UniProt ID
stringlengths
6
10
Protein Sequence
stringlengths
5
15.6k
Functional Description
stringlengths
6
12.4k
P11269
MGQTVTTPLSLTLEHWGDVQRIASNQSVEVKKRRRVTFCPAEWPTFDVGWPQDGTFNLDIILQVKSKVFSPGPHGHPDQVPYIVTWEAIAYEPPSWVKPFVSPKLSLSPTAPILPSGPSTQPPPRSALYPALTPSIKPRPSKPQVLSDNGGPLIDLLTEDPPPYGEQGPSSPDGDGDREEATYTSEIPAPSPMVSRLRGKRDPPAADSTTSRAFPLRLGGNGQLQYWPFSSSDLYNWKNNNPSFSEDPGKLTALIESVLTTHQPTWDDCQQLLGTLLTGEEKQRVLLEARKAVRGNDGRPTQLPNEVNSAFPLERPDWDY...
Plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag, or to Gag binding host factors. Interaction with HECT ubiquitin ligase...
Q8EJJ5
MNLKHKWDVYSRLTRLDRPIGTLLLLWPCLMALVLAAGGMPDLKVLIIFIIGVVIMRACGCIINDYADRDLDSHVERTKSRPLASGEISTKEALLLFVILGLAAFGLVLLLNGLVVKLSVVGIILTIIYPFTKRVTNMPQMFLGVVWSWSIPMAYAAQTGEVPIEAWWLFAANWFWTVAYDTMYAMVDRDDDLKIGIKSTAILFGKYDRQIIGLFQIAALFCFVAAGWSADRGLVYGLGLLTFVGFSTYQQMLIFGRERAPCFKAFLNNNWAGLVLFVSLGADYLF
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-...
Q8DDG1
MPKYRSATTTHGRNMAGARALWRATGVKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASMRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDEQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFISAGQRIVELTKRYYEQDDESALPRNIATKAAFENAMALDIAMGGSTNTVLHLLAAAQEGEVDFDMTDIDRMSRMVPHLCKVAPSTQK...
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (...
Q1LPV5
MLLAIKDFFNSLLLKELFKGMALTGRYLFARKITVQFPEEKTPMSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAISIESDVRNDGTRRTTRYDIDLTKCIFCGFCEEACPVDAIVETHILEYHGEKRGDLYFTKDMLLAVGDRYEPQIAAAKAADAKYR
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t...
B7NRB1
MKKNQFLKESDVTAESVFFMKRRQVLKALGISAAAFSLPHAAHADLLSWFKGNDRPPAPAGKPLEFSKPAAWQNNLPLTPADKVSGYNNFYEFGLDKADPAANAGSLKTDPWTLKISGEVAKPLTLDHDDLTRRFPLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNAKYVAFETIYAPEQMPGQQDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTRERPPTTWNLAAPDEYGFYANVNPHVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYADQ...
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essentia...
P57688
MKSYLKALVFAVLFLFILGFVYPTVTSLITEHALPFQSEGQPVEIDGHIYGSYLLAEAFNSSFFFHPRPSAIDYNLSESGSYDYSLGNPAMLNLTEKYLHRFLSENPGVNISEIPYAMISYSGSGLDPGIPLQGAIIQIPRISIAIHNITNLSVSDLYSYLYNLVNSTKTQNFPFFGSYYVNVVRLNVDIVEFLLKGGYISQSQI
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation...
P51469
MVKVGINGFGCIGRLVTRAAFDSGKVQVVAINDPFIDLDYMVYMFKYDSTHGRFKGTVKAENGKLIINDQVITVFQERDPSSIKWGDAGAVYVVESTGVFTTTEKASLHLKGGAKRVVISAPSADAPMFVVGVNHEKYENSLKVVSNASCTTNCLAPLAKVINDNFGIVEGLMTTVHAFTATQKTVDGPSGKLWRDGRGAGQNIIPASTGAAKAVGKVIPELNGKITGMAFRVPTPNVSVVDLTCRLQKPAKYDDIKAAIKTASEGPMKGILGYTQDQVVSTDFNGDTHSSIFDADAGIALNENFVKLVSWYDNECGYSN...
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) int...
Q8LE93
MEAQIHILEQEAYSAVLRAFQAQADEFSWDKATVMTNLRKELRISDDENRQLLNNVHNDDLIKRIRDSRPRGGNQVVRHQSLDVHPSPTFSASRKKQKTFQSYPSIGSTRSKSFNNRVVSANEPAEALIGRKVWTKWPEDNSFYEAVVTQYNANEGRHALVYDINTVNETWEWVDLNEIPTKDIRWDGEEDGVTLNVGHGGGTTRGNRRTLSHGGRGRGPRTQPRREHLATENGGGRKFFGEIELFNTDSLVKEVERVFDSNLPDPHELDKAKKLLKEHEQALIAAIARLTDASDYESDGEEPYSHELPMLLG
Probably involved in the regulation of chromatin states (Probable). Contributes to RPP7-mediated and basal immunity, especially against Hyaloperonospora arabidopsidis isolate Hiks1. Regulates negatively EDM2-dependent floral transition (PubMed:21830950). Interacts with EDM2 in nucleus. Slightly induced by heat stress. ...
B3QCH2
MPLRLVFMGTPEFAVPTLLALAAHGHDIAAVYTREPKPAGRGMKLQETPVALAAHRLQAPVLTPKTLRTDEALANFRAHEADAAVVVAYGMILPQAILDAPELGCYNLHGSLLPRWRGAAPLNRAIMAGDAETGVMVMKMDAGLDTGDVAMAERIAITDAMTVTDVHDQLARLGADLMVRAMAALERGGLQLTKQSEDGVTYAAKIDKAEAKIDFAKPAWAVLRHIHGLSPFPGAWCELPIEGQPVRIKVLRCAIADGRGEPGEVIDDHLTIACGDGAIRVSQLQRAGKQPMTAEEFLRGTPIAKGVRVG
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. (6S)-10-formyltetrahydrofolate + L-m...
A7NEH3
MTKKYLKVDVVSPLGSVFKGEADMVSLRGSAGEMGIVYGHTELLSTLPAGVVNVRKGQHTDVLYVSGGIVEVTPTRVTIMVDDMERAENLNQAEAEKARARAKEVLKNPDASKLDIEAANKRLKEADARLKALNSSNGLYYSKDD
Produces ATP from ADP in the presence of a proton gradient across the membrane. F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Belongs to the AT...
O28380
MSSDMEGGMITMKANDTTKYLIHAEIEAEGVVERPDVVGAIFGQTEGLLGGDLDLRELQKTGRIGRIEVKIESKGGRSFGEIKVPSSLDKVETAILAAALETIERVGPCSAKIKVLKIEDVRASKRKRIVERAMNILREHFEEPEIESERIVEIVRQAIRADEIVEYGEEKLPAGPAIDESDAIIVVEGRADVLNLLKHGIKNVIAVEGTNIPKTIVELSKKKTVTAFLDGDRGGDLILKELLQVAEVDYVARAPEGKEVEDLTQKEILKSLRNKVPVEQLHVLKKEAKEGREREKLAEMPKDSISDVLRKHTESVKGRL...
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the ex...
Q50945
LQAVAVFKQLPEAAALAAANKRVQNLLKKADAALGEVNESLLQQDEEKALYAAAQGLQPKIAAAVAEGNFRTALSELASVKPQVDAFFDGVMVMAEDAAVKQNRLNLLNRLAEQMNAVADIALLGE
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly) Tetramer of two alpha and two beta subunits. Belongs to the class-II aminoacyl-tRNA synthetase family.
