Sequence To Structured Output Tasks
Collection
NER, Information Extraction • 3 items • Updated
input_text stringlengths 27 4.83k | output_text dict |
|---|---|
Treatments of preterm premature rupture of the membranes : a meta-analysis . The objective of this overview was to critically evaluate published randomized controlled trials on treatments in preterm premature rupture of the membranes . The Oxford data base on perinatal trials , MEDLINE , Excerpta Medica , and Index Med... | {
"P": [
"preterm premature rupture of the membranes :",
"preterm premature rupture of the membranes ."
],
"I": [
"corticosteroids",
"Tocolysis , prophylactic antibiotics"
],
"O": [
"respiratory distress syndrome",
"endometritis",
"neonatal infections and cesarean section rates"
... |
Nicardipine is superior to esmolol for the management of postcraniotomy emergence hypertension : a randomized open-label study . BACKGROUND Emergence hypertension after craniotomy is a well-documented phenomenon for which natural history is poorly understood . Most clinicians attribute this phenomenon to an acute and t... | {
"P": [
"emergence hypertension",
"hypertension",
"Fifty-two subjects",
"40"
],
"I": [
"Nicardipine",
"esmolol",
"nicardipine and esmolol",
"nicardipine or esmolol",
"( labetalol or hydralazine"
],
"O": [
"hypertension",
"systolic blood pressure ( SBP )",
"SBP"... |
[ Total parenteral nutrition in colon surgery ] . | {
"P": [
"colon surgery ]"
],
"I": [
"parenteral nutrition",
"colon surgery"
],
"O": [
"parenteral nutrition"
]
} |
Pacifier as a risk factor for acute otitis media . | {
"P": [
"acute otitis media"
],
"I": [
"Pacifier"
],
"O": []
} |
Effect of sensory stimulation ( acupuncture ) on sympathetic and parasympathetic activities in healthy subjects . UNLABELLED It has been postulated that sensory stimulation ( acupuncture ) affects the cardiovascular system via the autonomic nervous system . Previously , skin temperature , thermography , plethysmography... | {
"P": [
"healthy subjects .",
"Twelve healthy volunteers",
"six",
"men",
"women",
"mean age 34.4 ( range 23-48 )"
],
"I": [
"sensory stimulation",
"sensory stimulation ( acupuncture )",
"needle sensation",
"short acupuncture needle"
],
"O": [
"skin temperature",
... |
Baseline distribution of participants with depression and impaired quality of life in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial . BACKGROUND Previous studies have demonstrated the psychosocial effect of heart failure in patients with reduced ejection fraction . Howev... | {
"P": [
"depression",
"impaired quality of life",
"patients with reduced ejection fraction .",
"heart failure",
"preserved ejection fraction",
"Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial ( TOPCAT",
"3400 patients",
"younger",
"impaired QOL and de... |
Coping strategies as mediators of the effect of the START ( strategies for RelaTives ) intervention on psychological morbidity for family carers of people with dementia in a randomised controlled trial . BACKGROUND Family carers of people with dementia frequently become depressed or anxious . In observational studies ,... | {
"P": [
"dementia",
"Family carers of people with dementia",
"260",
"187"
],
"I": [
"START ( strategies for RelaTives ) intervention",
"START"
],
"O": []
} |
Transdermal nitroglycerin in angina pectoris : efficacy of intermittent application . Continuous application of transdermal nitroglycerin appears to result in tolerance to the antianginal effect . In a double-blind study the effects of continuous ( 24 h/day ) and intermittent ( 16 h/day ) application of transdermal nit... | {
"P": [
"angina pectoris",
"12"
],
"I": [
"Transdermal nitroglycerin",
"transdermal nitroglycerin",
"transdermal nitroglycerin in",
"placebo",
"beta-adrenergic blocking",
"calcium channel blocking agents"
],
"O": [
"tolerance to the antianginal effect",
"Exercise perfo... |
The safety and efficacy of terazosin in the treatment of essential hypertension in blacks . Terazosin , a new selective alpha 1-adrenergic receptor antagonist , has been found to be an effective antihypertensive agent . In a series of studies , the safety and efficacy of terazosin , alone and in combination with other ... | {
"P": [
"essential hypertension in blacks .",
"1180",
"mild to moderate essential hypertension",
"elderly",
"hypertensive"
],
"I": [
"terazosin",
"Terazosin",
"antihypertensive agents",
"propranolol",
"2.5 mg of methyclothiazide",
"methyclothiazide"
],
"O": [
"... |
Differential effects of amino acid and ketoacid on protein metabolism in humans . We examined the effects of insulin , amino acid ( AA ) , and branched-chain ketoacid ( KA ) availability on leucine kinetics in eight healthy volunteers ( age = 22 +/- 2 y , body mass index = 24 +/- 1 kg ) by using the euglycemic insulin ... | {
"P": [
"healthy volunteers",
"age = 22 +/- 2 y",
"body mass index = 24 +/- 1 kg"
],
"I": [
"euglycemic insulin clamp",
"and [ 1-14C ]",
"leucine turnover",
"techniques"
],
"O": [
"endogenous leucine flux ( ELF )",
"leucine oxidation ( LOX )",
"non-oxidative leucine di... |
Synthetic serum substitute ( SSS ) : a globulin-enriched protein supplement for human embryo culture . OBJECTIVE The purpose of the present study was to evaluate whether an IVF protein supplement prepared from human serum albumin ( HSA ) and human globulins would retain performance characteristics equivalent to those r... | {
"P": [
"seven"
],
"I": [
"Synthetic serum substitute ( SSS )",
"Plasmatein",
"Plasmanate",
"human tubal fluid medium ( HTF )",
"HSA ( 5 mg/mL )",
"( 10 % , v/v ; 5 mg/ml )",
"HSA",
"SSS",
"Synthetic serum substitute"
],
"O": [
"performance characteristics",
"f... |
Chronic fatigue syndrome versus neuroendocrineimmune dysfunction syndrome : differential attributions . Since 1988 , when the term chronic fatigue syndrome ( CFS ) was coined , considerable discussion has occurred about stigma associated with this diagnostic term . In particular , patients with CFS have felt that this ... | {
"P": [
"patients with CFS"
],
"I": [
"syndrome : differential attributions",
"case study of a patient with symptoms of CFS",
"medical sounding term ( CNDS )"
],
"O": [
"attributions",
"medical sounding term"
]
} |
Motion style acupuncture treatment ( MSAT ) for acute low back pain with severe disability : a multicenter , randomized , controlled trial protocol . BACKGROUND Acupuncture is widely-used to treat patients with low back pain , despite insufficient evidence of the technique 's efficacy for acute back pain . Motion style... | {
