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[ { "id": "1", "type": "title", "text": [ "A sequential procedure for monitoring clinical trials against historical controls." ], "offsets": [ [ 0, 82 ] ] }, { "id": "2", "type": "abstract", "text": [ "In this paper, we develop a sequenti...
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59
[ { "id": "60", "type": "title", "text": [ "Tolerance and efficacy of rituximab and changes in serum B cell biomarkers in patients with systemic complications of primary Sjögren's syndrome." ], "offsets": [ [ 0, 146 ] ] }, { "id": "61", "type": "a...
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139
139
[ { "id": "140", "type": "title", "text": [ "Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas." ], "offsets": [ [ 0, 114 ] ] }, { "id": "141", "type": "abstract", "text": [ ...
[ { "id": "142", "type": "SNP & Sequence variations", "text": [ "inactivated Axin1" ], "offsets": [ [ 24, 41 ] ], "normalized": [] }, { "id": "143", "type": "Genes & Molecular Sequences", "text": [ "inactivated Axin1" ], "offs...
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189
189
[ { "id": "190", "type": "title", "text": [ "ATM regulates ionizing radiation-induced disruption of HDAC1:PP1:Rb complexes." ], "offsets": [ [ 0, 78 ] ] }, { "id": "191", "type": "abstract", "text": [ "Ionizing radiation elicits signaling...
[ { "id": "192", "type": "Genes & Molecular Sequences", "text": [ "ATM" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "193", "type": "Genes & Molecular Sequences", "text": [ "HDAC1:PP1:Rb" ], "offsets": [ [ ...
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216
216
[ { "id": "217", "type": "title", "text": [ "Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma." ], "offsets": [ [ 0, 108 ] ] }, { "id": "218", "type": "abstract", "text": [ "Circa...
[ { "id": "219", "type": "SNP & Sequence variations", "text": [ "Ala394Thr" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "220", "type": "Genes & Molecular Sequences", "text": [ "clock" ], "offsets": [ [ ...
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[ { "id": "251", "type": "PA", "arg1_id": "249", "arg2_id": "250", "normalized": [] }, { "id": "254", "type": "PA", "arg1_id": "252", "arg2_id": "253", "normalized": [] }, { "id": "257", "type": "PA", "arg1_id": "255", "arg2_id": "256", "normalized":...
301
301
[ { "id": "302", "type": "title", "text": [ "Association study of putative promoter polymorphisms in the neuroplastin gene and schizophrenia." ], "offsets": [ [ 0, 96 ] ] }, { "id": "303", "type": "abstract", "text": [ "A previous study r...
[ { "id": "304", "type": "SNP & Sequence variations", "text": [ "promoter polymorphisms in the neuroplastin" ], "offsets": [ [ 30, 72 ] ], "normalized": [] }, { "id": "305", "type": "Genes & Molecular Sequences", "text": [ "promoter p...
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390
390
[ { "id": "391", "type": "title", "text": [ "Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response." ], "offsets": [ [ 0, 151 ] ] }, { "id": "392", "ty...
[ { "id": "393", "type": "Genes & Molecular Sequences", "text": [ "Caspase-3" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "394", "type": "Genes & Molecular Sequences", "text": [ "protein tyrosine phosphatase PEST" ], ...
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430
430
[ { "id": "431", "type": "title", "text": [ "The 2nd ADAO Asbestos Conference." ], "offsets": [ [ 0, 33 ] ] }, { "id": "432", "type": "abstract", "text": [ "On National Asbestos Awareness Day 2006, a conference was held at Mount Sinai, th...
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443
443
[ { "id": "444", "type": "title", "text": [ "Novel CCR5 monoclonal antibodies with potent and broad-spectrum anti-HIV activities." ], "offsets": [ [ 0, 84 ] ] }, { "id": "445", "type": "abstract", "text": [ "To identify monoclonal antibod...
[ { "id": "446", "type": "Genes & Molecular Sequences", "text": [ "CCR5" ], "offsets": [ [ 6, 10 ] ], "normalized": [] }, { "id": "447", "type": "Chemicals & Drugs", "text": [ "monoclonal antibodies" ], "offsets": [ [ ...
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541
541
[ { "id": "542", "type": "title", "text": [ "Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo." ], "offsets": [ [ 0, 121 ] ] }, { "id": "543", "type": "abstract", "text": [...
[ { "id": "544", "type": "Chemicals & Drugs", "text": [ "peroxisome proliferator-activated receptor delta-selective agonists" ], "offsets": [ [ 32, 99 ] ], "normalized": [] }, { "id": "545", "type": "Genes & Molecular Sequences", "text": [ ...
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621
621
[ { "id": "622", "type": "title", "text": [ "Spinal cord infarction secondary to cocaine use." ], "offsets": [ [ 0, 48 ] ] }, { "id": "623", "type": "abstract", "text": [ "A 27-yr-old woman recreationally inhaled cocaine. Several hours la...