A8EY39
MTNVITRFAPSPTGFLHIGSARTALFNYLFARHHNGKFLLRIEDTDKERSTNEAVEAIFSGLKWLGLDWDGEVIFQSKRNDLYKETALKLLQAGKAYYCFTSQEEIEKQRQKALENKQYFIFNSDWRDKDPAAYPTDIKPVIRLKTPREGSITIRDTLQGDVVIENSHIDDMVLLRSDGTATYMLAVVVDDHDMGITHIIRGDDHLTNAARQIAIYQACGYAVPSMTHIPLIHGADGAKLSKRHGALGVAAYKDMGYLPESVCNYLLRLGWSHGDDEIISMDQAIKWFNLDSLGKSPAKLDFANMNSLNAHYLRLLDNDS...
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu) Monomer. Belongs to the class-I aminoacyl-tRNA synthetase family....
Q9K6Z0
MSKPFMFEKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIARLVASSLKDRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNALLMDVVGNEQRADRLRRFLYEKNYVGYREHVKSLNLSTIDKSRLMNLLSLRGGRAAIEEARGLIQTEKGKTALAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDLL...
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. Heteromultimer composed of HisG and HisZ subunits. This f...
Q1XHV8
MSVMDLANTCSSFQSDLDFCSDCGSVLPLPGAQDTVTCIRCGFNINVRDFEGKVVKTSVVFHQLGTAMPMSVEEGPECQGPVVDRRCPRCGHEGMAYHTRQMRSADEGQTVFYTCTNCKFQEKEDS
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits. Belongs to the archaeal RpoM...
A5VIS1
MTQKLHIALLFGGNSSEHDVSKRSAHNIYDALDKEKYDVSLFMFTKDGILLGNEDSQKIFDGEPEDQVVAEAYQKMDMSSPLAPIMALNEQKEIDFFFPVIHGNLGEDGTIQGLFKLLNKPYVGSNIAASAMSFDKDLTKKIISQAGIRNTPYVVVTPENQADYSWGRIEEKLGNLTFVKPAKQGSSVGIHRVTNAEEYEKALDDAFKYDYKILVEQGIANPQEIEISILGNEHPIASKLGAVRVPKDDPFYDYENKFVDASGVVFELPVKLPQYLVDEITDMALKAYKALGMKGMARIDFLVDSNNVPYLGEPNTLPGF...
Cell wall formation. ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate Binds 2 magnesium or manganese ions per subunit. Cell wall biogenesis; peptidoglycan biosynthesis. Belongs to the D-alanine--D-alanine ligase family.
B9DY39
MKIDIIISADDIKKEKILHKSVIVVDMLRATSVIITAINNGCREVIPVLTIEEALEIYHKNREKYVMGGERKALKIEGFHCSNSPLEYSRQVVENKTLVITTSNGTKAIKGSIMAKNILIGALINADEVANRSINLNNDVVIVNAGTCGQFSIDDFICSGYMINCVIKKIKVDLTDIARTALYIYEQNPDIITFIKKASHYKRIKKLKLYDDLEYCCRKDIIKIVPEYIDGIIKCNKLIY
(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate Belongs to the ComB family.
Q9M9E3
MEGLIQTRGILSLPAKPIGVRRLLQPSHGLKQRLFTTNLPALSLSSNGHKKFQAFQQIPLGISVSHKERSRGFICKAEAAAAGGGNVFDEGDTAAMAVSPKIFGVEVTTLKKIVPLGLMFFCILFNYTILRDTKDVLVVTAKGSSAEIIPFLKTWVNLPMAIGFMLLYTKLSNVLSKKALFYTVIVPFIVYFGAFGFVMYPLSNLIHPEALADKLLATLGPRFMGPLAIMRIWSFCLFYVMAELWGSVVVSVLFWGFANQITTVDEAKKFYPLFGLGANVALIFSGRTVKYFSNMRKNLGPGVDGWAVSLKAMMSIVVGM...
Belongs to the ADP/ATP translocase tlc (TC 2.A.12.2) family.
A8Z426
MVKTVYVTGYKSFELNIFKDDAPEVHYLKQFIKHKIEQLLDEGLEWVLIQGQMGIELWTAEVVIELQRTYDSLKFAVITPFQGHTEKWNEHNQSKYANIIKHADYVDSIFHTSYQGPFQFKQADQFMLEHSDQTLLIYDEEQEASPKFFKQMLVDFMDKTNYTCDIVTFDELTAFINDLQWSEDQSF
Belongs to the UPF0398 family.
Q1JPD6
MAAVDSDIEPLPRGGFRCCLCHITTANQPSLDAHLGGRKHRHLVELRATRKAQGLRSVFVSGFPRDVDSTQLSEYFQAFGPVASVVMDKDKGVFAIVEMGDLGAREAVLSQPQHSLGGRRLRVRPREQIEFQSPASRSPKRVAPDSHQLIKALAEAPDVEAQMVKLVGLRELSEAERQLRSLVVALMQEVFAEFFPGCVVHPFGSSINSFDVHGCDLDLFLDLGDLDEPQPAPKAPESPSLDSALASPLDPQALACTPASPPDSQPPASPQDSEALDFEAPSSSLAPRTPDSALASETLASPRSLPPASPLQEDQGDGDQ...
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pr...
Q9D132
MASAATEGEKGSPVVVGLLVVGNIIILLSGLALFAETVWVTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFVVASFGVGAALCRRRYMILTYLLLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTYYSADTDQGQELTRLWDRIMIEQECCGTSGPMDWVNYTSAFRAATPEVVFPWPPLCCRRTGNFIPINEDGCRVGHMDYLFTKGCFEHIGHAIDSYTWGISWFGFAILMWTLPVMLIAMYFYTTL
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane...
Q023P9
MIQPDSYVRSLLKRSPGESVTARGWVKTRRDSKNVHFIQLNDGSSPVDLQVVLDAGVVPEDVVAKITTGACISVEGDLVASMGKGQAVEIKARALTVHGTADPEHYPLQKKKHTLETLRELGHLRTRSNTFGAVFRVRNALACAIHKFFQDRGFMYVHTPVISASDAEGAGSMFQVTTLDLQSPKPADFTGDFFGKHTYLTVSGQLEAEIFAHAFANVYTFGPTFRAENSNTPRHLAEFYMIEPEMAFCDLKDNQDLAEAFLKSQVEYVVNACGPDLDFLAKWYDPELRKTLDGLMNASFERITYTEAIDLLQRSGRSFE...
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn) Homodimer. Belongs to the class-II aminoacyl-tRNA synthetase family.
P34604
MVQESIISSFRGKLENDPSKSTSLATVETLLEVLDRSRATTVAEFQNELNQVVAALEKTDYSSTSIRSAADLFTRFTSLAPAALLDQEDFSQVLDLYRQRARSFIKNVRGSRAKISKCARLFFTHHMNILTHSYSKVVLETILDAHKSGYHLHVWVTESQPDASGKLVFEELKKNGVPTTLVLDSCVGYVMERIQAVLVGAEGVMETGGIINKIGTVNVCIIAKSRHVPVYVCAETIKFVREFPLNQADIPQEFKYRTSVIERNNLELEHPDVDYTAPEFLTLIITDVGAMKPEAVGEELIKMYI
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Complex of five different subunits; alpha, beta, gamma, delta and epsilon. Belongs to the eIF-2B alpha/beta/delta subunits family.
B7NKV9
MYQDLIRNELNEAAETLANFLKDDANIHAIQRAAVLLADSFKGGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHISCVGNDFGFNDIFSRYVEAVGREGDVLLGISTSGNSANVIKAIAAAREKGMKVITLTGKDGGKMAGTADIEIRVPHFGYADRIQEIHIKVIHILIQLIEKEMVK
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. 2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate Binds 1 zinc ion per subunit. Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosy...