"P": [
"acute low back pain",
"patients with low back pain",
"Korea",
"Participants with acute low back pain and severe functional disability"
],
"I": [
"Motion style acupuncture treatment ( MSAT )",
"acupuncture",
"nonsteroidal anti-inflammatory drug ( NSAID )",
"injection",
... |
Translucency of zirconia copings made with different CAD/CAM systems . STATEMENT OF PROBLEM Zirconia cores are reported to be less translucent than glass , lithium disilicate , or alumina cores . This could affect the esthetic appearance and the clinical choices made when using zirconia-based restorations . PURPOSE The... | {
"P": [
"zirconia copings",
"9"
],
"I": [
"zirconia copings",
"lithium disilicate glass ceramic"
],
"O": [
"translucency",
"Translucency",
"values of"
]
} |
Monitoring tumour cells in the peripheral blood of small cell lung cancer patients . BACKGROUND Flow cytometry was used to enumerate tumour cells in longitudinal studies of peripheral blood from small cell lung cancer ( SCLC ) patients , together with magnetic bead selection to isolate and identify these cells . As par... | {
"P": [],
"I": [
"Flow cytometry",
"chemotherapy",
"ifosfamide",
"carboplatin",
"etoposide ( ICE )",
"accelerated ( two weekly ) ICE with filgrastim",
"granulocyte colony-stimulating factor [ G-CSF ]",
"autologous stem cell support"
],
"O": [
"Circulating tumour cells",
... |
Impact of a 16-community trial to promote judicious antibiotic use in Massachusetts . OBJECTIVES Reducing unnecessary antibiotic use , particularly among children , continues to be a public health priority . Previous intervention studies have been limited by size or design and have shown mixed results . The objective o... | {
"P": [
"16",
"children who were aged 3 to < 72 months",
"223,135"
],
"I": [
"multifaceted , community-wide intervention on overall antibiotic use",
"physician behavior-change strategy that included guideline dissemination , small-group education , frequent updates and educational materials ,... |
Wavefront-guided versus standard LASIK enhancement for residual refractive errors . OBJECTIVE To assess efficacy , safety , predictability , stability , and changes in higher-order aberrations ( HOAs ) and contrast sensitivity ( CS ) after wavefront-guided and standard LASIK enhancement for the correction of residual r... | {
"P": [
"Twenty eyes of 20 consecutive patients",
"20 eyes",
"20 consecutive patients",
"residual refractive error enhancement"
],
"I": [
"Wavefront-guided",
"wavefront-guided Zyoptix Ablation Refinement software ( ZAR ) LASIK",
"ZAR",
"Planoscan",
"Wavefront-guided LASIK"
]... |
The short-term effects of transcranial direct current stimulation on electroencephalography in children with autism : a randomized crossover controlled trial . Abnormal synaptic maturation and connectivity are possible etiologies of autism . Previous studies showed significantly less alpha activity in autism than norma... | {
"P": [
"children",
"autism",
"Twenty",
"male"
],
"I": [
"transcranial direct current stimulation",
"anodal tDCS",
"active and sham tDCS stimulation"
],
"O": [
"changes in a measure of cortical activity",
"tDCS ( PAF )",
"ATEC",
"PAF",
"ATEC .",
"results sh... |
Tolerance and efficacy of combined diethylcarbamazine and albendazole for treatment of Wuchereria bancrofti and intestinal helminth infections in Haitian children . This randomized , placebo-controlled trial investigated the tolerance , efficacy , and nutritional benefit of combining chemotherapeutic treatment of intes... | {
"P": [
"Wuchereria bancrofti and intestinal helminth infections",
"children",
"Children",
"infected with Ascaris ( 30.7 % ) , Trichuris ( 53.4 % ) , and hookworm ( 9.7 % ) with 69.9 % having more than one of these parasites",
"Wuchereria bancrofti microfilariae",
"Trichuris-infected",
"b... |
Pharmacodynamic analysis of intravenous recombinant urate oxidase using an indirect pharmacological response model in healthy subjects . AIM Pharmacodynamic analysis of intravenous recombinant urate oxidase produced by Escherichia coli was performed in healthy subjects using a pharmacokinetic/pharmacodynamic ( PK/PD ) ... | {
"P": [
"indirect pharmacological response model in healthy subjects .",
"healthy",
"pharmacokinetic/pharmacodynamic",
"40"
],
"I": [
"intravenous recombinant urate oxidase",
"placebo-controlled",
"uricase"
],
"O": []
} |
Perceptual wind-up in the human oesophagus is enhanced by central sensitisation . BACKGROUND Oesophageal acid infusion induces enhanced pain hypersensitivity in non-acid exposed upper oesophagus ( secondary hyperalgesia ) in patients with non-cardiac chest pain , thus suggesting central sensitisation contributes to vis... | {
"P": [
"human oesophagus",
"eight",
"healthy",
"seven",
"males",
"mean age 32 years"
],
"I": [
"electrical stimuli",
"2 Hz"
],
"O": [
"Perceptual wind-up",
"Wind-up",
"pain threshold decreased",
"Wind-up to the 2 Hz train",
"UO"
]
} |
Enhancing antiepileptic drug adherence : a randomized controlled trial . Suboptimal adherence to antiepileptic drug ( AED ) treatment is commonplace , and increases the risk of status epilepticus and sudden unexplained death in epilepsy . This randomized controlled trial was designed to demonstrate whether an implement... | {
"P": [],
"I": [
"antiepileptic drug",
"antiepileptic drug ( AED ) treatment",
"self-administered questionnaire",
"AED",
"intention intervention"
],
"O": [
"improved adherence relative to controls",
"doses taken in total",
"correct dose was taken",
"doses taken on schedule"
... |
Anxiety disorders in typically developing youth : autism spectrum symptoms as a predictor of cognitive-behavioral treatment . Symptoms of autism spectrum disorder ( ASD ) were assessed ( Social Responsiveness Scale-Parent ( SRS-P ) ; coded in-session behavior ) in typically-developing , anxiety-disordered children ( N ... | {
"P": [],
"I": [
"cognitive-behavioral treatment"
],
"O": [
"At-home exposure completion",
"anxiety"
]
} |
Topical retapamulin ointment ( 1 % , wt/wt ) twice daily for 5 days versus oral cephalexin twice daily for 10 days in the treatment of secondarily infected dermatitis : results of a randomized controlled trial . BACKGROUND New antibacterial agents with activity against pathogenic strains resistant to established antibi... | {
"P": [
"secondarily infected dermatitis :",
"patients with secondarily infected dermatitis ( SID ) .",
"Patients with SID",
"patients with SID"
],
"I": [
"Topical retapamulin ointment",
"cephalexin",
"topical retapamulin ointment",
"retapamulin ointment",
