "GROUP",
"offsets": [
[
115,
124
]
],
"text": [
"thiazides"
],
"normalized": []
},
{
"id": "Acarbose_ddi_T2",
"type": "GROUP",
"offsets": [
[
135,
144
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Acarbose_ddi_T17",
"arg2_id": "Acarbose_ddi_T22",
"id": "Acarbose_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Acarbose_ddi_T18",
"arg2_id": "Acarbose_ddi_T22",
"id": "Acarbose_ddi_R2",
"type": "MECHANISM",
"normalized": []
},
{
"a... |
Acebutolol_ddi | Acebutolol_ddi | [
{
"id": "Acebutolol_ddi__text",
"type": "abstract",
"text": [
"Catecholamine-depleting drugs, such as reserpine, may have an additive effect when given with beta-blocking agents. Patients treated with acebutolol plus catecholamine depletors should, therefore, be observed closely for evidence of ma... | [
{
"id": "Acebutolol_ddi_T1",
"type": "GROUP",
"offsets": [
[
0,
29
]
],
"text": [
"Catecholamine-depleting drugs"
],
"normalized": []
},
{
"id": "Acebutolol_ddi_T2",
"type": "DRUG",
"offsets": [
[
39,
48
]
... | [] | [] | [
{
"arg1_id": "Acebutolol_ddi_T1",
"arg2_id": "Acebutolol_ddi_T3",
"id": "Acebutolol_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Acebutolol_ddi_T2",
"arg2_id": "Acebutolol_ddi_T3",
"id": "Acebutolol_ddi_R2",
"type": "EFFECT",
"normalized": []
},
{
... |
Acetazolamide_ddi | Acetazolamide_ddi | [
{
"id": "Acetazolamide_ddi__text",
"type": "abstract",
"text": [
"DIAMOX modifies phenytoin metabolism with increased serum levels of phenytoin. This may increase or enhance the occurrence of osteomalacia in some patients receiving chronic phenytoin therapy. Caution is advised in patients receivin... | [
{
"id": "Acetazolamide_ddi_T1",
"type": "BRAND",
"offsets": [
[
0,
6
]
],
"text": [
"DIAMOX"
],
"normalized": []
},
{
"id": "Acetazolamide_ddi_T2",
"type": "DRUG",
"offsets": [
[
16,
25
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Acetazolamide_ddi_T1",
"arg2_id": "Acetazolamide_ddi_T2",
"id": "Acetazolamide_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Acetazolamide_ddi_T1",
"arg2_id": "Acetazolamide_ddi_T3",
"id": "Acetazolamide_ddi_R2",
"type": "MECHANISM",
"norma... |
Acetohydroxamic Acid_ddi | Acetohydroxamic Acid_ddi | [
{
"id": "Acetohydroxamic Acid_ddi__text",
"type": "abstract",
"text": [
"Concomitant use with iron supplements may result in the reduced absorption of iron."
],
"offsets": [
[
0,
83
]
]
}
] | [
{
"id": "Acetohydroxamic Acid_ddi_T1",
"type": "GROUP",
"offsets": [
[
21,
36
]
],
"text": [
"iron supplement"
],
"normalized": []
},
{
"id": "Acetohydroxamic Acid_ddi_T2",
"type": "DRUG",
"offsets": [
[
78,
82
... | [] | [] | [] |
Aciclovir_ddi | Aciclovir_ddi | [
{
"id": "Aciclovir_ddi__text",
"type": "abstract",
"text": [
"Co-administration of probenecid with acyclovir has been shown to increase the mean half-life and the area under the concentration-time curve. Urinary excretion and renal clearance were correspondingly reduced. The clinical effects of th... | [
{
"id": "Aciclovir_ddi_T1",
"type": "DRUG",
"offsets": [
[
21,
31
]
],
"text": [
"probenecid"
],
"normalized": []
},
{
"id": "Aciclovir_ddi_T2",
"type": "DRUG",
"offsets": [
[
37,
46
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Aciclovir_ddi_T1",
"arg2_id": "Aciclovir_ddi_T2",
"id": "Aciclovir_ddi_R1",
"type": "MECHANISM",
"normalized": []
}
] |
Acitretin_ddi | Acitretin_ddi | [
{
"id": "Acitretin_ddi__text",
"type": "abstract",
"text": [
"Ethanol:Clinical evidence has shown that etretinate can be formed with concurrent ingestion of acitretin and ethanol. Glibenclamide: In a study of 7 healthy male volunteers, acitretin treatment potentiated the blood glucose lowering eff... | [
{
"id": "Acitretin_ddi_T1",
"type": "DRUG",
"offsets": [
[
0,
7
]
],
"text": [
"Ethanol"
],
"normalized": []
},
{
"id": "Acitretin_ddi_T2",
"type": "DRUG",
"offsets": [
[
41,
51
]
],
"text": [
"et... | [] | [] | [
{