B9L889
MAVPKRRNSKTRGAKRRTHYKIKLSSVIKCSNCGAYKRPHRVCPSCGEY
Belongs to the bacterial ribosomal protein bL32 family.
P25414
AVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEDNQWICYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPTYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRACYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTTLRHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHSGTVVGKLEGEREMTLGFVDLLRDDFIEKDRARGIFFTQDWVSMPGVI...
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site (By similarity)...
Q1JJ36
MAKPTRKRRVKKNIESGVAHIHATFNNTIVMITDVHGNALAWSSAGALGFKGSRKSTPFAAQMAAEAAAKSAQEHGLKTVEVTVKGPGSGRESAIRALAAAGLEVTAIRDVTPVPHNGARPPKRRRV
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. Belongs to the universal ribosomal protein uS11 family.
Q9H5E9
MLSPVSRDASDALQGRKCLRPRSRRLPLPAAVRAHGPMAELTDSARGCVVFEDVFVYFSREEWELLDDAQRLLYHDVMLENFALLASLGIAFSRSRAVMKLERGEEPWVYDQVDMTSATEREAQRGLRPGCWHGVEDEEVSSEQSIFVAGVSEVRTLMAELESHPCDICGPILKDTLHLAKYHGGKARQKPYLCGACGKQFWFSTDFDQHQNQPNGGKLFPRKEGRDSVKSCRVHVPEKTLTCGKGRRDFSATSGLLQHQASLSSMKPHKSTKLVSGFLMGQRYHRCGECGKAFTRKDTLARHQRIHTGERPYECNECGK...
May be involved in transcriptional regulation. Belongs to the krueppel C2H2-type zinc-finger protein family.
B3PHR3
MLGLIQRVRRASVEVDQQVVGEIDQGMLLLLGIQKTDTEASADKLIDKLLAYRLFADADNRMNCNLQQVDGGILVVSQFTLAADTKKGLRPSFSSAAPPAQAQQLYDYFVTQLRSRHAKVATGIFAADMQVSLVNDGPVTFMLEMD
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By rec...
P06504
MSKAGTKITFFEDKNFQGRHYDSDCDCADFHMYLSRCNSIRVEGGTWAVYERPNFAGYMYILPRGEYPEYQHWMGLNDRLSSCRAVHLSSGGQYKLQIFEKGDFNGQMHETTEDCPSIMEQFHMREVHSCKVLEGAWIFYELPNYRGRQYLLDKKEYRKPVDWGAASPAVQSFRRIVE
Crystallins are the dominant structural components of the vertebrate eye lens. Monomer. Has a two-domain beta-structure, folded into four very similar Greek key motifs. Belongs to the beta/gamma-crystallin family.
Q1JM42
MELQFLGTGAGQPAKQRNVSSLALKLLDEINEVWMFDCGEGTQRQILETTIKPRKIRKIFITHLHGDHIFGLPGFLSSRSFQASEEQTDLDIYGPIGIKTYVLTSLKVSGARVPYQIHFHEFDDKSLGKIMETDKFEVYAERLAHTIFCMGYRVVQKDLEGTLDAEALKAAGVPFGPLFGKIKNGQDVELEDGRLICAKDYISAPKKGKIITIIGDTRKTSASVKLAKDADVLVHESTYGKGDERIARNHGHSTNMQAAQIAHEAGAKRLLLNHVSARFLGRDCRQMEKDAATIFENVKMVQDLEEVII
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the ...
Q04E23
MAKKDKHDDALARNRRASFNYFIGETYEAGIQLTGTEIKSVRLGQITIGDAYITVRDQQAFLNNANISPYKQGNQFNVDPLRRRKLLLHKKEILALDRAVSKEGKTIVPLRVYIVKGFAKILIAIGTGKKNYDKRQTIKERDLKRELGKNLKNFH
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemb...
B7JJ50
MNEQQRLASQQVNSSTKKEEKDYSKYFESVYQPPSLKDAKKRGKEEVKIERDFGLPEEFRNFGTGRKFYIRTYGCQMNEHDTEVMAGIFTALGYEPTFSTEDADVVLLNTCAIRENAENKVFGELGHLKSLKRRNPDLLIGVCGCMSQEESVVNKIMQKNQHVDMVFGTHNIHRLPYILKDAMFSKETVVEVWSKEGDVIENLPKVRRGDIKAWVNIMYGCDKFCTYCIVPYTRGKERSRRPEDIIQEIRHLAANGYKEITLLGQNVNAYGKDFEDIEYGLGDLMDELRKVDIARIRFTTSHPRDFDDHLIEVLGKGGNL...
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-me...
Q8P001
MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTREEFEELIKTGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVFVFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALMREYDYAVVNDEVALAAERVKRIIETEHFRVERVIGRYDKMIKITKNPFKAK
Essential for recycling GMP and indirectly, cGMP. ATP + GMP = ADP + GDP Belongs to the guanylate kinase family.
O27957
MLYLGVIGYPIKHSVSPAMHNAALQHEGIEGIYLAFEVKPDRLRDAVFGAKALGFRGLNVTIPFKESVVEFVELEGEAAKIKTVNTIDLVEMVGYNTDVYGVKAALSGTELGGKTALVVGAGGAGKAAALALLDMGSTVIVANRTEEKGREAVEMLRRYGECIFWPLSRVEELKGKVDVVVNATPLGMRGFKAEIPVPPSMLDGVELVFDTVYNPMETPLIREAKKRGCKVVYGIEMLVHQGAKAFEIWTGIEPDVGVMREAALRALRF
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH Metabolic intermediate biosynthesis; chorismate biosynthe...
B4S5M6
MELKVINTAGAETGEVISLDDKVFAAKVSEHAVYLDVKSLLANKRQGTHKVKNRSEVRGGGKKPYRQKGTGHARQGSSRSGLMSGGGSIFGPQPHGYDLKVNRKIKRLARRSALSSKAGEGRIIVIEDFTFEQIKTRQFADILKNLGLDQKKTLVLLPEHNEIINRSGRNIPVLNIRVADQASTYDILDCQTVVMQKAAVKKIEETLA
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. Forms part of the polypeptide exit tunnel. Part of...
Q2GLH3
MVGYIGDIHISESDAEVAECLSAEYKRQNTSLQMIASENFVSRAVLQAQGSVLTNKYAEGYPGSRYYCGCSEVDVAETLAVERLCKLFGCKYANVQPHSGSQANQQVYMALLKPGDTVLGMSLDSGGHLTHGAGPNVSGKWFNAVPYNVRRDTNLLDMGEIEEIALRVKPNLIIAGASSYPRRIDFKAFRAIADKVGAYFLADIAHYSGLIAGGQYPTPFGYAHVVTSTTHKTLRGPRGGVIMTDDEEIHKKLRSAVFPGMQGGALMHVIAAKAVAFREAMSPDFKVYVSQILDNSRALAAVLATGGLDVVTGGTDSHMV...
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent a...
Q7U9K4
MDTHAFKRSLHHSERYNRRGFGRAEEVAESLEQAYQSGLIGTIRDNGYKLSHGRLTVRLAEAFGFCWGVERAVAMAYETRKHYPAERLWITNEIIHNPSVNDHLREMDVQFIPVEQGVKDFSGVTSGDVVILPAFGATVQEMQLLNERGCHIVDTTCPWVSKVWTTVEKHKKHTITSIIHGKVKHEETLATSSFAGTYLVVLDMEEAQIVADYILGKGDRDAFMQRFSAACSPGFDPDRDLSRLGVANQTTMLKSETEEIGRLFERTMLSKYGPAELNDHFVAFNTICDATQERQDAMFSLVDEPLDLMVVIGGFNSSNT...
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredox...