"oral cephalexin",
... |
Factors associated with inadequate colorectal cancer screening with flexible sigmoidoscopy . BACKGROUND AND STUDY AIM Inadequate colorectal cancer screening wastes limited endoscopic resources . We examined patients factors associated with inadequate flexible sigmoidoscopy ( FSG ) screening at baseline screening and re... | {
"P": [
"Prostate , Lung , Colorectal , and Ovarian Cancer",
"64,554 participants",
"aged 55-74 )",
"39,385"
],
"I": [
"colorectal cancer screening with flexible sigmoidoscopy",
"flexible sigmoidoscopy",
"repeat screening",
"FSG",
"inadequate",
"alternative colorectal canc... |
BNP-guided vs symptom-guided heart failure therapy : the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure ( TIME-CHF ) randomized trial . CONTEXT It is uncertain whether intensified heart failure therapy guided by N-terminal brain natriuretic peptide ( BNP ) is superior... | {
"P": [],
"I": [
"Intensified vs Standard Medical Therapy",
"symptom-guided therapy",
"BNP-guided therapy"
],
"O": [
"18-month survival free of all-cause hospitalizations and quality of life as assessed by structured validated questionnaires .",
"survival free of all-cause hospitalizations"... |
National Surgical Adjuvant Breast and Bowel Project 's Breast Cancer Prevention Trial . The Breast Cancer Prevention Trial is the largest breast cancer prevention study ever undertaken . Administered by the National Surgical Adjuvant Breast and Bowel Project , it is the first trial seeking to demonstrate whether a drug... | {
"P": [
"tamoxifen"
],
"I": [
"tamoxifen"
],
"O": [
"reducing the incidence of invasive breast cancer",
"reducing breast cancer mortality",
"reducing deaths from cardiovascular disease",
"reducing bone fractures",
"side effects ,",
"toxicity",
"quality of life"
]
} |
Ketorolac versus fentanyl for gynaecological day-case surgery . The effectiveness of fentanyl and ketorolac in providing analgesia for day-case gynaecological procedures was evaluated in 55 healthy volunteers in a single blinded fashion . Fentanyl ( 1 mcg/kg iv ) and ketorolac ( 30 mg im ) were administered immediately... | {
"P": [
"gynaecological day-case surgery",
"day-case gynaecological procedures",
"55",
"healthy volunteers"
],
"I": [
"Ketorolac versus fentanyl",
"fentanyl",
"ketorolac",
"Fentanyl",
"propofol",
"nitrous oxide",
"enflurane"
],
"O": [
"pain",
"additional an... |
Enhancing the application and evaluation of a discrete trial intervention package for eliciting first words in preverbal preschoolers with ASD . This study evaluates the effectiveness of an intervention package including a discrete trial program ( Rapid Motor Imitation Antecedent Training ( Tsiouri and Greer , J Behav ... | {
"P": [
"preverbal preschoolers",
"ASD",
"children",
"little or no spoken language",
"Three of five"
],
"I": [
"discrete trial intervention package",
"discrete trial program ( Rapid Motor Imitation Antecedent Training",
"combined with parent education for"
],
"O": [
"funct... |
Secretin and sleep in children with autism . The objectives of this pilot study were 1 ) to examine possible effects of secretin infusions on sleep-wake state organization in children with autism , and 2 ) to assess the feasibility of home recordings using time-lapse videosomnography in children with autism . Participa... | {
"P": [],
"I": [
"Secretin",
"secretin",
"porcine secretin",
"saline infusions",
"synthetic human secretin",
"secretin , porcine or synthetic"
],
"O": [
"behavior , language",
"IQ",
"gastrointestinal function .",
"Children 's Sleep Habits Questionnaire and daily sleep di... |
Effects of a common variant in the CD38 gene on social processing in an oxytocin challenge study : possible links to autism . The intranasal application of oxytocin ( OT ) has been shown to influence behavioral and neural correlates of social processing . These effects are probably mediated by genetic variations within... | {
"P": [],
"I": [
"oxytocin",
"oxytocin ( OT )",
"OT application",
"placebo-controlled",
"OT",
"pharmacological treatment"
],
"O": [
"social processing",
"behavioral and neural correlates of social processing .",
"neural processing of social stimuli",
"behavioral and neur... |
Aerobic exercise improves self-reported sleep and quality of life in older adults with insomnia . OBJECTIVE To assess the efficacy of moderate aerobic physical activity with sleep hygiene education to improve sleep , mood and quality of life in older adults with chronic insomnia . METHODS Seventeen sedentary adults age... | {
"P": [
"older adults",
"insomnia",
"Seventeen",
"adults",
"> or=55 years",
"61.6 [ SD±4.3 ] years",
"female",
"chronic insomnia"
],
"I": [
"Aerobic exercise",
"moderate aerobic physical activity"
],
"O": [
"self-reported sleep",
"quality of life",
"efficac... |
Comparison of indicators for a primary care medical home between children with autism or asthma and other special health care needs : National Survey of Children 's Health . OBJECTIVE To assess the extent to which parents of children with autism compared with parents of children with asthma or other special health care... | {
"P": [
"children",
"autism",
"asthma",
"special health care needs",
"495",
"6716",
"11,403"
],
"I": [
"National Survey for Children 's Health 2003-2004 telephone interview"
],
"O": [
"odds of parents reporting care consistent with that in a medical home",
"less likely... |
Effect of soy protein containing isoflavones on blood lipids in moderately hypercholesterolemic adults : a randomized controlled trial . BACKGROUND Dietary intake of soy protein with isoflavones may be associated with reductions in serum cholesterol . OBJECTIVES To compare the effects of a water-washed soy protein conc... | {
"P": [
"hypercholesterolemic",
"adults",
"hyperlipidemic",
"men",
"women .",
"159"
],
"I": [
"soy protein containing isoflavones",
"Dietary intake",
"soy protein with isoflavones",
"water-washed soy protein concentrate",
"milk-protein based control",
"milk protein... |
Effect of thermal stress , restricted feeding and combined stresses ( thermal stress and restricted feeding ) on growth and plasma reproductive hormone levels of Malpura ewes under semi-arid tropical environment . A study was conducted to assess the effect of thermal , nutritional and combined stresses ( thermal and nu... | {
"P": [
"Twenty-eight",
"adult"
],
"I": [
"restricted feeding",
"combined stresses ( thermal stress and restricted feeding )",
"control )",
"thermal stress )",
"restricted feeding )",
"combined stress )",