"arg1_id": "Acitretin_ddi_T3",
"arg2_id": "Acitretin_ddi_T4",
"id": "Acitretin_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Acitretin_ddi_T6",
"arg2_id": "Acitretin_ddi_T7",
"id": "Acitretin_ddi_R2",
"type": "EFFECT",
"normalized": []
},
{
"ar... |
Adalimumab_ddi | Adalimumab_ddi | [
{
"id": "Adalimumab_ddi__text",
"type": "abstract",
"text": [
"Methotrexate: HUMIRA has been studied in rheumatoid arthritis patients taking concomitant MTX. The data do not suggest the need for dose adjustment of either HUMIRA or MTX. Anakinra: Concurrent administration of anakinra (an interleuki... | [
{
"id": "Adalimumab_ddi_T1",
"type": "DRUG",
"offsets": [
[
0,
12
]
],
"text": [
"Methotrexate"
],
"normalized": []
},
{
"id": "Adalimumab_ddi_T2",
"type": "BRAND",
"offsets": [
[
14,
20
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Adalimumab_ddi_T7",
"arg2_id": "Adalimumab_ddi_T9",
"id": "Adalimumab_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Adalimumab_ddi_T8",
"arg2_id": "Adalimumab_ddi_T9",
"id": "Adalimumab_ddi_R2",
"type": "EFFECT",
"normalized": []
},
{
... |
Adapalene_ddi | Adapalene_ddi | [
{
"id": "Adapalene_ddi__text",
"type": "abstract",
"text": [
"As DIFFERIN Gel has the potential to produce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying e... | [
{
"id": "Adapalene_ddi_T1",
"type": "BRAND",
"offsets": [
[
3,
11
]
],
"text": [
"DIFFERIN"
],
"normalized": []
},
{
"id": "Adapalene_ddi_T2",
"type": "DRUG",
"offsets": [
[
429,
435
]
],
"text": [
... | [] | [] | [] |
Adefovir Dipivoxil_ddi | Adefovir Dipivoxil_ddi | [
{
"id": "Adefovir Dipivoxil_ddi__text",
"type": "abstract",
"text": [
"Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: aminoglycosides (e.g., gentamicin, amikacin), amphotericin B, cyclosporine, non-steroidal... | [
{
"id": "Adefovir Dipivoxil_ddi_T1",
"type": "GROUP",
"offsets": [
[
138,
153
]
],
"text": [
"aminoglycosides"
],
"normalized": []
},
{
"id": "Adefovir Dipivoxil_ddi_T2",
"type": "DRUG",
"offsets": [
[
161,
171
... | [] | [] | [] |
Adenosine_ddi | Adenosine_ddi | [
{
"id": "Adenosine_ddi__text",
"type": "abstract",
"text": [
"Intravenous Adenocard (adenosine) has been effectively administered in the presence of other cardioactive drugs, such as quinidine, beta-adrenergic blocking agents, calcium channel blocking agents, and angiotensin converting enzyme inhi... | [
{
"id": "Adenosine_ddi_T1",
"type": "BRAND",
"offsets": [
[
12,
21
]
],
"text": [
"Adenocard"
],
"normalized": []
},
{
"id": "Adenosine_ddi_T2",
"type": "DRUG",
"offsets": [
[
23,
32
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Adenosine_ddi_T7",
"arg2_id": "Adenosine_ddi_T9",
"id": "Adenosine_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Adenosine_ddi_T8",
"arg2_id": "Adenosine_ddi_T9",
"id": "Adenosine_ddi_R2",
"type": "EFFECT",
"normalized": []
},
{
"arg1_... |
Adinazolam_ddi | Adinazolam_ddi | [
{
"id": "Adinazolam_ddi__text",
"type": "abstract",
"text": [
"Co-administration with antifungal agents such as ketoconazole or itraconazole is not recommended. Nafazodone, fluvoxamine, cimetidine (consider Xanax dose reduction). Fluoxetine, OCs, sertraline, diltiazem, macrolide antibiotics (exerc... | [
{
"id": "Adinazolam_ddi_T1",
"type": "GROUP",
"offsets": [
[
23,
40
]
],
"text": [
"antifungal agents"
],
"normalized": []
},
{
"id": "Adinazolam_ddi_T2",
"type": "DRUG",
"offsets": [
[
49,
61
]
],
"tex... | [] | [] | [
{
"arg1_id": "Adinazolam_ddi_T4",
"arg2_id": "Adinazolam_ddi_T7",
"id": "Adinazolam_ddi_R1",
"type": "ADVISE",
"normalized": []
},
{
"arg1_id": "Adinazolam_ddi_T5",
"arg2_id": "Adinazolam_ddi_T7",
"id": "Adinazolam_ddi_R2",
"type": "ADVISE",
"normalized": []
},
{
... |
Agalsidase beta_ddi | Agalsidase beta_ddi | [
{
"id": "Agalsidase beta_ddi__text",
"type": "abstract",
"text": [
"No drug interaction studies were performed. No in vitro metabolism studies were performed."