Q1C744
MKLLKDSGAALLALFFVLVYLLPVNSRLLWQPDETRYAEISREMLQRGDWVVPYFMDIRYFEKPVAGYWFNNISQWIFGDSNFAVRFGSIFSTALSAVLVYWLATLLWRNRSTSVLATLIYLSFLLVFGIGTYAVLDPMISLWLTAAMVSFYLTLKAENWQQKVGAYALLGVACGMGFMTKGFLALAVPVIAVLPIVIQQKRIKDLVVFGPIAIVCAVLLSLPWALAIAQREPDFWNYFFWVEHIQRFAEASAQHKSPIWYYLPILCIGVLPWLGLLPGALFKGWRERATKPELFFLLSWVVMPLLFFSVAKGKLPTYIL...
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate...
A8Z1Q8
MEHTIAVIPGSFDPITYGHLDIIERSTDRFDEIHVCVLKNSKKEGTFSLEERMDLIEQSVKHLPNVKVHQFSGLLVDYCEQVGAKTIIRGLRAVSDFEYELRLTSMNKKLNNEIETLYMMSSTNYSFISSSIVKEVAAYRADISEFVPPYVEKALKKKFK
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Homohexamer. Belongs to the bacterial C...
Q979T3
MGRKEDNIEKALRIVEHTELVRNIGIVAHIDHGKTTLSDNLIAGAGMMSEELAGKQLVLDYDEQEQARGITINAAVASMVHAFQGKEYLINLIDTPGHVDFGGDVTRAMRAVDGVIVVVDSVEGVMPQTETVIRQALREYVKPVLFINKIDRLINELRLNSDEMQKRFTKIISDVNKLISKYAPKEFTKEWQVSVQDGKVAFGSAYNNWAISVPSMAETKITFKDIVEYVKNGKQKELAQKNQLHKIILNMVIRHLPDPKTAQSYRIKQIWKGDLETEVGKSMVSCDFKGPVAMMVTKIIIDPHAGEIAIGRLFSGTVKK...
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respective...
Q4UT63
MHRIAVPAAKGAPTAQAPVKVAARNLDFYYDKYHALKGINIEIPEKRVTALIGPSGCGKSTLLRIFNRIYALYPKLEARGEVLLDGENILSPKYPMNRLRSKVGMVFQKPVPFPMTIFENVAYGIRHHEKLSKADMQNRVEHALRQGALWDEVKDKLGQSALGLSGGQQQRLCIARAVALRPDVLLLDEPTSALDPISTSRIEQLVEELKRDYTIVIVTHNMQQAARVSDYTAFMYLGDLIEHDRTETIFSQPSKQQTEDYITGRFG
Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system. ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in) The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein...
A1INV5
MPDFSMSNLAVAFSITLAAGLFTVLGSGLVMFSKTPNPRVLSFGLAFAGGAMVYVSLTEIFSKSSEAFAEIYDKDHAFAAATMAFLAGMGGIALIDRLVPNPHETLDAQDPSFQESKRRHIARVGMMAAFAITAHNFPEGLATFFATLENPAVGMPLALAIAIHNIPEGISIAAPVYFATRSRKKTVWACLLSGLAEPLGAALGYLVLQPFLSPAVFGSVFGVIAGVMVFLALDELLPAAKRYSDGHETVYGLTMGMAVIAVSLVLFHF
Mediates zinc uptake. May also transport other divalent cations (By similarity). Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
Q15UW6
MNLHEYQGKQLFAEYGLPVSEGYAAETPQAAVEAADRIGGTEWVVKCQVHAGGRGKAGGVKLVKNKDEIKAFAQKWLGQNLVTYQTDEAGQPVSKILVESCTDIAQELYLGAVVDRASRRVVFMASTEGGVEIETVAEETPEKILKAEIDPLVGAQPYQAREIAFKLGLKGVQIKQFTQIFMGLAKLFEEKDIALIEVNPLVIKDDGNLHCLDAKVAMDSNAAYRQPKLQEMHDPSQEDAREAQAAKWELNYVALDGNIGCMVNGAGLAMGTMDIVNLHGGSPANFLDVGGGATKERVAEAFKIILSDSNVAAVLVNIFG...
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinat...
Q313K7
MTKKKSSGGALIAQNKKARHLYELLEFFEAGIALAGTEVKSLRAGQVSFTDSYVTIHNNEAWIVGMHIAPYANAGYVQHDPDRDRKLLLHAREIDTLRARVEQKGLTVVPVKLYFKNSRVKLEIAVGRGKKLHDKRQDIKQRDVERETRREIMRH
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemb...
Q8NLG1
MKLILTAAVENLGVAGDIVEVKNGYGRNLLLPRGLAIVATPGAEKQIEGIKRAQEAREIRDLDHAREVKVALEALEGVTIAVRTSESGKLFGSVKTDDIVDAVKAAGGPNLDKRAIVLPKNLVKTTGKYQVEAKLTDGIVSRVKFEVVAA
Binds to the 23S rRNA. Belongs to the bacterial ribosomal protein bL9 family.
A7X426
MHFETVIGLEVHVELKTDSKMFSPSPAHFGAEPNSNTNVIDLAYPGVLPVVNKRAVDWAMRAAMALNMEIATESKFDRKNYFYPDNPKAYQISQFDQPIGENGYIDIEVDGETKRIGITRLHMEEDAGKSTHKGEYSLVDLNRQGTPLIEIVSEPDIRSPKEAYAYLEKLRSIIQYTGVSDVKMEEGSLRCDANISLRPYGQEKFGTKAELKNLNSFNYVRKGLEYEEKRQEEELLNGGEIGQETRRFDESTGKTILMRVKEGSDDYRYFPEPDIVPLYIDDAWKERVRQTIPELPDERKAKYVNELGLPAYDAHVLTLT...
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated ...
A1T5H1
MTTPLTFDNIRRAPKALLHDHLDGGLRPSTVLELAEQYGYEDLPAHDADGLATFFRTAAHSGSLVRYLEPFAHTVGVMQNPDALHRVARECVEDLAADNVVYAEVRFAPELHIDGGLSLDAVVDAVLAGFADGEKAAAADGRAITVRCLVTAMRHAARSREIAELAIRFRDKGVVGFDIAGAEAGYPPSRHLDAFEYMRSNNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDIEIDADGNAKLGRLASLLRDKRIPFEMCPSSNVQTGAVASIAEHPFDRLARLRFRVTVNTDNRLMSDTSMSMEMLRLVEAF...
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subf...
B4SYJ9
MKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLANELERWKQDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine Homodimer. Belongs to the RNA methyltransferase RlmH family.
A6WS34
MSAAIVNAVKQCGYFNQGQCLSCRHIQQPLAQQVAVKTQTLQQLLAPFIPANSAELFLPPITGDDSGFRNKAKMVVLGAAHEPVLGIVSPSGEAVDLCDCLLYPGDMQALLHRLTRFVQQAGLPPYRVDKAKGELKFILLTRSQVRGEYLLRFVLRSHNGIERIERELPALLAEYPQIKVVSVNIQPIHMAILEGDEEIFLTENTRLEERFNHVPLFIRPKSFFQTNPQVAAQLYQTARDWVAEFSPRSLWDLFCGVGGFGLHCASNDITLTGIEIEAEAIACAQMSAQMMGLENVQFMALDSTDFAKGKSAADKPDLII...
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA. S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfami...
Q07VD3
MPDPMRSYLDFEKPVAELDSKIDELHALAAGGSNIGEEIAKIEEKALAALTELYAALTPWQKTQVARHPQRPHCVDYIEGLITEFTPLAGDRKFGEDEALIGGFGRFRGESVCVLGQEKGFSTETRLKHNFGMARPEGYRKAVRLMEMADRFGLPVLSLVDTAGAYPGIGAEERGQAEAIARSTEACLKLGVPNVAVVIGEGGSGGAIAIATANKVLMLEHAIYSVISPEAASSILWRDSSKAQEAATSMKITAQDLLRFGVIDQILTEPRGGAHRDSAAMIAKAGDAIAKSFADLSSLDSDAIRAQRRQKFLDIGRKLG
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-...
