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Sort these into breakfast or dinner foods: Waffles, pancakes, turkey, chicken noodle soup, salad, bacon and eggs, egg drop soup | The breakfast foods are waffles, pancakes and bacon and eggs. The dinner foods are turkey, chicken noodle soup, salad, and egg drop soup | |
Do salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation? | Compared with other non-steroid anti-inflammatory drugs (NSAIDs), aspirin is not correlated to hypertension. It has been shown that aspirin has unique vasodilator action in vivo, offering an explanation for the unique blood pressure effect of aspirin. In the present study, we investigate the mechanism whereby salicylates (aspirin and sodium salicylate) dilate blood vessels. | Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation and thus lower blood pressure. |
Do perioperative factors determine outcome after surgery for severe acute pancreatitis? | There is evidence that postponing surgery in critically ill patients with severe acute pancreatitis (SAP) leads to improved survival, but previous reports included patients with both sterile and infected pancreatic necrosis who were operated on for various indications and with different degrees of organ dysfunction at the moment of surgery, which might be an important bias. The objective of this study is to analyze the impact of timing of surgery and perioperative factors (severity of organ dysfunction and microbiological status of the necrosis) on mortality in intensive care unit (ICU) patients undergoing surgery for SAP. | In this cohort of critically ill patients operated on for SAP, there was a trend toward higher mortality in patients operated on early in the course of the disease, but in multivariate analysis, only greater age, severity of organ dysfunction at the moment of surgery, and the presence of sterile necrosis, but not the timing of the surgical intervention, were independently associated with an increased risk for mortality. |
Is rs219780 SNP of Claudin 14 Gene Related to Clinical Expression in Primary Hyperparathyroidism? | The CLDN14 gene encodes a protein involved in the regulation of paracellular permeability or ion transport at epithelial tight junctions as in the nephron. The C allele of the rs219780 SNP (single nucleotide polymorphism) of CLDN14 has been associated with renal lithiasis, high levels of parathormone (PTH), and with low bone mineral density (BMD) in healthy women. Our aim is to study the relationship between rs219780 SNP of CLDN14 and renal lithiasis, fractures, and BMD in patients with primary hyperparathyroidism (PHPT). | rs219780 SNP of CLDN14 does not appear to be a risk factor for the development of PHPT nor does it seem to influence the clinical expression of PHPT. |
Which NFL team has the most Super Bowl championship wins? | The Pittsburgh Steelers and the New England Patriots are tied for the most Super Bowl championship wins. Both teams have won 6 Super Bowl championships. The Steelers were the first team to achieve this in 2008, while the Patriots earned their sixth championship win in 2018. | |
What happens to the insider trade profits? | You seem to have a little confusion over terminology that should be cleared up: You are calling this "day-trading" Day-trading is the term for performing multiple trading actions in a single day. While it appears that the COO has performed a buy and a sell on the same day, most people would consider this a 'single trade'. In reality, it seems that the COO had 'stock options' [a contract providing the option for the holder to buy stock at a specific price, at some point in the future], provided as part of his compensation package. He decided or was required to 'exercise' those options today. This means he bought the shares using his special 'option price'. It is extremely common for employees who exercise stock options, to sell all of the resulting stock immediately. This is very different from usual day-trading, which implies that he would have bought stock in the morning at a low price, and then sold it later at a high price. You are calling this 'insider trading'. That term specifically often implies some level of unethical behavior. In general, stock options offered to executive employees are strictly limited in how they can be exercised. For example, most stock option plans require employees to wait x number of years before they can exercise them. This gives the employee incentive to stay longer, and for a high-level executive with the ability to strongly impact company performance, it gives incentive to do well. Technically you are correct, this is likely considered an 'insider trade', but given that it seems to have been a stock option exercise, it does not necessarily imply that there was any special reasoning for why he did the trade today. It could simply be that today was the first day the stock option rules allowed him to exercise. As to your final question - no, these profits are the COO's, to do with as he likes. | |
Where can I get a list of all Stocks that were acquired or went bankrupt | Where can I download all stock symbols of all companies "currently listed" and "delisted" as of today? That's incredibly similar . You can also do it with a Bloomberg terminal but there's no need to pay to do this because he data changes so slowly. | |
How is initial stock price (IPO) of a stock determined | Who determines company value at IPO? The Owners based on the advice from Lead Bankers and other Independent auditors who would determine the value of the company at the time of listing. At times instead of determining a fixed price a range is given [lower side and higher side]. The Market participants [FI / Institutional Investor Segments] then decide the price by bidding at an amount. There are multiple aspects in play that help stabalize the IPO and roles of various parties. A quick read of question with IPO tag is recommended Edits: Generally at a very broad level, one of the key purpose of the IPO is to either encash Owner equity [Owner wants some profits immediately] or Raise additional Capital. More often it is a mix of both. If the price is too low, one loose out on getting the true value, this would go to someone else. If the price is too high, then it may not attract enough buyers or even there are buyers, there is substantial -ve sentiment. This is not good for the company. Read the question From Facebook's perspective, was the fall in price after IPO actually an indication that it went well? This puts determining the price of IPO more in the realm of art than science. There are various mechanism [Lead bankers, Institutional Investors, Underwriters] the a company would put in place to ensure the IPO is success and that itself would moderate the price to realistic level. More often the price is kept slightly lower to create a positive buzz about the stock. | |
Pay off entire mortgage or put into investments | At the area where I live (Finland), banks typically charge a lot more for additional mortgage credit taken after purchasing the house. So, if you are planning to purchase a house, and pay it with a mortgage, you get a very good rate, but if you pay back the mortgage and then realize you need additional credit, you get a much worse rate. So, if this is applicable to your area as well, I would simply buy stocks after you have paid enough of the mortgage that it is only 50% of the house price or so. This is especially good advice if you are young. Also, if your mortgage is a fixed rate and not an adjustable rate mortgage, you probably have a very low permanent interest rate on it as interest rates are low currently (adjustable rate mortgages will also have a low rate but it will surely go up). Some people say there's a bubble currently in the stock market, but actually the bubble is in the bond market. Stocks are expensive because the other alternatives (bonds) are expensive as well. Paying back your mortgage is equivalent to investing money in bonds. I don't invest in bonds at the current ridiculously low interest rates; I merely invest in stocks and have a small cash reserve that will become even smaller as I discover new investment opportunities. I could pay back a significant percentage (about 50%) of the loans I have by selling my stocks and using my cash reserves. I don't do that; I invest in stocks instead, and am planning to increase my exposure to the stock market at a healthy pace. Also, consider the fact that mortgage is cheap credit. If you need additional credit for consumption due to e.g. becoming suddenly unemployed, you will get it only at very expensive rates, if at all. If you're very near the retirement age (I'm not), this advice may not be applicable to you. Edit: and oh, if your mortgage is fixed rate, and interest rates have come down, the bank will require you to pay the opportunity cost of the unpaid interests. So, you may need to pay more than you owe the bank. Edit2: let's assume the bank offered you a 4% fixed rate for a 10-year loan, which you agreed to. Now let's also assume interest rates of new agreements have come down to 2%. It would be a loss to the bank to pay back the amount of the loan (because the bank cannot get 4% by offering somebody else a new loan, only 2%), unless you paid also 10 years * (4% - 2%) * amount = 20% * amount of lost interest income. At least where I live, in fixed rate loans, one needs to pay back the bank this opportunity cost of unpaid interests. | |
Inherited Stock | Since you reference SS, I surmise you are in the US. Stock you inherit gets a stepped up basis when it's inherited. (so long as it was not contained within a tax deffered retirement account.) When you sell, the new basis is taken from that day you inherited it. It should be minimal compared to your desire to diversify. | |
Are β-catenin and Kras/Foxm1 signaling pathway critical to restrict Sox9 in basal cells during pulmonary branching morphogenesis? | Lung morphogenesis is regulated by interactions between the canonical Wnt/β-catenin and Kras/ERK/Foxm1 signaling pathways that establish proximal-peripheral patterning of lung tubules. How these interactions influence the development of respiratory epithelial progenitors to acquire airway as compared to alveolar epithelial cell fate is unknown. During branching morphogenesis, SOX9 transcription factor is normally restricted from conducting airway epithelial cells and is highly expressed in peripheral, acinar progenitor cells that serve as precursors of alveolar type 2 (AT2) and AT1 cells as the lung matures. | Interactions between the Wnt/β-catenin and the Kras/ERK/Foxm1 pathways are essential to restrict SOX9 expression in basal cells. Developmental Dynamics 245:590-604, 2016. © 2016 Wiley Periodicals, Inc. |