[ { "id": "624", "type": "Diseases & Disorders", "text": [ "Spinal cord infarction" ], "offsets": [ [ 0, 22 ] ], "normalized": [] }, { "id": "625", "type": "Diseases & Disorders", "text": [ "secondary" ], "offsets": [ [ ...
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669
669
[ { "id": "670", "type": "title", "text": [ "The variation in Fas localization and the changes in Fas expression level upon stimulation with growth factors." ], "offsets": [ [ 0, 111 ] ] }, { "id": "671", "type": "abstract", "text": [ "Al...
[ { "id": "672", "type": "Genes & Molecular Sequences", "text": [ "Fas" ], "offsets": [ [ 17, 20 ] ], "normalized": [] }, { "id": "673", "type": "Genes & Molecular Sequences", "text": [ "Fas" ], "offsets": [ [ 53...
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707
707
[ { "id": "708", "type": "title", "text": [ "Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells." ], "offsets": [ [ 0, 146 ] ] }, { "id": "709", "type": ...
[ { "id": "710", "type": "Chemicals & Drugs", "text": [ "manganese" ], "offsets": [ [ 65, 74 ] ], "normalized": [] }, { "id": "711", "type": "Chemicals & Drugs", "text": [ "manganese" ], "offsets": [ [ 175, ...
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740
740
[ { "id": "741", "type": "title", "text": [ "The histone deacetylase inhibitors depsipeptide and MS-275, enhance TRAIL gene therapy of LNCaP prostate cancer cells without adverse effects in normal prostate epithelial cells." ], "offsets": [ [ 0, 178 ] ] }, ...
[ { "id": "743", "type": "Genes & Molecular Sequences", "text": [ "TRAIL" ], "offsets": [ [ 68, 73 ] ], "normalized": [] }, { "id": "744", "type": "Diseases & Disorders", "text": [ "prostate cancer" ], "offsets": [ [ ...
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[ { "id": "765", "type": "PA", "arg1_id": "763", "arg2_id": "764", "normalized": [] }, { "id": "768", "type": "PA", "arg1_id": "766", "arg2_id": "767", "normalized": [] }, { "id": "771", "type": "PA", "arg1_id": "769", "arg2_id": "770", "normalized":...
779
779
[ { "id": "780", "type": "title", "text": [ "The Connectivity Map: a new tool for biomedical research." ], "offsets": [ [ 0, 57 ] ] }, { "id": "781", "type": "abstract", "text": [ "The ultimate objective of biomedical research is to conne...
[ { "id": "782", "type": "Diseases & Disorders", "text": [ "diseases" ], "offsets": [ [ 124, 132 ] ], "normalized": [] }, { "id": "783", "type": "Diseases & Disorders", "text": [ "still" ], "offsets": [ [ 267, ...
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785
785
[ { "id": "786", "type": "title", "text": [ "Urtica ferox neuropathy." ], "offsets": [ [ 0, 24 ] ] }, { "id": "787", "type": "abstract", "text": [ "A 21-year-old student developed an acute, symmetrical, predominantly motor polyneuropathy ...
[ { "id": "788", "type": "Diseases & Disorders", "text": [ "Urtica ferox neuropathy" ], "offsets": [ [ 0, 23 ] ], "normalized": [] }, { "id": "789", "type": "Chemicals & Drugs", "text": [ "Urtica ferox neuropathy" ], "offsets"...
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808
808
[ { "id": "809", "type": "title", "text": [ "Effect of botulinum toxin type a on tear production after treatment of lateral canthal rhytids." ], "offsets": [ [ 0, 95 ] ] }, { "id": "810", "type": "abstract", "text": [ "PURPOSE: To evaluat...
[ { "id": "811", "type": "Chemicals & Drugs", "text": [ "botulinum toxin type a" ], "offsets": [ [ 10, 32 ] ], "normalized": [] }, { "id": "812", "type": "Diseases & Disorders", "text": [ "tear" ], "offsets": [ [ ...
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[ { "id": "831", "type": "PA", "arg1_id": "829", "arg2_id": "830", "normalized": [] }, { "id": "834", "type": "PA", "arg1_id": "832", "arg2_id": "833", "normalized": [] }, { "id": "837", "type": "PA", "arg1_id": "835", "arg2_id": "836", "normalized":...
857
857
[ { "id": "858", "type": "title", "text": [ "Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites." ], "offsets": [ [ 0, 134 ] ] }, { "id": "859", "type": "abstract", ...
[ { "id": "860", "type": "Genes & Molecular Sequences", "text": [ "Low-density lipoprotein receptor-related protein 5" ], "offsets": [ [ 0, 50 ] ], "normalized": [] }, { "id": "861", "type": "SNP & Sequence variations", "text": [ "(LR...