Q81E30
MEKVDVKESAVGREMRIRKQWNEQNIFEQSIQNREGAQSFVFYEGPPTANGLPHVGHALGRTIKDLVARYKTMAGYKVLRKAGWDTHGLPVELGVEKQLGISGKHEIEEYGIEPFIQKCKESVFTYEKQWREFTESIGYWVDMDDPYVTLKNPYIESVWHILGTIHEKGLLYKGHRVSPYCPSCQTSLSSHEVAQGYKTVKDLSATVKFKVKDSENEYFLGWTTTPWTLPANVALAVHPNMEYVKAKQESHVYIVAKERVQEVLKENYEVLSVHKGEELLNTSYTAPFPMKEVTNGYRVIAADFVTGDSGTGLVHIAPAY...
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrol...
Q5E8Q8
MIIKQLPLTDLHRHLDGNIRIETILDLGQKFGLDLPAYDIEALRPHVQIVEAEPSLVAFLSKLDWGVAVLGDLDACRRVAYENVQDAMNAQIDYAELRFSPYYMAMKHNLPIAGVVEAVVDGVEAGCRDFGIKANLIGIMSRTFGQDACQQELDGLLTQKHKLVAIDLAGDELGQPGDLFVNHFKQVKDADLRVTVHAGEAAGAASMWQAINELGAVRIGHGVKAIEDPKLMEYLAKNNIGIESCLTSNIQTSTVASFESHPIKTFLDYGVKVCLNTDDPAVEGIELPHEYEVAAPKVGLTPEQLKQIQINGLDLAFLSD...
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. adenosine + H(+) + H2O = inosine + NH4(+) 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) Binds 1 zinc ion per subunit. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subf...
B8K287
MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKA...
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:...
Q9CUH3
MKLIIYLTILAGTALVTHSSVQKEDHAPYLAYLKSNFNPCVGVLIKASWVLAPSHCYLPNLRVMLGNFKSRVRDGTEQTIYPIQIIRYWNYSHTAPQDDLMLIKLAKPATFNHKVQVLPIATTNVRPGTVCTLSGLDWSQENNGRHPDLRQNLEAPVMTDKDCQKTQQGSSHRNSLCVRFVKVFSRIFGEVAVATVICKNKLQGIEVGHFMGGDVGIYTNIYSYVPWIEKTTKEKMT
Plays a role in male fertility (PubMed:23553430). May have a role in sperm migration or binding to zona-intact eggs (PubMed:23553430). Involved in the activation of the proacrosin/acrosin system (By similarity). Testis-specific (PubMed:23553430). Expressed in spermatids (PubMed:23553430). Weakly expressed in mature spe...
Q72DU5
MPPRPQRLAPVADLPPVFAGIDEAGRGCLAGPVVAAAVILPQEYALPGLTDSKKLTAARRESLAEGIRSCAVTWGIGVVWPRDIDRINILQATFRAMARAVRVLRQPPPAILIDGDKTLPPHVLTSLSCDGHLPTQRAIIGGDGCIPAISAASILAKTFRDRLMDTLDRRYHGYGFAKHKGYGTAEHLAAIAAHGPCAQHRLTFRGVRPNPAAEEQLTLW
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Endonucleolytic cleavage to 5'-phosphomonoester. Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. Belongs to the RNase HII family.
A8M2A2
MATRDSGGQSQTGRSQQGEEIEDVTTEASPEVAERHAEITEDVDDLLDEIDSVLEENAEEFVRGYVQKGGE
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Protein degradation; proteasomal Pup-dependent pathway. Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic i...
Q8HZN8
FNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRH...
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity...
Q1JF50
MRYNQFSYIPTSLERAAEELKELGFDLDLQKTAKANLESFLRKLFFHYPDSDYPLSHLIAKNDMDALSFFQSEQELSKEVFDLLALQVLGFIPGVDFTEADAFLDKLAFPIHFDETEIIKHIHHLLATRCKSGMTLIDDLVSQGMLTMDNDYHFFNGKSLATFDTSQLIREVVYVEAPLDTDQDGQLDLIKVNIIRPQSQKPLPTLMTPSPYHQGINEVANDKKLYRMEKELVVKKRRQITVEDRDFIPLETQPCKLPIGQNLESFSYINSYSLNDYFLARGFANIYVSGVGTAGSTGFMTSGDYAQIESFKAVIDWLNG...
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Hydrolyzes Xaa-Pro-|- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-|-p-nitroanilide and (sequentially) Tyr-Pro-|-Phe-Pro-|-Gly-Pro-|-Ile. H...
Q7D7Q0
MTYVLDTNVVSALRVPGRHPAVAAWADSVQVAEQFVVAITLAEIERGVIAKERTDPTQSEHLRRWFDDKVLRIFVFARRGTNLIMQPLAGHIGYSLYSGISWF
Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB14 (By similarity). Belongs to the PINc/VapC protein family.
A8GYX9
MAVIKCKPTSPGRRHLVKVVNSDLHKGKPFAGLLAKKSKSGGRNNTGRITVRHIGGGHKQHYRLIDFKRNKDGIPAKVERLEYDPNRTANIALVLYADGERRYILAAKGMKAGDKIQSGIDAEIKSGNALPLRNIPVGSVVHAVEMKPAKGAQIARSAGAYVQVIARDGAYATLRLRSGEMRKVPVDCRATLGEVGNAEHMLRQLGKAGAKRWRGVRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGQPTKGYKTRSNKRTDKYIVRRRNKK
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. ...
Q4V7W5
MTSGNGSSPVPTAATGNRTQNGENKPPQAVVKPQILTHFIEGFVIQEGAQPFPSHRSRAVLEVGHSSLLTGAQEKYQQSLLAEKVPQQDNNTTTTTTDSEMEETLVPGFPESKGDGDPPKLKCELCGRVDFEYKFKRSKRFCSMACAKRYNVGCTKRVGLFHPDRSKLQKPTVAKHARRRSRKTPLQTVGADPKKQQAAPVTPMNPGPIPSPSALKLSNSQEDSSRCSDNSSYEEPLSPMSASSSLSRARQEHNVEPPNLHSRDPIAMSQDFLPSDPTKWNVEDVYDFVRSLPGCQEISEEFRAQEIDGQALLLLKEDHL...
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histo...
Q9HJ17
MYKGIVTPMITPMGQNGEIDYRATEILIDNLADFGVDGLFPMGSTGLFPMFSTDEKKKFLGFVRDHSKKIEVYAGVGSSSTQESVELSKYTEDIGIKVRVLMPTYYIKPDEDWMYRHFSTVISAASNDLFIYNIPQLSGSWISESLIEKLTREFSNVKGIKDSSGDMRFFSRIIRHKNEKFDIFQGQDDLLFLSLSIGASGGVCGLSNISPYITNLYHEFSAGNLEKARKIQIDEVNPLMYAINEATFPAGYYYAFYKMNGIKGGYRAPMVEPTTDQKKKIDQELTKIPKKQ
Homotetramer. Belongs to the DapA family.
Q13520
MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTSGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV
Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Belo...
Q62821
MSSEQVRAGSPGSRVPGARRTGAVWTAPSENLDSSTIPALCVSLLFPSQPLDVVVTMGHNTLGMRQLWKLALQRPQLLSGSTGVKPQWQQTAPSFHLNVKQENPIEPYNVKNEQSYAEYMEHFGKKGKLLDQIDDTRSAPSTSRSKVKSPHKERENFRSTLVNVIMQQDSSLEPDVTDESGIPKATTSAIEKDILRYYYYIHHGIDTDNVAPMEDSWLEHVLQLVPQHLKVLTNSITVLSDEMREDYLLSVKKSIVDFVLKDPREKEDDTKITELPPHRAEMEVLPKPWRRSFLSACSYIRDHLNAMNPTMLAVLDLWHS...
