Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
O67108 | 5.6.2.2 | ACT_SITE 121; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01384" | MENRENLVEIPIEEEVKQAYIDYAMSVIVGRAIPDVRDGLKPVQRRILYSMYEMGLLPDKPFKKSARIVGETLGKYHPHGDQAVYEALVRMAQDFTMRYPLIIGQGNFGSIDGDPAAQMRYTEAKLSPLAVEMLTDIDKDTVDFQPNFDDTLMEPEVLPSKFPNLLCNGTSGIAVGLATSIPPHNLTEVGNALVKLAQNPQISVDEIMEILKGPDFPTGGVIENFAQVKEIYKTGRGIIKVKGKAHVEKVQGGRERIVITEIPYQVNKAELIKKIADNVRNGKIKEISDIRDETDKEGIRIVVELKRDAKGEEVLKKLYK... | 222 |
Q8P4F9 | 3.5.1.88 | ACT_SITE 137; /evidence="ECO:0000255|HAMAP-Rule:MF_00163" | MALLPILEFPDPRLRTKAVPVDAAEVVSPAFQTLLDDMFQTMYEAPGIGLAASQVDVHKRFMVIDVSEEKDAPQVFINPEIVTRQGEQVYQEGCLSVPGIFADVSRADAITVRYLDRQGQPQELSTDGLLAVCIQHEMDHLDGKLFVDYLSPLKREMVRKKLAKLRKHVA | 183 |
K3ZCU4 | 4.1.1.50 | ACT_SITE 68; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 82; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 248; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MASSGFEGFEKRLELVFSLPSCGDGARAQHGLRLLPVGALREALDTVQCAVVSAAGNAAFDAYVLSESSLFVYPSRAILKTCGTTRLLRAVPILLRAAAGELGLALRSCRYSRGSYLFPEAQPFPHADFADEIRFLDGAVLSALRFRRSSVMPPSQRHSQQQHKWHVYAASTSDDDQHVDGATHFTVEVCMTELDRTLARQFYLTTTPGDGRRTSHAIGDAMTAASGLGDVNPRSLAFGYAFAPCGYSMNALDGARYATVHVTPEDGHSYASYECGGAEAGCALASVGKAIAVFRPATVSVSVCYDGAGTEAINTASIWS... | 196 |
Q55624 | 1.11.1.24 | ACT_SITE 50; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:P0A251" | MTEVLRVGQPAPDFTATAIVDQSFQTVKLSTYRGKYLVLFFYPLDFTFVCPTEIIAFSDRHSEFTALDTEVVGISVDSEFSHLAWIQTERKMGGIGNINYPLVSDLKKEISQAYNVLEPDAGIALRGLFIIDREGILQYATVNNLSFGRSVDETLRVLKAIRHVQSHPNEVCPVDWQEGDKTMIPDPEKAKTYFETVAEP | 12 |
B3RZS0 | 1.2.1.12 | ACT_SITE 151; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1" | MVKVGINGFGRIGRLVFRASIAKGGVDVVALNDPFLDAEYMAYLLRYDSTHGRFSGSIEVKNGNLVVNGSEIKVFAIRNPAEIPWGVSGADYVVESTGVFTTLDKAKAHLTGGAKKVVISAPSADAPMFVMGVNHTKYDAKSMDVVSNASCTTNCLAPLAKIIDDNFGIEEGLMTTIHAFTATQKTVDGPSGKKWRDGRGAGQNVIPASTGAAKAVGKVIPELNGKLTGMAFRVPVPDVSVVDLTCRLKKETTYEAIKEAVSKASKSSEFQGIMGYTEDDVVSSDFVGDTHSSIFDAKAGIMLSGTFVKLVSWYDNEFGY... | 22 |
F1A1T9 | 3.1.3.1 | ACT_SITE 109; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MSHFLLEEDFTKKQRFTSVHKRIFYLLISLAIIATVVLLIAFLLPRGWEPPIKKTNIIMMVGDGMGPASLTMARISFSKDFTEEKSLFLDPYLVGTVRTYSHSNDVTDSAAAATAYASGIKTTNDVVGVDHLNKPAGTLFEAAKLKQMKTGVVVTTRISDATPACYFSHSVNRNYEYFIINQLLEKDLDVVLGGGKMYFGDNFDKIQSYNYTFVNTTEQMNNVASGKIMGLFADYNIPWEIDRLNDPILKKNVPSLSEMTKKALDLINQNNEHGFILMVEGSKIDVAAHINDAPTQIYETREFDNTFELVREWAEKDGNT... | 141 |
A0A3B3I852 | 2.7.11.23 | ACT_SITE 137; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | MSVDVKTRSKRYEKLDFLGEGQFATVYKARDKLTDTIVAIKKIKVGHRTEAKDGINRTALREIKLLQELHHSNIIGLLDAFGHKSNISLVFDFMETDLEVVIKDTSLVLTPANIKAYILMTLQGLEYMHQHWILHRDLKPNNLLLDGSGVLKLADFGLAKAFGSPNRVYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRIPFLAGDSDLDQLTKIFEALGTATDETWPGMSSLPDFVSFKIFPGTPLEHIFSAAGDDLLELLQGLFTFNPTTRTTATQALKMKYFSNRPGPTPGPQLPRPNCSAEALREK... | 103 |
O67547 | 6.2.1.5 | ACT_SITE 249; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01988" | MAILVNKDTKVVVQGITGKEGSFHAKQCKEYGTQVVAGVTPGKGGMEVEGIPVFNTVKEAVKETGANCSLIFVPAPFAADAIVEALDAGIELVVCITEGIPVKDMMMVKDYMLKNYPNAKLVGPNCPGVITPGEAKVGIMPGHIFKRGKIGIVSRSGTLTYEAAYQLTKYGLGQSTAVGIGGDPVHGLTHRDVIEMFNKDPETEAILMIGEIGGTEEEEAAEYIEKEVDKPVFAYIAGITAPPGKRMGHAGAIIMGGKGTAKAKMEALEKAGAYVIENPAKIGETVAKILKVIELEEEERTSDAE | 247 |
Q10309 | 7.6.2.1 | ACT_SITE 408; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250|UniProtKB:Q9Y2Q0" | MDSRLNRIQSKMKLWIKDKNLSNPSIPLKVLNKSFRSSRQSSVSNGHGLYSLDRDETESLMSSHEASNAGISLDSSFRVIQVGQPEPQYGNNAVTNTKYDLFTFLPKCLYEQFRYFYNMYFLLVSLSQLIPPLKIGYLSTYIAPLIFVLLITLTKEAVDDLKRRRRDSYANNEIYTVNDSPCAAQNIQAGDVVYIAKDQRIPADMILLETTVGNEAFIRTDQLDGETDWKLRIPCSNQHTEGIVHADAPIKSVHHFYGTFTLNNQKRPISVDHTLWANTVLASDGVYGVVVYTGKDTRQSMNSSKAKTKVGLLEKEINFY... | 259 |
A0A3Q7F1C1 | 1.11.1.7 | ACT_SITE 84; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MLLYKNSSIVSHQFCNTLRKMENLCLVFLLIVSIVFPVLGQGGLKTGFYSSSCPNAESIVKSTVQAEFDKDPTIAAGLLRLHFHDCFVRGCDGSVLISGSSAERNAVTNTGLRGFEVIDDAKSKLEASCLGVVSCADILALAARDAVDLVGGPSWGVPTGRRDGRNSSSSEAMNLPSPFDTVEVQRSKFAAKGLDDHDLVTLVGAHTIGQTDCRFVSYRLYNFTKTGNADPSIDQQFLTQLKTMCPKDGDGSKKVDLDKDSQLNFDVSFFKNIRNGNGILESDQRLFGDSSTKDVVDKYAGSIRGLLGLRFNYNFKQAMI... | 14 |
A9A450 | 1.1.1.37 | ACT_SITE 173; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P61889" | MITIIGSGKVGGDAALFSALKRLDDQILLLDVAEGLPQGEAMDINHMLSEQGIDVEVKGSNNFEDMKGSNIVVVVAGSGRKPGMTRMDLLKINASIVKSVVENVKKYADDSMIIPVTNPLDPMAYITYKVSGFDRSRVFGMGGMLDLSRFRQFIHEATGHSRDSIRALVIGEHGENMLPLPRFSSVSGIPLPSLLPKEKLEELVQNTKQVAAKVIELKGATVHAPGNAISAIVEAVVRDRKQVIPVATYLDGEYDHSDVTIGVPAVIGKNGVEKIIELDLNDEEKQVFNKAVENVKGALSGVEI | 5 |
A0A1U8JHJ2 | 3.1.1.11 | ACT_SITE 435; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDSMKSFQSYCKADELEEQAYRRRTRKRLIIIGLSTIVLIAIIIGAVFGTLFPVKSSKSNENPPTYTAESIKAICDVTRYPASCGSSIAAIRSSSNDTDPNPGPSKVFTLSMQVAAGELIRLSSLPQKIISSNVNIDPMVREELEICENLFEDAVEYINDSISAVQGGQGDEMVLSTAKINDIKTWLSSAITNQETCLDGLMEAANHAAIPQEMENATRNSTEFSSNSLAIATHIMTILQSFQVPIHRKLLKFDRHHHGLEFDPRFPLWVRRGDRRLLQEENPIPNITVAKDGSGDFRTISEAVELIPKKKKTRFVIYVK... | 125 |