Given a reference text about the Kaziranga Elephant Festival, tell me who organizes it. | The Kaziranga Elephant Festival is a yearly elephant festival held in the Kaziranga National Park of Assam for the conservation and protection of Asiatic elephant. The festival is jointly organised by the Forest Department and Tourism Department of Assam with an objective to highlight and find ways to resolve the increasing man-elephant conflict. Hundreds of domestic Asiatic elephants, decorated from head to toe, participate in the program. They take part in parade, races, football and dance earning praises from the spectators. | The Kaziranga Elephant Festival is organized by the Forest and Tourism Departments of Assam. |
Is the stock market too risky for long term retirement funds? Why should a 20- or 30-something person invest in stocks? | I'm going to go the contrarian route and suggest you stay completely out of the stock market for the foreseeable future. We're entering a period of time this country and world has never seen before. Our country is broke / insolvent. We are printing money to buy our own debt. This is beyond stupid. It will destroy us, just like it did Germany in the 1920's. Many states are on the verge of bankruptcy. The only thing stopping them is a constitutional issue. California, Illinois, Michigan, New York etc. are all broke. They are billions in debt and massive underfunding of pensions. More than a half-dozen European countries are on the verge of financial implosion. The Euro is just as bad off as our dollar. There are extremely powerful forces at work bent on destroying this country and the US dollar, to usher in a One World Government and financial system. IMO, buy as much gold and silver has you can. Not necessarily as an investment vehicle. I would do it as a survival vehicle. And, I don't mean gold/silver stocks. I mean you buy gold/silver and you take physical possession. | |
Capitalize on a falling INR | By no means is this a comprehensive list, but a few items to consider: | |
With what opera company is the late soprano and master voice teacher Ellen Faull Gordon most associated? | New York City Opera, the company dubbed "The people opera" by Fiorello La Guardia. | |
What is the difference between it's and its? | "It's" is a contraction for "it is". Whereas "its" is the possessive pronoun for it | |
Tell me which of the following are the names of mathematicians: David Hilbert, Augustin-Louis Cauchy, William Shakespeare. | David Hilbert and Augstin-Louis Cauchy are both mathematicians. William Shakespeare is not a mathematician, but is a writer. | |
Where can I find historical P/E ratios for companies? | The mathematics site, WolframAlpha, provides such data. Here is a link to historic p/e data for Apple. You can chart other companies simply by typing "p/e code" into the search box. For example, "p/e XOM" will give you historic p/e data for Exxon. A drop-down list box allows you to select a reporting period : 2 years, 5 years, 10 years, all data. Below the chart you can read the minimum, maximum, and average p/e for the reporting period in addition to the dates on which the minimum and maximum were applicable. | |
Does hepatocyte growth factor stimulate proliferation and migration during wound healing of retinal pigment epithelial cells in vitro? | A defect in retinal pigment epithelial (RPE) cells may cause dysfunction of the neural retina, so rapid recovery of differentiated RPE cells is required after RPE injury. We investigated the effect of hepatocyte growth factor (HGF) on wound healing in RPE cells. | HGF stimulated wound closure in cultured RPE cells, and rendered restituted cells epithelioid in shape. HGF may become a therapeutic candidate for RPE wound healing. |
Does aeromonas piscicola AH-3 express an extracellular collagenase with cytotoxic properties? | The aim of this study was to investigate the presence and the phenotypic expression of a gene coding for a putative collagenase. This gene (AHA_0517) was identified in Aeromonas hydrophila ATCC 7966 genome and named colAh. We constructed and characterized an Aeromonas piscicola AH-3::colAh knockout mutant. Collagenolytic activity of the wild-type and mutant strains was determined, demonstrating that colAh encodes for a collagenase. ColAh-collagen interaction was assayed by Far-Western blot, and cytopathic effects were investigated in Vero cells. We demonstrated that ColAh is a gluzincin metallopeptidase (approx. 100 kDa), able to cleave and physically interact with collagen, that contributes for Aeromonas collagenolytic activity and cytotoxicity. ColAh possess the consensus HEXXH sequence and a glutamic acid as the third zinc binding positioned downstream the HEXXH motif, but has low sequence similarity and distinct domain architecture to the well-known clostridial collagenases. In addition, these results highlight the importance of exploring new microbial collagenases that may have significant relevance for the health and biotechnological industries. | Collagenases play a central role in processes where collagen digestion is needed, for example host invasion by pathogenic micro-organisms. We identified a new collagenase from Aeromonas using an integrated in silico/in vitro strategy. This enzyme is able to bind and cleave collagen, contributes for AH-3 cytotoxicity and shares low similarity with known bacterial collagenases. This is the first report of an enzyme belonging to the gluzincin subfamily of the M9 family of peptidases in Aeromonas. This study increases the current knowledge on collagenolytic enzymes bringing new perspectives for biotechnology/medical purposes. |
What do you think to keep you alive | Travel and Food | |
Is induction of matrix metalloproteinase 1 gene expression regulated by inflammation-responsive transcription factor SAF-1 in osteoarthritis? | To identify specific transcription factors that are activated in the cartilage tissue of osteoarthritis (OA) patients and are involved in the expression of matrix metalloproteinase 1 (MMP-1). | The results indicate that SAF-1 is involved in the regulation of MMP1 gene expression and it is highly abundant in the articular cartilage chondrocytes of OA patients. The data also demonstrate that control of SAF-1 activity can suppress induced expression of MMP-1. Conceivably, SAF-1 could be a potential therapeutic target to control the overexpression of MMP-1 associated with the pathogenesis of OA. |
Does the small-molecule inhibitor BI 2536 reveal novel insights into mitotic roles of polo-like kinase 1? | The mitotic kinases, Cdk1, Aurora A/B, and Polo-like kinase 1 (Plk1) have been characterized extensively to further understanding of mitotic mechanisms and as potential targets for cancer therapy. Cdk1 and Aurora kinase studies have been facilitated by small-molecule inhibitors, but few if any potent Plk1 inhibitors have been identified. | Our results suggest that Plk1's accumulation at centrosomes and kinetochores depends on its own activity and that this activity is required for maintaining centrosome and kinetochore function. Our data also show that Plk1 is not required for prophase entry, but delays transition to prometaphase, and that Emi1 destruction in prometaphase is not essential for APC/C-mediated cyclin A degradation. |
Do cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats? | Both in experimental colitis and in inflammatory bowel disease, colonic eicosanoid generation is enhanced and may contribute to the pathogenesis of the inflammatory response. | The effective nimesulide and SC-236-induced amelioration of the severity of the colitis in acetic acid and iodoacetamide-treated rats confirms the role of eicosanoids in their pathogenesis and suggests that COX-2 inhibitors may be of value in the treatment of inflammatory bowel disease. |
Does speB of Streptococcus pyogenes differentially modulate antibacterial and receptor activating properties of human chemokines? | CXC chemokines are induced by inflammatory stimuli in epithelial cells and some, like MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11, are antibacterial for Streptococcus pyogenes. | SpeB destroys most of the signaling and antibacterial properties of chemokines expressed by an inflamed epithelium. The exception is CXCL9 that preserves its antibacterial activity after hydrolysis, emphasizing its role as a major antimicrobial on inflamed epithelium. |
Ms. Murmu becomes 2nd woman to hold the post after | Ms.Pratibha Patil | |
Preferred vs Common Shares in Private Corporation | Preferred dividends and common dividends are completely separate transactions. There's not a single "dividend" payment that is split between preferred and common shares. Dividends on preferred shares are generally MUCH higher than common dividends, and are generally required by the terms of the preferred shares, again unlike common dividends, which are discretionary. | |
Does vitamin E regulate changes in tissue antioxidants induced by fish oil and acute exercise? | Prooxidant effects of fish oil supplementation could unfavorably affect the cardiovascular benefits of fish oil. We tested the effects of 8 wk vitamin E cosupplementation with fish oil on antioxidant defenses at rest and in response to exhaustive exercise in rats. | Vitamin E supplementation markedly decreased fish oil induced antioxidant enzyme activities in all tissues. Sparing of glutathione may be an important mechanism by which vitamin E decreased tissue protein oxidative damage. |
Does body size affect measures of ovarian reserve in late reproductive age women? | To examine the association between obesity and serum and ultrasound measures of ovarian reserve in late reproductive age women. | Although antral follicle count did not differ by body size, antimullerian hormone was lower in obese compared with normal weight late reproductive age women. These data suggest that lower antimullerian hormone levels in obese late reproductive age women result from physiologic processes other than decreased ovarian reserve. |