],
"offsets": [
[
0,
90
]
]
}
] | [] | [] | [] | [] |
Albendazole_ddi | Albendazole_ddi | [
{
"id": "Albendazole_ddi__text",
"type": "abstract",
"text": [
"Dexamethasone: Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in eight neurocysticercosis patients. Praziquante... | [
{
"id": "Albendazole_ddi_T1",
"type": "DRUG",
"offsets": [
[
0,
13
]
],
"text": [
"Dexamethasone"
],
"normalized": []
},
{
"id": "Albendazole_ddi_T2",
"type": "DRUG",
"offsets": [
[
53,
74
]
],
"text": ... | [] | [] | [
{
"arg1_id": "Albendazole_ddi_T3",
"arg2_id": "Albendazole_ddi_T4",
"id": "Albendazole_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Albendazole_ddi_T6",
"arg2_id": "Albendazole_ddi_T7",
"id": "Albendazole_ddi_R2",
"type": "MECHANISM",
"normalized": []
... |
Alclometasone_ddi | Alclometasone_ddi | [
{
"id": "Alclometasone_ddi__text",
"type": "abstract",
"text": [
"No information provided"
],
"offsets": [
[
0,
23
]
]
}
] | [] | [] | [] | [] |
Aldesleukin_ddi | Aldesleukin_ddi | [
{
"id": "Aldesleukin_ddi__text",
"type": "abstract",
"text": [
"PROLEUKIN may affect central nervous function. Therefore, interactions could occur following concomitant administration of psychotropic drugs (e.g., narcotics, analgesics, antiemetics, sedatives, tranquilizers). Concurrent administrat... | [
{
"id": "Aldesleukin_ddi_T1",
"type": "BRAND",
"offsets": [
[
0,
9
]
],
"text": [
"PROLEUKIN"
],
"normalized": []
},
{
"id": "Aldesleukin_ddi_T2",
"type": "GROUP",
"offsets": [
[
123,
141
]
],
"text": [... | [] | [] | [
{
"arg1_id": "Aldesleukin_ddi_T8",
"arg2_id": "Aldesleukin_ddi_T14",
"id": "Aldesleukin_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Aldesleukin_ddi_T9",
"arg2_id": "Aldesleukin_ddi_T14",
"id": "Aldesleukin_ddi_R2",
"type": "EFFECT",
"normalized": []
},
... |
Alefacept_ddi | Alefacept_ddi | [
{
"id": "Alefacept_ddi__text",
"type": "abstract",
"text": [
"No formal interaction studies have been performed. The duration of the period following treatment with AMEVIVE before one should consider starting other immunosuppressive therapy has not been evaluated. Carcinogenesis, Mutagenesis, and... | [
{
"id": "Alefacept_ddi_T1",
"type": "BRAND",
"offsets": [
[
103,
110
]
],
"text": [
"AMEVIVE"
],
"normalized": []
},
{
"id": "Alefacept_ddi_T2",
"type": "GROUP",
"offsets": [
[
154,
171
]
],
"text": [
... | [] | [] | [] |
Alemtuzumab_ddi | Alemtuzumab_ddi | [
{
"id": "Alemtuzumab_ddi__text",
"type": "abstract",
"text": [
"Drug/Laboratory Interactions No formal drug interaction studies have been performed with Campath. An immune response to Campath may interfere with subsequent diagnostic serum tests that utilize antibodies ."