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[ { "id": "908", "type": "PA", "arg1_id": "906", "arg2_id": "907", "normalized": [] }, { "id": "911", "type": "PA", "arg1_id": "909", "arg2_id": "910", "normalized": [] }, { "id": "914", "type": "SA", "arg1_id": "912", "arg2_id": "913", "normalized":...
964
964
[ { "id": "965", "type": "title", "text": [ "A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease." ], "offsets": [ [ 0, 154 ] ] }, { "id": "966", ...
[ { "id": "967", "type": "Chemicals & Drugs", "text": [ "oral beclomethasone dipropionate" ], "offsets": [ [ 42, 74 ] ], "normalized": [] }, { "id": "968", "type": "Chemicals & Drugs", "text": [ "prednisone" ], "offsets": [ ...
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[ { "id": "994", "type": "PA", "arg1_id": "992", "arg2_id": "993", "normalized": [] }, { "id": "997", "type": "SA", "arg1_id": "995", "arg2_id": "996", "normalized": [] }, { "id": "1000", "type": "SA", "arg1_id": "998", "arg2_id": "999", "normalized"...
1035
1035
[ { "id": "1036", "type": "title", "text": [ "Malic enzyme 2 and susceptibility to psychosis and mania." ], "offsets": [ [ 0, 57 ] ] }, { "id": "1037", "type": "abstract", "text": [ "Previous studies have identified a putative gene locus ...
[ { "id": "1038", "type": "Genes & Molecular Sequences", "text": [ "Malic enzyme 2" ], "offsets": [ [ 0, 14 ] ], "normalized": [] }, { "id": "1039", "type": "Diseases & Disorders", "text": [ "psychosis" ], "offsets": [ [...
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1111
1111
[ { "id": "1112", "type": "title", "text": [ "p53 and the pathogenesis of skin cancer." ], "offsets": [ [ 0, 40 ] ] }, { "id": "1113", "type": "abstract", "text": [ "The p53 tumor suppressor gene and gene product are among the most divers...
[ { "id": "1114", "type": "Genes & Molecular Sequences", "text": [ "p53" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "1115", "type": "Diseases & Disorders", "text": [ "pathogenesis" ], "offsets": [ [ ...
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[ { "id": "1146", "type": "PA", "arg1_id": "1144", "arg2_id": "1145", "normalized": [] }, { "id": "1149", "type": "PA", "arg1_id": "1147", "arg2_id": "1148", "normalized": [] }, { "id": "1152", "type": "PA", "arg1_id": "1150", "arg2_id": "1151", "nor...
1196
1196
[ { "id": "1197", "type": "title", "text": [ "Endothelin-1 and its receptors ET(A) and ET(B) in drug-induced gingival overgrowth." ], "offsets": [ [ 0, 83 ] ] }, { "id": "1198", "type": "abstract", "text": [ "BACKGROUND: The purpose of th...
[ { "id": "1199", "type": "Chemicals & Drugs", "text": [ "Endothelin-1" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "1200", "type": "Diseases & Disorders", "text": [ "drug-induced gingival overgrowth" ], "offsets"...
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[ { "id": "1220", "type": "PA", "arg1_id": "1218", "arg2_id": "1219", "normalized": [] }, { "id": "1223", "type": "PA", "arg1_id": "1221", "arg2_id": "1222", "normalized": [] }, { "id": "1226", "type": "PA", "arg1_id": "1224", "arg2_id": "1225", "nor...
1243
1243
[ { "id": "1244", "type": "title", "text": [ "Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways." ], "offsets": [ [ 0...
[ { "id": "1246", "type": "Chemicals & Drugs", "text": [ "Paeonol" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "1247", "type": "Genes & Molecular Sequences", "text": [ "intercellular adhesion molecule-1" ], "offset...
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[ { "id": "1286", "type": "PA", "arg1_id": "1284", "arg2_id": "1285", "normalized": [] }, { "id": "1289", "type": "PA", "arg1_id": "1287", "arg2_id": "1288", "normalized": [] }, { "id": "1292", "type": "PA", "arg1_id": "1290", "arg2_id": "1291", "nor...
1345
1345
[ { "id": "1346", "type": "title", "text": [ "Pulmonary alveolar proteinosis: a rare pulmonary toxicity of sirolimus." ], "offsets": [ [ 0, 71 ] ] }, { "id": "1347", "type": "abstract", "text": [ "The aim of our paper is to describe an un...
[ { "id": "1348", "type": "Diseases & Disorders", "text": [ "Pulmonary alveolar proteinosis" ], "offsets": [ [ 0, 30 ] ], "normalized": [] }, { "id": "1349", "type": "Diseases & Disorders", "text": [ "pulmonary toxicity" ], "o...