A0BYR7 | 2.7.11.1 | ACT_SITE 159; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MQTGLVINQVKERILFFSPTVQGKMEREACTQDFEVIQGLGQGAFGKVFKVRHKKTKMVFALKQIAKKQIKQQKMTQQIINEVKIMYGLEHPNIVKLYNHYEEEDYIYLILECATGGQLWQKLNRVGRFDEKTVKQFMQEAMSAIEYLHTRNPPIIHRDIKPENILLDANGHIKIADFGWSNINNHQRTTYCGTLDYLAPEMILECGHDEKIDNWSLGVLIYELLTGKAPFAPSSQIKDQKESQKILEDNILKVKINFPNDFPSLAKSLVQGLLQRDPQKRFNIQKMREHPWFANCQIQQEVQSEQKVKAENIKDIIKDD... | 99 |
A0A2G3AK10 | 3.1.1.11 | ACT_SITE 408; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGGKIMISLISLILLVGVIVGIVVIVNKDGNSKDDKSIKVQMKKVHEFCQATEFQDACAKSLQGVAKNESATVQDYIIAAFQNTLDALKKGLNETGKTSVDKKSDPYNYMAVDDCKKLVQFAIEELDDSLNIVAETDTQSLHKYTYDLLNWLSGVYAYQSICIDAIEKPEYKSAIGNGLMNATQLTSNALHIVAEMSSLLKAFNIQIPEDHHDNDSSPHRRLLDFNKVDQDGYPTWFPAADRKLLGKSKEGKGKGGKGGDAGPPLPPVGSGPLTPNAVVAKDGSGKFKTVSDAVKAYPPNHQGRYIIYIKAGVYNEQVLV... | 125 |
Q6ZRP7 | 1.8.3.2 | ACT_SITE 91; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 94; /note="Nucleophile"; /evidence="ECO:0000250" | MAAAGAAVARSPGIGAGPALRARRSPPPRAARLPRLLVLLAAAAVGPGAGGAARLYRAGEDAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNHTEGSRPPACPRLDPIQPSDVLSLLDNRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTRALDGDKAFLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDVRKKSLPLPEKPHKEENSEIVVWREFDKS... | 38 |
F6R3G8 | 3.1.1.3 | ACT_SITE 144; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 168; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 255; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | RGICFKRLGCFRDDPPWGGIPQRRLKILPCSPEYINTRFLLYTNENPNRCQEIKATDPQSILASNFKTNRKTHFIIHGFIDKGEGNWLTDMCQKIIQAEQTNCICVDWRRGSRTFYSQAVNNIRVVGAKELRYSPSNVHIIGHSLGAHAAGEAGKRTTGEIGRITGLDPAEPCFQGAPEDVRLDPSDALFVDVIHTDSAPMIPCKGFGMSQTVGHLDFFPNGGKQMPGCKKNMLSTIMDINGIWEGTQAFVACNHLRSYKYYAESIINPEGFLGYPCDSYDDFEKNKCFPCPPEGCPQMGHFADRFKGNISEVGQTFYLN... | 128 |
Q5AZ53 | 3.2.1.78 | ACT_SITE 196; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q99036"; ACT_SITE 313; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q99036" | MIFSTLLSLALLATTATARKGFVTTKGDKFQLDGKDFYFAGSNAYYFPFNNNQTDVELGLSAAKKAGLLVFRTWGFNDKNVTYIEDGLPQYGGEGAGTTEVVFQWWQNGTSTIDLEPFDKVVNAAAKTGIKLIVTLVNNWADYGGMDVYTVNLGGQYHDDFYRLPQIKKAYKRYVKEMVTRYRNSPAIMAWELANEPRCGADGVRNLPASDECTPELLTSWIDEMSTYVKRLDPHHLVTWGGEGGFNYDSDDWAYNGSDGGDFEAELKLKNIDFGVFHSYPDWWSKTVEWTNKWIVDHARAARRVGKPVVHEEYGWLTPQ... | 172 |
F4NVM6 | 6.2.1.5 | ACT_SITE 294; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03222, ECO:0000256|PIRSR:PIRSR001553-1" | MSSLIRQIPSVTSSGLMRASPAYAARRTLASTMTTSYNNTALNMMIDKNTKVICQGFTGKMGTLHSKAAIEYGTRMVGGTSPSKAGTTHLGLPVFGSVKEAVSEVKPDASVIYVPPPGAAAAIIEAIQAEIPLVVCITEGIPQQDMVKVKKILLNQNKSRLIGPNCPGIIKPDQCKIGIMPGHIHRPGKIGIVSRSGTLTYEAVAQTTAAGLGQTLCVGIGGDPFNGTNFVDCLKVFLADPETEGIVLIGEIGGSAEEDAAEYLMQHNMSRSNPKPVVSFIAGLSAPPGRRMGHAGAIISGGKGKAEDKVAALQRAGVIV... | 247 |
A0A803TKL3 | 2.3.2.26 | ACT_SITE 940; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MATGMVEPVYGLSEEEEESRVLRVKVVAGIDLAKKDIFGASDPYVKLSLYASDESRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLNHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQEDDNDQREDSEHGWEVVDSNDSPAQRQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVASESDNNIRQINQEAAHRRFRSRRHISEDLDPEPLESGDVPEPWETISEENASSDSLSLSLPPPPASPVSRTTPQELSDELNRRLQITPDSN... | 65 |
F6PI53 | 3.5.4.5 | ACT_SITE 60; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MATKYTTPEALIALADGAKQRAYCPYSKFQVGAAVVVENGDVFTGCNVENACYPVGVCAERTAICKAVSEGHTKLVAVAVITNGKTVNFPCGLCRQSIREFGTDVTIYCAKKDRSYQTHKLKELLPLSFGAENLIQ | 187 |
Q9KTP8 | 2.7.1.23 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MKKPFNVLAIIGKPRDQQAIQTHKEIYHWLRSLGYTVFIDDRLREILTDLPTEHFASLIELGKKADLAIVVGGDGNMLGAARVLSRFDISVIGVNRGNLGFLTDLNPEDFQQRLQEVLDGHYLQETRFLLEAEIHRHGQVKSHNAALNEAVLHPGKIAHMIEFEVYIDDNFAFSQRSDGLIVSTPTGSTAYSLSGGGPILSPSLNAITLVPMFPHTLSCRPLVVGGNQRIKLVVSPENRGTQEVSCDGQVSLPVSPGDEIHIYQSPNVLKLIHPQDYSYYHVLRTKLGWSSKLF | 89 |
Q8LBZ4 | 3.4.19.12 | ACT_SITE 176; /evidence="ECO:0000255"; ACT_SITE 179; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q96G74"; ACT_SITE 299; /evidence="ECO:0000250|UniProtKB:Q96G74" | MMICYSPITTCSRNAISIKRHLGSRLYGVVAHGSSKFSCYSLLSGLSRRHYTGFRVSVSNRPSSWHDKGLFGSVLINRPTVAPKEKLEVSFLSPEANMKCSKIESNMRNLYCYSRFAYTGVIVSLLVCYSSTSQSAYADSSRDKDANNVHHHSSDGKFHNGKRVYTDYSIIGIPGDGRCLFRSVAHGFCLRSGKLAPGEKMQRELADELRTRVADEFIQRRQETEWFVEGDFDTYVRQIRDPHVWGGEPELFMASHVLQMPITVYMKDDKAGGLISIAEYGQEYGKDDPIRVLYHGFGHYDALLLHESKASIPKSKL | 175 |
P49615 | 2.7.11.1 | ACT_SITE 126; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP | 99 |
A2QAN3 | 3.2.1.23 | ACT_SITE 200; /note="Proton donor"; /evidence="ECO:0000305|PubMed:28391618"; ACT_SITE 298; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:28391618" | MKLSSACAIALLAAQAAGASIKHRINGFTLTEHSDPAKRELLQKYVTWDDKSLFINGERIMIFSGEFHPFRLPVKELQLDIFQKVKALGFNCVSFYVDWALVEGKPGEYRADGIFDLEPFFDAASEAGIYLLARPGPYINAESSGGGFPGWLQRVNGTLRSSDKAYLDATDNYVSHVAATIAKYQITNGGPIILYQPENEYTSGCCGVEFPDPVYMQYVEDQARNAGVVIPLINNDASASGNNAPGTGKGAVDIYGHDSYPLGFDCANPTVWPSGDLPTNFRTLHLEQSPTTPYAIVEFQGGSYDPWGGPGFAACSELLN... | 163 |
P24102 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor" | MGFSPSFSCSAIGALILGCLLLQASNSNAQLRPDFYFGTCPFVFDIIGNIIVDELQTDPRIAASLLRLHFHDCFVRGCDASILLDNSTSFRTEKDAAPNANSARGFNVIDRMKVALERACPGRVSCADILTIASQISVLLSGGPWWPVPLGRRDSVEAFFALANTALPSPFFNLTQLKTAFADVGLNRTSDLVALSGGHTFGRAQCQFVTPRLYNFNGTNSPDPSLNPTYLVELRRLCPQNGNGTVLVNFDVVTPDAFDSQYYTNLRNGKGLIQSDQELFSTPGADTIPLVNQYSSDMSVFFRAFIDAMIRMGNLRPLTG... | 14 |