],
"offsets": [
... | [
{
"id": "Alemtuzumab_ddi_T1",
"type": "BRAND",
"offsets": [
[
89,
96
]
],
"text": [
"Campath"
],
"normalized": []
},
{
"id": "Alemtuzumab_ddi_T2",
"type": "BRAND",
"offsets": [
[
120,
127
]
],
"text": [... | [] | [] | [] |
Alendronate_ddi | Alendronate_ddi | [
{
"id": "Alendronate_ddi__text",
"type": "abstract",
"text": [
"Intravenous ranitidine was shown to double the bioavailability of oral alendronate. The clinical significance of this increased bioavailability and whether similar increases will occur in patients given oral H2-antagonists is unknown;... | [
{
"id": "Alendronate_ddi_T1",
"type": "DRUG",
"offsets": [
[
12,
22
]
],
"text": [
"ranitidine"
],
"normalized": []
},
{
"id": "Alendronate_ddi_T2",
"type": "DRUG",
"offsets": [
[
71,
82
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Alendronate_ddi_T1",
"arg2_id": "Alendronate_ddi_T2",
"id": "Alendronate_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Alendronate_ddi_T4",
"arg2_id": "Alendronate_ddi_T6",
"id": "Alendronate_ddi_R2",
"type": "MECHANISM",
"normalized": []
... |
Alfentanil_ddi | Alfentanil_ddi | [
{
"id": "Alfentanil_ddi__text",
"type": "abstract",
"text": [
"Both the magnitude and duration of central nervous system and cardiovascular effects may be enhanced when ALFENTA is administered in combination with other CNS depressants such as barbiturates, tranquilizers, opioids, or inhalation gen... | [
{
"id": "Alfentanil_ddi_T1",
"type": "BRAND",
"offsets": [
[
106,
113
]
],
"text": [
"ALFENTA"
],
"normalized": []
},
{
"id": "Alfentanil_ddi_T2",
"type": "GROUP",
"offsets": [
[
156,
171
]
],
"text": [... | [] | [] | [
{
"arg1_id": "Alfentanil_ddi_T1",
"arg2_id": "Alfentanil_ddi_T2",
"id": "Alfentanil_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Alfentanil_ddi_T1",
"arg2_id": "Alfentanil_ddi_T3",
"id": "Alfentanil_ddi_R2",
"type": "EFFECT",
"normalized": []
},
{
... |
Alfuzosin_ddi | Alfuzosin_ddi | [
{
"id": "Alfuzosin_ddi__text",
"type": "abstract",
"text": [
"Drug-Drug Interactions: The pharmacokinetic and pharmacodynamic interactions between UROXATRAL and other alpha-blockers have not been determined. However, interactions may be expected, and UROXATRAL should NOT be used in combination wit... | [
{
"id": "Alfuzosin_ddi_T1",
"type": "BRAND",
"offsets": [
[
85,
94
]
],
"text": [
"UROXATRAL"
],
"normalized": []
},
{
"id": "Alfuzosin_ddi_T2",
"type": "GROUP",
"offsets": [
[
105,
119
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Alfuzosin_ddi_T3",
"arg2_id": "Alfuzosin_ddi_T4",
"id": "Alfuzosin_ddi_R1",
"type": "ADVISE",
"normalized": []
}
] |
Alglucosidase alfa_ddi | Alglucosidase alfa_ddi | [
{
"id": "Alglucosidase alfa_ddi__text",
"type": "abstract",
"text": [
"No drug interaction studies have been performed."