"stall fed with a diet consisting of 60 % roughage and 40 % concentrate ... |
Transdermal scopolamine patch in addition to ondansetron for postoperative nausea and vomiting prophylaxis in patients undergoing ambulatory cosmetic surgery . STUDY OBJECTIVE To determine the efficacy of transdermal scopolamine in addition to ondansetron in decreasing the incidence of postoperative nausea and vomiting... | {
"P": [
"undergoing ambulatory cosmetic surgery .",
"postoperative nausea and vomiting",
"PONV",
"126",
"ASA physical status I and II patients undergoing outpatient plastic surgery",
"three or more risk factors for PONV"
],
"I": [
"Transdermal scopolamine patch",
"ondansetron",
... |
Carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in very platinum-sensitive ovarian cancer patients : results from a subset analysis of the CALYPSO phase III trial . AIM To perform a subset analysis of patients with very platinum-sensitive recurrent ovarian cancer ( ROC ) enrolled in th... | {
"P": [
"very platinum-sensitive ovarian cancer patients :",
"subset analysis of the CALYPSO phase III trial",
"patients with very platinum-sensitive recurrent ovarian cancer ( ROC ) enrolled in the phase III CALYPSO trial .",
"total of 259",
"platinum-sensitive patients were included (",
", ... |
Direct and indirect effects of interdental hygiene in a clinical trial . Many randomized controlled trials ( RCTs ) in dental research test the efficacy of interventions on more than one outcome variable . Univariate methods , such as the t test or analysis of covariance , can not evaluate the efficacy of interventions... | {
"P": [
"persons using interdental brushing than in those flossing",
"smokers"
],
"I": [
"interdental hygiene",
"structural equation modeling",
"pre-curved interdental brushes and flossing"
],
"O": [
"PPD",
"BOP",
"efficiency in plaque removal"
]
} |
Caudal analgesia for perianal surgery . A comparison between bupivacaine and diamorphine . Seventy-three patients undergoing elective perianal surgery were randomly divided into a control group , a group who received a caudal injection of 20 ml bupivacaine 0.5 % plain and a group who received diamorphine 2.5 mg in 10 m... | {
"P": [
"Seventy-three",
"elective perianal surgery"
],
"I": [
"bupivacaine",
"diamorphine",
"caudal injection"
],
"O": [
"analgesia",
"Side effects",
"some degree of urinary retention",
"temporary catheterisation",
"."
]
} |
A double-blind comparison of oral ketoprofen 'controlled release ' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening . A double-blind , double-dummy , crossover study was carried out in 8 centres to compare the efficacy and tolerability ... | {
"P": [
"out-patients with definite or classical rheumatoid arthritis ."
],
"I": [
"oral ketoprofen 'controlled release",
"indomethacin suppository",
"'controlled-release ' ketoprofen tablets",
"indomethacin suppositories",
"ketoprofen",
"indomethacin"
],
"O": [
"'controlled-r... |
[ Potentiation of the effect of non-depolarizing muscle relaxants by acylaminopenicillins . Studies on the example of vecuronium ] . In a prospective controlled clinical study interactions between nondepolarizing muscle relaxants and acylaminopenicillins were investigated electromyographically . Six patients in each gr... | {
"P": [
"Six"
],
"I": [
"acylaminopenicillins",
"nondepolarizing muscle relaxants",
"apalcillin , azlocillin , mezlocillin or piperacillin"
],
"O": [
"Muscle relaxation",
"prolongation of the duration of action",
"mean increase",
"shortest time",
"depression",
"EMG-res... |
Virtual reality intervention for older women with breast cancer . This study examined the effects of a virtual reality distraction intervention on chemotherapy-related symptom distress levels in 16 women aged 50 and older . A cross-over design was used to answer the following research questions : ( 1 ) Is virtual reali... | {
"P": [
"older",
"women",
"breast cancer",
"16",
"50 and older"
],
"I": [
"Virtual reality intervention",
"virtual reality distraction intervention",
"virtual reality",
"a head-mounted display ( Sony PC Glasstron PLM - S700 ) was used to display encompassing images and block c... |
Montelukast treatment of moderate to severe atopic dermatitis in adults : a randomized , double-blind , placebo-controlled trial . In a randomized , double-blind , placebo-controlled 4-week trial , 59 patients with moderate to severe atopic dermatitis were treated orally with 10 mg of the leukotriene antagonist montelu... | {
"P": [
"severe atopic dermatitis in adults :"
],
"I": [
"Montelukast treatment",
"placebo-controlled",
"leukotriene antagonist montelukast",
"montelukast",
"placebo"
],
"O": [
"No difference in efficacy"
]
} |
A comparative study of ofloxacin and cefixime for treatment of typhoid fever in children . The Dong Nai Pediatric Center Typhoid Study Group . BACKGROUND Despite concerns about safety in children , fluoroquinolone antibiotics have become the treatment of choice in patients with multidrug-resistant typhoid fever in Viet... | {
"P": [
"typhoid fever",
"children",
"multidrug-resistant typhoid fever",
"82",
"70",
"uncomplicated typhoid fever"
],
"I": [
"ofloxacin",
"cefixime",
"fluoroquinolone antibiotics",
"Cefixime",
"cephalosporin",
"cefixime-treated"
],
"O": [
"fever clearance ... |
Topical treatment of tinea pedis using 6 % coriander oil in unguentum leniens : a randomized , controlled , comparative pilot study . BACKGROUND The antifungal activity of coriander oil has already been demonstrated in vitro . OBJECTIVE Evaluation of the efficacy and tolerability of 6 % coriander oil in unguentum lenie... | {
"P": [],
"I": [
"coriander oil",
"6 % coriander oil",
"placebo",
"Coriander oil"
],
"O": [
"efficacy",
"tolerability",
"clinical signs",
"number of positive fungal cultures"
]
} |
Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I ( 131 ) KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma . BACKGROUND Advanced pancreatic cancer has a poor prognosis , and the current standard... | {
"P": [
"patients with unresectable pancreatic adenocarcinoma .",
"Advanced pancreatic cancer",
"Patients with histological/cytological proven inoperable adenocarcinoma of the head of pancreas were randomised to receive KAb 201",
"Between February 2003 and July 2005 , 25 patients were enrolled . Nine... |
Multiple risk factor intervention reduces cardiovascular risk in hypertensive patients with echolucent plaques in the carotid artery . OBJECTIVE In a previously published randomized 6-year study we observed that multiple risk factor intervention reduced cardiovascular risk in high-risk hypertensive men , and that this ... | {