A0A3Q1MNU5 | 3.1.1.4 | ACT_SITE 67; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 112; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MGLSLLCALLVFAGVAPAEADILDLNEMVRQVTGKIPIFFYSSYGCYCRIGGQGQPRDATDWCCYDHNCCYGYLTPHNCDYLYDHYDYTFFQGNVQCSTKGSWCEQQLCACDKTLAFCLQRNLNTYKNHLRHLSRCEGETLACPPAS | 130 |
F6I4G6 | 1.11.1.7 | ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MPTLLFCIMFFLTVSVSSASLKVGFYKYTCPSAETIVRKVVNKAVSQNPGMAAGLIRMHFHDCFVRGCDGSVLLDSTPGNPSEKENPANNPSLRGFEVIDAAKAEIEAQCPQTVSCADVLAFAARDSAYKVGGINYAVPSGRRDGRVSLKDEPSLHLPPPFFNAKQLEDNFARKGLTLDEMVTLSGAHSIGVSHCSSFSNRLYSFNATHPQDPSMDPEFARHLKTKCPPPSNTGSDPTVPLEIQTPNKLDNKYYKDLKNTGAYWHQIRLFSTALQQRGW | 14 |
Q74AI3 | 4.2.1.20 | ACT_SITE 49; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MSRIAGTFAELKHNSRKALVTFITAGDPDLAATEALIPLLAESGADIVELGVPFSDPMADGPTIQLSSERALAAGTTLPKILDMVRRVRTRCQVPIVLMGYYNPILIHGLERFAADASAAGVDGVLLVDLPPEEAAEFKACADRHGLDVIFLLTPTSDEGRIRKVARQARGFVYYVSVTGVTGARSGVEASVSSNVAAIREAITVPVVVGFGISTPDQAAQVAASADGVVVGSAIVKLFERFTAAELGREVATFVSALREAIGN | 202 |
A0CZH4 | 2.7.11.1 | ACT_SITE 214; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MNRFCDYKSCQYFIKQPTIEQRSKLNKVMCPLCMGANYCSTRCRDLDWPIYHKEICKKSQPDRARSCNDTIDSCSTTSVRRRPEEFEIITIGSKQELGRGSYGSVKLVKDKQNGLLYAMKIMNKRQVFEYCSVENLKREIKIQRKLAHPHICKLHHYFEDKENVYLILEYAQNGSLFNYIKKRSKLPENEAFVYFFQTCLGIDYLHKNKIIHRDLKPENLLLDHDGNVKICDFGWSAESLTEKRMTFCGTYEYMAPEMLNKQPHDFSLDVWSLGILLYELLHGNAPYRGRNNEELGNKIKSGQPINFAPTLSKEVITLIK... | 99 |
Q5EAV9 | 3.4.19.12 | ACT_SITE 15; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 116; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 131; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MSESVFHERQRLELCAVHALNNLLQKPEFSQQRAEEICRGLAPNSMINPHRSLLGTGNYDVNVIMAALQTMDYAAVWWDKRRSLESLVPSEIFGFILNIPSPVSLGFLSLPITRKHWIAVRQIDGVYYNLDSKLKAPIKLGGTKELKEFLHGCMSRGSCEILLVVGRDVEDARLWIRTEEQAAT | 175 |
E9HZ30 | 1.11.1.6 | ACT_SITE 10; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 83; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MQPISLRILHSLLRGAFGYFEVTHDISKYCKAAVFGQVGKKTPVAVRFSTVGGESGSADTARDPRGFAVKFYTEEGNWDLVGNNTPIFFIRDPILFPSFIHTQKRNPVTHLKDPDMFWDFISLRPETTHQVCFLFSDRGTPDGYRFMNGYGSHTFKLVNAEGKPIYCKFHFKTDQGIRNLDAGKAHQLTADDPDYATRDLYNAISKADFPSWSVKIQVMTFEEAEKFKWNPFDLTKTWPQADFPLIPVGRMVLDRNPKDYFAEVEQIAFSPAHLVPGIEPSPDKMLQGRLFSYTDTHRHRLGTNYLHLPVNCPYRSKTLN... | 13 |
A0A8V0ZLR3 | 3.1.1.4 | ACT_SITE 100; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 144; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MKLLVLLVCREYPLHGDGARLGLMAPLFSPFLEGSLSNANNSISPVAVLAPAGCNIAQFGIMIKEKTGKPALSYNGYGCHCGLGGSKYPVDATDWCCHAHDCCYKRLSSVTCVPHLATYKFSIKRGQITCGSGSSCQRAACECDKKAAECFKRNLRTFNKSYQNYLNFKCKGSRPSC | 130 |
P32660 | 7.6.2.1 | ACT_SITE 667; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250|UniProtKB:Q9Y2Q0" | MSGTFHGDGHAPMSPFEDTFQFEDNSSNEDTHIAPTHFDDGATSNKYSRPQVSFNDETPKNKREDAEEFTFNDDTEYDNHSFQPTPKLNNGSGTFDDVELDNDSGEPHTNYDGMKRFRMGTKRNKKGNPIMGRSKTLKWARKNIPNPFEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTE... | 259 |
O02658 | 3.1.3.16 | ACT_SITE 123; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P36873" | MTAPMDVDNLMSRLLNVGMSGGRLTTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDVNFLFLGDYVDRGRQNIETICLMLCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKSMRRG | 144 |
A0A804JWL8 | 3.1.3.48 | ACT_SITE 26; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 28; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MVDRTPAVTFGEDQEISKPTTVYIWDMDETLILLKSLLDGTYAGVFNGMKDTKKGFEIGKHWENHILRVCDEFFFYEVIENYNEPYLDALSEYDDGRDLSNYDFSNDGFSSPYDDANKRKLAYRHRSIAEKYSQGLHKVLDQQMIKLWNDLYSLTDSYTGGWLSSAHALLEQTLAKTKPSASDHSSEMTPRSIITKDQSINVLVTSGSLVPSLAKCLLYRLDDVISANNVYSSWEVGKLQCFSWIKERFGSPNVRFCVIGDGTEECAAAETMRWPFIKIDIRPASPYRFPGLTMEMVQSYIDVIYGPQDSKDEKMKG | 149 |
Q01389 | 2.7.11.1 | ACT_SITE 1303; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPFLRKIAGTAHTHSRSDSNSSVKFGHQPTSSVASTKSSSKSPRATSRKSIYDDIRSQFPNLTPNSTSSQFYESTPVIEQSFNWTTDDHISAGTLENPTSFTNSSYKNDNGPSSLSDSRKSSGGNSVNSLSFDKLILSWDPTDPDEWTMHRVTSWFKFHDFPESWILFFKKHQLFGHRFIKLLAYDNFAVYEKYLPQTKTASYTRFQQLLKKTMTKNVTNSHIRQKSASKLKSSRSSSESIKSKLKNSKSQEDISNSRSTSESALSPTKSGPSKTDEKNFLHSTSTHQKTKSASSLYRRSFISLRGSSSSNASSAKSPSN... | 99 |
B8E0F4 | 6.3.4.2 | ACT_SITE 381; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000256|HAMAP-Rule:MF_01227"; ACT_SITE 506; /evidence="ECO:0000256|HAMAP-Rule:MF_01227"; ACT_SITE 508; /evidence="ECO:0000256|HAMAP-Rule:MF_01227" | MSDTKFIFVTGGVISSLGKGLTTASLGRILKSKGFNVTALKFDPYINVDAGTMNPYQHGEVFVTEDGAETDLDLGHYERFLDVNLSAINNVTTGKIYSSVIRKEREGKYLGSTVQIIPHITEEIKNSIKLVAKETGADIVLVEIGGTVGDIEGLPFLEAARQFRKDVGKDNVIYLHVTLVPSLFPTGELKTKPTQHSVKELRSIGIQPDIILCRAKTKLPKSIREKIALFTDVEPEAVITGVDVEDLYAIPLYFEEEGLGDLVCKLLGLENRKSNLEDWKAMVNKELLGEVNITILGKYVTLPDAYISVVQALKHATRFY... | 252 |
A0A0K9PLU3 | 3.1.1.11 | ACT_SITE 403; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAAASISSPFFQLVLVLLVIQAATMATAVTHQTMDVIKSTCKATPHPELCMNTLTNSSAVISIPTNPTLNFAAHTLDSAISKARKLSSFLADTGTGGTKELHDCKELHDISMSCLRRSASMCGINTGSLGKKELADINIYLSAALTNKITCLQGLSTVTGAKKDSLVNYLTDVYKYVSNSLAIVSKSKSSKSKLPSTVIHNRRLMGEMIPTWLPLRDRKVLQIGGINIGSGGNNEGYKGNDDNNGGTDIEAMLTLKVSADGSETYRTISDAVLDVPENSNSRTIIQIKAGVYEENVVIPSNKMNVAFVGEGADVTIIRGN... | 125 |