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). The dynein complex consists of at least two heavy chains and a number of intermediate and light chains...
A4TMZ6
MSVVPVVDVLQGRAAVGSEVTVRGWVRTRRDSKAGISFVAVYDGSCFDPLQAVVNNTLPNYQDEVLHLTTGCSVEVTGTVVASPGEGQSFEIQATAINVVGWVDDPDTYPMAAKRHSIEYLREVAHLRPRTNLIGAVARVRHTLAQAIHRFFDENGYFWVSTPLITASDTEGAGEMFRVSTLDLENLPRTDTGAVDFSEDFFGKEAFLTVSGQLNGETYACALSKVYTFGPTFRAENSNTSRHLAEFWMVEPEVAFASLDDVAGLAEKMLKYVFQAVLNERADDMKFFAERVDKDAVDRLQRFVTSDFAQVDYTDAIEIL...
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn) Homodimer. Belongs to the class-II aminoacyl-tRNA synthetase family.
Q2GDJ8
MTVIKELNFGPQHPAAHGVLRLIMQLDGETVERLDPHIGFLHRGTEKLIEHKTYLQALPYFDRLDYVSPMAQEHAYSLCVEKLLGITVPPRAQYLRVIFVEITRILNHLLNVTTHALDVGAMNPLFWMFEEREKMLSFYEKASGARFHAAYIRPGGLAADIPDGLDEEIMSFLESFTHKLDDVADVLTDNPIFKQRLVDIGKVSKREAVALGFSGPVLRASGVPWDLRKSQPYEVYESLDFAIPVGSCGDSYDRYLVRMAEMYESVKIIKQCIDKLPEGPVVVDDRKVAPPSRAEMKTSMEALIHHFKLYSEGYHVPEGE...
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t...
P49504
MPVKEKVGIVVSNKMQKTIVVKVESRYSHPIYSKTMTKTRKYLAHDEMGECNIGDQVLVQECRPLSKRKRWTLSKVLSKSSLVS
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. Part of the 30S ribosomal subunit. Belongs to the universal ribosomal protein uS17 family.
B8BJ22
MAAAPVLLLAAAAAVVVVAMVLRWLLLLGGPAAGRLGKRALMPPGSTGLPLIGETLRLISAYKTPNPEPFIDERVARHGGVFTTHVFGERTVFSADPAFNRLLLAAEGRAVHSSYPSSIATLLGARSLLLTRGAAHKRLHSLTLTRLGRPASPPLLAHIDRLVLATMRQWEPAATVRLMDEAKKITFNLTVKQLVSIEPGPWTESLRREYVKLIDGFFSIPFPLANLLPFTTYGQALKARKKVADALREVIKKRMEEKAENGGSIGDDEGKKEKKDMVEELLEAEGGSFSEEEMVDFCLSLLVAGYETTSVLMTLAVKFL...
Catalyzes the C23-alpha-hydroxylation step in brassinosteroid biosynthesis (By similarity). Converts 6-deoxocathasterone (6-deoxoCT) to 6-deoxoteasterone (6-deoxoTE) in the late C6-oxidation pathway and cathasterone (CT) to teasterone (TE) in the early C6-oxidation pathway of brassinolide (BL) biosynthesis (By similari...
Q98N66
MAQTQTFNGRRRVRKFFGKIPEVAEMPNLIEVQKASYDQFLMVDEPKGGRPDEGLQAVFKSVFPISDFSGSSMLEFVKYEFEGPKFDVDECRQRDLTYAAPLKVTLRLIVFDIDEDTGAKSIKDIKEQDVYMGDMPLMTLNGTFIVNGTERVIVSQMHRSPGVFFDHDKGKSHSSGKLLFAARVIPYRGSWLDIEFDSKDVVHARIDRRRKIPVTSLLMALGMDGEEILSTFYNKITYVRAGDHWRIPFNVERFRGLKAVGDLVDADTGEIVVEAGKKITARQARQLGEKGLKAIKATDEDLLGNYLAEDIVNYATGEIF...
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with ...
B8ZKQ6
MAYRKLGRTSSQRKAMLRDLTTDLLINESIVTTEARAKEIRKTVEKMITLGKRGDLHARRQAAAFVRNEIASENYDEATDKYTSTTALQKLFSEIAPRYAERNGGYTRILKTEPRRGDAAPMAIIELV
Part of the 50S ribosomal subunit. Contacts protein L32. Belongs to the bacterial ribosomal protein bL17 family.
Q5FLX8
MLQPIGDRVIVKVKEEEEKTVGGIVLASNAKQKPTEGEVVAVGEGAYTSNGDKLPMVVKKGDVVLYDKYSGTNVEYEGEKYLVLHEKDILAIEK
Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of ...
Q30KM0
MALIKKTFFFLFAMFFILVQLSSGCQAGLDFSQPFPSGEFAVCESCKLGRGKCRKECLENEKPDGNCRLNFLCCRQRI
Has antimicrobial activity. Belongs to the beta-defensin family.
Q55GG1
MNPIQPIPKSKIEIRIKCKDLTSKDLLSQSDPQAIVYLKQQQRNDWIQQGKTEKLKNQKSPEFKQSITVDYHFEEVQLLKIVVIDIDKDIKLLKDFDDHDLIGEVNVSLGSILSSPGGRMKMSLTKNGILSGSITISTEEIRETGANIYFALEGNHLDKKDLLSSDPYFKIYKSGGTLVYQSDVIKNTLNPTFPPVYLKLEELNGGDMFRELTFEFMDWDKIGDHDLIGRFTTNTDTILRGGALEFEIINPKKVGKSGYKNSGIIKFYIARIQGDPTFLDYLHGGLEINLMVAIDCTASNMPPDVSTSLHYNTPTQPSQY...
Expressed at relatively high levels in vegetative cells. The expression goes down until the 8th hour of development and then goes up at 14 to 16 hours. Belongs to the copine family.
Q0WWH1
MESIMEEADSYIEYVSVAERRAIAAQKILQRKGKASELEEEADKEKLAEAKPSLLVQATQLKRDVPEVSATEQIILQEKEMMEHLSDKKTLMSVRELAKGITYTEPLLTGWKPPLHIRKMSSKQRDLIRKQWHIIVNGDDIPPPIKNFKDMKFPRPVLDTLKEKGIVQPTPIQVQGLPVILAGRDMIGIAFTGSGKTLVFVLPMIMIALQEEMMMPIAAGEGPIGLIVCPSRELARQTYEVVEQFVAPLVEAGYPPLRSLLCIGGIDMRSQLEVVKRGVHIVVATPGRLKDMLAKKKMSLDACRYLTLDEADRLVDLGFE...
ATP + H2O = ADP + H(+) + phosphate The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. Belongs to the DEAD box helicase family. DDX41 subfamily.
Q9SVW1
MAVPLLTKKVVKKRSAKFIRPQSDRRITVKESWRRPKGIDSRVRRKFKGVTLMPNVGYGSDKKTRHYLPNGFKKFVVHNTSELELLMMHNRTYCAEIAHNVSTKKRKAIVERASQLDVVVTNRLARLRSQEDE
Belongs to the eukaryotic ribosomal protein eL32 family.