"P": [
"high-risk hypertensive men"
],
"I": [
"Multiple risk factor intervention",
"B-mode ultrasound",
"High resolution B-mode ultrasound",
"usual care group",
"intervention group",
"multiple risk intervention programme"
],
"O": [
"plaque characteristics",
"cardiovascula... |
REVIVE Trial : Retrograde Delivery of Autologous Bone Marrow in Patients With Heart Failure . UNLABELLED Cell therapy is an evolving option for patients with end-stage heart failure and ongoing symptoms despite optimal medical therapy . Our goal was to evaluate retrograde bone marrow cell delivery in patients with eith... | {
"P": [],
"I": [
"Cell therapy",
"bone marrow aspirate concentrate",
"retrograde",
"BMAC infusion",
"control",
"BMAC"
],
"O": [
"left ventricular ejection fraction",
"significant improvement",
"end-systolic diameter decreased significantly",
"delivery is safe .",
"le... |
Effects of weight reduction interventions by community pharmacists . OBJECTIVE To compare a meal replacement ( MR ) program with a conventional reduced-calorie diet ( RCD ) for weight management using the pharmacy as the setting and the pharmacist as the point of contact for dietary advice . DESIGN Randomized , control... | {
"P": [
"Ninety-five",
"88"
],
"I": [
"weight reduction interventions",
"meal replacement ( MR ) program",
"conventional reduced-calorie diet ( RCD )",
"dietary advice",
"MR",
"RCD"
],
"O": [
"Weight changes .",
"significant amount of weight",
"waist circumference ... |
Prediction of metabolic and cardiopulmonary responses to maximum cycle ergometry : a randomised study . All of the most widely-cited studies for the prediction of maximum exercise responses have utilized either volunteers or referred subjects . Therefore , selection bias , with overestimation of the reference values , ... | {
"P": [
"either volunteers or referred subjects",
"120",
"sedentary individuals",
"60",
"males",
"females",
"aged 20-80",
"randomly-selected from > 8,000 subjects"
],
"I": [
"maximum cycle ergometry",
"maximum ramp-incremental cycle ergometry",
"dual energy X-ray absor... |
Influence of two different doses of antithymocyte globulin in patients with standard-risk disease following haploidentical transplantation : a randomized trial . To evaluate the effect of the different doses of antithymocyte globulin ( ATG ) on the incidence of acute GVHD among patients receiving hematopoietic SCT with... | {
"P": [
"standard-risk disease",
"haploidentical transplantation",
"224 patients",
"standard-risk hematological malignancy",
"One hundred and twelve patients"
],
"I": [
"antithymocyte globulin",
"antithymocyte globulin ( ATG )"
],
"O": []
} |
Step-down approach using either cyclosporin A or methotrexate as maintenance therapy in early rheumatoid arthritis . OBJECTIVE To evaluate the feasibility and outcome of the step-down approach using either cyclosporin A ( CSA ) or methotrexate ( MTX ) as maintenance therapy following 6 months treatment with these 2 age... | {
"P": [
"rheumatoid arthritis .",
"nonerosive RA",
"7 of the 57 patients",
"early RA"
],
"I": [
"cyclosporin A",
"methotrexate",
"cyclosporin A ( CSA )",
"methotrexate ( MTX )",
"CSA",
"MTX in combination",
"single-agent",
"MTX"
],
"O": [
"feasibility and o... |
Early reperfusion and late clinical outcomes in patients presenting with acute myocardial infarction randomly assigned to primary percutaneous coronary intervention or streptokinase . BACKGROUND Primary percutaneous coronary intervention ( PCI ) has become an alternative to thrombolytic therapy as a reperfusion strateg... | {
"P": [
"patients presenting with acute myocardial infarction",
"ST-elevation acute myocardial infarction ( AMI ) .",
"ischemic chest pain",
"58",
"54",
"68",
"women",
"> 70 years"
],
"I": [
"primary percutaneous coronary intervention",
"streptokinase",
"Primary percut... |
Mortality in patients with small choroidal melanoma . COMS report no . 4 . The Collaborative Ocular Melanoma Study Group . OBJECTIVE To describe the clinical characteristics and survival experience of a prospectively followed up group of patients with small choroidal melanoma . METHODS The Collaborative Ocular Melanoma... | {
"P": [],
"I": [
"radiotherapy",
"enucleation"
],
"O": [
"Mortality",
"mortality",
"median length",
"died",
"deaths",
"metastatic melanoma",
"choroidal lesions"
]
} |
Comparative effects of pinacidil and nifedipine in the treatment of arterial hypertension . | {
"P": [
"arterial hypertension ."
],
"I": [
"pinacidil",
"nifedipine"
],
"O": []
} |
A comparison between the effect of oxytocin only and oxytocin plus propranolol on the labor ( a double blind randomized trial ) . OBJECTIVE The comparison between the effect of oxytocin alone or in combination with propranolol on labor . METHODS A double blind randomized controlled trial was performed on 150 nulliparas... | {
"P": [
"150",
"nulliparas",
"pregnancy",
"Bishop score of < or =5"
],
"I": [
"oxytocin only",
"oxytocin plus propranolol",
"oxytocin alone",
"in combination with propranolol",
"oxytocin",
"( propranolol",
"propranolol",
"Propranolol"
],
"O": [
"labor",
... |
Development of a telehealth intervention for head and neck cancer patients . Treatment for head and neck cancer precipitates a myriad of distressing symptoms . Patients may be isolated both physically and socially and may lack the self-efficacy to report problems and participate as partners in their care . The goal of ... | {
"P": [
"head and neck cancer",
"head and neck cancers"
],
"I": [
"telehealth intervention",
"Health Buddy ( R )"
],
"O": [
"Clinician and patient acceptance",
"feasibility",
"technology issues",
"feasible",
"affordable",
"acceptable"
]
} |
Cardiovascular and behavioral effects of aerobic exercise training in healthy older men and women . The cardiovascular and behavioral adaptations associated with a 4-month program of aerobic exercise training were examined in 101 older men and women ( mean age = 67 years ) . Subjects were randomly assigned to an Aerobi... | {
"P": [
"older",
"men and women",
"101"
],
"I": [
"aerobic exercise",
"aerobic exercise training",
"Aerobic Exercise",
"group",
"Yoga",
"and",
"Flexibility control",
"Waiting List control group",
"Waiting List"
],
"O": [
"Physiological measures included mea... |
Intravenous lipid emulsion improves recovery time and quality from isoflurane anaesthesia : a double-blind clinical trial . Recovery time and quality after general anaesthesia is important for patient safety . This study aimed to determine whether intravenous lipid emulsion could improve recovery profiles from isoflura... | {