A0A0Q3FHP1 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGRSSGVVVLVAVVAGMLLCVAEAQTQLKPGYYDQTCKDAEAIVFDEVRKAWNADRSVPAALLRLHFHDCFVNGCDGSVLLESWDRQAEKDAPPNKSLRGYEVIDRAKARLEMACRQTVSCADILAYAARDSVKVATGGFHYAVPGGRPDGTVSRATMANSNLPPPTQRNVDLLAQAFINKGLSKDDLIVLSGAHTLGVTRCGTFDYRLSNSNDKGMDPWFLNSLRAQCNRDASRVVPLDDGSQFAFDTKYYANVIANRGVLESDAALNSPSTVARVRQLRDGTPQTFHGAFAAAMGRMGALRGANPGKVRDHCRRVRT | 14 |
A0A0D1E894 | 2.7.11.1 | ACT_SITE 329; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MESQLANLHLDGGSTADLKQGSRPSHAQASHGNRHVHPTNSSLRPLAPSSSIASNMGINMGVNMQHFNRLAASSTGLTNPNSIAQGMSRAAQQPLNGSRPSTQQQPTQAHIKSRPPSVAGGLNAAAGPSYRPAAPAAQSTKQPASAGSAVASVDLGRYDGGLERDEARGRRGTMQFDPLTLSSADAGKQHPPTRVWSLKDFEMGRPLGKGKFGRVYMVRTRAAPNKGYIIALKCMYKNELVENKVEKQLRREIEIQMNLRHPHILRLHGYFHDEGRVFLMIEFAGRGELYKLMNKLHDRRFEEKVAATYIAQMADALSYL... | 99 |
Q8IKK7 | 1.2.1.12 | ACT_SITE 153; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1" | MAVTKLGINGFGRIGRLVFRAAFGRKDIEVVAINDPFMDLNHLCYLLKYDSVHGQFPCEVTHADGFLLIGEKKVSVFAEKDPSQIPWGKCQVDVVCESTGVFLTKELASSHLKGGAKKVIMSAPPKDDTPIYVMGINHHQYDTKQLIVSNASCTTNCLAPLAKVINDRFGIVEGLMTTVHASTANQLVVDGPSKGGKDWRAGRCALSNIIPASTGAAKAVGKVLPELNGKLTGVAFRVPIGTVSVVDLVCRLQKPAKYEEVALEIKKAAEGPLKGILGYTEDEVVSQDFVHDNRSSIFDMKAGLALNDNFFKLVSWYDNE... | 22 |
A0A0K9P7C1 | 2.1.1.33 | ACT_SITE 159; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MTRNGKQMEMNKNSSHHPRKRFYRARAHSNPLSDSHFPIPISPSEVDYSHHYPYFYPDGWNSNVNSNDGTASKIQFADIGCGFGGLLVSLSQLFPDTLMIGMELRDKVSEYVKERILALRMSIPGQYENISVVRTNSMKYLPNYFTKKQLTKMFFLFPDPHFKEKNHRRRVISPHLLDEYAYTLQTGGIIYTITDVEELGDWMRSCLEEHPLFQAVPEHELEADPVVKLLSGATEEGQKVARNEGQTFQAIYRRIELED | 45 |
A0A067E8G7 | 3.1.1.11 | ACT_SITE 169; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | IVFASITATCGFSATIPKDISTAVLIRVEKYGRGDFRTIQEAIDSVPANNSELVFISVAPGIYKEKIIVPANKPFITISGTKASHTKITWSDGGSILDSATLTVLASHFVARSLTIQNTYGSFGKAVALRVSADKAAFYGCRILSYQHTLLDDTGNHYYSKCYIEGATDFISGNANSFFERCLIHSLSTWGGAITAQKRVSSEENTGFTFLDCKISGVGKAVLGRPWGAYSRVVYALTYMSDVIVPQGWNDLNDHAKHNKLYYGEYRCSGPGADRSKRIAWSNSLSDVEASTFLSKDLTGRGTWLRNAALKFKDDFTIND... | 125 |
H2L099 | 2.7.11.1 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MTTTSSDELPRQADDDSMKWDRIYIQKLDPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILVDLIERAAEYRLRTGVSSDSDLDEDS... | 99 |
Q9Z7T0 | 1.2.1.12 | ACT_SITE 151; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00362" | MKVVINGFGRIGRLVLRQILKRNSSVEVLAINDLVPGDALTYLFKFDSTHGRFPEDVRCEADHLIVGKRKIQFLSERNVQNLPWKDLGVDLVIECTGLFTKKEDAEKHIQAGAKRVLISAPGKGDIPTFVMGVNHKTFNPEKDFVISNASCTTNCLAPIAKVLLDNFGITEGLMTTVHAATATQLVVDGPSKKDWRGGRGCLQNIIPASTGAAKAVTLCLPELKGKLTGMAFRVPIEDVSVVDLTVRLDKSTTYDDICKAMKQASETDLKGILDYTDEQVVSSDFIGSEYSSIFDALAGIALNDRFFKLVAWYDNETGYA... | 22 |
B7QJK7 | 2.3.1.286 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MSCDYASGLSDYADKGVCGQPEQFDDAALLDDKIARLADWMQSSKHVVVITGAGISTSAGIPDFRGPNGVWTLEQKGEKPTLNISFDDAVPTPTHMALVALAERAKLQFLVSQNVDGLHLKSGFPLDTLADLHGNMFVDRCNQCRRQFIRDTATRTVGQKPTGEPCPVPKRNGRLCRGRLHDSILDWEDELPEDAIEAADAHCRVADLVLCLGSTLQIVPCGTLPLLAKKSAGKIIVCNLQPTKLDKSANLILRAYVDDVMTKLMAKLGIDIPSYSPGRDPTKGKRELPPVYPRLRLPKVAKALGSGRRPKQRTKKPQKR... | 58 |
Q54U31 | 2.7.11.1 | ACT_SITE 400; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKRFFSNLFKRKQDQNSHIKQINGPTTSTPTTTPTTPTTPTTTQTPTPQNNNTNNNTNNNNNTNSNNSNQQKKEQAQASPSTNQTQTPSNNTISTSPTVTTQPSFTPGVISTSKLTTSPPESPRPPTSTTNTTQPSTTTTTATNSTNTNTASAPTKTASPSSPSATASPNNNSNNTTTTAATTTTTTTTTTTTNANQTASVNHTSSDQSLNAQNVTQTNNNNNNNNNNNNNNNANNTKPINPNDYIPLDFVDSTPKVDNNQPKRKASGPPEILPEEIDRTDFLGQGSFGSVYKGKCRGQEVAVKIPRKQKLSLYELTSFR... | 99 |
K7KJK8 | 3.1.1.11 | ACT_SITE 249; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MEQSVNAQIHITWLGSKCRSKQEKAAWSDCVTLYQDTINILNQALNPTKQSTSYDLQTWLTTSLTNTDTCQTGFHKVGVGNNVLPLIPNKNISKIISDFLTLNNASSFIPPKTNKNGFPRWLSPNDRKLLEDFKTIKEALKAVPKLSPKRFVIYVKHSVYNENIEYYVVCRSVGGGSTTFNSTNVDGFIARGITFRNTEGPENHQAGALRCGADLSVFHRCAFEGYQDTLYVHSQRQFYKECHIFGTVDFIFGNAAVVFQSCNIYATRSMQKQKNAIAAEDPNQNTGICIQNSRVMAVEDLVPVLSSFKTFLGRPWREYS... | 125 |
A0A9R1VGP5 | 3.1.1.11 | ACT_SITE 408; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNSHLFAGMPDFGNNKKFFFRVFASILLFSAVNGIVVGVNSQSPNINIESSTAHVIVKSSCSATLHPDLCYSTLSGIPEITEKITTPKDVIELAVNKTKEIVQRNYFTIKKLTVKTDLTKRQKIALHDCLEMVAETLQELNQVLAILSAYPMKKGSRRHVDGLMTLMSTTLTNQETCIDGFSHDKHDRKLRESLIAGEIHAEKLCSISLAMIKNMTDTDMANQVEINGRKLKEEEDDEWPEWLSIGDRKLLQLGTVTPNVTVAANGSGNFTTISAAVAAAPASSATRYVIRIAAGVYRENVNIPSNKRNLMFLGSGRTST... | 125 |
A0A8I3N744 | 2.7.11.25 | ACT_SITE 279; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1" | MAWPGAEGAADRPVSPGRGGPVGSASSSSASSGGSASASASASASASASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASLPPPPPPPPPRPGSPVHVDFARLQLQELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAAAASPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLERIEHDDFCNKTLKITDFGLAREWHRTTKMSA... | 105 |
Q9Y9L0 | 1.11.1.24 | ACT_SITE 50; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00401, ECO:0000269|PubMed:16214169, ECO:0000269|PubMed:18436649" | MPGSIPLIGERFPEMEVTTDHGVIKLPDHYVSQGKWFVLFSHPADFTPVCTTEFVSFARRYEDFQRLGVDLIGLSVDSVFSHIKWKEWIERHIGVRIPFPIIADPQGTVARRLGLLHAESATHTVRGVFIVDARGVIRTMLYYPMELGRLVDEILRIVKALKLGDSLKRAVPADWPNNEIIGEGLIVPPPTTEDQARARMESGQYRCLDWWFCWDTPASRDDVEEARRYLRRAAEKPAKLLYEEARTHLH | 12 |