Is anticholinergic burden associated with recurrent and injurious falls in older individuals? | While the anticholinergic activity of medications has been linked to cognitive decline, few studies have linked anticholinergic burden with falls in older people. We evaluated the relationship between anticholinergic burden and recurrent and injurious falls among community-dwelling older adults. | The association between recurrent and injurious falls and the use of any medications listed in the ACB scale was mediated through gait and balance impairment but not by muscular weakness, providing a novel insight into the potential mechanistic link between ACB and falls. Future studies should determine whether TUG and FR measurements could help inform risk to benefit decisions where ACB medications are being considered. |
I spend too much money. How can I get on the path to a frugal lifestyle? | Gail Vaz-Oxlade from the television show Til Debt Do Us Part has a great interactive budget worksheet that helps you set up a "jar" or envelope system for each month based on your income and fixed expenses. We have used this successfully in the past. What we found most useful was, as others have said, writing everything down, keeping receipts, and thus being accountable and aware of our spending. | |
Buying USA Stocks from Sri Lanka | I'm not aware of any method to own US stocks, but you can trade them as contract for difference, or CFDs as they are commonly known. Since you're hoping to invest around $1000 this might be a better option since you can use leverage. | |
Why do people like to run very long distances like marathons? | As with all endurance sports, long distance running can pose an enjoyable challenge for some people. Some athletes are known to like running for its health benefits, its feeling of calm or meditative relaxation, or companionship with other runners. Whether running for fun or in a competitive race event, the feeling of accomplishment that comes from tackling a long distance by foot brings joy to many people. It may not be the best activity for all people though, and some may find activities such as bike riding or water-sports a more enjoyable way to achieve the same feeling. | |
What is fleece? | Fleece is light, warm, quick-drying synthetic material often used for winter clothing. It does not do well as protection from the wind so is often used as an inner layer underneath a wind block like a gortex shell. | |
Got a "personal" bonus from my boss. Do I have to pay taxes and if so, how do I go about that? | I actually think your boss is creating a problem for you. Of course it's taxable. The things IRS will look at (and they very well might, as it does stand out) what kind of payment is that. Why did it not go through payroll? The company may be at risk here for avoiding FICA/FUTA/workers' compensation insurance/State payroll taxes. Some are mandatory, and cannot be left to the employee to pay. On your side it raises your taxable income without the appropriate withholding, you may end up paying underpayment penalties for that (that is why you've been suggested to keep proofs of when you were paid). Also, it's employment income. If it is not wages - you're liable for self-employment taxes (basically the portion of FICA that the employer didn't pay, and your own FICA withholding). When you deposit the check is of no matter to the IRS, its when you got it that determines when you should declare the income. You don't have a choice there. I suggest asking the company payroll why it didn't go through them, as it may be a problem for you later on. | |
Does loss of Parp-1 affect gene expression profile in a genome-wide manner in ES cells and liver cells? | Many lines of evidence suggest that poly(ADP-ribose) polymerase-1 (Parp-1) is involved in transcriptional regulation of various genes as a coactivator or a corepressor by modulating chromatin structure. However, the impact of Parp-1-deficiency on the regulation of genome-wide gene expression has not been fully studied yet. | These results suggest that Parp-1 is required to maintain transcriptional regulation of a wide variety of genes on a genome-wide scale. The gene expression profiles in Parp-1-deficient cells may be useful to delineate the functional role of Parp-1 in epigenetic regulation of the genomes involved in various biological phenomena. |
Will the ex-homeowner still owe money after a foreclosure? | It is in the bank's interest to sell the property for as much as they can (although it is doubtful they will put as much effort/time into selling it as the owner might). They will certainly not sell it for $1. The main reason for this is that the bank would prefer to own $100k, than a loan to them from a customer for $100k. Banks have to discount the value of loans to take into account the likelihood of the loan not being repaid. They classify certain loans as riskier than others, and these are discounted more heavily. An unsecured home loan to a customer that has already defaulted, has no collateral, and now needs to pay rent AND loan repayments would count as an extremely risky loan. | |
How does a transistor amplify a signal? | A transistor is a constructed from materials that behave as semiconductors--which is to say that these materials conduct electrical current but only when certain conditions are met. By combining these materials into a device called a transistor we are able to create an electronic component that will only conduct electricity when a small electric current is applied to the so-called Base pin of the transistor.
One obvious use of such behavior is to use the transistor as a switch--by applying or removing current to the base pin we are able to control whether the transistor conducts electricity via its collector and emitter pins. When no current is present at the Base pin the transistor will block electrical transmission through its emitter and collector pins.
Generally speaking, the electrical current required to control the transistor at the base pin is very small. Much larger currents can be transferred through the device through the collector and emitter pins. Thus, in effect, a transistor uses a very small input current to control the flow of a much larger current.
An audio signal, for example, is transmitted as a very low power electrical current--in it's original form it is too small to be able to drive a loudspeaker to make sounds that are audible to the human ear. To amplify this signal so that is usable for audio playback we can apply the audio signal to a transistor's base pin--this will allow a much larger current to flow between the emitter and collector pins and through the transistor. Since the flow of this large current will mirror the much smaller current of the audio signal we will have effectively created a much stronger version of the original input signal. | |
When a company liquidates, are earlier investors paid back first? | All shares of the same class are considered equal. Each class of shares may have a different preference in order of repayment. After all company liabilities have been paid off [including bank debt, wages owing, taxes outstanding, etc etc.], the remaining cash value in a company is distributed to the shareholders. In general, there are 2 types of shares: Preferred shares, and Common shares. Preferred shares generally have 3 characteristics: (1) they get a stated dividend rate every year, sometimes regardless of company performance; (2) they get paid out first on liquidation; and (3) they can only receive their stated value on liquidation - that is, $1M of preferred shares will be redeemed for at most $1M on liquidation, assuming the corporation has at least that much cash left. Common Shares generally have 4 characteristics: (1) their dividends are not guaranteed (or may be based on a calculation relative to company performance), (2) they can vote for members of the Board of Directors who ultimately hire the CEO and make similar high level business decisions; (3) they get paid last on liquidation; and (4) they get all value remaining in the company once everyone else has been paid. So it is not the order of share subscription that matters, it is the class. Once you know how much each class gets, based on the terms listed in that share subscription, you simply divide the total class payout by number of shares, and pay that much for each share a person holds. For companies organized other-than as corporations, ie: partnerships, the calculation of who-gets-what will be both simpler and more complex. Simpler in that, generally speaking, a partnership interest cannot be of a different 'class', like shares can, meaning all partners are equal relative to the size of their partnership interest. More complex in that, if the initiation of the company was done in an informal way, it could easily become a legal fight as to who contributed what to the company. | |
Identify which instrument is string or percussion: Tsuzumi, Auto-harp | Auto-harp is string, Tsuzumi is percussion. | |
Shares; are they really only for the rich/investors? | As a matter of fact, I invest small sums in stable stocks every month (in fact, much lesser than the $50 you are talking about). More than the return on investment, I gained a lot of knowledge keeping track of my stocks and this now helps me pick my stocks better. And the portfolio is doing great too. So, it is a good idea to start small and invest regularly. | |
Does nephrectomy modify renal angiotensin II effects in kidney donors? | Age, gender, menopausal status, a family history of hypertension, and renal vascular response to angiotensin II are involved in the progression of renal failure from its very beginning. | In normotensive donors with a normal compensatory response to nephrectomy, baseline renal reactivity to angiotensin II can influence renal and glomerular hemodynamics 1 year after nephrectomy. |
Given this text about the nutrition profile of peanut butter, what vitamins is peanut butter rich in? | In a 100 gram amount, smooth peanut butter supplies 597 Calories and is composed of 51% fat, 22% protein, 22% carbohydrates (including 5% dietary fiber), and 1% water (table). Both crunchy and smooth peanut butter are sources of saturated and monounsaturated fats (mainly oleic acid) as 25% of total serving amount, and polyunsaturated fat (12% of total), primarily as linoleic acid).