"P": [
"adult",
"laparoscopic cholecystectomy",
"Sixty-six",
"Sixty patients"
],
"I": [
"Intravenous lipid emulsion",
"isoflurane anaesthesia :",
"intravenous lipid emulsion",
"isoflurane anaesthesia",
"isoflurane",
"lipid emulsions",
"saline solution",
"lipid emu... |
[ Postlaparoscopic pain syndrome . Results of a prospective , randomized study ] . The so-called post-laparoscopic algesia is a specific impairment of about 63 % of the patients who undergo laparoscopic surgical operations . This impairment takes the form of mild to moderate shoulder pain . Eliminating the causes of pa... | {
"P": [
"laparoscopic surgical operations",
"42"
],
"I": [
"laparoscopic surgical operations",
"higher or lower insufflation pressures",
"chemically inert insufflation gas",
"control"
],
"O": [
"analgetics",
"lung function",
"operation duration",
"amount of insufflated... |
Motion aftereffects with horizontally moving sound sources in the free field . A horizontally moving sound was presented to an observer seated in the center of an anechoic chamber . The sound , either a 500-Hz low-pass noise or a 6300-Hz high-pass noise , repeatedly traversed a semicircular arc in the observer 's front... | {
"P": [],
"I": [
"horizontally moving sound",
"500-Hz low-pass noise",
"6300-Hz high-pass noise",
"moving probe"
],
"O": [
"auditory motion aftereffect ( MAE )",
"MAE"
]
} |
Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma ( LUX-Lung 3 and LUX-Lung 6 ) : analysis of overall survival data from two randomised , phase 3 trials . BACKGROUND We aimed to assess the effect of afatinib on overall survival of patients with EGFR mutation-positive lung adeno... | {
"P": [
"EGFR mutation-positive lung adenocarcinoma ( LUX-Lung 3",
"LUX-Lung 6",
"patients with EGFR mutation-positive lung adenocarcinoma",
"adenocarcinoma",
"n=345",
"n=364",
"345",
"patients with EGFR",
"229 patients",
"239 patients",
"patients with del19 EGFR mutations... |
A randomized , double-blind , vehicle-controlled study to assess 5 % imiquimod cream for the treatment of multiple actinic keratoses . BACKGROUND Actinic keratoses ( AKs ) are precancerous epidermal lesions found most frequently on areas of the skin exposed to the sun . Several case studies published recently have indi... | {
"P": [
"multiple actinic keratoses",
"45 to 85",
"52",
"men and women"
],
"I": [
"imiquimod cream",
"imiquimod"
],
"O": [
"multiple actinic keratoses",
"Actinic keratoses ( AKs )",
"AK",
"AK lesions",
"number and appearance of lesions",
"adverse effects",
... |
Levamisole versus placebo as an adjunct to primary therapy of laryngopharyngeal epidermoid carcinoma . Evaluation of the immune status . Twenty-four patients , with a biopsy-proven laryngeal or hypopharyngeal carcinoma , received as an adjunct to their primary treatment ( surgery and/or radiotherapy ) , levamisole ( 15... | {
"P": [],
"I": [
"Levamisole",
"placebo",
"levamisole"
],
"O": [
"immune",
"immunity"
]
} |
Total anthelmintic failure to control nematode parasites of small ruminants on government breeding farms in Sabah , East Malaysia . Government-owned small-ruminant breeding farms in Malaysia provide the source of sheep and goats to smallholder farmers in the country . In the eastern Malaysian state of Sabah , high-leve... | {
"P": [
"nematode parasites",
"nematode parasite Haemonchus contortus"
],
"I": [
"faecal egg count reduction test",
"benzimidazole , imidothiazole , macrocyclic lactone",
"salicylanilide"
],
"O": [
"anthelmintic efficacy",
"faecal egg count reduction test ( FECRT )",
"failure ... |
Efficacy of outpatient induction with low-dose intravaginal prostaglandin E2 : a randomized , double-blind , placebo-controlled trial . OBJECTIVE Our purpose was to determine whether a protocol for outpatient induction is safe and effective for initiating labor . STUDY DESIGN A randomized , double-blind , placebo-contr... | {
"P": [
"100",
"pregnancies",
"Bishop score < or = 6",
"38 to 40 weeks ' gestation",
"50",
"unfavorable cervix"
],
"I": [
"prostaglandin E2 :",
"placebo-controlled",
"intravaginal prostaglandin E2 gel or placebo",
"prostaglandin E2",
"placebo",
"prostaglandin E2-tr... |
Internet-based program for coping with cancer : a randomized controlled trial with hematologic cancer patients . OBJECTIVE Psychosocial patient care in oncology is no longer limited to the inpatient setting . Outpatient services are in demand . Internet-based interventions could aid in optimizing service delivery acros... | {
"P": [
"hematologic cancer",
"One hundred eighty-six registrants",
"One hundred eleven patients"
],
"I": [
"Internet-based program",
"Internet-based interventions",
"4-week cognitive-behavioral program for coping",
"intervention group",
"waiting list"
],
"O": [
"'mental a... |
The immunogenicity of three Haemophilus influenzae type B conjugate vaccines after a primary vaccination series in Philippine infants . Serum antibody responses to three Haemophilus influenzae type b ( Hib ) capsular polysaccharide-protein conjugate vaccine ( PRP-OMP , PRP-T , and HbOC ) were evaluated in 174 Philippin... | {
"P": [
"infants",
"174",
"primary vaccination"
],
"I": [
"Haemophilus influenzae type B conjugate vaccines",
"Haemophilus influenzae type b ( Hib ) capsular polysaccharide-protein conjugate vaccine ( PRP-OMP , PRP-T , and HbOC )",
"Hib vaccines ( Hib groups )",
"control group",
"... |
FloSeal hemostatic matrix in persistent epistaxis : prospective clinical trial . OBJECTIVE Although most cases of epistaxis are managed conservatively , occasionally they can progress to significant hemorrhage requiring more involved management or surgery . Endoscopic ligation surgery is the current institutional stand... | {
"P": [
"persistent epistaxis :",
"80 % of patients with persistent epistaxis"
],
"I": [
"FloSeal hemostatic matrix"
],
"O": [
"surgical intervention",
"discharged from hospital"
]
} |
Components of working memory and visual selective attention . Load theory ( Lavie , N. , Hirst , A. , De Fockert , J. W. , & Viding , E. [ 2004 ] . Load theory of selective attention and cognitive control . Journal of Experimental Psychology : General , 133 , 339-354 . ) proposes that control of attention depends on th... | {
"P": [
"visual selective attention"
],
"I": [
"attentional capture task alone ( single-task )",
"working memory task ( dual-task )"
],
"O": [
"control of attention",
"amount and type of load",