A0A251TF74 | 1.8.1.4 | ACT_SITE 477; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MAMANLFRRKATRDVLRYSLYRGFASESEVNDVVVIGGGPGGYVAAIKAAQLGLKTTCIEKRGALGGTCLNVGCIPSKALLHSSHLYHEAKTKFANHGVKCSDVQVDLPAMMAQKDKAVFNLTKGVEALFKKNKVNYVKGAATFLSPSQISVEEEEEQGEKKTVVGKNIIIATGSDVKGLPGITIDEKRIVSSTGALALTQIPNKLIVIGAGYIGLEMGSVWARLGSEVTVVEFAPVIVPTMDGEIRRQFQRSLEKQKMKFMLNTKVMGVDTSSSDVVKLTLEPSAGGGDQTVLEADVVLVSAGRTPYTAGLGLENIGVE... | 36 |
A0A1B6QFX5 | 3.1.1.11 | ACT_SITE 220; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQQASACFSSTTSSSLLVMPVVALVMVVPLLLGLLSTTPSLAWAAPVSRTITVDCHGRGDVRTVQSAVDSVPDGNRDWIKIHVMAGSYWEKVSIPKQKGYILLEGDGSSTTDISFDAHAHAGIDDIMGRPNLTVDEQSPTFQSATFTVLADNFVARGIAFKNTYRAPDDQLSKENQAVAALVGGDKSAFYGCEFQGFQDTLCDYQGRHYFRGCQVRGAVDFVFGFGQSIYEDCALVSDMPPGPQPGWVTAHARGAAGSPGGLVFKGGAVQAAGGGGQTYLGRAWNAFAAVVFYRTRMDGVVVPQGWQAWNAAGNVSSVTF... | 125 |
A0A1L8FJD6 | 2.7.7.7 | ACT_SITE 315; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MEPRGIVKAFPKVKRLRENATLEDGGKKIKTAVDIHGTVFDGVLAHILQAGIGLARSEIFQKQIIQNGGQVTSQFSSEVTHIIVDEQMDCDRAFRLLKLEKISHHVQLVKSTWLSICINEKQMVNTAGYRIFIPDRYLDLKDRAEKEQSCESKGNYRKQHDELPHVPDKLNEAGNPQTQHVSDFPLLNYSNTSKTQNSDDEASDTEDTGVTQGDLDALISGQRPVLTSVKSHEVTNNVTGKWVCAHSSESKKTNYNQFITDKLEVLAKAYSVQGDRWRALGYSKAINALKSYHKPVTSCEEAASIPGIGKKMAEKIEEIL... | 121 |
A0A9R0K247 | 2.1.1.37 | ACT_SITE 427; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MADTMAEENVSMKRSFAECPVPCPKKKRVVSKDDIDECRFTGNPVPVQQAKEQWPHRYLCKAKEANAASFKIEWNCEEILQASNHYTQALVDGIIIKLHDDVYIQGDEGKPNYIAKIVEFFEGIDKKQYLTAQWFYRADDSVIKDHANFIDKKQVFFSDVKDDNELGCIVEKVKIDINPSDVGADKPNEYLYCKMRYRLPYLTFENMVQDEQNEGTGSDTSSTISSDHSSNEAVDDDSSTAKKEFSLLDLYSGCGAMSTGLCLGATLSGIKLVNRWAVDLNEYACESIRNNHPETKVRNEMAGDFLALLMEWEKLCNEYV... | 47 |
Q5WA72 | 5.3.4.1 | ACT_SITE 97; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 436; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 439; /note="Nucleophile"; /evidence="ECO:0000250" | MRARRVVAAAAVLLLFAVVAVARLDLDDDGDDSEVLDELLAVDEEEERGELGGGGEAAAAEAVRRAQSMVLVLDNDNARRAVEENAEVLLLGYAPWCERSAQLMPRFAEAAAALRAMGSAVAFAKLDGERYPKAASAVGVKGFPTVLLFVNGTEHQFTGLHTKDAIVTWVRKKTGAPASRIQSKDSAEEFLKKDQTFAVGLFKNFEGAEYEEFVKAATSENEVQFVETNDRNVAKILFPGIASEEQFLGLVKSEPEKFEKFNGAFEEKEIIQFVELNKFPLITVFTDLNSGKVYGSPIKLQVFTFAEAYDFEDLESMIQE... | 215 |
A0A2R6WYS8 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAQFRSLLLAAILMFSGVVVDAYGPRDNGYVGLKDDYYGSSCKDAETVIKKAVQTELAKNLKHAAGVLRMHFHDCFVEGCDASVLLDGPATEKTAPVNAKLAGFEVIDAAKAAVEEICPGVVSCADILAYAARDSTVELNGTAWAVQGGRKDGTVSLASRAEAELPPPEFQVSQLIDSFARRGLSAKQMVVLSGSHTVGVSFCDKFVSRLYNFNSTFFTDPSIDPAYATELKNICPQHTFNTTIEVFMDVITPTSAGVFEANYYKTLQEHKGLFTSDQSLFDDTRTKAMVTSLLNNRRFQKEFGKAMRAMGRVGVKTKGQ... | 14 |
A0A8I3SCF8 | 3.4.19.9 | ACT_SITE 134; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MASLGRLLCVLGLLLWAAAGPGSCSPRASSSSKPIIGVLMQKCRNKELKSLGKYYIAASYVKYLESAGARVVPIRPDLTNEEYKKLFQSINGILFPGGSVDLKKSGYALAAKTFYNFAKQSFDDGDYFPVWGTCLGFEELSYLISGQCLLTLTHTDGITMPLNFTKDASQSRMFQNFPPDLLKSLSVEPLTANFHKWSLSVTNFTKNENLKEFFNVLTTNTDGKTEFISTMEGYKYPVYGVQWHPEKAPYEWGQLKGISHAPNAVKAAFYLAEFFVAEARKNSHHFESAVEENEALIYQFRPVYTGNISSFQQSYIFD | 176 |
Q58643 | 6.2.1.5 | ACT_SITE 251; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01988" | MVLRDKMILLDENTKAIVQGITGRQGSFHTKKMLECGTKIVGGVTPGKGGQNVHGVPVFDTVKEAVKETDANASVIFVPAPFAKDAVFEAIDAGIELIVVITEHIPVHDTMEFVNYAEDVGVKIIGPNTPGIASPKVGKLGIIPMEVLKEGSVGMVSRSGTLTYEIAHQIKKAGFGVSTCVGIGGDPIVGLRYKEVLDLFEKDDETEAIVMIGEIGGGAEEEAAKFIEKMKKPVIGYIAGQSAPEGKRMGHAGAIVEKGKGTAESKMKALEEAGAYVAKNISDIPKLLAGILGK | 247 |
P9WN49 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"; ACT_SITE 619; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164" | MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTVRRRAGRLANLEEAVAEMPSTALSGTTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVHNGIIENFAVLRRELETAGVEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRLEGHFTLVFANADDPGTLVAARRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQAVVITADGYRISDFDGNDGLQAGRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGL... | 81 |
Q3TIW9 | 3.1.4.12 | ACT_SITE 72; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q6UWV6" | MGHSAVLLCVALAILPACVTGAPVQRQHKLLLVSFDGFRWNYDQDVDTPNLDSMAQEGVKAQYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMFYNTTSTVRLPYHATLGIQRWWDNGSIPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTMSRKEGVLHNYKNETEWRGNVDTVMKWFLEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRHHLSDSLNLIITSDHGMTTVNKKASDLVEFHKFSNFTFQDIQFELLDYGPIGMLIPKEGMLEKVYSVLKDAHPRLHVYKKEDFPKNFHYAN... | 154 |
Q0V0C5 | 2.7.1.11 | ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MAPTQVPPPLEGKKRRIGVMTSGGDAPGMNGAVRAVVRMAIHNNCEAYAIYEGYDGLVKGGDMIKEMTWDDVRGFLSEGGTLIGTARCMEFMQRDGRRTAAKNMIIKGIDALIICGGDGSLTGADKFRAEWPELLKELVEKKELTAEQIDPFKHLNIVGLVGSIDNDLSMTDATIGCYTSLGRICEAIDSVDTTAVSHQRAFVIEVMGRHCGWLALSSGVATGADFVFTPENPPDEGWQADMCRQIKKHRDMGKRKTIVVVAEGAIDRQLNKITSQQVKDILSNEAHLDTRITTLGHVQRGGTPCAYDRMLSTLQGSEAV... | 84 |
O14047 | 2.7.11.1 | ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MEKHQYRDLQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSVHITKYYASFVDGFRLWITMEYCDGGSCLDLLKLSGTFSERVIAEVMRQVLEALVYLHGQGKMHRDIKAANILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFWMAPEVVKQTGYNYKADIWSLGITAYELATGEPPYSGIHPMKVLLLIPKHSPPSLERSKFSRAFCDFVSNCLKKNPKDRATAEYLSKHKFIKKYCPNTSVKEVVASYAKWKESELLPEATPYNSTMGNSANTIDEVVWDFGTVRR | 99 |