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[ { "id": "1374", "type": "PA", "arg1_id": "1372", "arg2_id": "1373", "normalized": [] }, { "id": "1377", "type": "PA", "arg1_id": "1375", "arg2_id": "1376", "normalized": [] }, { "id": "1380", "type": "SA", "arg1_id": "1378", "arg2_id": "1379", "nor...
1400
1400
[ { "id": "1401", "type": "title", "text": [ "Production of polyclonal antibodies against the human respiratory syncytial virus nucleoprotein and phosphoprotein expressed in Escherichia coli." ], "offsets": [ [ 0, 145 ] ] }, { "id": "1402", "type":...
[ { "id": "1403", "type": "Diseases & Disorders", "text": [ "virus" ], "offsets": [ [ 76, 81 ] ], "normalized": [] }, { "id": "1404", "type": "Genes & Molecular Sequences", "text": [ "virus" ], "offsets": [ [ 76,...
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1426
1426
[ { "id": "1427", "type": "title", "text": [ "Sequential metabolism is responsible for diltiazem-induced time-dependent loss of CYP3A." ], "offsets": [ [ 0, 88 ] ] }, { "id": "1428", "type": "abstract", "text": [ "Kinetic parameters (k(in...
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1518
1518
[ { "id": "1519", "type": "title", "text": [ "Response to IL-1-receptor antagonist in a child with familial cold autoinflammatory syndrome." ], "offsets": [ [ 0, 93 ] ] }, { "id": "1520", "type": "abstract", "text": [ "Familial cold auto-...
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[ { "id": "1538", "type": "PA", "arg1_id": "1536", "arg2_id": "1537", "normalized": [] } ]
1540
1540
[ { "id": "1541", "type": "title", "text": [ "Effect of itraconazole on pharmacokinetics of paroxetine: the role of gut transporters." ], "offsets": [ [ 0, 87 ] ] }, { "id": "1542", "type": "abstract", "text": [ "A recent in vitro study h...
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1589
1589
[ { "id": "1590", "type": "title", "text": [ "A facile lentiviral vector system for expression of doxycycline-inducible shRNAs: knockdown of the pre-miRNA processing enzyme Drosha." ], "offsets": [ [ 0, 134 ] ] }, { "id": "1591", "type": "abstract"...
[ { "id": "1592", "type": "Chemicals & Drugs", "text": [ "doxycycline" ], "offsets": [ [ 52, 63 ] ], "normalized": [] }, { "id": "1593", "type": "Genes & Molecular Sequences", "text": [ "shRNAs" ], "offsets": [ [ ...
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End of preview. Expand in Data Studio

Dataset Card for EU-ADR

Corpora with specific entities and relationships annotated are essential to train and evaluate text-mining systems that are developed to extract specific structured information from a large corpus. In this paper we describe an approach where a named-entity recognition system produces a first annotation and annotators revise this annotation using a web-based interface. The agreement figures achieved show that the inter-annotator agreement is much better than the agreement with the system provided annotations. The corpus has been annotated for drugs, disorders, genes and their inter-relationships. For each of the drug-disorder, drug-target, and target-disorder relations three experts have annotated a set of 100 abstracts. These annotated relationships will be used to train and evaluate text-mining software to capture these relationships in texts.

Citation Information

@article{VANMULLIGEN2012879,
title = {The EU-ADR corpus: Annotated drugs, diseases, targets, and their relationships},
journal = {Journal of Biomedical Informatics},
volume = {45},
number = {5},
pages = {879-884},
year = {2012},
note = {Text Mining and Natural Language Processing in Pharmacogenomics},
issn = {1532-0464},
doi = {https://doi.org/10.1016/j.jbi.2012.04.004},
url = {https://www.sciencedirect.com/science/article/pii/S1532046412000573},
author = {Erik M. {van Mulligen} and Annie Fourrier-Reglat and David Gurwitz and Mariam Molokhia and Ainhoa Nieto and Gianluca Trifiro and Jan A. Kors and Laura I. Furlong},
keywords = {Text mining, Corpus development, Machine learning, Adverse drug reactions},
abstract = {Corpora with specific entities and relationships annotated are essential to train and evaluate text-mining systems that are developed to extract specific structured information from a large corpus. In this paper we describe an approach where a named-entity recognition system produces a first annotation and annotators revise this annotation using a web-based interface. The agreement figures achieved show that the inter-annotator agreement is much better than the agreement with the system provided annotations. The corpus has been annotated for drugs, disorders, genes and their inter-relationships. For each of the drug–disorder, drug–target, and target–disorder relations three experts have annotated a set of 100 abstracts. These annotated relationships will be used to train and evaluate text-mining software to capture these relationships in texts.}
}
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