],
"offsets": [
[
0,
48
]
]
}
] | [] | [] | [] | [] |
Aliskiren_ddi | Aliskiren_ddi | [
{
"id": "Aliskiren_ddi__text",
"type": "abstract",
"text": [
"Effects of Other Drugs on Aliskiren Based on in-vitro studies, aliskiren is metabolized by CYP 3A4. Co-administration of lovastatin, atenolol, warfarin, furosemide, digoxin, celecoxib, hydrochlorothiazide, ramipril, valsartan, metformin... | [
{
"id": "Aliskiren_ddi_T1",
"type": "DRUG",
"offsets": [
[
26,
35
]
],
"text": [
"Aliskiren"
],
"normalized": []
},
{
"id": "Aliskiren_ddi_T2",
"type": "DRUG",
"offsets": [
[
63,
72
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Aliskiren_ddi_T15",
"arg2_id": "Aliskiren_ddi_T16",
"id": "Aliskiren_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Aliskiren_ddi_T17",
"arg2_id": "Aliskiren_ddi_T18",
"id": "Aliskiren_ddi_R2",
"type": "MECHANISM",
"normalized": []
},
{
... |
Alitretinoin_ddi | Alitretinoin_ddi | [
{
"id": "Alitretinoin_ddi__text",
"type": "abstract",
"text": [
"Patients who are applying Panretin gel should not concurrently use products that contain DEET (N, N-diethyl-m-toluamide), a common component of insect repellent products. Animal toxicology studies showed increased DEET toxicity when ... | [
{
"id": "Alitretinoin_ddi_T1",
"type": "BRAND",
"offsets": [
[
26,
34
]
],
"text": [
"Panretin"
],
"normalized": []
},
{
"id": "Alitretinoin_ddi_T2",
"type": "DRUG",
"offsets": [
[
89,
93
]
],
"text": [... | [] | [] | [
{
"arg1_id": "Alitretinoin_ddi_T1",
"arg2_id": "Alitretinoin_ddi_T2",
"id": "Alitretinoin_ddi_R1",
"type": "ADVISE",
"normalized": []
},
{
"arg1_id": "Alitretinoin_ddi_T1",
"arg2_id": "Alitretinoin_ddi_T3",
"id": "Alitretinoin_ddi_R2",
"type": "ADVISE",
"normalized": []
... |
Allopurinol_ddi | Allopurinol_ddi | [
{
"id": "Allopurinol_ddi__text",
"type": "abstract",
"text": [
"The following drug interactions were observed in some patients undergoing treatment with oral allopurinol. Although the pattern of use for oral allopurinol includes longer term therapy, particularly for gout and renal calculi, the exp... | [
{
"id": "Allopurinol_ddi_T1",
"type": "DRUG",
"offsets": [
[
94,
105
]
],
"text": [
"allopurinol"
],
"normalized": []
},
{
"id": "Allopurinol_ddi_T2",
"type": "DRUG",
"offsets": [
[
144,
155
]
],
"text"... | [] | [] | [
{
"arg1_id": "Allopurinol_ddi_T5",
"arg2_id": "Allopurinol_ddi_T6",
"id": "Allopurinol_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Allopurinol_ddi_T5",
"arg2_id": "Allopurinol_ddi_T7",
"id": "Allopurinol_ddi_R2",
"type": "MECHANISM",
"normalized": []
... |
Almotriptan_ddi | Almotriptan_ddi | [
{
"id": "Almotriptan_ddi__text",
"type": "abstract",
"text": [
"Ergot-Containing Drugs: These drugs have been reported to cause prolonged vasospastic reactions. Because there is a theoretical basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like dih... | [
{
"id": "Almotriptan_ddi_T1",
"type": "GROUP",
"offsets": [
[
0,
22
]
],
"text": [
"Ergot-Containing Drugs"
],
"normalized": []
},
{
"id": "Almotriptan_ddi_T2",
"type": "DRUG",
"offsets": [
[
177,
187
]
],
... | [] | [] | [
{
"arg1_id": "Almotriptan_ddi_T2",
"arg2_id": "Almotriptan_ddi_T6",
"id": "Almotriptan_ddi_R1",
"type": "ADVISE",
"normalized": []
},
{
"arg1_id": "Almotriptan_ddi_T3",
"arg2_id": "Almotriptan_ddi_T6",
"id": "Almotriptan_ddi_R2",
"type": "ADVISE",
"normalized": []
},
... |
Alosetron_ddi | Alosetron_ddi | [
{
"id": "Alosetron_ddi__text",
"type": "abstract",
"text": [
"Because alosetron is metabolized by a variety of hepatic CYP drug-metabolizing enzymes, inducers or inhibitors of these enzymes may change the clearance of alosetron. Fluvoxamine is a known strong inhibitor of CYP1A2 and also inhibits C... | [
{
"id": "Alosetron_ddi_T1",
"type": "DRUG",
"offsets": [
[
8,
17
]
],
"text": [
"alosetron"
],
"normalized": []
},
{
"id": "Alosetron_ddi_T2",
"type": "DRUG",
"offsets": [
[
156,
165
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Alosetron_ddi_T6",
"arg2_id": "Alosetron_ddi_T7",
"id": "Alosetron_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Alosetron_ddi_T8",