B5XRE3
MASYDLVERLNDTFRQIELELQTLQQALSSCRLLAARVFELPAVSKDAEHDPLANIPVVQHSGKAALALALRHYSHLFIQQQSENRSSKAAVRLPGAICLQVTAAEQQDLQARIQHINALKATFEKIVTVDSGLPPTARFEWVHRHLPGLITLSAYRTLTPLIDPSTIRFGWANKHVIKNLTRDQVLMMLEKSLQSPRAVPPWTREQWQSKLEREYQDIAALPQRARLKIKRPVKVQPIARVWYASEQKQVQYACPSPLIALISGSQGVSVPDIGELLNYDADNVQYRYKPEAQSLRLLIPRLHLWLASE
Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence. Belongs to the Tus family.
P81509
DCPSDWSSYEGHCYRVFQQEMTWDDAEKFCTQQHTGGHLVSFRSSEEVDFLVSILKFDLFWMGWRDIWNERRLQWSDGTKVNYKAWSAEPECIVCRATDNQWLSTSCSKTHNVVCKF
Binds to the subunit GPIbalpha (GP1BA) of the platelet GPIb/V/IX receptor system. It inhibits ristocetin- and vWF-induced platelet aggregation in platelet-rich plasma by inhibiting the binding of vWF to GPIbalpha. Heterodimer of subunits alpha and beta; disulfide-linked. Expressed by the venom gland. Belongs to the sna...
A6V7Y9
MNADHAPFRHYLDLADARLGSQVVAVSDEWFAPASRMLQAGEPVWKEGVFDDSGKWMDGWETRRKRFEGHDQAVIRLGVSGVLKGVDIDTRFFTGNHPPAASLDGCFCAEGDPDDGTSWSEVLPSVELQGDRHHYHAIDDERPWTHLRLNIYPDGGIARLRVYGVPYRDWRSQTPGTALDLAAAINGGRALACSDQHFGPMVNLLKPGRALNMGDGWETGRRRTPGHDWAIIALGHPGSIEAAVVDTLHFKGNYPESCSIQAAFVEDGNEARIEAQSLFWRELLPAQKLEMHHEHRFERQLNALGPVSHVRLNIFPDGGV...
allantoate + H2O = (S)-ureidoglycolate + urea Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1. Belongs to the allantoicase family.
B1LM86
MKKPVVIGLAVVVLAAVVAGGYWWYQSRQDNGLTLYGNVDIRTVNLSFRVGGRVESLAVDEGDAIKAGQVLGELDHKPYEIALMQAKAGVSVAQAQYDLMLAGYRDEEIAQAAAAVKQAQAAYDYAQNFYNRQQGLWKSRTISANDLENARSSRDQAQATLKSAQDKLRQYRSGNREQDIAQAKASLEQAQAQLAQAELNLQDSTLIAPSDGTLLTRAVEPGTVLNEGGTVFTVSLTRPVWVRAYVDERNLDQAQPGRKVLLYTDGRPDKPYHGQIGFVSPTAEFTPKTVETPDLRTDLVYRLRIVVTDADDALRQGMPV...
Belongs to the UPF0194 family.
Q7XY82
MAFISGPALPTARVNRTVAATPVRMASGEDTPVVSRRALLSSTLAAAAAALLSAAAPAKADREYGNVGFLGGGDKIDVNNANVRVYGRLPGMYPTLAGLIVANGPYKSVGDLYNIPGLDDKQTGLLKKYEDSFVALEPRPEYEIDKFNNGLYR
Stabilizes the structure of photosystem II oxygen-evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation. The oxygen-evolving complex in red algae is composed of PsbO (OEC33), PsbQ', cytochrome c-550 and PsbU. Associated with photosystem II at the lumenal ...
Q6B8U0
MLDIISLGWGSLLAIFSFSIALVVWGRNGF
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. The 4 large subunits of the cytochrome b6-f complex are cytochrome b6, subunit IV (17 kDa polypeptide, PetD), cytochrome f and the Rie...
P37282
MSKDIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIELAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYISDAMERVGSDGVITIEESKGMQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILKTNRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVITEELGLDLKDATLEALGQAAK...
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. ATP + H2O + a folded polypeptide =...
Q14C12
MAPRPLGPLVLALGGAAAVLGSVLFILWKAYFGRGRERRWDRGEAWWGADTARLPQWDEWEPEDEEDEPALEELEQREVLVLGLDGSGKSTFLRMLAGKPPVEGHVPTWGFNSVRLPTKNFEVDLLEIGGSQNLRFYWKEFVNEVDVLVFMVDSTDRLRLPWARQELQKLLDRDPDLPVVIVANKQDLSGAMNMVELQQELGLLASYNQREVFLLAASIAPAGSGFGEPGTVHIWKLLLQLLS
Belongs to the small GTPase superfamily. Arf family.
V5IPD9
MSLPRRPGPSPPHEEPRRYRQSGSRRSRPPPADVETGYAPMAGERPSQQQRVPSISSFPETLPSPNPNVERDPLAPTPEPAHPSGIPQRKRSLIRPERNRIGKDHPNYHYRKHAANMNTLPSSTGHDPIYEDLEGATDDVSGTGSRNDDDVSEESPPRRKHSTKMQVIETEKSGDERRRRRKSDTTKHGKIVKASKGKREKSGGLPTPSFWNIYCGFVTFWCPGFVLKCFGMPEMAQQRAWREKMGLISIILLIMGFVGFITFGFTQVVCGKPPLRLRINEVGSGYMIFHGSAYDLTKSHHPPAEGIPRRPDGLGANVIY...
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP Belongs to the...
C4K2H7
MSSYKYYDLIRKPIITEKTTTLSEQNKYAFYVDKFAEKLTIKKAIEEIFKVKVKKVNILNVKGKKKRFKGIIGTQINRKKAIVTLEKDHNIDFAGGIK
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome. Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the...
Q2G8E3
MRAMQTHTEIAPMPIPGHVDPVPVPREVTPREDGRIDLIGLPRKQIAELFAQAGLDAKAAKLRAKQVFHWLYHRGVTDFDAMTDIAKTMRPWLAERFVIGRPEIVEAQVSTDGTRKWLLRTADKHDFEMVFIPDADRGTLCVSSQVGCTLNCRFCHTGTMRLVRNLTPGEIVGQVMLARDALGEWPKGANDSRVATMAGLDFDDEDEGSYTSDGRLLTNIVMMGMGEPLYNFDNVRDALKLVMDGDGLALSKRRITLSTSGVVPMMERCGEEIGVNLAVSLHAVTKDVRDEIVPINRKYGIEELLQACADYPGASNARRI...
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity. adenosine(2503) in 23S rRNA + 2 reduced [2Fe-...
Q5N893
MVPREQAEEAIVADSNGKEEEVGVMGVSAGEHGADDHHGGGGKFSMKNLLWHGGSVWDAWFSCASNQVAQVLLTLPYSFSQLGMLSGVLLQLFYGFMGSWTAYLISVLYVEYRSRKEKEGVSFKNHVIQWFEVLDGLLGPYWKAAGLAFNCTFLLFGSVIQLIACASNIYYINDRLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLGMTTYTAWYLAIAALLNGQAEGITHTGPTKLVLYFTGATNILYTFGGHAVTVEIMHAMWKPAKFKYIYLLATLYVFTLTLPSASAMYWAFGDELLTHSNAFSLLPKTGWRD...
Carrier protein involved in proton-driven auxin influx. May mediate the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips (By similarity). Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.1) subfamily.
Q2U9B0
MPVAEASPVASSEPGFVKMEDRKRAATSDHNDSAPPLKKQATSVNGGSKPHPDADMPWKDDLEVSLGLAGVVGFMSFQGGLRYPSSAEPTTSLTIKDAIWRQMQEYKREKVSLEAKLKDMSKAATRHNEHLRVIDTWYNQVCGSTLIDEVKLLLGAAEDIKGDRPTFQSSLSFDDVDNFEKHLKSRSNDIRDIISRLVKNTPKSPPEICELQSQLAKKLAEEKATIAELDKALSEKQQLEESLEEASLRYMVAEKKLDRARSLTVAKLEKQYILGPQRPGGDSASGQREEQSVSNGATPSAERGPELDEAHNKLVAISEK...