Peanut butter is a rich source (20% or more of the Daily Value, DV) of dietary fiber, vitamin E, pantothenic acid, folate, niacin, and vitamin B6 (table, USDA FoodData Central). Also high in content are the dietary minerals manganese, magnesium, phosphorus, zinc, copper, and sodium (added as salt during manufacturing). Peanut butter is a moderate source (10–19% DV) of thiamin, riboflavin, iron, and potassium (table). | Vitamins that peanut butter is rich in include vitamin E, pantothenic acid, folate, niacin, and vitamin B6. |
Do I have to explain the source of *all* income on my taxes? | Well, that's probably not even all of it. If that stranger did his taxes properly, then he already paid about a third of it to the government because wherever he got it from it was income for him and thus it must have been taxed. Now, the remainder is in your hands and yes, according to US law it is now your income and so now you too, must pay about a third of it to the government, and yes you are supposed to explain where it came from. Be careful giving it to somebody else or it'll be taxed yet again. disclaimer: I am not a US citizen | |
Should you keep your stocks if you are too late to sell? | You should distinguish between the price and the value of a company: "Price is what you pay, value is what you get". Price is the share price you pay for one share of the company. Value is what a company is worth (based on fundamental analysis, one of the principles of value investing). I would recommend selling the stock only if the company's value has deteriorated due to fundamental changes (e.g. better products from competitors, declining market) and its value is lower than the current share price. | |
Do llama-derived single-domain intrabodies inhibit secretion of hepatitis B virions in mice? | Hepatitis B virus (HBV) infections cause 500,000 to 700,000 deaths per year as a consequence of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Efficient and safe antivirals to treat chronically infected patients and consequently to prevent development of hepatocellular carcinoma are still awaited. We isolated five single-domain antibodies (VHHs) that recognize the most abundant envelope protein (S) of HBV. VHHs, when expressed and retained in the endoplasmic reticulum as intrabodies, reduced levels of secreted hepatitis B surface antigen (HBsAg) particles in a cellular HBV model. In a hydrodynamics-based HBV mouse model, these intrabodies caused a marked reduction in HBsAg concentrations and a 10- to >100-fold reduction in the concentration of HBV virions in plasma. | VHHs potently inhibited secretion of HBV virions in vivo, showing that this approach might be useful in the treatment of HBV. To our knowledge, this is the first report of intrabody-mediated inhibition of viral secretion in mammals. |
If a stock doesn't pay dividends, then why is the stock worth anything? | Shareholders can [often] vote for management to pay dividends Shareholders are sticking around if they feel the company will be more valuable in the future, and if the company is a target for being bought out. Greater fool theory | |
Is liver fat content associated with increased carotid atherosclerosis in a Chinese middle-aged and elderly population : the Shanghai Changfeng study? | Nonalcoholic fatty liver disease is closely associated with metabolic syndrome and cardiovascular disease (CVD). We investigated whether the liver fat content (LFC) is independently associated with carotid artery intima-media thickness (CIMT) and evaluated the contribution of the LFC to the increased CIMT. | These results suggest that the LFC is independently associated with carotid atherosclerosis in the Chinese population, and that the risk of atherosclerosis is proportional to the degree of hepatic steatosis. |
What animals are famously depicted playing poker in a painting? | Dogs | |
The following are some reasons to start a restaurant. the reasons should be categorized as 'great', 'neutral', 'terrible' -
It will provide food to people
Potential to become a millionaire
Help you follow your passion
All your savings will go into opening it
You dont know how to cook
The world needs more farm to table services
You may be able to build a career out of it
You will enjoy it
You will lose your job
You dont have money to open a restaurant | Great:
Help you follow your passion
The world needs more farm to table services
Potential to become a millionaire
Neutral:
You will enjoy it
It will provide food to people
You may be able to build a career out of it
Terrible:
All your savings will go into opening it
You will lose your job
You dont know how to cook
You dont have money to open a restaurant | |
Why might it be advisable to keep student debt vs. paying it off quickly? | If the interest rate on the student loan is lower than inflation, then the student loan will be "cheaper" the longer you take to pay it. This is now a very rare instance, but there were programs and loan consolidation opportunities in the mid-200x's that allowed savvy student's to convert their loans to have an interest rate of around 1.5%. Right now the inflation rate is actually quite low, but it's not expected to stay there, and wasn't that low just a few years ago, so in the long run this type of debt will only be cheaper the longer it takes to pay off. It is risky, as others point out, as it can't be written off in bankruptcy, but there are other situations where it can be written off more easily than other debts, so on balance the risks aren't better or worse than other loans in general. For specific individual situations the risk equation might work out differently, though. Further, student loans aren't considered traditional debt by some lenders for specific lending opportunities, thus allowing you to go into greater debt for certain types of purchases. Whether this is good for you or not depends on the importance of the purchase. If you need to buy a house and the interest rate is higher than your student loan rate, it will be better, financially, to pay off the house first, while paying the minimum on the student loans. If you have no other debt with a higher interest, and the student loan interest is higher than inflation, there is no reason to delay paying off the student loan. | |
Is tap water safe to drink in Japan? | Yes, tap water is safe to drink in Japan. | |
Based on the reference text, provide a summary of how the monthly benefit amount for social security is calculated. | Primary Insurance Amount and Monthly Benefit Amount calculations
Main article: Primary Insurance Amount
Workers in Social Security covered employment pay FICA (Federal Insurance Contributions Act) or SECA (Self Employed Contributions Act) taxes and earn quarters of coverage if earnings are above minimum amounts specified in the law. Workers with 40 quarters of coverage (QC) are "fully insured" and eligible for retirement benefits. Retirement benefit amounts depend upon the average of the person's highest 35 years of "adjusted" or "indexed" earnings. A person's payroll-taxable earnings from earlier years are adjusted for economy-wide wage growth, using the national average wage index (AWI), and then averaged. If the worker has fewer than 35 years of covered earnings these non-contributory years are assigned zero earnings. The sum of the highest 35 years of adjusted or indexed earnings divided by 420 (35 years times 12 months per year) produces a person's Average Indexed Monthly Earnings or AIME.
The AIME is then used to calculate the Primary Insurance Amount or PIA. For workers who turn 62 in 2021, the PIA computation formula is:
(a) 90 percent of the first $996 of average indexed monthly earnings, plus
(b) 32 percent of average indexed monthly earnings between $996 and $6,002, plus
(c) 15 percent of average indexed monthly earnings over $6,002
For workers who turn 62 in the future, the 90, 32, and 15 percent factors in the computation formula will remain the same but the dollar amounts in the formula (called bend points) will increase by wage growth in the national economy, as measured by the AWI. Because the AIME and the PIA calculation incorporate the AWI, Social Security benefits are said to be wage indexed. Because wages typically grow faster than prices, the PIAs for workers turning 62 in the future will tend to be higher in real terms but similar relative to average earnings in the economy at the time age 62 is attained.
Monthly benefit amounts are based on the PIA. Once the PIA is computed, it is indexed for price inflation over time. Thus, Social Security monthly benefit amounts retain their purchasing power throughout a person's retirement years.
A worker who first starts receiving a retirement benefit at the full retirement age receives a monthly benefit amount equal to 100 percent of the PIA. A worker who claims the retirement benefit before the full retirement age receives a reduced monthly benefit amount and a worker who claims at an age after the full retirement age (up to age 70) receives an increased monthly amount.
The 90, 32, and 15 percent factors in the PIA computation lead to higher replacement rates for persons with lower career earnings. For example, a retired individual whose average earnings are below the first bend point can receive a monthly benefit at the full retirement age that equals 90 percent of the person's average monthly earnings before retirement. The table shows replacement rates for workers who turned 62 in 2013.