"arg2_id": "Alosetron_ddi_T9",
"id": "Alosetron_ddi_R2",
"type": "ADVISE",
"normalized": []
},
{
"ar... |
Alprazolam_ddi | Alprazolam_ddi | [
{
"id": "Alprazolam_ddi__text",
"type": "abstract",
"text": [
"The benzodiazepines, including alprazolam, produce additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol, and other drugs which themselves produce CNS depres... | [
{
"id": "Alprazolam_ddi_T1",
"type": "GROUP",
"offsets": [
[
4,
19
]
],
"text": [
"benzodiazepines"
],
"normalized": []
},
{
"id": "Alprazolam_ddi_T2",
"type": "DRUG",
"offsets": [
[
31,
41
]
],
"text":... | [] | [] | [
{
"arg1_id": "Alprazolam_ddi_T1",
"arg2_id": "Alprazolam_ddi_T3",
"id": "Alprazolam_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Alprazolam_ddi_T1",
"arg2_id": "Alprazolam_ddi_T4",
"id": "Alprazolam_ddi_R2",
"type": "EFFECT",
"normalized": []
},
{
... |
Alprostadil_ddi | Alprostadil_ddi | [
{
"id": "Alprostadil_ddi__text",
"type": "abstract",
"text": [
"No drug interactions have been reported between Prostin VR Pediatric and the therapy standard in neonates with restricted pulmonary or systemic blood flow. Standard therapy includes antibiotics, such as penicillin and gentamicin; vaso... | [
{
"id": "Alprostadil_ddi_T1",
"type": "BRAND",
"offsets": [
[
48,
68
]
],
"text": [
"Prostin VR Pediatric"
],
"normalized": []
},
{
"id": "Alprostadil_ddi_T2",
"type": "GROUP",
"offsets": [
[
182,
193
]
],
... | [] | [] | [] |
Alteplase_ddi | Alteplase_ddi | [
{
"id": "Alteplase_ddi__text",
"type": "abstract",
"text": [
"The interaction of Activase with other cardioactive or cerebroactive drugs has not been studied. In addition to bleeding associated with heparin and vitamin K antagonists, drugs that alter platelet function (such as acetylsalicylic acid... | [
{
"id": "Alteplase_ddi_T1",
"type": "BRAND",
"offsets": [
[
19,
27
]
],
"text": [
"Activase"
],
"normalized": []
},
{
"id": "Alteplase_ddi_T2",
"type": "DRUG",
"offsets": [
[
137,
144
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Alteplase_ddi_T2",
"arg2_id": "Alteplase_ddi_T7",
"id": "Alteplase_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Alteplase_ddi_T3",
"arg2_id": "Alteplase_ddi_T7",
"id": "Alteplase_ddi_R2",
"type": "EFFECT",
"normalized": []
},
{
"arg1_... |
Altretamine_ddi | Altretamine_ddi | [
{
"id": "Altretamine_ddi__text",
"type": "abstract",
"text": [
"Concurrent administration of HEXALEN and antidepressants of the MAO inhibitor class may cause severe orthostatic hypotension.Cimetidine, an inhibitor of microsomal drug metabolism, increased altretamines half-life and toxicity in a ra... | [
{
"id": "Altretamine_ddi_T1",
"type": "BRAND",
"offsets": [
[
29,
36
]
],
"text": [
"HEXALEN"
],
"normalized": []
},
{
"id": "Altretamine_ddi_T2",
"type": "GROUP",
"offsets": [
[
41,
83
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Altretamine_ddi_T1",
"arg2_id": "Altretamine_ddi_T2",
"id": "Altretamine_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Altretamine_ddi_T3",
"arg2_id": "Altretamine_ddi_T4",
"id": "Altretamine_ddi_R2",
"type": "MECHANISM",
"normalized": []
},... |
Amantadine_ddi | Amantadine_ddi | [
{
"id": "Amantadine_ddi__text",
"type": "abstract",
"text": [
"Careful observation is required when amantadine is administered concurrently with central nervous system stimulants. Coadministration of thioridazine has been reported to worsen the tremor in elderly patients with Parkinsons disease; h... | [
{
"id": "Amantadine_ddi_T1",
"type": "DRUG",
"offsets": [
[
37,
47
]
],
"text": [
"amantadine"
],
"normalized": []
},
{
"id": "Amantadine_ddi_T2",
"type": "GROUP",
"offsets": [
[
82,
115
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Amantadine_ddi_T1",
"arg2_id": "Amantadine_ddi_T2",
"id": "Amantadine_ddi_R1",
"type": "ADVISE",
"normalized": []
}
] |
Amifostine_ddi | Amifostine_ddi | [
{
"id": "Amifostine_ddi__text",
"type": "abstract",
"text": [
"Special consideration should be given to the administration of ETHYOL in patients receiving antihypertensive medications or other drugs that could cause or potentiate hypotension."