E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine ...
Q8K997
MLKDYLEITKPRIIIGNIILIIGSFLFSSFPFFNVFLFFFTILGTSLVIASSCIFNNLIDIDIDTKMNRTKNRVLVKNLISPTSASIFASFIGIVGFFILGLFVNILSMFLSFIGFVIYVFFYTFFLKRKSMYSTFIGSFSGSIPSVIGHTAISNSIDLFCFLLFIIFIFWQMSHFYAIAILYINDYRKANLPFFPVVKGILKTKKHIFYYITCFIIASSMLTFLGYLSYIFLLFFSFFSFYWLYISYLSIREKDDRKFSSKLFYYSIAVVILFNFLISIDFIF
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1...
B8GVE7
MRVGLYPGTFDPVTNGHLDIIGRAVKLVDKLVIGVAINIGKGPLFSLEERVEILERETAHLKKIAEIEVRPFDSLLMHFARDVNAQMIVRGLRAVADFEYEFQMTAMNQQLDREIETVFLMADPRHQAIASRLVKEIATLGGDIGKFVPPGVAQQLLAKVGKG
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Homohexamer. Belongs to the bacterial C...
Q58E95
MDETDSQITCADSSVDKLSHLKRNEVKSCPLPELHGADEMLPELNKSCLTNPDILRYSRQLVLPDLGVQGQLKLSKASVLVIGCGGLGCPVAQYLAASGIGRLGLLDYDVVEMSNLHRQVLHGENRLGMSKSVSVAKTLRKLNSAVVYLPYHISLNPENALQIIQQYDIIADCSDNVPTRYLVNDTCVLAGKPLVSASALRWEGQLTVYNYHQGPCYRCLFPKPPPSETVTNCADGGVLGIVPGIIGSLQALEVLKIASGMAPSYSGVLLMFDALEGRFRNIKIRGKKNDCAACSNPSETAILQDYEAFCGSSASDKCRM...
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs...
Q8CQ78
MSEKVKFEKRESLKEKPDTANLGFGQYFTDYMLSVDYDADQGWHDMKIVPYAPFEISPAAQGLHYGQAVFEGLKAYKHNGEVVLFRPDQNFKRINNSLARLEMPEVDEEALLEGLKQLIDVERDWVPEGEGQSLYIRPFVFATEGVLGVRSSHQYKLLIILSPSGAYYGGDTLKSTKIYVEDEYVRAVRGGVGFAKVAGNYAASLLAQTNANKLGYDQVLWLDGVEQKYVEEVGSMNIFFVENGKVVTPALNGSILPGITRKSIIQLAEDLGYEVEERRVSIEELFNAYDKGELTEVFGSGTAAVISPVGTLRYEDREIV...
Acts on leucine, isoleucine and valine. 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2...
Q4WHT9
MPVTQFSHPDPYSYQTGFDSYHETEAVKGALPVGQNSPQKAPYGLYAEKLSGTAFTAPRHENKQTWVYRILPAAAHENFKAEDADSYHTSMTTETHKLHHIPNQLRWDPFDLDETVDWVHGLHLVAGAGDPTLKHGLGIILYAAGKDMGKEAFYSADGDFLIVPQHGVLDIQTELGRLMVRPNEICVIPRGVRYRVTLPAGPVRGYICELYQGHYQLPELGPIGSNCLANARDFQAPVASFEDEEEPTEWRLYSKFNNTLFSARQDHTPFDIVAWHGNYYPYKYDLGRFNTIGSISFDHPDPSIFTVLTGPSDHAGTAIA...
Homogentisate 1,2-dioxygenase; part of the L-tyrosine degradation gene cluster that mediates the biosynthesis of the brownish pigment pyomelanin as an alternative melanin (PubMed:19028908, PubMed:19715768, PubMed:22046314). The 4-hydroxyphenylpyruvate dioxygenase hppD catalyzes the conversion of 4-hydroxyphenylpyruvate...
P48585
MAIANKNIIFVAGLGGIGLDTSREIVKSGPKNLVILDRIDNPTAIAELKAINPKVTVTFYPYDVTVPVAETTKLLKTIFAQLKTVDLLINGAGILDDHQIERTIAVNFTGTVNTTTAIMEFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLARLAPITGVTAYSINPGITRTPLVHRFNSWLDVEPRVGELLLEHPTQTTLECAQNFVKAIEANKNGAIWQLDLGQLIAVEWTKHWDSHI
a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Homodimer. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
C1CHW2
MTKRVLISVSDKAGIVEFAQELKKLGWEIISTGGTKVALDNAGVDTIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDLDSHLEAAKDNKIELIDLVVVNLYPFKETILKPDVTYADAVENIDIGGPSMLRSAAKNHASVTVVVDPADYAVVLDELAANGETSYETRQRLAAKVFRHTAAYDALIAKYFTAQVGESKPEKLTLTYDLKQPMRYGENPQQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDSPTVVALKHMNPCGIGQADDIETAWEYAYESDPVSIFGGIVVLNREVDAATAEK...
(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Purine metabolism; IMP biosynthesis via de novo pathway; 5-form...
D6VVV3
MNLRFELQKLLNVCFLFASAYMFWQGLAIATNSASPIVVVLSGSMEPAFQRGDILFLWNRNTFNQVGDVVVYEVEGKQIPIVHRVLRQHNNHADKQFLLTKGDNNAGNDISLYANKKIYLNKSKEIVGTVKGYFPQLGYITIWISENKYAKFALLGMLGLSALLGGE
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:2644273, PubMed:7615509, PubMed:10206957, PubMed:11058593). Specifically cleaves N-terminal signal pept...
P08479
DPPPAIGREVDCSSYKGKGSQIACPRHLQPICGTDHNTYSNECMFCALTLNKEFEVRKLQDTACDIECTEYSDMCTMDYRPLCGSDGKNYSNKCIFCNAVVRSRGTIFLAKHGEC
This inhibitor is composed of two homologous actively inhibiting halves: one which inhibits trypsin, the other which inhibits elastase.
P31921
MLIKVNFMEHYLLNKQFELASAIKSRNKILIHKLVSDVLVSYNSLCYAVYKTLKNSDDKSSSNIQKKKKKKKNFQNLVDSLKCFVLNYDFYKIRCLNLYYLRNFIDCKDQFLHFHFLDIALQNLYSFIFFPFLESNLDKFTYGPRVFRSSIDAVKVLFLLGKQKKYSNYNKYLFCFAFNYTIVKCFDAVFNSWVLSNVSFIDKSILSFWVKNGFDNFYSGDQFFFQKKNFEINRGTSLIFLVIFNFVFMGMQFFLESSILSKFGFFSKFVLITDLNSVVILSSDLKTAKIVKSSLLIFFHSRGICQNFRDNSIVDFFCKN...
To group II intron maturases.
B8IZT9
MALEKTRGRRISVGETAVVVGAGRSGLAAARLLCREGAQVRLLDSNADAFSGREALAGELRQLGISIELGPHKPDQFENAAFVVPSPGMPVARLAGLVDEERAEILAEMELAWRYLENEPVLAVTGTSGKTTTASLAAAMLHEQGYAVFLGGNIGTPLSEYVLSGHKADVLVLEISSFQLQTCSTFCPRAGILLNITPNHLDYHKDMAEYTEAKFRLFRCQDEGDLAVLGESLRSLAARYGLKARQVYVSDAGRFSGSSLMGAHNRVNEEAAWQACRLFGVSEENAARALARFAPLPHRLERVRELEGVLFVNDSKCTTV...
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate Cell wall biogenesis; peptidoglycan biosynthesis. Belongs t...