The PIA computation formula for disabled workers parallels that for retired workers except the AIME is based on fewer years to reflect disablement before age 62. The monthly benefit amount of a disabled worker is 100 percent of PIA.
Benefits for spouses, children, and widow(er)s depend on the PIAs of a spouse or a deceased spouse. Aged spouse and divorced spouse beneficiaries can receive up to 50 percent of the PIA. Survivor benefit rates are higher and aged widow(er)s and aged surviving divorced spouses can receive 100 percent of the PIA.
Federal, state and local employees who have elected (when they could) NOT to pay FICA taxes are eligible for a reduced FICA benefits and full Medicare coverage if they have more than forty quarters of qualifying Social Security covered work. To minimize the Social Security payments to those who have not contributed to FICA for 35+ years and are eligible for federal, state and local benefits, which are usually more generous, Congress passed the Windfall Elimination Provision, WEP. The WEP provision will not eliminate all Social Security or Medicare eligibility if the worker has 40 quarters of qualifying income, but calculates the benefit payments by reducing the 90% multiplier in the first PIA bendpoint to 40–85% depending on the number of Years of Coverage. Foreign pensions are subject to WEP.
A special minimum benefit, based on an alternative PIA calculation, is available for some workers with long careers but low earnings. However, it is rarely higher than the regularly-computed PIA and thus few workers qualify for the special minimum benefit. Only 32,000 individuals received the special minimum benefit in 2019.
The benefits someone is eligible for are potentially so complicated that potential retirees should consult the Social Security Administration directly for advice. Many questions are addressed and at least partially answered on many online publications and online calculators. | The monthly benefit amount for social security is calculated by determining an individual's highest 35 years of "indexed" earnings. The sum of the highest 35 years of "indexed" earnings is divided by 420, which is the number of months in 35 years, to determine an individuals Average Indexed Monthly Earnings, which is referred to as AIME. Once an individuals AIME is determined, the formula to calculate the monthly benefit is as follows:
- 90 percent of the first $996 of AIME, plus
- 32 percent of AIME between $996 and $6,002, plus
- 15 percent of AIME over $6,002 |
What publicly available software do professional stock traders use for stock analysis? | Factset also provides a host of tools for analysis. Not many people know as they aren't as prevalent as Bloomberg. CapitalQ and Thomson Reuters also provide analysis tools. Most of the market data providers also provide analysis tools to analyze the data they and others provide. | |
When filing a US 1065 as a General Partnership, do we combine our expenditures for a home office? | Your home doesn't belong to the partnership, it belongs to you. So you can (if qualified) deduct home office usage as a business expense on your individual tax return. Same goes to your partner. Similarly any other unreimbursed expense. | |
Why would you elect to apply a refund to next year's tax bill? | If you expect your taxes to be higher next year, it saves you the trouble of sending estimates or changing the withholding levels. But yes, its basically a free loan you're giving to the government. | |
What is another name for the Great Pyramid in Egypt? | Giza, Khufu | |
Does an insulin-like growth factor-I gene polymorphism modify the risk of microalbuminuria in subjects with an abnormal glucose tolerance? | Microalbuminuria (MA) is related to cardiovascular disease both in diabetic patients and non-diabetic subjects. | In subjects with AGT, a higher risk for MA was observed in variant carriers than in carriers of the wild type genotype of this IGF-I gene polymorphism. Since MA is primarily associated with cardiovascular disease in subjects with AGT, our study suggests that variant carriers have a higher risk for cardiovascular disease than carriers of the wild type when they develop an AGT. |
Why are In-N-Out cheeseburgers so good? | In-N-Out cheeseburgers are seen as good for a few reasons. The meat is never frozen and tight quality controls at their processing plants insure a consistent and high quality meat patty. The incentive structure for the In-n-out employee results in workers staying at the fast food chain longer with the manager frequently in charge of employees and the actual cooking of the burger patties. This method is opposite of competing fast food restaurants who assign the burger cooking to entry level employees and customer management to higher levels. In-n-out maintains a smaller menu focusing on a few key items instead of an expansive or seasonally themed menu making it easier to maintain high standards of quality. Lastly their slow growth and enthusiastic fans provide a positive atmosphere lending itself to people thinking more highly of In-n-out where without this influence might be neutral on the brand. | |
Does the phospholipase A ( 2 ) inhibitor methyl indoxam suppress diet-induced obesity and glucose intolerance in mice? | Previous results have shown that mice lacking in the group 1B phospholipase A(2) (Pla2g1b) are resistant to obesity and diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. This study examined the potential of using the Pla2g1b inhibitor methyl indoxam as therapy to suppress diet-induced obesity and diabetes. | These results show that oral supplementation of a diabetogenic diet with the Pla2g1b inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes in mice. This suggests that Pla2g1b inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes. |
Do time lapse and comorbidities influence patient knowledge and pursuit of medical care after traumatic splenectomy? | There is insufficient knowledge of infectious risk in patients after splenectomy; minimal data exists specifically for trauma patients. This study evaluated patient knowledge and practices regarding infection risk after traumatic splenectomy. Our hypothesis was that patients with poor knowledge regarding their asplenic state would be less likely to pursue medical care in the event of an illness than those with good knowledge. | Trauma patients retain minimal knowledge about infection risk after splenectomy and are not likely to pursue appropriate medical care. Time since injury negatively influences patient actions. Healthcare providers must be more proactive to develop new strategies in educating these patients, particularly those without comorbidities and those greater than 3 years postsplenectomy. |
Tell me whether these golfers are American, Canadian, or neither: Mike Weir, Corey Conners, Max Homa, Tiger Woods, Justin Thomas, Viktor Hovland | Mike Weir: Canadian
Corey Conners: Canadian
Max Homa: American
Tiger Woods: American
Justin Thomas: American
Viktor Hovland: Neither | |
How trading in currency pair works, underlying techniques and mechanisms | Without going into minor details, an FX transaction works essentially like this. Let's assume you have SEK 100 on your account. If you buy 100 USD/RUB at 1.00, then that transaction creates a positive cash balance on your account of USD 100 and a negative cash balance (an overdraft) of RUB 100. So right after the transaction (assuming there is not transaction cost), the "net equity" of your account is: 100 SEK + 100 USD - 100 RUB = 100 + 100 - 100 = 100 SEK. Let's say that, the day after, the RUB has gone down by 10% and the RUB 100 is now worth SEK 90 only. Your new equity is: 100 SEK + 100 USD - 100 RUB = 100 + 100 - 90 = 110 SEK and you've made 10%(*): congrats! Had you instead bought 100 SEK/RUB, the result would have been the same (assuming the USD/SEK rate constant). In practice the USD/SEK rate would probably not be constant and you would need to also account for: (*) in your example, the USD/RUB has gone up 10% but the RUB has gone down 9.09%, hence the result you find. In my example, the RUB has gone down 10% (i.e. the USD has gone up 11%). | |
Does aspirin inhibit the acute venodilator response to furosemide in patients with chronic heart failure? | We sought to determine the effect of aspirin on the venodilator effect of furosemide in patients with chronic heart failure (CHF) BACKGROUND: Furosemide has an acute venodilator effect preceding its diuretic action, which is blocked by nonsteroidal anti-inflammatory, drugs. The ability of therapeutic doses of aspirin to block this effect of furosemide in patients with CHF has not been studied. For comparison, the venodilator response to nitroglycerin (NTG) was also studied. | In patients with CHF, venodilation occurs within minutes of the administration of intravenous dose of furosemide. Our observation that aspirin inhibits this effect further questions the use of aspirin in patients with CHF. |
Is self-reported long total sleep duration associated with metabolic syndrome : the Guangzhou Biobank Cohort Study? | To examine the association between total sleep duration and the prevalence of metabolic syndrome (MetSyn) in older Chinese. | Long sleep duration was associated with greater risk of MetSyn in older Chinese. Confirmation through longitudinal studies is needed. The mechanisms mediating the link between long sleep duration and MetSyn require further investigation. |
Where is the Birthplace of 'Silicon Valley | The original incarnation of the Hewlett-Packard Company, commonly shortened to Hewlett-Packard (/ˈhjuːlɪt ˈpækərd/ HYEW-lit PAK-ərd) or HP, was an American multinational information technology company headquartered in Palo Alto, California. HP developed and provided a wide variety of hardware components, as well as software and related services to consumers, small and medium-sized businesses (SMBs), and large enterprises, including customers in the government, health, and education sectors. The company was founded in a one-car garage in Palo Alto by Bill Hewlett and David Packard in 1939, and initially produced a line of electronic test and measurement equipment. The HP Garage at 367 Addison Avenue is now designated an official California Historical Landmark, and is marked with a plaque calling it the "Birthplace of 'Silicon Valley'". | The HP Garage at 367 Addison Avenue |
Classify the following as living things and non-living things: Car, Desk, Parrot, Cheetah, Phone | The list can be classified as living things and non-living things as follows:
Car- Non-living thing.