],
"offsets": [
[
0,
179... | [
{
"id": "Amifostine_ddi_T1",
"type": "BRAND",
"offsets": [
[
63,
69
]
],
"text": [
"ETHYOL"
],
"normalized": []
},
{
"id": "Amifostine_ddi_T2",
"type": "GROUP",
"offsets": [
[
92,
120
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Amifostine_ddi_T1",
"arg2_id": "Amifostine_ddi_T2",
"id": "Amifostine_ddi_R1",
"type": "ADVISE",
"normalized": []
}
] |
Amiloride_ddi | Amiloride_ddi | [
{
"id": "Amiloride_ddi__text",
"type": "abstract",
"text": [
"When amiloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, the risk of hyperkalemia may be increased. Therefore, if concomitant use of these agents is indicated because of demonstrated hypokalemia,... | [
{
"id": "Amiloride_ddi_T1",
"type": "DRUG",
"offsets": [
[
5,
14
]
],
"text": [
"amiloride"
],
"normalized": []
},
{
"id": "Amiloride_ddi_T2",
"type": "GROUP",
"offsets": [
[
57,
96
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Amiloride_ddi_T1",
"arg2_id": "Amiloride_ddi_T2",
"id": "Amiloride_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Amiloride_ddi_T3",
"arg2_id": "Amiloride_ddi_T4",
"id": "Amiloride_ddi_R2",
"type": "ADVISE",
"normalized": []
},
{
"arg1_... |
Aminocaproic Acid_ddi | Aminocaproic Acid_ddi | [
{
"id": "Aminocaproic Acid_ddi__text",
"type": "abstract",
"text": [
"Drug Laboratory Test Interactions: Prolongation of the template bleeding time has been reported during continuous intravenous infusion of AMICAR at dosages exceeding 24 g/day. Platelet function studies in these patients have not... | [
{
"id": "Aminocaproic Acid_ddi_T1",
"type": "BRAND",
"offsets": [
[
138,
144
]
],
"text": [
"AMICAR"
],
"normalized": []
},
{
"id": "Aminocaproic Acid_ddi_T2",
"type": "DRUG",
"offsets": [
[
384,
388
]
],
... | [] | [] | [] |
Aminoglutethimide_ddi | Aminoglutethimide_ddi | [
{
"id": "Aminoglutethimide_ddi__text",
"type": "abstract",
"text": [
"Cytadren accelerates the metabolism of dexamethasone; therefore, if glucocorticoid replacement is needed, hydrocortisone should be prescribed. Aminoglutethimide diminishes the effect of coumarin and warfarin."
],
"offset... | [
{
"id": "Aminoglutethimide_ddi_T1",
"type": "BRAND",
"offsets": [
[
0,
8
]
],
"text": [
"Cytadren"
],
"normalized": []
},
{
"id": "Aminoglutethimide_ddi_T2",
"type": "DRUG",
"offsets": [
[
39,
52
]
],
"... | [] | [] | [
{
"arg1_id": "Aminoglutethimide_ddi_T1",
"arg2_id": "Aminoglutethimide_ddi_T2",
"id": "Aminoglutethimide_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Aminoglutethimide_ddi_T5",
"arg2_id": "Aminoglutethimide_ddi_T6",
"id": "Aminoglutethimide_ddi_R2",
"type":... |
Aminohippurate_ddi | Aminohippurate_ddi | [
{
"id": "Aminohippurate_ddi__text",
"type": "abstract",
"text": [
"Renal clearance measurements of PAH cannot be made with any significant accuracy in patients receiving sulfonamides, procaine, or thiazolesulfone. These compounds interfere with chemical color development essential to the analytica... | [
{
"id": "Aminohippurate_ddi_T1",
"type": "DRUG",
"offsets": [
[
32,
35
]
],
"text": [
"PAH"
],
"normalized": []
},
{
"id": "Aminohippurate_ddi_T2",
"type": "GROUP",
"offsets": [
[
103,
115
]
],
"text": ... | [] | [] | [
{
"arg1_id": "Aminohippurate_ddi_T1",
"arg2_id": "Aminohippurate_ddi_T2",
"id": "Aminohippurate_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Aminohippurate_ddi_T1",
"arg2_id": "Aminohippurate_ddi_T3",
"id": "Aminohippurate_ddi_R2",
"type": "EFFECT",
"norma... |