Q7U5E8 | 2.2.1.2 | ACT_SITE 135; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MATLLDQLSAMTVVVADTGDLEAIRKFTPRDATTNPSLILAAAQIPAYQSLIDEALRSSRKLIGDAAPVEDVVHEALDEISVIFGKEILKIVPRRVSTEVDARLSYDTDATIEKGRKLIRLYNDAGISNDRVLIKIASTWEGIKAAEVLEKEGIHCNLTLLFGFGQAVACAEAGVTLVSPFVGRILDWYKADTGRDSYPGPEDPGVISVTRIFNYYKTYGYKTEVMGASFRNLDEITELAGCDLLTISPKLLDQLRESDASLSQKLDATNPSGGEEQIHVDRERFDAMMAADRMATDKLGEGIKGFSKAIETLEHQLAHR... | 52 |
B7P0P3 | 3.1.1.4 | ACT_SITE 411; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 587; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | VSIPPADGAVSCSLLRTKDQVAAEVSFVQLRDKLPLLLECVPDLLSKDLVQEVVLLVRNNPSWTLAHLAAHLGLVDCFKNQKVAAQICQPAQDTLATPLHIAVRAQKLNSVQVLMGMDAPLNLTDHNGDTIYHAAAVTTKELIKALSVRPAPTAVINQVNNDGYTPLQLACLTDKPECVRELLKEGADVNSASSRGSNCTFFFFFSLGRDHVEQNGHNFQIEDMKHGGTPLHWAKTTQCLETMIELGCDLDAKNFQGNTALHIMVARGRLACVISLLSHGASVNAVGCDGDTPLHAAVRGDVSLIHALIVFGADVNQPNQ... | 130 |
Q6BXN1 | 2.4.1.18 | ACT_SITE 353; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q04446"; ACT_SITE 414; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q04446" | MSLSTGSTGSERSNQSLIKGALDLDPWLEPFSGQLIHRQLNLRKWYDEFKQNEGSLTNFASAYEKYGLHANWDTKEVFINEYIPNVVEVSLVGDFNNWDTNTHKLKPVNDFGLWSLTIKPTENNEFAVPHDSRYKISMVTASGERIYRLCPWLKRATPSTENNLYEGRFWNPQPTETYKFKHERPRLESKDGIKIYEAHVGISTPEPKVGSYKNFTTKVLPVIHKLGYNTIQLMAVMEHAYYASFGYQVTNFFAISSRFGTPEDLKELIDEAHRLGIRVLLDVVHSHSSKNVEDGLNMFNGTDHYLFHGGTKGSHELWDS... | 73 |
A0A8I6A5T6 | 2.7.10.1 | ACT_SITE 1198; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000617-1" | MGLLLPLLQASLLLMLLLRLPEASTNLDWQCPRIPFAASRDFSVKYVVPSFSAGGRVQATAVYEDSKNSAVFVAIRNRLHVLGPDLQYIESLTTGPIGDPGCQTCASCGPGPHGPPNDTDTLVLVMEPGLPALVSCGSTLQGRCFLHELEPQGEALHLAAPACLFSASNNKPEACTDCVASHLGTRVTVVEQGHASYFYVASSLDPELAASFSPRSVSIRRLKSDTSGFQPGFPSLSVLPKYLASYLIKYVHSFHSGDFVYFLTVQPMDVRSPPSALQTRLVRLNAIEPEIGDYRELVLDCHFAPKRRRRSGAPKSLQAY... | 97 |
P45283 | 6.3.4.4 | ACT_SITE 14; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 42; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011" | MGKSVVILGAQWGDEGKGKIVDLLTDRVKYVVRYQGGHNAGHTLIINGEKTVLRLIPSGMLHPNVTCLIGNGVVVSPEALMKEMGELESRGIKVRERLLISEACPLILPYHVAMDHAREAALGKKAIGTTGRGIGPAYEDKVARRGLRVGDLFNKEAFAEKLKNILEYYNFQLVNYYKVEPVDYQKTLDDVMAIADVITGMVADITTILDTARKNGEHILFEGAQGTMLDIDHGTYPYVTSSNTTAGGVATGSGFGPRNLDYVLGIIKAYCTRVGGGPFTTELFDDVGAEIARKGNEFGAVTGRPRRCGWFDAVAIRRAI... | 253 |
F4IVI0 | 2.7.11.1 | ACT_SITE 347; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTIGYRDAAGDPLFPWLMEIKNSMEDLYAGKNSGYDLDKLLFDCISTYKKDSRYRNDLRFLKIWFLYLEGREDFERVYREIEETEICKGHSLLYEWYAIFLEVKGLWRRANSVYQTGLSRKAEPFDRLKEAHSLFLQRISKRTKASSLEKVGDDAQATDLETGFVNPWETSTVNGLIHKIKPQLVKYDGYHVSNKVFPGKANLSSLQNYSRNKIIEIGGRKYQMKGCAGQGGFAQVFKAFIDSNPDEVVALKVQKPPFPWEFHMYRQLDCRIPDSQRSSFGLAQRVHVYSDYSILVCDYLSHGTLQDVINSYVVVGKSME... | 99 |
A8I2V3 | 1.11.1.24 | ACT_SITE 48; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MVAKIGAPAPKFKAQAVVNGEIKEISLDDYKGKYVVLFFYPLDFTFVCPTEIVAFSDRVEEFRAINTEVIGASIDSQFTHLAFSNTPRTKGGLGGCKYPLVADLTKQIAKDYGVLIEDGPDAGVTLRGLFIISPTGVLRQITINDLPVGRSVDETLRLVKAFQFTDEHGEVCPANWNPGAKTMKADPTKSLEYFSTLS | 12 |
Q03306 | 2.7.11.1 | ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTSRKRSPHDFIFKEELGHGSYSTVFKALDKKSPNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKHHAGIIKLYYTFHDEENLYFVLDFAPGGELLSLLHKMGTFNDIWTRHFTAQLIDALEFIHSHGIIHRDLKPENVLLDRDGRLMITDFGAAATIDPSLSGDSAKFNSDSNGSKDNQNCASFVGTAEYVSPELLLYNQCGYGSDIWALGCMIYQFVQGQPPFRGENELKTFEKIVALDYPWGPNNRINNSTSPINPLVINLVQKILVIEVNERISLEQIKRHPYFSKVDWNDKIKIWRGIWQSQGQSLQQTT... | 99 |
Q3V129 | 2.7.11.1 | ACT_SITE 121; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MENFVLYEEIGRGSRTVVYKGRRKGTINFVAILCTEKCKRPEITNWVRLTHEIKHKNIVTFHEWYETSNHLWLVVELCTGGSLETVIAQDENLPEDVVREFGVDLVTGLHHLHRLGILFCDLSPGKILLEGPGTLKFSNFCLAKVAGESLEEFFALVAAEEGGGDSGENALKKSMKTRVRGSLIYAAPEIVKGTEFSVTSDLWSLGCLLYEMFSGKPPFFSETVSELVEKILYEDPLPPIPKDSSFPKASSDFLNLLDGLLQKDPQKRFSWEGVLQHPFWKDALRGEDSGWASEDSPFSRNVMECSGPHDSRELLQSPKN... | 99 |
A0A8V0ZKY1 | 3.1.4.11 | ACT_SITE 347; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"; ACT_SITE 392; /evidence="ECO:0000256|PIRSR:PIRSR628391-1" | MASLLCNARECPGRGVRAGRWVESIHPPSWVPEAGGREVPSAMQPALPPGIQLTETLEKMQQGTLMRKVKSKSWKKQRYFKLQDDCMTIWYQSKRTGKTESAFSISDVETVREGHQSEVLQSLAEEFPPERCFTIVFYGRRGNLDLIAGTEEEAQCWVQGLRQLIEVATSMDQRERIDQWIRDWFQKADKNKDGRMNFKEVQRLLKMMNVDMNEDHALRLFQAADKSESGTLEGEEFVLFYKALTEREEVQSLFREFSEDGKKLTLLELVDFLRQEQLEEEGTEELAMELIDKYEPSETARARHALSADGFLMYLCSPEG... | 153 |
A0A0A0KUN8 | 3.1.1.11 | ACT_SITE 400; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNSLPFIFLLLLSLNFAGASVSPPPSTALCKSTLYPKLCRSILSTIRFSPSDPYGYGKFSVKQCIKQATKMSTVIGDYLNRGRDSRLNRPEAGALSDCRDLSDLNVEFLRSIERVLEAAEGVDEELVERVESILSAIVTNGQTCIDGLVESRSSLGNALSGPLLSAGELYSVSLGLVSNAMSRRWKKRREKGGGNGGVPGGGRSREPLDTLIKGLHKMEPCNNQSTKCLGRQRLLTDLGSTGILINNTVVVSSTGADNFTSIGDAIAFAPNNSMPQDGYFVIYVKEGYYEEYVVVPKFKTNIMLIGDGINRTIITGNHNV... | 125 |
I1NE76 | 2.7.1.21 | ACT_SITE 107; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR035805-1" | MASSSPSSLSLDTAKDLSHSFSEVHVIIGPMFAGKTTALLRRIKSELNAANNVALLKSSKDTRYAIDSVVTHDGIKFPCWALPDLLSFREKYGEDAYQKLDVIGIDEAQFFVDLYEFCCKAADEDGKTVIVAGLDGEYLRRSFGSVLHIIPLAESVTKLTARCELCGKRAFFTLRKTEQRETELIGGADVYMPVCRLHYINSQVAERSVLESENEKTDSLLEAATDV | 88 |