Desk- Non-living thing.
Parrot- Living thing.
Cheetah- Living thing.
Phone- Non-living thing.
You can classify anything that can breathe as a living thing and which cannot breathe as a non-living thing. | |
What are the top boba places in San Mateo County?? | There are a few great boba places in San Mateo 1. Yifang, 2. TP Tea, 3. Urban Ritual 4. Cha Express 5. Feng Cha | |
Can I transfer my West Australian rock lobster quota units into my SMSF? | SMSFs are generally prohibited from acquiring assets from related parties (whether it is purchased by the SMSF or contributed into the fund). There are some exceptions to the above rule for acquiring related party assets, including: • Listed securities (ie shares, units or bonds listed on an approved stock exchange, such as the ASX) acquired at market value. • Business real property (ie freehold or leasehold interests in real property used exclusively in one or more businesses) acquired at market value. • An in-house asset where the acquisition would not result in the level of the fund’s in-house assets exceeding 5%. • Units in a widely held unit trust, such as a retail ,managed fund. In-house asset rules An ‘in-house asset’ is generally defined as: • An investment by an SMSF in a related company or trust (ie a fund owns shares in a related company or units in a related trust). • An asset of an SMSF that is leased to a related party. • A loan made by an SMSF to a related company or trust. An investment, lease or loan that is an in-house asset is not prohibited, but is limited to 5% of the market value of the fund’s assets. The Answer: If your pre-owned Western Australian Rock Lobster fishery quota units are not included in the exceptions then you cannot transfer them into your SMSF. | |
Are povidone-iodine rectal cleansing and targeted antimicrobial prophylaxis using rectal swab cultures in men undergoing transrectal ultrasound-guided prostate biopsy associated with reduced incidence of postoperative infectious complications? | The aim of this study was to evaluate the effect of povidone-iodine rectal disinfection and targeted antimicrobial prophylaxis in men undergoing transrectal ultrasound-guided prostate biopsy based on rectal swab culture results. | In the era of quinolone resistance, the combination of povidone-iodine rectal cleansing and targeted antibiotic prophylaxis may reduce the rate of infectious complications. |
Do histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations? | Testicular germ cell tumours are the most common malignancies in young males. Molecular biology studies of these tumours are often contradictory. Two histological groups, seminoma and non-seminoma, differ both morphologically and in malignant behaviour. Although a common cytogenetic feature is seen, namely the amplification of the 12p chromosomal region, the development mechanisms of less aggressive seminomas and more aggressive non-seminomas are unknown. | Occurrence of genetic alterations correlates with clinical behaviour of these tumours and may indicate that such alterations could occur early in the development of seminomas and non-seminomas. |
Does an ultrasound-assisted approach facilitate spinal anesthesia for total joint arthroplasty? | Spinal anesthesia can be challenging in patients undergoing total joint arthroplasty because of poorly palpable surface landmarks and age-related changes in the lumbar spine. We hypothesized that pre-procedural ultrasound imaging would be effective in identifying the lumbar intervertebral spaces and would provide an accurate measure of the depth to the intrathecal space. | Ultrasound imaging of the lumbar spine provides clinically useful information that can facilitate spinal anesthesia in the older orthopedic patient population. |
Have plenty of cash flow but bad credit | A) The Credit Rating Agencies only look at the month-end totals that are on your credit card, as this is all they ever get from the issuing bank. So a higher usage frequency as described would not make any direct difference to your credit rating. B) The issuing bank will know if you use the credit with the higher frequency, but it probably has little effect on your limit. Typically, after two to three month, they reevaluate your credit limit, and it could go up considerably if you never overdrew (and at this time, it could indirectly positively affect your credit rating). You could consider calling the issuing bank after two month and try to explain the history a bit and get them to increase the limit, but that only makes sense if your credit score has recovered. Your business paperwork could go a long way to convince someone, if you do so well now. C) If your credit rating is still bad, you need to find out why. It should have normalized to a medium range with the bad historic issues dropped. | |
What typically happens to unvested stock during an acquisition? | I've been through two instances where I worked for a public company that was merged (for stock) into another company. In both cases the options I had were replaced with equivalent options in the merged company with the number of shares and strike price adjusted at the same rate as the actual stock was converted, and the vesting terms remained essentially the same. In other words, the options before and after were in essence equivalent. | |
Why certain currencies are considered safe havens in times of turmoil | It's a combination of neutrality, economic power, economic freedom, a history of stability, and tradition. In the case of the Japanese yen, it's obviously economic power that is the determining factor, as Japan is the world's third largest economy. Switzerland, on the other hand, is only the 19th largest economy, but ranks very high in all the other criteria. | |
Does Jukebox contain many original songs? | Jukebox is the eleventh studio album by Australian pop vocal group Human Nature released in October 2014. It contains covers from the 1950s and 1960s, with one original song, "End of Days" | No, it contains covers from the 1950s and 1960s, with only one original song. |
What was the first name of the city that became Austin, Texas? | The first European settlers in the present-day Austin were a group of Spanish friars who arrived from East Texas in July 1730. They established three temporary missions, La Purísima Concepción, San Francisco de los Neches and San José de los Nazonis, on a site by the Colorado River, near Barton Springs. The friars found conditions undesirable and relocated to the San Antonio River within a year of their arrival. Following Mexico's Independence from Spain, Anglo-American settlers began to populate Texas and reached present-day Central Texas by the 1830s. The site where Austin is located was surveyed by Edward Burleson in 1838, calling it Waterloo. It was incorporated in January, 1839, only months before selection as the site of the new capital, ending its existence. Early Austin resident and chronicler Frank Brown says the first and only settler in 1838 was Jacob Harrell who may have been living there already. Living in a tent with his family, he later built a cabin and small stockade near the mouth of Shoal Creek. In its short lifespan of less than two years the population of Waterloo grew to only about twelve people made up of four families. | The site that became Austin was previously incorporated as Waterloo in 1839. |
What's the purpose of having separate checking and savings accounts? | A checking account is instant access. It can be tapped via check or debit card. A savings account is supposed to be used to accumulate cash for a goal that is is longer term or for an emergency. Many people need to separate these funds into different accounts to be able to know if they are overspending or falling short on their savings. In the United States the Federal Reserve also looks at these accounts differently. Money in a checking account generally can't be used to fund loans, money in a savings account can be used as a source of loans by the bank. An even greater percentage of funds in longer term accounts can be used to fund loans. This includes Certificates of Deposit, and retirement accounts. | |
Tell me about the RMS Adriatic | RMS Adriatic was a British ocean liner of the White Star Line. She was the fourth of a quartet of ships of more than 20,000 GRT, dubbed The Big Four. The ship was the only one of the four which was never the world's largest ship. However, she was the largest, the fastest, and the most luxurious of the Big Four, being the first ocean liner to have an indoor swimming pool and a Turkish bath.
She began her career on the brand new route from Southampton to New York before joining, from 1911, her sister ships on the secondary route from Liverpool. They were in fact slow liners intended to provide a service at moderate prices. When World War I broke out, the Adriatic was among the ships that continued their civilian transatlantic service, while carrying many provisions. In 1917, she was requisitioned and served as a troop transport.