Aminolevulinic acid_ddi | Aminolevulinic acid_ddi | [
{
"id": "Aminolevulinic acid_ddi__text",
"type": "abstract",
"text": [
"There have been no formal studies of the interaction of LEVULAN KERASTICK for Topical Solution with any other drugs, and no drug-specific interactions were noted during any of the controlled clinical trials. It is, however, po... | [
{
"id": "Aminolevulinic acid_ddi_T1",
"type": "BRAND",
"offsets": [
[
56,
73
]
],
"text": [
"LEVULAN KERASTICK"
],
"normalized": []
},
{
"id": "Aminolevulinic acid_ddi_T2",
"type": "GROUP",
"offsets": [
[
269,
292
... | [] | [] | [
{
"arg1_id": "Aminolevulinic acid_ddi_T2",
"arg2_id": "Aminolevulinic acid_ddi_T9",
"id": "Aminolevulinic acid_ddi_R1",
"type": "EFFECT",
"normalized": []
},
{
"arg1_id": "Aminolevulinic acid_ddi_T3",
"arg2_id": "Aminolevulinic acid_ddi_T9",
"id": "Aminolevulinic acid_ddi_R2",
... |
Aminosalicylic Acid_ddi | Aminosalicylic Acid_ddi | [
{
"id": "Aminosalicylic Acid_ddi__text",
"type": "abstract",
"text": [
"Aminosalicylic acid may decrease the amount of digoxin (Lanoxin, Lanoxicaps) that gets absorbed into your body. In the case that you are taking digoxin while taking aminosalicylic acid, higher doses of digoxin may be needed. A... | [
{
"id": "Aminosalicylic Acid_ddi_T1",
"type": "DRUG",
"offsets": [
[
0,
19
]
],
"text": [
"Aminosalicylic acid"
],
"normalized": []
},
{
"id": "Aminosalicylic Acid_ddi_T2",
"type": "DRUG",
"offsets": [
[
47,
54
... | [] | [] | [
{
"arg1_id": "Aminosalicylic Acid_ddi_T1",
"arg2_id": "Aminosalicylic Acid_ddi_T2",
"id": "Aminosalicylic Acid_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Aminosalicylic Acid_ddi_T1",
"arg2_id": "Aminosalicylic Acid_ddi_T3",
"id": "Aminosalicylic Acid_ddi_R2",... |
Amiodarone_ddi | Amiodarone_ddi | [
{
"id": "Amiodarone_ddi__text",
"type": "abstract",
"text": [
"Amiodarone is metabolized to desethylamiodarone by the cytochrome P450 (CYP450) enzyme group, specifically cytochromes P450 3A4 (CYP3A4) and CYP2C8. The CYP3A4 isoenzyme is present in both the liver and intestines. Amiodarone is also k... | [
{
"id": "Amiodarone_ddi_T1",
"type": "DRUG",
"offsets": [
[
0,
10
]
],
"text": [
"Amiodarone"
],
"normalized": []
},
{
"id": "Amiodarone_ddi_T2",
"type": "DRUG",
"offsets": [
[
29,
47
]
],
"text": [
... | [] | [] | [
{
"arg1_id": "Amiodarone_ddi_T13",
"arg2_id": "Amiodarone_ddi_T14",
"id": "Amiodarone_ddi_R1",
"type": "MECHANISM",
"normalized": []
},
{
"arg1_id": "Amiodarone_ddi_T17",
"arg2_id": "Amiodarone_ddi_T18",
"id": "Amiodarone_ddi_R2",
"type": "ADVISE",
"normalized": []
},
... |
End of preview. Expand
in Data Studio
Dataset Card for DDI Corpus
The DDI corpus has been manually annotated with drugs and pharmacokinetics and pharmacodynamics interactions. It contains 1025 documents from two different sources: DrugBank database and MedLine.
Citation Information
@article{HERREROZAZO2013914,
title = {
The DDI corpus: An annotated corpus with pharmacological substances and
drug-drug interactions
},
author = {
María Herrero-Zazo and Isabel Segura-Bedmar and Paloma Martínez and Thierry
Declerck
},
year = 2013,
journal = {Journal of Biomedical Informatics},
volume = 46,
number = 5,
pages = {914--920},
doi = {https://doi.org/10.1016/j.jbi.2013.07.011},
issn = {1532-0464},
url = {https://www.sciencedirect.com/science/article/pii/S1532046413001123},
keywords = {Biomedical corpora, Drug interaction, Information extraction}
}
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