"distractor rejection .",
"distractor effects ;",
"visual selective attention .",
... |
Dark-phase light contamination disrupts circadian rhythms in plasma measures of endocrine physiology and metabolism in rats . Dark-phase light contamination can significantly disrupt chronobiologic rhythms , thereby potentially altering the endocrine physiology and metabolism of experimental animals and influencing the... | {
"P": [
"endocrine physiology and metabolism",
"6 per group"
],
"I": [
"Dark-phase light contamination",
"photobiologic light-exposure chambers",
"light : dark cycle without dark-phase light contamination"
],
"O": [
"plasma",
"physiology",
"metabolism",
"chronobiologic rhy... |
A randomized trial of a behavioral intervention for black MSM : the DiSH study . OBJECTIVE To test a new behavioral intervention for black MSM in reducing sexual risk and increasing social support and intentions to use condoms . DESIGN A single-site , unblinded randomized trial in New York City with 3-month follow-up .... | {
"P": [
"283"
],
"I": [
"behavioral intervention",
"social-cognitive theory-based intervention",
"or",
"control comparison"
],
"O": [
"number of male partners , number of unprotected anal intercourse partners , proportion reporting unprotected sex , number of acts protected by condoms... |
Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension : a pilot trial . OBJECTIVES We assessed the short-term antihypertensive effects of soluble fiber-rich whole oat cereals when added to a standard American diet . In addition , multiple assessments of insulin sen... | {
"P": [
"patients with mild or borderline hypertension :"
],
"I": [
"Oat ingestion",
"soluble fiber-rich whole oat cereals",
"oat cereal group ( standardized to 5.52 g/day beta-glucan )",
"a low-fiber cereal control group ( less than 1.0 g/day total fiber )",
"oat cereals",
"Soluble f... |
Prospective randomized comparison between transperitoneal laparoscopic pyeloplasty and retroperitoneoscopic pyeloplasty for primary ureteropelvic junction obstruction . BACKGROUND AND OBJECTIVES To compare laparoscopic transperitoneal versus retroperitoneoscopic pyeloplasty for primary ureteropelvic junction obstructio... | {
"P": [
"primary ureteropelvic junction obstruction",
"transperitoneal laparoscopic pyeloplasty",
"retroperitoneoscopic laparoscopic pyeloplasty"
],
"I": [
"transperitoneal laparoscopic pyeloplasty",
"retroperitoneoscopic pyeloplasty",
"laparoscopic transperitoneal",
"retroperitoneosc... |
Immunologic profiles of persons recruited for a randomized , placebo-controlled clinical trial of hookworm infection . Data from epidemiologic studies suggest that hookworm infections , in establishing an immunologic phenotype conducive to parasite survival , may protect against the development of allergic disease . We... | {
"P": [],
"I": [
"placebo-controlled",
"iatrogenic hookworm infection",
"hookworm infection"
],
"O": [
"eosinophilia",
"specific IgG response .",
"IgE responses to the environmental allergens to which the participants were sensitized",
"systemic immune regulation",
"level of inf... |
Predictors of blood pressure change in a series of controlled dietary intervention studies . Three controlled dietary intervention studies were carried out in 1981-1983 in North Karelia , Finland , to asses the impact of dietary fat intake modification on blood pressure ( BP ) . All these studies involved middle-aged m... | {
"P": [
"1981-1983 in North Karelia , Finland",
"middle-aged men and women in rural or semirural areas and comprised a baseline period , a six week ( or 12 weeks in the third study ) intervention period and a four to six week return to baseline ."
],
"I": [
"dietary intervention",
"fat intake",
... |
Sodium kinetics in white and black normotensive subjects : possible relevance to salt-sensitive hypertension . The hypothesis that sodium ( Na ) kinetics are not a first order process was tested . Twelve normotensive white and 12 normotensive black men were given 10 , 200 , and 400 mmol/d Na as the chloride salt for 7 ... | {
"P": [
"Twelve normotensive white",
"12 normotensive black men"
],
"I": [
"sodium",
"Na as the chloride salt",
"Na"
],
"O": [
"blood pressure",
"half-life ( T1/2 )",
"T1/2 increased",
"accumulated",
"T1/2 increases",
"effect",
"accumulate more Na"
]
} |
Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for malignant lymphoma : a Southwest Oncology Group Study . Between 1977 and 1983 the Southwest Oncology Group ( SWOG ) evaluated chemotherapy alone ( cyclophosphamide , doxorubicin , vin... | {
"P": [
"715",
"malignant lymphoma",
"281",
"ML",
"388"
],
"I": [
"Chemotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisone alone or with levamisole or with levamisole plus BCG for",
"chemotherapy alone ( cyclophosphamide , doxorubicin , vincristine , prednisone... |
Multiple sclerosis risk after optic neuritis : final optic neuritis treatment trial follow-up . OBJECTIVE To assess the risk of developing multiple sclerosis ( MS ) after optic neuritis and the factors predictive of high and low risk . DESIGN Subjects in the Optic Neuritis Treatment Trial , who were enrolled between Ju... | {
"P": [
"optic neuritis",
"Three hundred eighty-nine",
"acute optic neuritis"
],
"I": [
"Optic Neuritis Treatment",
"brain MRI"
],
"O": [
"Multiple sclerosis risk",
"risk of developing multiple sclerosis ( MS )",
"Development of MS",
"neurologic disability assessment",
... |
Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a... | {
"P": [
"children",
"autism"
],
"I": [
"social-interaction-based therapy",
"MEHRIT , a social-interaction-based intervention",
"MEHRIT"
],
"O": [
"effectiveness",
"communicative language acts",
"outperformed",
"MLUm , number of utterances produced , and various speech act ... |
Folate and arsenic metabolism : a double-blind , placebo-controlled folic acid-supplementation trial in Bangladesh . BACKGROUND Populations in South and East Asia and many other regions of the world are chronically exposed to arsenic-contaminated drinking water . To various degrees , ingested inorganic arsenic ( InAs )... | {
"P": [
"chronically exposed to arsenic-contaminated drinking water",
"Two hundred",
"adults",
"low plasma concentrations of folate ( < /=9 nmol/L )",
"low plasma folate"
],
"I": [
"placebo-controlled",
"folic acid-supplementation",
"folic acid supplementation",
"supplementati... |
