pmcid stringlengths 6 6 | title stringlengths 9 374 | abstract stringlengths 2 4.62k ⌀ | fulltext stringlengths 167 106k | file_path stringlengths 64 64 |
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526202 | PCOGR: Phylogenetic COG ranking as an online tool to judge the specificity of COGs with respect to freely definable groups of organisms | Background The rapidly increasing number of completely sequenced genomes led to the establishment of the COG-database which, based on sequence homologies, assigns similar proteins from different organisms to clusters of orthologous groups (COGs). There are several bioinformatic studies that made use of this database to... | Background The COG-database has become a powerful tool in the field of comparative genomics. The construction of this data base is based on sequence homologies of proteins from different completely sequenced genomes. Highly homologous proteins are assigned to clusters of orthologous groups (COGs) [ 1 , 2 ]. Each of the... | /Users/keerthanasridhar/biomedlm/data/PMC000xxxxxx/PMC526202.xml |
524373 | The fallacy of enrolling only high-risk subjects in cancer prevention trials: Is there a "free lunch"? | Background There is a common belief that most cancer prevention trials should be restricted to high-risk subjects in order to increase statistical power. This strategy is appropriate if the ultimate target population is subjects at the same high-risk. However if the target population is the general population, three as... | Background Some prevention trials are restricted to high-risk subjects. If the investigators are only interested in the effects of the intervention on subjects at increased risk [ 1 ] or if the study is designed to be a preliminary investigation in preparation for a definitive study in the general population, we think ... | /Users/keerthanasridhar/biomedlm/data/PMC000xxxxxx/PMC524373.xml |
545955 | Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo | Background Probimane (Pro), an anti-cancer agent originating in China, was derived from razoxane (ICRF-159, Raz), a drug created in Britain, specifically targeting at cancer metastasis and as a cardioprotectant of anthrocyclines. Pro and Raz are bisdioxopiperazine compounds. In this work, we evaluated the anti-tumor an... | Background Razoxane (ICRF-159) ( Raz ), first developed in UK, was the earliest agent against spontaneous metastasis for the murine model (Lewis lung carcinoma) in 1969 [ 1 ]. A large volume of papers and projects have been published in the utilities and mechanisms of Raz for anticancer actions, like assisting radiothe... | /Users/keerthanasridhar/biomedlm/data/PMC000xxxxxx/PMC545955.xml |
524367 | Perceived personal, social and environmental barriers to weight maintenance among young women: A community survey | Background Young women are a group at high risk of weight gain. This study examined a range of perceived personal, social and environmental barriers to physical activity and healthy eating for weight maintenance among young women, and how these varied by socioeconomic status (SES), overweight status and domestic situat... | Introduction In many developed countries, overweight and obesity have reached epidemic proportions [ 1 - 8 ]. One group at particular risk of weight gain and the development of obesity is young women[ 2 , 9 , 10 ]. In the US, for example, one study that tracked weight in a large population sample over a 10-year period ... | /Users/keerthanasridhar/biomedlm/data/PMC000xxxxxx/PMC524367.xml |
526216 | Imbalance in the health workforce | Imbalance in the health workforce is a major concern in both developed and developing countries. It is a complex issue that encompasses a wide range of possible situations. This paper aims to contribute not only to a better understanding of the issues related to imbalance through a critical review of its definition and... | Introduction Imbalance in the health workforce is a major challenge for health policy-makers, since human resources – the different kinds of clinical and non-clinical staff who make each individual and public health intervention happen – are the most important of the health system's inputs [ 1 ]. Imbalance is not a new... | /Users/keerthanasridhar/biomedlm/data/PMC000xxxxxx/PMC526216.xml |
517949 | Comparison of the NEI-VFQ and OSDI questionnaires in patients with Sjögren's syndrome-related dry eye | Background To examine the associations between vision-targeted health-related quality of life (VT-HRQ) and ocular surface parameters in patients with Sjögren's syndrome, a systemic autoimmune disease characterized by dry eye and dry mouth. Methods Forty-two patients fulfilling European / American diagnostic criteria fo... | Background Dry eye is a common disorder of the ocular surface and tear film and is estimated to affect from 2% to over 15% of persons in surveyed populations, depending on the definition used [ 1 - 6 ]. Symptoms of dry eye are a major reason to seek ophthalmic care: a study by Nelson and co-workers found that 1.3% of M... | /Users/keerthanasridhar/biomedlm/data/PMC000xxxxxx/PMC517949.xml |
527875 | Statistical design considerations for pilot studies transitioning therapies from the bench to the bedside | Pilot studies are often used to transition therapies developed using animal models to a clinical setting. Frequently, the focus of such trials is on estimating the safety in terms of the occurrence of certain adverse events. With relatively small sample sizes, the probability of observing even relatively common events ... | Introduction In the translational research setting, statisticians often assist in the planning and analysis of pilot studies. While pilot studies may vary in the fundamental objectives, many are designed to explore the safety profile of a drug or a procedure [ 1 , 2 ]. Often before applying a new therapy to large group... | /Users/keerthanasridhar/biomedlm/data/PMC000xxxxxx/PMC527875.xml |
548295 | "Expression pattern and regulation of genes differ between fibroblasts of adhesion and normal human (...TRUNCATED) | "Background Injury to the peritoneum during surgery is followed by a healing process that frequently(...TRUNCATED) | "Background Peritoneal adhesions resulting from surgical injury are often associated with pelvic pai(...TRUNCATED) | /Users/keerthanasridhar/biomedlm/data/PMC000xxxxxx/PMC548295.xml |
535530 | "A trial design for evaluation of empiric programming of implantable cardioverter defibrillators to (...TRUNCATED) | "The delivery of implantable cardioverter defibrillator (ICD) therapy is sophisticated and requires (...TRUNCATED) | "Background Over the past decade ICD implantation has become increasingly straightforward, yet ICD p(...TRUNCATED) | /Users/keerthanasridhar/biomedlm/data/PMC000xxxxxx/PMC535530.xml |
545941 | Differential regulation of Aβ42-induced neuronal C1q synthesis and microglial activation | "Expression of C1q, an early component of the classical complement pathway, has been shown to be ind(...TRUNCATED) | "Introduction Alzheimer's disease (AD) is the most common form of dementia in the elderly. Its main (...TRUNCATED) | /Users/keerthanasridhar/biomedlm/data/PMC000xxxxxx/PMC545941.xml |
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