After the war, she was refitted several times, and was gradually used for cruises, which became her main services in the 1930s. When Cunard Line and White Star Line merged in 1934, she was quickly deemed unnecessary and sold at the end of the year. She was scrapped in Osaka in 1935. | The RMS Adriatic was a British ocean liner of the White Star Line. She was the fourth of a quartet of ships of more than 20,000 GRT, dubbed The Big Four. The ship was the only one of the four which was never the world's largest ship. However, she was the largest, the fastest, and the most luxurious of the Big Four, being the first ocean liner to have an indoor swimming pool and a Turkish bath. |
Can you write me a page long essay on whether capitalism needs to be reexamined and amended? Is such a reexamination one of incremental or transformational change? If so, why? If not, why not? | How can I fully participate in a capitalistic society without examining it in the first place? That is
the necessary first step to then “re-examine” capitalism, which I unequivocally support. Blindly
following a belief, even an economic one, without critically assessing it can run the danger of
making me complicit in contributing to the consequences of that belief even without any intent.
I can only fully speak from my experience, so that is the lens through which I approach this
class; on the larger scale, however, a re-examination is also called for to discern whether
capitalism is the best course of action in the long term.
Upon this re-examination, I conclude that capitalism is not broken: it is functioning as intended,
to create economic value for the majority groups who popularized it.
Capitalism in the United States has achieved such fast-paced progress because Black slaves, minority immigrants, and unpaid domestic laborers have assumed the lion’s share of building the
system, and the legacies of these systems result in the inequities of race, class, and gender as
discussed in class. Such inequities are not only shameful, but plainly unnecessary to continue making such strides in industry, health, longevity, and sharing of ideas. Therefore, capitalism should be amended so that workers more equitably reap the fruits of their labor. Exorbitant CEO pay and the
distribution of the majority of profits towards shareholders; global factories which exploit
children while imposing unclean and unsafe working conditions on many; unfettered
production decimating the planet – should all be amended. Capitalism has grown automation,
technology, and AI as well as the development and sharing of thought to remarkable levels. Such progress can be leveraged to address these issues and more. This isn’t idealistic or wishful thinking; though economic situations can seem like “given”
circumstances, they are not to be taken for granted; capitalism is a human institution which
requires human participation to uphold them. Therefore, capitalism also can be amended.
Introducing another consideration is not a limitation on profits; rather, considering additional
parameters inspires innovation, as embraced by many leading organizations.
But at what pace shall capitalism be amended? The modern United States has necessary checks
and balances in the legal systems to uphold the laws and enforce the regulations, which makes
me believe that change should be incremental as to learn from our past and carefully curate a
new future. It takes time to engage the partners vital to change – academics, politicians, social
leaders, business leaders – and transformative change may leave some key stakeholders
behind. Over time, incremental change is transformative and can achieve the changes imagined above. | |
Why are so many US Hollywood films made in the state of Georgia? | While film in the United States as an audience artform started in New York it moved to Los Angeles for the stated reason of longer and sunnier days. Another part of the story was a patent dispute in 1898 between Thomas Edison and his patent for the Kinetograph. Edison stated that he effectively had a say in how films were made and wanted royalties for their use. Moving from New York near where Edison was based to Los Angeles was a simple way to grow the industry and distance themselves from a patent war.
This mobility at the start of the modern film era due to costs continued through the 1960's and 1970's with westerns being shot in Spain. The 1980's and 1990's continued this trend primarily shooting in Canada or Mexico. At the turn of the century state legislators in the United States started provided steep tax rebates. The practical outworking of this is studios are encouraged to hire local talent and use local services when producing their film. The ratios for these rebates is fairly complicated and have created a new industry of tax professionals serving the film industry.
So then why Georgia? Georgia currently provides one of the highest incentive structures at 20% with minimal restrictions on talent and a very low minimum budget of $500,000. | |
Do prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts? | During early to late-fetal liver development, bipotential hepatoblasts proliferate and differentiate into hepatocytes and cholangiocytes. The prospero-related homeobox 1 gene (Prox1) is expressed in hepatoblasts, and the inactivation of Prox1 causes defective early liver development, in particular, faulty migration of fetal hepatoblasts. Prox1 binds to another hepatocyte-enriched transcription factor, liver receptor homolog 1 (Lrh1), and suppresses its transcriptional activity. However, the molecular mechanism by which Prox1 and Lrh1 regulate the characteristics of fetal hepatic cells remains unknown. We investigated the contribution of Prox1 and Lrh1 in early liver development. Embryonic day 13 liver-derived CD45-Ter119-Dlk+ cells were purified as fetal hepatic stem/progenitor cells, and formation of colonies derived from single cells was detected under low-density culture conditions. We found that overexpression of Prox1 using retrovirus infection induced migration and proliferation of fetal hepatic stem/progenitor cells. In contrast, overexpression of Lrh1 suppressed colony formation. Prox1 induced the long-term proliferation of fetal hepatic stem/progenitor cells, which exhibited both high proliferative activity and bipotency for differentiation. Prox1 up-regulated expression of cyclins D2, E1, and E2, whereas it suppressed expression of p16(ink4a), the cdk inhibitor. In addition, overexpression of Prox1 significantly inhibited the proximal promoter activity of p16(ink4a). | These results suggested that Prox1 and Lrh1 coordinately regulate development of hepatic stem/progenitor cells and that Prox1 induces fetal hepatocytic proliferation through the suppression of the promoter activity of p16(ink4a). |
Does confocal endomicroscopy show food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome? | We investigated suspected food intolerances in patients with irritable bowel syndrome (IBS) using confocal laser endomicroscopy (CLE) for real-time visualization of structural/functional changes in the intestinal mucosa after food challenge. Patients with functional changes after food challenge (CLE+) were placed on personalized exclusion diets and followed up for long-term symptom relief. | Based on CLE analysis of IBS patients with a suspected food intolerance, exposure to candidate food antigens caused immediate breaks, increased intervillous spaces, and increased IELs in the intestinal mucosa. These changes are associated with patient responses to exclusion diets. Registered at clinicaltrials.gov (registration number: NCT01692613). |
How much should I be contributing to my 401k given my employer's contribution? | You can only contribute up to 5% of your salary? Odd. Usually 401(k) contributions are limited to some dollar amount in the vicinity of $15,000 or so a year. Normal retirement guidelines suggest that putting away 10-15% of your salary is enough that you probably won't need to worry much when you retire. 5% isn't likely to be enough, employer match or no. I'd try to contribute 10-15% of my salary. I think you're reading the rules wrong. I'm almost certain. It's definitely worth checking. If you're not, you should seriously consider supplementing this saving with a Roth IRA or just an after-tax account. So. If you're with Fidelity and don't know what to do, look for a target date fund with a date near your retirement (e.g. Target Retirement 2040) and put 100% in there until you have a better idea of what going on. All Fidelity funds have pretty miserable expense ratios, even their token S&P500 index fund from another provider, so you might as let them do some leg work and pick your asset allocation for you. Alternatively, look for the Fidelity retirement planner tools on their website to suggest an asset allocation. As a (very rough) rule of thumb, as you're saving for retirement you'll want to have N% of your portfolio in bonds and the rest in stocks, where N is your age in years. Your stocks should probably be split about 70% US and 30% rest-of-world, give or take, and your US stocks should be split about 64% large-cap, 28% mid-cap and 8% small-cap (that's basically how the US stock market is split). | |
Extract the population for Paris mentioned in the paragraph | Paris (English: /ˈpærɪs/; French pronunciation: [paʁi] (listen)) is the capital and most populous city of France, with an official estimated population of 2,102,650 residents as of 1 January 2023 in an area of more than 105 km² (41 sq mi), making it the fourth-most populated city in the European Union as well as the 30th most densely populated city in the world in 2022. Since the 17th century, Paris has been one of the world's major centres of finance, diplomacy, commerce, fashion, gastronomy, and science. For its leading role in the arts and sciences, as well as its early and extensive system of street lighting, in the 19th century it became known as "the City of Light". Like London, prior to the Second World War, it was also sometimes called the capital of the world. | The official estimated population of Paris is 2,102,650 residents |
Saving $1,000+ per month…what should I do with it? | I like the other answers. But, here's one thing that concerns me that hasn't specifically been addressed yet: You mentioned your student loans are at low rates of interest. Are those rates fixed or variable? If those interest rates are variable, I would not count on rates remaining low indefinitely. If you could imagine those rates going up by say 2% or 4% or more over time, would such rates make you change your mind about the debt and the pace at which you're paying it off? I would suggest that as the economy recovers over the next couple of years, the spectre of inflation will force the Fed to raise interest rates. You don't want to be holding variable-rate debt when rates are rising. For that reason, if your loan rate is variable, I would increase your payment amount so you can eliminate your debt sooner than later. Also – You mention in one of your comments that buying a home is 4+ years away. That's not a long time, so I wouldn't commit the bulk of your savings to investing in the stock market, which can be temperamental over short periods of time. You don't want to be in a large loss position just when it's time to buy your first home. However, it may be worth having some of your skin in the game, so to speak. Personally, I would take a balanced approach: 1/3 debt repayment, 1/3 high interest cash savings, and 1/3 in some broad diversified index funds – and not all in the U.S. Although, I also like the idea of getting some travel in while young, so perhaps 1/4 allocations to the money stuff, and 1/4 towards travel? :-) Good luck. | |
What is it like being alone in the world after an apocolypse? | I had always imagined the world would be in chaos or destruction. However, it's the same, just that there are no people. It's eerily quiet. Books are now the only source of "human connection" I have. I've never been much of a reader, but I anticipate much of my "free time" will be spent reading. I'm also quickly learning how much I relied on others. I knew I relied on others to do many things like farming, electricity, etc., but it goes much deeper and further than that. | |
What are some popular social media applications? | Popular social media applications are Facebook, Instagram, TikTok, Twitter, Reddit, and Youtube | |
Identify which instrument is string or percussion: Erxian, Alfaia | Erxian is string, Alfaia is percussion. | |
Which classical composer wrote the Hungarian Rhapsody | Franz Liszt | |
Does cognitive-behavioural therapy reduce unwanted thought intrusions in generalized anxiety disorder? | Voluntary attempts to suppress certain thoughts can paradoxically increase their intrusive return. Particular impairments in thought suppression are thought to be key mechanisms in the pathogenesis of mental disorders. To assess the role of this processing bias in the maintenance of generalized anxiety disorder (GAD), we investigated whether it is susceptible to cognitive-behavioural treatment (CBT). | This study could not clarify whether the demonstrated effect mediates other changes, or how it relates to other cognitive biases in GAD. |
Who was Henry Ford? | Henry Ford (July 30, 1863 – April 7, 1947) was an American industrialist and business magnate. He was the founder of Ford Motor Company, and chief developer of the assembly line technique of mass production. Ford created the first automobile that middle-class Americans could afford, and his conversion of the automobile from an expensive luxury into an accessible conveyance profoundly impacted the landscape of the 20th century.