Q9U6D2 | 2.7.11.24 | ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MASTSVPENYYVVPIGETQMVILKRYENLRLIGSGAQGIVCAATDMVTNKPVAIKKLSRPFQNVTHAKRAYREFILMNLVNHKNIIGLLNAFSPQREVEEFNDLYIVMELMDANLCQVIQMDLDHERLSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAVEAFMMTPYVVTRYYRAPEVILGMGYGENVDVWSVGCIFGELIRGRVLFPGADHIDQWTRIIELLGTPEPQFLARLQTTVRNYVENRQKYQPVPFETLFADNMFPPGADNARLTAAKARDLLSRMLVIDPEKRISVDDALAHEY... | 104 |
B9FDE0 | 2.7.11.1 | ACT_SITE 183; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGGRVSKAVACCCCRSQHHGVVVESSEKTAEEDHGESYELPAFQEFSFEQLRLATSGFAVENIVSEHGEKAPNVVYKGKLDAQRRIAVKRFNRSAWPDPRQFLEEAKSVGQLRSKRLANLLGCCCEGDERLLVAEYMPNDTLAKHLFHWEAQAMKWPMRLRVVLYLAEALEYCTSKGRALYHDLNAYRVLFDDDCNPRLSCFGLMKNSRDGKSYSTNLAFTPPEYMRTGRITPESVIYSFGTLLLDVLSGKHIPPSHALDLIRDRNFNMLTDSCLEGQFSNEEGTELVRLASRCLHYEPRERPNVRSLVQALAPLQKDLE... | 99 |
A0A1Y1IGG1 | 3.4.19.9 | ACT_SITE 155; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 270; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 270; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MASLPCLVVLLLSLLVQLGTSAALDLAQAPAAAPENYFRPPHPLTQTPIVGMLTLPVTVPHQLKYGSASFAASYVRWIEAGGARVAPIHYDSSPEELYALLGSVNGVVWTGGLVDFNPTVDDPEGGKYLATTQAILEYVLARNEAGTYYPFWATCLGFERLTQLLARDVNSTIIDTVDAENLDINLNLTPAGWLSRMLGGMSYELFKEVASPLGHLAFNNHGLGITPAKFRGSSAYEYLKILSIDKDRNGKEFVSTVEGRSLPIYGTQWHPEKAAWEWDTRLRLSHVEHAVEFSSYLGSYFANECKFNNHTFASPEAEAR... | 176 |
Q9NB31 | 2.7.11.1 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MPPSTDSSRRNSEEGSSDGFKLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFIKNAPGCDIMQLMIQDAQEKAILGQAPMAASSGND... | 99 |
A0A1U8JCB0 | 2.7.1.11 | ACT_SITE 248; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MANLSQPEATNLAAGQNPPPEQQLQDRLDDHAFSFSPITLKKLPHLSDYLQDLRPAGPNPLDHNPFFHPSDGFYVNTSDIVLRQVACRLSPSGTIASPSHHLAYIRAGPRKQIFFDHCATRAAIVTCGGLCPGMNTVIRELVVGLWDLYGVRQIYGIKAGYRGFYSIHPIELNPKMVHNWHRRGGTVLETSRGGFDLTKIVDAIENHGFNQVYIIGGDGTMRGAVKIFEEVRRRKLKVGVTGIPKTVDNDVGIIDRSFGFQTAVEMAEQAIHAAHVEAESAVNGIGLVKLMGRSTGHIALHATLSSRDVDCCLIPETEFY... | 84 |
A0A060X7Z0 | 2.7.1.11 | ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MSHTSMDPTKMGIGRSIAVLTSGGDAQGMNAAVRATVRVGIYTGAKVYFVHEGYQGLVDGGDNIKLATWESVSMMLQLGGTVIGSARCMDFRAREGRMKAALNLVKLGITNLCVIGGDGSLTGANQFRKEWATLLVDLVKAGKITDDEARKSCHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAITTTAQSHQRTFILEVMGRHCGYLALVTALACGADWVFIPEMPPDDGWEGHLCRRLADQRARGSRLNVIIVAEGAMDRAGNPISSEDIKKASSTSYYFKVLRFYCIVMLVEKNLGFDTRTTVLGHVQRGG... | 84 |
Q9W462 | 3.4.19.12 | ACT_SITE 48; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 506; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10093" | MESEKILMAAGVTVAAVVGAFVFWGPSGSRLRQRRGQIAGLHNFGLTCFLNTLLQAMAACPQFIAWLQLYNNASPDRKSLITSMLNTLEVVNGTHATLRGDPYSPGAVLRALNALGWVIPQEEHDAHELFHVLLTCLEEEAIRPQPLGCLSDALPTDNDDNSSLAGTATPVGGFRSFSSMAAGLGASQRIGDQPNRPSSAMLTDFLNMEYDESTSLQRLVRSEAHTPDSPASVCERDGNDRLGSVLLDAVSPGTPFGFPLVSNPDSLATPMLGGERSSRPRLPQSQQQQDEGLNRRVSSSCRSLERLHRGPGRVSIWSNM... | 175 |
Q9LFS4 | 2.7.11.1 | ACT_SITE 435; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MESTIVMMMMITRSFFCFLGFLCLLCSSVHGLLSPKGVNFEVQALMDIKASLHDPHGVLDNWDRDAVDPCSWTMVTCSSENFVIGLGTPSQNLSGTLSPSITNLTNLRIVLLQNNNIKGKIPAEIGRLTRLETLDLSDNFFHGEIPFSVGYLQSLQYLRLNNNSLSGVFPLSLSNMTQLAFLDLSYNNLSGPVPRFAAKTFSIVGNPLICPTGTEPDCNGTTLIPMSMNLNQTGVPLYAGGSRNHKMAIAVGSSVGTVSLIFIAVGLFLWWRQRHNQNTFFDVKDGNHHEEVSLGNLRRFGFRELQIATNNFSSKNLLGK... | 99 |
A0A0Q3PR06 | 1.11.1.7 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MANASRRPATATMALLLLLVLLELAAMTGLSQGQLQVGFYSESCPDAEDIVSSAVQDAAASDPTLLPALVRLQFHDCFVRGCDGSVLIAGAEVKNSKHQGLRGLDVVDAAKALLEEQCPGVVSCADVLALAARDAIGMTNGPSFDVPTGRRDGLASNVRDADVLPDASDNIQTLRSKFATAGLDDRDLVLLTAAHTIGTTACFFVKDRLYGASGSDPGIPAGYLAELKARCAPGDFNTRVPLDRGSEARFDGSILRNIQAGLVPIASDAALVADNATAALVGAYIGSPRFRRDFVGAMVKMGTIGVITGGNGEIRDVCSA... | 14 |
G5EFD2 | 2.7.11.1 | ACT_SITE 600; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MMQTQVASRAGYSNLPQFGAGIAQDIKTQAINNLKECLKLTTINRFLTSSYEEDAKSVERKIFSAVYQMTKIGLIDREKREINAIWFTFVGLSAQNIRHLEICSITDFNALFSITNQELRSLADRGRLDVETKRKLLQSTVILQNHWNAYHSRTSSGSTDEPSGQSTPAIVTPSPKFNVPSLSVTSAKMIQSSSMGFATTPKSPKTSSRLVHAIPHKWHRSTKFRFSGDAVCHFCQRPLGFGFLNAWEKCRSCKWKVHTQCKGRVGDSCGLTPDHLRFLFDKLIQENNGGMWKDPQSVPGSRSMNEPAFQFPDTAIDSSS... | 99 |
Q7NJ09 | 3.4.21.89 | ACT_SITE 57; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 102; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MVEHPNSTEPSRPSVAHGFWRWFSSQRENLQTIVLAVFLALFIRSFVAEARYIPSGSMEPTLRIDDRLIVEKLSYEFQQPERGQVIVFTPPKRTNIDQAFIKRVIGLPGDTIEVKNGKVLLNGRTLNEPYIATPPAYILPRQKVPAGHFFVMGDNRNNSFDSHLWGFLPRQNVIGRAVFRFWPLERVGAIE | 178 |
P0A744 | 1.8.4.11 | ACT_SITE 52; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000269|PubMed:10964927" | MSLFDKKHLVSPADALPGRNTPMPVATLHAVNGHSMTNVPDGMEIAIFAMGCFWGVERLFWQLPGVYSTAAGYTGGYTPNPTYREVCSGDTGHAEAVRIVYDPSVISYEQLLQVFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAAMLAADDDRHITTEIANATPFYYAEDDHQQYLHKNPYGYCGIGGIGVCLPPEA | 39 |
P21696 | 1.1.1.8 | ACT_SITE 232; /note="Proton acceptor"; /evidence="ECO:0000250" | MSGYGQQGVSAANIDSIRPKKRLSIGVVGSGNWGTAIAKICGENARAHGHHFRSKVRMWVFEEEIEYKGEKRKLTEVFNEAHENVKYLPGIECPPNVIAVPDVREVARRADILVFVVPHQFIERVCDQMVGLIRPGAVGISCIKGVAVSKEGVRLYSEVISEKLGIYCGVLSGANVANEVAREQFCETTIGFNPPNEVDIPREQIAAVFDRPYFSVVSVDDVAGVALGGALKNVVAMAVGFADGLEWGGNTKAAIMRRGLLEMQKFATTFFDSDPRTMVEQSCGIADLVTSCLGGRNNRCAEAFVKTGKSLETLEKELLG... | 7 |