Clinical significance and prognostic importance of left ventricular hypertrophy in non-Q-wave acute myocardial infarction . Left ventricular ( LV ) hypertrophy is known to be an independent risk factor for cardiac death , but its significance in non-Q-wave acute myocardial infarction ( AMI ) has not been assessed previ... | {
"P": [
"non-Q-wave acute myocardial infarction",
"non-Q-wave acute myocardial infarction ( AMI )"
],
"I": [
"diltiazem-placebo-controlled"
],
"O": [
"mortality",
"hospitalization",
"progression to Q waves",
"reinfarction by CK-MB criteria",
"angina",
"reinfarction",
"... |
Custom tray application of peroxide gel as an adjunct to scaling and root planing in the treatment of periodontitis : results of a randomized controlled trial after six months . OBJECTIVE Scaling and root planing ( SRP ) is the primary non-surgical treatment for periodontitis , but its effectiveness is limited . Conseq... | {
"P": [
"periodontitis",
"chronic periodontitis",
"30",
"13 test",
"15 control"
],
"I": [
"peroxide gel",
"scaling",
"and",
"root planing",
"Scaling and root planing ( SRP )",
"SRP",
"hydrogen peroxide gel",
"combined",
"1.7 % hydrogen peroxide gel ( Perio ... |
Central 5-HT4 receptor binding as biomarker of serotonergic tonus in humans : a [ 11C ] SB207145 PET study . Identification of a biomarker that can inform on extracellular serotonin ( 5-HT ) levels in the brains of living humans would enable greater understanding of the way brain circuits are modulated by serotonergic ... | {
"P": [
"humans :",
"living humans"
],
"I": [
"placebo-controlled",
"oral dosing with placebo",
"fluoxetine , 40 mg per day",
"( 11 ) C ] SB207145 positron emission tomography ( PET )"
],
"O": [
"Brain 5-HT4R binding",
"positron emission tomography",
"brain 5-HT4R binding"... |
Efficacy and safety of zidovudine and zalcitabine combined with a combination of herbs in the treatment of HIV-infected Thai patients . A randomized double blind placebo controlled trial to determine the efficacy and safety of combined-herbs ( SH ) given with zidovudine ( ZDV ) and zalcitabine ( ddC ) for the treatment... | {
"P": [
"HIV-infected Thai patients",
"HIV",
"Thai adults",
"HIV-infected",
"adults",
"infections",
"60 evaluable subjects",
"40",
"20"
],
"I": [
"zidovudine and zalcitabine",
"placebo",
"zidovudine",
"zalcitabine",
"anti-retrovirals",
"ZDV",
"ddC",... |
Efficacy of topical azithromycin ophthalmic solution 1 % in the treatment of posterior blepharitis . INTRODUCTION Azithromycin , a broad-spectrum antibiotic with potent anti-inflammatory activities , has the potential to effectively treat blepharitis , an inflammatory disease of the eyelid with abnormal eyelid flora as... | {
"P": [
"posterior blepharitis",
"blepharitis",
"inflammatory disease",
"Twenty-one",
"Twenty"
],
"I": [
"azithromycin",
"Azithromycin",
"warm compresses"
],
"O": [
"Efficacy",
"blepharitis",
"eyelid debris",
"eyelid redness",
"eyelid swelling",
"meibom... |
Single-agent irinotecan or FOLFIRI as second-line chemotherapy for advanced colorectal cancer ; results of a randomised phase II study ( DaVINCI ) and meta-analysis [ corrected ] . BACKGROUND Second-line treatment with irinotecan for advanced or metastatic colorectal cancer prolongs survival . It is uncertain whether i... | {
"P": [],
"I": [
"irinotecan",
"FOLFIRI",
"chemotherapy",
"5-fluorouracil",
"fluoropyrimidine",
"folinic acid",
"irinotecan-based",
"Combination treatment"
],
"O": [
"advanced colorectal cancer",
"survival .",
"Toxicity",
"grade 3/4 diarrhoea",
"overall QOL c... |
A pilot randomised control trial of a parent training intervention for pre-school children with autism . Preliminary findings and methodological challenges . Few attempts have been made to conduct randomised control trials ( RCTs ) of interventions for pre-school children with autism . We report findings of a pilot RCT... | {
"P": [
"pre-school children with autism",
"Twenty-four children",
"meeting ICD-10 criteria for childhood autism",
"( mean age = 23 months )"
],
"I": [
"parent training intervention",
"parent training",
"local services",
"home-based behavioural intervention"
],
"O": [
"lan... |
Ebeltoft project : baseline data from a five-year randomized , controlled , prospective health promotion study in a Danish population . BACKGROUND There is increasing political pressure on the medical profession to approach welfare diseases , such as coronary heart disease and diabetes , through prevention . General pr... | {
"P": [
"healthy",
"2000",
"30 and 50",
"1370",
"456",
"Eleven"
],
"I": [
"regular health checks",
"health checks",
"control",
"health check which included being screened for cardiovascular risk factors , lung and liver function , fitness , sight and hearing and an optiona... |
Acute cardiac effects of nicotine in healthy young adults . BACKGROUND Nicotine is known to have many physiologic effects . The influence of nicotine delivered in chewing gum upon cardiac hemodynamics and conduction has not been well-characterized . METHODS We studied the effects of nicotine in nonsmoking adults ( 6 ma... | {
"P": [],
"I": [
"nicotine",
"nicotine gum ( 4 mg )",
"placebo",
"echocardiograms and signal-averaged electrocardiograms",
"nicotine gum"
],
"O": [
"end-systolic wall stress ( ESWS ) , shortening fraction ( SF ) , systemic vascular resistance ( SVR ) , velocity for circumferential fiber... |
Carvedilol increases plasma vascular endothelial growth factor ( VEGF ) in patients with chronic heart failure . | {
"P": [
"patients with chronic heart failure"
],
"I": [
"Carvedilol"
],
"O": [
"plasma vascular endothelial growth factor ( VEGF )"
]
} |
JobTIPS : a transition to employment program for individuals with autism spectrum disorders . This study evaluated the effectiveness of an internet accessed training program that included Theory of Mind-based guidance , video models , visual supports , and virtual reality practice sessions in teaching appropriate job i... | {
"P": [],
"I": [
"internet accessed training program"
],
"O": [
"effectiveness",
"internet accessed training program",
"Content and Delivery",
"effective verbal content skills"
]
} |
Scaling clinical judgments of symptom pathology by means of the psychophysiological method of magnitude estimation . Summing scores across heterogeneous symptom items without consideration of their differing psychopathological significance has been criticized as producing an inadequate picture of an individual 's clini... | {
"P": [],
"I": [
"Steven 's psychophysical method of magnitude estimation ."
],
"O": [
"age and sex",
"magnitude estimation ratings of symptom pathology"
]
} |
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