Ford was born on a farm in Michigan's Springwells Township to a Belgian family, leaving home at age 16 to work in Detroit. It was a few years before this time that Ford first experienced automobiles, and throughout the later half of the 1880s, Ford began repairing and later constructing engines, and through the 1890s worked with a division of Edison Electric. He officially founded Ford Motor Company in 1903, after prior failures in business but success in constructing automobiles.
Ford's 1908 introduction of the Model T automobile revolutionized both transportation and American industry. As the Ford Motor Company sole owner, he became one of the richest and best-known people in the world. He is credited with "Fordism", the mass production of inexpensive goods coupled with high wages for workers. Ford was also among the pioneers of the five-day work week. Ford had a global vision, with consumerism as the key to peace. His intense commitment to systematically lowering costs resulted in many technical and business innovations, including a franchise system that put dealerships throughout North America and major cities on six continents.
Ford was widely known for his pacifism during the first years of World War I. In the 1920s Ford promoted antisemitic content through his newspaper The Dearborn Independent, and the book, The International Jew. After his son Edsel died in 1943, Ford resumed control of the company but was too frail to make decisions and quickly came under the control of subordinates. He turned over the company to his grandson Henry Ford II in 1945. He died in 1947 after leaving most of his wealth to the Ford Foundation, and control of the company to his family. | |
What is a GIS? | A GIS is a tool for making and using spatial information. Among the many definitions of GIS, we choose: A GIS is a computer-based system to aid in the collection, maintenance, storage, analysis, output, and distribution of spatial information. When used wisely, GIS can help us livehealthier, wealthier, and safer lives. Each GIS user may decide what features and attributes are important. For example, forests are good for us. They may protect water supplies, yield wood, harbor wildlife,and provide space to recreate.We are concerned about the level of harvest, the adjacent land use, pollution from nearby industries, or where forests burn. Informed management requires knowledge of all these related factors and, perhaps above all, the spatial arrangement of these factors. Buffer strips near rivers may protect water supplies,clearings may prevent the spread of fire, and polluters upwind may harm our forests. A GIS helps us analyze these spatial interactions, and is also particularly useful at displaying spatial data and analysis. A GIS is often the only way to solve spatially-related problems. | |
American taxes if living outside the US and get paid by US company on a US bank account | Technically, if you earn in US (being paid there, which means you have a work visa) and live in other country, you must pay taxes in both countries. International treaties try to decrease the double-taxation, and in this case, you may pay in your country the difference of what you have paid in US. ie. your Country is 20% and USA is 15%, you will pay 5%, and vice-versa. This works only with certain areas. You must know the tax legislation of both countries, and I recommend you seek for advisory. This site have all the basic information you need: http://www.irs.gov/Individuals/International-Taxpayers/Foreign-Earned-Income-Exclusion Good luck. | |
Does gait analysis correlate with clinical and MR imaging parameters in patients with symptomatic lumbar spinal stenosis? | Parameters of MR imaging play a pivotal role in diagnosing lumbar spinal stenosis (LSS), and serve as an important tool in clinical decision-making. Despite the importance of MR imaging, little is known about the correlation between MRI parameters, objective gait analysis, and clinical presentation of patients with lumbar spinal stenosis. | According to the results of this study MRI findings failed to show a major clinical relevance when evaluating the walking distance in patients with lumbar spinal stenosis and, therefore, should be treated with some caution as a predictor of walking distance. In determining the disease pattern of spinal stenosis functional back capacity and BMI might play a more active role than previously thought. |
Is cerebral vasoreactivity influenced by the prandial state among migraineurs? | To test if the cerebral vasoreactivity among migraineurs is influenced by the prandial state. | Our findings suggest that migraineurs have a higher reactivity to hypercapnia during the PP period. |
Did an additional $32 billion necessarily get invested into Amazon.com stock on October 26th, 2017? | Stock A last traded at $100. Stock A has 1 million shares outstanding. No seller is willing to sell Stock A for less than $110 a share. One buyer is willing to buy 1 share for $110. The order executes. The buyer pays the seller $110. Stock A's new price is $110. An $110 investment increased the market cap by $10 million. Neat trick (for all who own Stock A). | |
I'd like a list of the last five Prime Ministers of New Zealand. Give it to me in a bulleted list with the format <name> (<start date> - <end date>) | Here is a list of the last five Prime Ministers of New Zealand:
- Chris Hipkins (25 January 2023 - now)
- Jacinda Ardern (26 October 2017 - 25 January 2023)
- Bill English (12 December 2016 - 26 October 2017)
- John Key (19 November 2008 - 12 December 2016)
- Helen Clark (10 December 1999 - 19 November 2008) | |
Why does pollution in Delhi increase during the months of Nov-Dec each year? | Delhi is the capital of India and one of India's largest city. It has over 30 million residents and an estimated 100+ million vehicles. Delhi is surrounded by the agricultural states of Punjab and Haryana. During the period Sep-Nov, the states of Punjab and Haryana harvest rice they have grown during the summer months. Post the harvest, in order to prepare the fields for sowing again they burn the left over rice husk and dried plants. The month of November marks the onset of winter in the north Indian plains and during this time the north westerly winds stop. The combination of high vehicle number, large scale burning of post harvest leftover and onset of winter with no winds results in the months of Nov-Dec being the most polluted in the year. | |
Given this paragraph about Riot Games' history, which game was used an indication that games could be supported and monetized long-term? | Riot Games' founders Brandon "Ryze" Beck and Marc "Tryndamere" Merrill became friends while roommates at the University of Southern California, where the two studied business. Beck and Merrill believed too many video game developers diverted their focus from game to game too often, distinguishing Defense of the Ancients as an indication that games could be supported and monetized long-term. They also drew inspiration from Asian video game designers who released their games for no up-front cost and instead charged for additional perks. | Defense of the Ancients (DotA) |
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