A2F9H1 | 2.3.1.286 | ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MSEDRKLKSFDMDGVVDYIKSGKAKKIIFLTGAGISTAAGIPDFRSIGTGFYSNLQKYNLPEPSDVFNIKYFKENQEPFYDLCPSLLPGKYKPTFIHYFGAYMAKKGILLKQYTQNIDGLERIAGVPEDKLVESHGTFSTAHCTECKKEWKLEEIRDKLLLGKPLHCTDPDCKGFIKPDIVFFGENLPTSFQHNARIDLRSCDMLLISGTSLKVNPFASLPGTAPEDVPRVLINLDKVAQYTEEEMDMGGEIVKVTPPNFRSLLRYDHPSNTRDVYLGGDCQETFKELARRLGWYDDIIAMMPK | 58 |
O74201 | 2.3.2.23 | ACT_SITE 88; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MSTPARRRLMRDFKRMQQDPPSGVSASPLPDNVMKWNAVIIGPSDTPFEDGTFRLLLSFDEQYPNKPPQVKFISEMFHPNVYASGELCLDILQNRWSPTYDVSSILTSVQSLLNDPNISSPANVEAANLYKDHRSLYVKRVRETVENSWNDDDDEEEEEEDEDEAEDEDDDDDDNIDED | 64 |
A0A2I4FD37 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAPIVALFPSLVLMMVFSSFSQRADSLSLNYYEKTCPNAESIVTNAVKSAVSKDKTVPAALLRLHFHDCFIRGCDASVLLYSKGSNKAEKDGPPNVSLHALYVIDSAKKELEAWCPGVVSCADILALAARDAVSLSGGPSWEVPKGRKDGRTSKASETTQLPAPTFNISQLQQSFSQRGLSMDDLVALSGGHTLGFSHCSSFQNRIHNFNSTHEIDPSMHPSFAANLKSVCPKNNKAKNAGTAMDPSSTTFDNTYFKLILQGKGLFSSDQALLDFPKTKDLVSKFASSREAFTKAFVNSMIKMSSITGGQEIRKDCRVVN | 14 |
A0A1U8B161 | 3.1.1.11 | ACT_SITE 406; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MATQFFSISYFISLYVVLLLSFSHLSLAIVPPSANVSQDAACRSTPYPYFCKSVLPRNENRNITDYGRFSVRRSLSAARKFLGLVDRYLRNRSNLSQAAIRVLEDCRLLAGLNIDFLFSSFKTLNSTKILPSLEAEDVQTLLSAILTNQQTCSDEIQVTESAWRVRNGMSLPLSNDTKLYSVSLALFTRGWVYKHKGKRRKPKPGRKLIFSDMEVVRHGHLPLRMSRRNREIYEYVGRRKLLQNSMESVLVRDIVVVSQDGNGNFTTINDAVAAAPNNTKIDDGYFLIYIVGGVYEEYVSIAKNKKNLMMIGDGINQTIL... | 125 |
P0CD62 | 2.7.11.1 | ACT_SITE 825; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDSRCGVCKYIISDCERYVSDNTFYHVKCFICKICKCELPPCFRGKHASLMCGDCEIKLNAPKCFKSHFPIHSVSVVARNKEFHNNCFTCISCNEIIKGGFQYSDELFYCSKCDIIKPPPLPPPLIYKAPIATSKATTSITSPLPTKIPILSTANLIPPLSSSSPLATQISPKTSTIATTTVETTTAETTLPSPFKISQLKNSGDNIYSLSSPSSSSSSSSSSSSSSSSPPNTFNKSSDFLRNPLNNNVKSSSSSIGGNFVNKSQQQQQPIDSCSKSSISISPSSPRPTEDDIKEQVFLLQKQSVQLQIQQQLQQRQIEQ... | 99 |
B8BVD6 | 3.4.21.92 | ACT_SITE 96; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 121; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | LVPVVLESGTTGERAFDIYSRLLRERIICVHGEVTDSMASLVTAQLLFLEAEAPEKPVYMYINSPGGLVTAGMAMYDTMQYIHPEVHTICMGQAASMGSLLLAGGSAGCRFALPNARIMLHQPSGGAQGMASDIDIQAREILRTRANLNQLYVHHTGRELEEIERVMDRDTFMDVRQAVDFGVIDEVLTKR | 179 |
M1AM70 | 2.4.1.18 | ACT_SITE 429; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 484; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MEINFNVLSKPIRGSFPSFSPKVSSGASRNKICFPSQHSTGLKFGSQERSWDISSTPKSRVRKDERMKHSSAISAVLTDDNSTMAPLEEDVKTENIGLLNLDPTLEPYLDHFRHRMKRYVDQKMLIEKYEGPLEEFAQGYLKFGFNREDGCIVYREWAPAAQEAEVIGDFNGWNGSNHMMEKDQFGVWSIRIPDVDSKPVIPHNSRVKFRFKHGNGVWVDRIPAWIKYATADATKFAAPYDGVYWDPPPSERYHFKYPRPPKPRAPRIYEAHVGMSSSEPRVNSYREFADDVLPRIKANNYNTVQLMAIMEHSYYGSFGY... | 73 |
A7SAZ2 | 2.7.11.1 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 512; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | ANLTEAQDEKVGIENFELLRVLGTGAYGKVFLARKRGGHHDGRLFAMKVLKKATIVQKAKTAEHTRTERQVLEAVRRCPFLVTLHWAFQTEAKLHLIMDYVNGGELFTHLYQREKFTEDEVRLYIGEIVVALDHLHQLGIIYRDIKLENILLDKDGHVVLTDFGLSKEFAAPNSGERAYSFCGTIEYMAPEVVKGGSRGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQSEISKRILHNNPPMPHDLSAEAIDLLHKLLQKDPKKRLGAKGAHELKAHPFFKAFDWADLAEKRIPAPFKPRIRDELDVSNFSEEFTD... | 99 |
F7A0P0 | 2.7.11.1 | ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | EKASTSGRATASSAKDNASDTWSLKNFDIGKPLGRGKFGSVYLAREKKSKFIVALKVLFKSQLMKSNVEHQLRREIEIQSHLRHPHILRLYGYFHDETRVYLILEYASRGEMYKELQKQGKFTEEMSATYIAELADALNYCHSKQVIHRDIKPENLLMGLRGELKIADFGWSVHAPSSKRQTLCGTLDYLPPEMIEAKDHDANVDLWTLGILCYEFLVGKPPFETKSTQETYLRITSLKYSFPPHVSEGARDLIRRLLKLEPRHRLPLESVMAHPWIKANAKPARRYASYKNAS | 99 |
A0A803SY32 | 3.1.4.11 | ACT_SITE 356; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"; ACT_SITE 401; /evidence="ECO:0000256|PIRSR:PIRSR628391-1" | MICGKWKKSRSESHRRGRHRHHQQQPPPPQTEPPVPAQTYGGVAAAAAKLSGHRAFKKLGLTDDDDIKVMLRGSFFWKVKTHRPRKQRLYRLQEDGMTIWFETRFKKAYSQHVFSILHIESVREGYQSEGLRKYGGCFPEDQCFTIVFRGKRKNLDLAAISVNEAQQWVRGLKKLMARGEAMSQREKLEHWIHDMLHQADKNKDNKMSFKEIKNMLRMINIDMNDIYAYRLFKECDRSNNDRLEEYEIEEFCTRLMERPELKEIFHRYSGEDCVLSAEELREFLHDQGEEATIKRATDIIQTYELNERARQHNLMMLDGF... | 153 |
Q9I165 | 3.2.1.28 | ACT_SITE 320; /note="Proton donor/acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01060"; ACT_SITE 503; /note="Proton donor/acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01060" | MPDRTALPRAMLAAWVLLLLAACSQGPAPTPPASWGWQDASGERAIAPDEAYPELFQAVQENRLFSDQKHFVDALPLREPARIRADYLRERERPGFDLRAFVGRNFEESGSVETAPPEAGADLASHISDLWPALTRHYEQVPAHSSLLPLPKPYVVPGGRFREVYYWDSYFTMLGLAESGQHQRVRDMLDNFAYLIDTYGHIPNGNRSYYLSRSQPPFFAYMVDLQARREGDAAYRRYLPQLQKEYAYWMEGSAGLRPNEARLHVVKLADGSLLNRYWDNRDTPRQESFLEDRATAARAPQRPAGEVYRDLRAGAESGWD... | 165 |
A0A7M7NGF1 | 2.3.2.26 | ACT_SITE 874; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MRMNPSREIDNASREEAVETEVEGSITDGGSASSDEMKRSQARGLIERYFYQLTNGCGNAGCCNEFCASSGRQTHLSSNEAAAMALDLFKRKATLCESAPNKQLKTGDVEDQSDGTTPMDVSPAAQPSTSFARNTPSTSSSDGDKQTLLPKPLDTQRSSSESDSIKDIYFLTEAKILEILKQCMESKNFSPLVRVIGRVFSCWQSLNKSFLRTVKQGLSDKERKQRDDKETDEMDEGLQSISTRLADHDLGECSSKATDTLEVDMESVQRVYEAITKLDEERVNNAMLNAVTSLAQMADVEVIVNPLFQDGSNQLNFIII... | 65 |
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